Tag: M.W=50-100

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 16545-68-9, formula is C3H6O, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Recommanded Product: Cyclopropanol

Goldsmith, C. Franklin;Magoon, Gregory R.;Green, William H. research published 《 Database of Small Molecule Thermochemistry for Combustion》, the research content is summarized as follows. High-accuracy ab initio thermochem. is presented for 219 small mols. relevant in combustion chem., including many radical, biradical, and triplet species. These values are critical for accurate kinetic modeling. The RQCISD(T)/cc-PV∞QZ//B3LYP/6-311++G(d,p) method was used to compute the electronic energies. A bond additivity correction for this method has been developed to remove systematic errors in the enthalpy calculations, using the Active Thermochem. Tables as reference values. On the basis of comparison with the benchmark data, the 3σ uncertainty in the standard-state heat of formation is 0.9 kcal/mol, or within chem. accuracy. An uncertainty anal. is presented for the entropy and heat capacity. In many cases, the present values are the most accurate and comprehensive numbers available. The present work is compared to several published databases. In some cases, there are large discrepancies and errors in published databases; the present work helps to resolve these problems.

Recommanded Product: Cyclopropanol, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Name: Cyclopropanol

Guo, Shuang;Xu, Mingshuo;Guo, Qi;Zhu, Fuqiang;Jiang, Xiangrui;Xie, Yuanchao;Shen, Jingshan research published 《 Discovery of pyrimidine nucleoside dual prodrugs and pyrazine nucleosides as novel anti-HCV agents》, the research content is summarized as follows. To explore the application potential of dual prodrug strategies in the development of anti-HCV agents, a variety of sofosbuvir derivatives with modifications at the C4 or N3 position of the uracil moiety were designed and synthesized. Some compounds exhibited potent anti-HCV activities, such as 4e and 8a-8c with similar EC₅₀ values (0.20-0.22 μM) comparative to that of sofosbuvir (EC₅₀ = 0.18 μM) in a genotype 1b based replicon Huh-7 cell line. Moreover, 8b displayed a good human plasma stability profile, and was easily metabolized in human liver microsomes expectantly. On the other hand, aiming to discover novel anti-HCV nucleosides, pyrazin-2(1H)-one nucleosides and their phosphoramidate prodrugs were investigated. Several active compounds were discovered, such as 25e (EC₅₀ = 7.3 μM) and S-29b (EC₅₀ = 19.5 μM). This kind of nucleosides were interesting and would open a new avenue for the development of antiviral agents.

Name: Cyclopropanol, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Name: Oxetan-3-ol

Felts, Andrew S.;Bollinger, Katrina A.;Brassard, Christopher J.;Rodriguez, Alice L.;Morrison, Ryan D.;Scott Daniels, J.;Blobaum, Anna L.;Niswender, Colleen M.;Jones, Carrie K.;Jeffrey Conn, P.;Emmitte, Kyle A.;Lindsley, Craig W. research published 《 Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5》, the research content is summarized as follows. This letter describes the further chem. optimization of VU0424238 (auglurant), an mGlu₅ NAM clin. candidate that failed in nonhuman primate (NHP) 28 day toxicol. due to accumulation of a species-specific aldehyde oxidase (AO) metabolite of the pyrimidine head group. Here, the authors excised the pyrimidine moiety, identified the min. pharmacophore, and then developed a new series of saturated ether head groups that ablated any AO contribution to metabolism Putative back-up compounds in this novel series provided increased sp³ character, uniform CYP₄₅₀-mediated metabolism across species, good functional potency and high CNS penetration. Key to the optimization was a combination of matrix and iterative libraries that allowed rapid surveillance of multiple domains of the allosteric ligand.

Name: Oxetan-3-ol, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Application In Synthesis of 16545-68-9

Feng, Yi-Si;Shu, Yong-Jin;Cao, Ping;Xu, Tao;Xu, Hua-Jian research published 《 Copper(I)-catalyzed ring-opening cyanation of cyclopropanols》, the research content is summarized as follows. In the presence of CuI in 1,2-dichloroethane, 1-alkyl and 1-aryl-1-cyclopropanols underwent chemoselective ring opening and cyanation reactions with a cyanobenzoiodoxole to give γ-oxonitriles in 42-79% yields. The ring opening and cyanation reaction was compatible with epoxides, silyl esters, benzoate and tosyl esters, and alkyl chlorides and alkenes and was performed in one case on gram scale. The reaction did not occur in the presence of TEMPO, BHT, or a nitrone, suggesting the presence of radical intermediates.

Application In Synthesis of 16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 16545-68-9, formula is C3H6O, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Recommanded Product: Cyclopropanol

Feng, Ziwen;Li, Qiuyu;Chen, Long;Yao, Hequan;Lin, Aijun research published 《 Palladium-catalyzed asymmetric carbamoyl-carbonylation of alkenes》, the research content is summarized as follows. An unprecedented palladium-catalyzed asym. carbamoyl-carbonylation of tethered alkenes with CO and alcs. was developed. This reaction provided an efficient route to access oxindoles I [R¹ = Me, Ph, 2-thienyl, etc.; R² = Me, i-Pr, Bn; R³ = Me, Et, CH₂CH₂TMS, etc.] and γ-lactams bearing β-carbonyl substituted quaternary carbons II [Ar = Ph, 3-MeC₆H₄, 4-MeOC₆H₄, 4-CF₃C₆H₄, 3-ClC₆H₄, 4-ClC₆H₄] in good yields with excellent chemo-, regio- and enantioselectivity. Gram-scale synthetic capability and facile transformations of the products to chiral spirooxindole and other functional mols. further illustrated the practicability of this reaction.

16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., Recommanded Product: Cyclopropanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Name: Cyclopropanol

Freeman-Cook, Kevin D.;Hoffman, Robert L.;Behenna, Douglas C.;Boras, Britton;Carelli, Jordan;Diehl, Wade;Ferre, Rose Ann;He, You-Ai;Hui, Andrea;Huang, Buwen;Huser, Nanni;Jones, Rhys;Kephart, Susan E.;Lapek, John;McTigue, Michele;Miller, Nichol;Murray, Brion W.;Nagata, Asako;Nguyen, Lisa;Niessen, Sherry;Ninkovic, Sacha;O′Doherty, Inish;Ornelas, Martha A.;Solowiej, James;Sutton, Scott C.;Tran, Khanh;Tseng, Elaine;Visswanathan, Ravi;Xu, Meirong;Zehnder, Luke;Zhang, Qin;Zhang, Cathy;Dann, Stephen research published 《 Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer》, the research content is summarized as follows. Control of the cell cycle through selective pharmacol. inhibition of CDK4/6 has proven beneficial in the treatment of breast cancer. Extending this level of control to addnl. cell cycle CDK isoforms represents an opportunity to expand to addnl. tumor types and potentially provide benefits to patients that develop tumors resistant to selective CDK4/6 inhibitors. However, broad-spectrum CDK inhibitors have a long history of failure due to safety concerns. In this approach, we describe the use of structure-based drug design and Free-Wilson anal. to optimize a series of CDK2/4/6 inhibitors. Further, we detail the use of mol. dynamics simulations to provide insights into the basis for selectivity against CDK9. Based on overall potency, selectivity, and ADME profile, PF-06873600 (22) was identified as a candidate for the treatment of cancer and advanced to phase 1 clin. trials.

Name: Cyclopropanol, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 7748-36-9, formula is C3H6O2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Synthetic Route of 7748-36-9

Friedrich, Louis E.;Lam, Patrick Yuk-Sun research published 《 Syntheses and reactions of 3-phenyloxete and the parent unsubstituted oxete》, the research content is summarized as follows. The elimination of 4-MeC₆H₄SO₃H and 2-O₂NC₆H₄Se(O)OH from I (R = Ph, R¹ = OSO₂C₆H₄Me-4; R = H, R¹ = OSeC₆H₄NO₂-2) gave II (R = Ph, H), resp. II (R = Ph) underwent the expected chem. as well as a facile addition of triplet oxygen to give PhCOCH₂OCHO. II (R = H) has a thermal half-life in solution at room temperature of ∼8 h.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Synthetic Route of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Computed Properties of 16545-68-9

Elango, Munusamy;Maciel, Glauciete S.;Lombardi, Andrea;Cavalli, Simonetta;Aquilanti, Vincenzo research published 《 Quantum chemical and dynamical approaches to intra and intermolecular kinetics: The CnH_2nO (n = 1, 2, 3) molecules》, the research content is summarized as follows. An account is given of isomerization and decomposition paths in the title mols., as obtained by characterizing stable isomers and transition states using quantum chem. and reaction rate theories. For n = 1 (formaldehyde) intrinsic reaction paths are calculated to provide rates for decomposition mechanisms dominated by quantum mech. tunneling. The n = 2 closed shell isomers are acetaldehyde, ethylene oxide, and vinyl alc., which interconvert and decompose through alternative paths. For n = 3, the very large number of isomers are characterized using an efficient automatic search algorithm recently made available by Ohno and Maeda. Interconversion paths are also found, including those involving chiral change mechanisms for propylene oxide. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2010.

Computed Properties of 16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Recommanded Product: Oxetan-3-ol

Falk, Eric;Makai, Szabolcs;Delcaillau, Tristan;Guertler, Laura;Morandi, Bill research published 《 Design and Scalable Synthesis of N-Alkylhydroxylamine Reagents for the Direct Iron-Catalyzed Installation of Medicinally Relevant Amines》, the research content is summarized as follows. Secondary and tertiary alkylamines are privileged substance classes that are often found in pharmaceuticals and other biol. active small mols. Herein, the authors report their direct synthesis from alkenes through an aminative difunctionalization reaction enabled by iron catalysis. A family of ten novel hydroxylamine-derived aminating reagents were designed for the installation of several medicinally relevant amine groups, such as methylamine, morpholine and piperazine, through the aminochlorination of alkenes. The method has excellent functional group tolerance and a broad scope of alkenes was converted to the corresponding products, including several drug-like mols. Besides aminochlorination, the installation of other functionalities through aminoazidation, aminohydroxylation and even intramol. carboamination reactions, was demonstrated, further highlighting the broad potential of these new reagents for the discovery of novel amination reactions.

Recommanded Product: Oxetan-3-ol, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Recommanded Product: Cyclopropanol

Dong, Jiaqiang;Huang, Jingjie;Zhou, Ji;Tan, Ye;Jin, Jing;Tan, Xi;Wang, Bei;Yu, Tao;Wu, Chengde;Chen, Shuhui;Wang, Tie-Lin research published 《 Discovery of 3-Quinazolin-4(3H)-on-3-yl-2,N-dimethylpropanamides as Orally Active and Selective PI3Kα Inhibitors》, the research content is summarized as follows. Phosphoinositide 3-kinases (PI3Ks) mediate a series of events related to cell growth, proliferation, survival, and differentiation. Overexpression of PI3Ks can lead to the dysregulation of cell homeostasis and cause tumorigenesis. In this study, rationally designed compounds were investigated as PI3Kα-selective inhibitors. Our efforts culminated in the discovery of a series of quinazolin-4(3H)-one derivatives with 2-substituted-N-methylpropanamide substitutions as PI3Kα-selective inhibitors. The best compound, I, has PI3Kα enzymic and cellular IC₅₀ values of 1.8 and 12.1 nM, resp. It exhibits biochem. selectivities for PI3Kα over PI3Kβ/δ/γ of 150/7.72/7.67-fold and cellular selectivities of 115/15.1/>826-fold, resp. Compound I is 59% orally bioavailable with a dose-normalized AUC of 3090 nM. These effects translated into in vivo conditions, as I significantly time- and dose-dependently inhibited phosphorylation of Akt in BT-474 s.c. xenograft mice and inhibited tumor growth.

Recommanded Product: Cyclopropanol, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts