Tag: M.W=50-100

Guin, Amit Kumar published the artcileRuthenium-Catalyzed Dehydrogenative Functionalization of Alcohols to Pyrroles: A Comparison between Metal-Ligand Cooperative and Non-cooperative Approaches, Safety of 2-Aminobutan-1-ol, the publication is Journal of Organic Chemistry (2022), 87(11), 7106-7123, database is CAplus and MEDLINE.

Herein, authors report the synthesis and characterization of two ruthenium-based pincer-type catalysts, I (X = Cl, PF₆) and II (R = H, Cl), containing two different tridentate pincer ligands, 2-pyrazolyl-(1,10-phenanthroline) and 2-(phenyldiazenyl)-1,10-phenanthroline; 2-((4-chlorophenyl)diazenyl)-1,10-phenanthroline), and their application in the synthesis of substituted pyrroles via dehydrogenative alc. functionalization reactions. In catalyst I (X = Cl, PF₆), the tridentate scaffold 2-pyrazolyl-(1,10-phenanthroline) is apparently redox innocent, and all the redox events occur at the metal center, and the coordinated ligands remain as spectators. In contrast, in catalysts II (R = H, Cl), the coordinated azo-aromatic scaffolds are highly redox-active and known to participate actively during the dehydrogenation of alcs. A comparison between the catalytic activities of these two catalysts was made, starting from the simple dehydrogenation of alcs. to further dehydrogenative functionalization of alcs. to various substituted pyrroles to understand the advantages/disadvantages of the metal-ligand cooperative approach. Various substituted pyrroles were prepared via dehydrogenative coupling of secondary alcs. and amino alcs., and the N-substituted pyrroles were synthesized via dehydrogenative coupling of aromatic amines with cis-2-butene-1,4-diol and 2-butyne-1,4-diol, resp.

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Safety of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Podjed, Nina published the artcileStructural diversity and magnetic properties of copper(II) quinaldinate compounds with amino alcohols, COA of Formula: C4H11NO, the publication is New Journal of Chemistry (2022), 46(15), 6899-6920, database is CAplus.

The reactions between [Cu(quin)₂(H₂O)] (quin^– = the anionic form of quinoline-2-carboxylic acid) and a series of aliphatic amino alcs. have yielded structurally very diverse copper(II) complexes, labeled a–g. Single-crystal X-ray structure anal. has revealed either intact amino alc. mols. or amino alcoholate ions serving as ligands. In type a complexes, the amino alcs. are bound in a monodentate manner via NH₂. Engagement of both functional groups in coordination was observed for types b and e (a bidentate chelating mode) and type c (a bidentate bridging one) complexes. In view of the strong bidentate chelating coordination of quinaldinate in [Cu(quin)₂(H₂O)], the formation of homoleptic amino alc. complexes e was not anticipated. Equally surprising was the transformation of a mononuclear starting material into a one-dimensional (1D) coordination polymer, [Cu(quin)₂]_n (g). Spontaneous deprotonation of some amino alcs. and coordination of, thus formed, amino alcoholates via both donors also took place. Dinuclear complexes (d) contained two bridging amino alcoholates, while bidentate chelating mode was observed for type f. Interestingly, the dinuclear complex exists as two isomers which differ in the position of quinaldinates with respect to the Cu(μ-OR)₂Cu core. DFT calculations on isolated syn- and anti-[Cu₂(quin)₂(3a1pO)₂] (3a1pO^– = anion of 3-amino-1-propanol) have shown the syn isomer to be more stable. The explanation lies in the intramol. π···π stacking of quinaldinates, possible only in this isomer. Magnetic susceptibility measurements revealed antiferromagnetic interactions between S = 1/2 copper(II) spins in all the studied compounds except in [Cu(quin)₂]_n (g) for which weak ferromagnetic couplings are detected.

New Journal of Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, COA of Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Podjed, Nina published the artcileHydrogen Bonding and Polymorphism of Amino Alcohol Salts with Quinaldinate: Structural Study, Name: 2-Aminobutan-1-ol, the publication is Molecules (2022), 27(3), 996, database is CAplus and MEDLINE.

Three amino alcs., 3-amino-1-propanol, 2-amino-1-butanol and 2-amino-2-methyl-1-propanol were reacted with quinoline-2-carboxylic acid, known as quinaldinic acid. This combination yielded three salts, I [R = 3-hydroxypropylammonium, 1-hydroxymethyl propylammonium, 2-hydroxy-1,1-dimethyl-Et ammonium]. The 2-amino-1-butanol and 2-amino-2-methyl-1-propanol systems produced two polymorphs each, labeled as salts I [R = 1-hydroxymethyl propylammonium, 2-hydroxy-1,1-dimethyl-Et ammonium] resp. The compounds were characterized by X-ray structure anal. on single-crystal. The crystal structures of all consisted of protonated amino alcs. with NH³⁺ moiety and quinaldinate anions with carboxylate moiety. The used amino alcs. contained one OH and one NH₂ functional group, both proned to participate in hydrogen bonding. Therefore, similar connectivity patterns were expected. This proved to be true to some extent as all structures contained the NH³⁺•••^–OOC heterosynthon. Nevertheless, different hydrogen bonding and π•••π stacking interactions were observed, leading to distinct connectivity motifs. The largest difference in hydrogen bonding occurred between polymorphs , I [R = 2-hydroxy-1,1-dimethyl-Et ammonium] as they had only one heterosynton in common.

Molecules published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Name: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Prasad, Durga published the artcileR-VAPOL-phosphoric acid based ¹H and ¹³C-NMR for sensing of chiral amines and acids, SDS of cas: 96-20-8, the publication is RSC Advances (2020), 10(4), 2303-2312, database is CAplus and MEDLINE.

Enantiomers have significant importance in pharmaceuticals, biol. and modern chem. and therefore distinguishing and quantifying the enantiomeric forms is of utmost importance. Herein, we propose diphenyl-3,3′-biphenanthryl-4,4′-diyl phosphate (R-VAPOL-PA) as a promising chiral solvating agent to discriminate amines and acids of poly-functional groups such as chiral amines, amino alcs. and hydroxy acids. The methodol. approach involves using the nature of hydrogen bonds and ion pairs as a mode of weak interactions to form diastereomers where the probe is associated with enantiomers. The resulting diastereomer difference in the NMR spectrum enables the chiral discrimination with a complete baseline peak separation and an accurate enantiomeric excess (ee) anal. We also carried out d. functional theory (DFT) calculations to understand the complex formation to explain enantiodiscrimination by analyzing the formation and stability of different chiral complexes. The binding energy differences between enantiomeric forms revealed by DFT calculations are qual. in agreement with the diastereomer difference in the NMR spectrum and unequivocally establishes the suggested exptl. protocol of R-VAPOL-PA-based enantiomeric discrimination.

RSC Advances published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, SDS of cas: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Paul, Aparup published the artcileDNA/protein binding and molecular docking studies of two tetranuclear Cu(II) complexes with double-open-cubane core like structure, Product Details of C4H11NO, the publication is Inorganica Chimica Acta (2019), 119005, database is CAplus.

Two Cu(II) complexes [Cu₄(L)₂(HL)₂(H₂O)₂](pv)₂ (1) and [Cu₄(L)₂(HL)₂(H₂O)₂](ssal) (2) [H₂L = 2-ethoxy-6-[(1-hydroxymethyl-propylimino)-methyl]-phenol; pv = pivalate; ssal = 2-Hydroxy-5-sulfosalicylate] have been synthesized and characterized by X-ray structure determination Structure determination reveals that both the complexes are tetranuclear with double open cubane core framework, and C-H···π interactions results the formation of 1D supramol. structure. At room temperature 1 and 2 show fluorescence (λ_ex = 267 nm, λ_em = 329, 516 and 620 nm for 1; λ_ex = 277 nm, λ_em = 315 and 413 nm for 2) with fluorescence quantum yield 0.41 and 0.46, resp. Interactions of complexes with calf thymus DNA (CT-DNA), bovine serum albumin (BSA) and human serum albumin (HSA) were studied using UV-vis absorption and fluorescence spectroscopic techniques, and the calculated values of intrinsic binding constants of 1 and 2 with CT-DNA are 2.71(±0.07) × 10⁴ M^-1 and 1.58(±0.11) × 10⁴ M^-1, resp. Mol. docking technique has been used to determine the mode of interaction of complexes with CT-DNA and serum albumins. The docking studies suggest that both the complexes can interact with DNA through groove binding mode, and possible binding sites of complexes with BSA and HSA are in the proximity of Tyr149 and Tyr150, resp.

Inorganica Chimica Acta published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Han, Siyu published the artcileBiogas upgrading with various single and blended amines solutions: Capacities and kinetics, Category: alcohols-buliding-blocks, the publication is Energy (Oxford, United Kingdom) (2022), 124195, database is CAplus.

Biogas is an important renewable energy and biogas upgrading which sep. CH₄/CO₂ to increase the heating value of biogas is necessary for its utilization. Amine scrubbing is a promising biogas upgrading technol. In this study, we applied various single and blended amines solutions for biogas upgrading and reconsidered the evaluation method by comparing the equilibrium CO₂ absorption capacity (qe) and optimal CO₂ absorption capacity under 90 vol% or 95 vol% pure CH₄ requirement (q₉₀%CH₄, q₉₅%CH₄). Three apparent kinetic models and Fourier-transform IR spectroscopy (FT-IR) were applied to study the kinetics. The results showed that, compared with the qe, the new indicator q₉₀%CH₄ and q₉₅%CH₄ could better reveal the difference and improvements between various amines solutions and be more accordance with the real situation of biogas upgrading. The q₉₀%CH₄ increased from 0.15 to 0.82-1.70 mol/kg after adding other amines with methyldiethanolamine (MDEA), but qe was almost the same. For kinetics, the fitting results of Avrami model are the best among the three models. FT-IR anal. before and after absorption showed CO₂ formed different groups with different amine mols. This study provided a new perspective and method on evaluation of amine scrubbing for biogas upgrading, contributing to future research and industrial application.

Energy (Oxford, United Kingdom) published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Landge, Vinod G. published the artcilePalladium-Catalyzed Regioselective Arylation of Unprotected Allylamines, Recommanded Product: 2-Aminobutan-1-ol, the publication is JACS Au (2021), 1(1), 13-22, database is CAplus and MEDLINE.

A simple protocol for the arylation of cinnamylamines and the diarylation of terminal allylamines to generate a of 3,3-diarylallylamine products using a Pd^II precatalyst was described. Key features of the method were the ability to access relatively mild conditions that facilitate a broad substrate scope as well as direct diarylation of terminal allylamine substrates. In addition, several complex and therapeutically relevant mols. were included to demonstrate the utility of the transformation.

JACS Au published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Van de Sande, C. C. published the artcileMetastable ion characteristics. XXXVII. Structure and formation of stable C3H6O.+ ions, Application of 1-Methylcyclobutan-1-ol, the publication is Journal of the American Chemical Society (1975), 97(16), 4617-20, database is CAplus.

The C3H6O•+ isomeric ions I, II, CH2:CHOMe•+(III), C2H5CHO•+, CH3CH:CHOH•+, CH3COCH3•+, and CH2:CH(OH)CH3•+ are stable, with lifetimes >10-5 sec, and can be identified from their collisional activation (CA) spectra. Aliphatic terminal epoxides give a mixture of ions I and III, suggesting that the rearrangements involved are stepwise, not concerted. The C3H6O•+ ions formed by the loss of CH2O from the 2-methyl- and 4-methyl-1,3-dioxolane mol. ions have structure I; in a similar manner, 1,4-dioxane yields the cyclic ion II. The results show that the size of the cyclic transition state in hydrogen rearrangements is sensitive to a number of competing factors.

Journal of the American Chemical Society published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C17H20ClN3, Application of 1-Methylcyclobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nakamura, Masaharu published the artcileDevelopment of silicon-containing bis-phenol derivatives as androgen receptor antagonists: Selectivity switching by C/Si exchange, SDS of cas: 57044-25-4, the publication is Bioorganic & Medicinal Chemistry (2013), 21(7), 1643-1651, database is CAplus and MEDLINE.

The authors previously reported that bis-phenol derivatives, including LG190178, possess not only vitamin D receptor (VDR) agonistic activity, but also androgen receptor (AR) antagonistic activity. Here, the authors describe the design, synthesis and evaluation of silicon-containing bis-phenol derivatives, with the objective of obtaining increased selectivity toward VDR or AR. The authors found that replacement of the quaternary carbon in the bis-phenol skeleton with silicon increased AR-antagonistic activity and reduced VDR-agonistic activity, i.e., the AR selectivity of the silicon-containing compounds was higher than that of corresponding carbon compounds To the authors’ knowledge, this is the first report of nuclear receptor (NR) selectivity switching by sila-substitution (C/Si exchange). Among the compounds synthesized, AR-selective ligand (I) exhibited more potent anti-androgenic activity (IC₅₀ = 0.072 μM) than hydroxyflutamide, a well-known androgen antagonist (IC₅₀ = 1.4 μM), in SC-3 cell proliferation assay. These results suggest that sila-substitution is a useful approach for structural development of selective AR ligands.

Bioorganic & Medicinal Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, SDS of cas: 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Salaciak, Kinga published the artcileSynthesis and evaluation of the antidepressant-like properties of HBK-10, a novel 2-methoxyphenylpiperazine derivative targeting the 5-HT1A and D2 receptors, Application In Synthesis of 96-20-8, the publication is Pharmaceuticals (2021), 14(8), 744, database is CAplus and MEDLINE.

The increasing number of patients reporting depressive symptoms requires the design of new antidepressants with higher efficacy and limited side effects. As our previous research showed, 2-methoxyphenylpiperazine derivatives are promising candidates to fulfill these criteria. In this study, we aimed to synthesize a novel 2-methoxyphenylpiperazine derivative, HBK-10, and investigate its in vitro and in vivo pharmacol. profile. After assessing the affinity for serotonergic and dopaminergic receptors, and serotonin transporter, we determined intrinsic activity of the compound at the 5-HT1A and D2 receptors. Next, we performed behavioral experiments (forced swim test, tail suspension test) to evaluate the antidepressant-like activity of HBK-10 in naive and corticosterone-treated mice. We also assessed the safety profile of the compound We showed that HBK-10 bound strongly to 5-HT1A and D2 receptors and presented antagonistic properties at these receptors in the functional assays. HBK-10 displayed the antidepressant-like effect not only in naive animals, but also in the corticosterone-induced mouse depression model, i.e., chronic administration of HBK-10 reversed corticosterone-induced changes in behavior. Moreover, the compound′s sedative effect was observed at around 26-fold higher doses than the antidepressant-like ones. Our study showed that HBK-10 displayed a favorable pharmacol. profile and may represent an attractive putative treatment candidate for depression.

Pharmaceuticals published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Application In Synthesis of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts