Tag: M.W=50-100

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Computed Properties of 7748-36-9

Larsen, Jens;Lambert, Maja;Pettersson, Henrik;Vifian, Thomas;Larsen, Mogens;Ollerstam, Anna;Hegardt, Pontus;Eskilsson, Cecilia;Laursen, Steen;Soehoel, Anders;Skak-Nielsen, Tine;Hansen, Lene M.;Knudsen, Nina Oe.;Eirefelt, Stefan;Soerensen, Morten D.;Stilou, Tatiana G.;Nielsen, Simon F. research published 《 Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel “Dual-Soft” PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis》, the research content is summarized as follows. We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft) while being stable in human skin. Compound 40 was selected as a clin. candidate as it was potent and rapidly degraded by blood and liver to inactive metabolites and because in preclin. studies it showed high exposure at the target organ: the skin. Preclin. and clin. data are presented confirming the value of the dual-soft concept in reducing systemic exposure.

Computed Properties of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Product Details of C3H6O2, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Lauber, Markus B.;Stahl, Shannon S. research published 《 Efficient Aerobic Oxidation of Secondary Alcohols at Ambient Temperature with an ABNO/NO_x Catalyst System》, the research content is summarized as follows. New highly practical methods are presented for aerobic oxidation of secondary alcs. with a nitroxyl radical in combination with HNO₃, NaNO₂, or both as cocatalysts. Diverse nitroxyls are compared, including several novel bicyclic derivatives Catalyst systems with the readily available nitroxyls, 9-azabicyclo[3.3.1]-nonane-N-oxyl (ABNO) and 9-azabicyclo[3.3.1]-nonan-3-one-N-oxyl (keto-ABNO), are optimized in acetic acid or acetonitrile as the solvent. The reactions are compatible with substrates bearing diverse functional groups and proceed efficiently under mild conditions at ambient pressure and temperature

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Product Details of C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 16545-68-9, formula is C3H6O, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Formula: C3H6O

Lazerwith, Scott E.;Bahador, Gina;Canales, Eda;Cheng, Guo-Feng;Chong, Lee;Clarke, Michael O.;Doerffler, Edward;Eisenberg, Eugene J.;Hayes, Jaclyn;Lu, Bing;Liu, Qi;Matles, Mike;Mertzman, Michael;Mitchell, Michael L.;Morganelli, Philip;Murray, Bernard P.;Robinson, Margaret;Strickley, Robert G.;Tessler, Megan;Tirunagari, Neeraj;Wang, Jian-Hong;Wang, Yu-Jin;Zhang, Jennifer R.;Zheng, Xu-Bin;Zhong, Wei-Dong;Watkins, William J. research published 《 Optimization of Pharmacokinetics through Manipulation of Physicochemical Properties in a Series of HCV Inhibitors》, the research content is summarized as follows. A novel series of HCV replication inhibitors based on a pyrido[3,2-d]pyrimidine core were optimized for pharmacokinetics (PK) in rats. Several associations between physicochem. properties and PK were identified and exploited to guide the design of compounds In addition, a simple new metric that may aid in the prediction of bioavailability for compounds with higher polar surface area is described (3*HBD-cLogP).

Formula: C3H6O, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Synthetic Route of 7748-36-9

Legnani, Luca;Prina-Cerai, Gabriele;Delcaillau, Tristan;Willems, Suzanne;Morandi, Bill research published 《 Efficient access to unprotected primary amines by iron-catalyzed aminochlorination of alkenes》, the research content is summarized as follows. Primary amines are essential constituents of biol. active mols. and versatile intermediates in the synthesis of drugs and agrochems. However, their preparation from easily accessible alkenes remains challenging. Here, the authors report a general strategy to access primary amines from alkenes through an operationally simple iron-catalyzed aminochlorination reaction. A stable hydroxylamine derivative and benign sodium chloride act as the resp. nitrogen and chlorine sources. The reaction proceeds at room temperature under air; tolerates a large scope of aliphatic and conjugated alkenes, including densely functionalized substrates; and provides excellent anti-Markovnikov regioselectivity with respect to the amino group. The reactivity of the 2-chloroalkylamine products, an understudied class of amphoteric mols., enables facile access to linear or branched aliphatic amines, aziridines, aminonitriles, azido amines, and homoallylic amines.

Synthetic Route of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 7748-36-9, formula is C3H6O2, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Safety of Oxetan-3-ol

Kiryukhin, M. V.;Nurieva, E. V.;Shishov, D. V.;Nuriev, V. N.;Zyk, N. V.;Zefirov, N. S.;Zefirova, O. N. research published 《 Synthesis of derivatives of adamantane and bicyclo[3.3.1]nonane with an oxetane moiety》, the research content is summarized as follows. The synthesis of 3-hydroxyoxetane esters with adamantane- and bicyclo[3.3.1]nonane-containing carboxylic acids, e.g., I and II, resp., is presented in the paper.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Safety of Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 16545-68-9, formula is C3H6O, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Reference of 16545-68-9

Kleinpeter, Erich;Krueger, Stefanie;Koch, Andreas research published 《 Anisotropy Effect of Three-Membered Rings in ¹H NMR Spectra: Quantification by TSNMRS and Assignment of the Stereochemistry》, the research content is summarized as follows. The spatial magnetic properties (through space NMR shieldings, TSNMRSs) of cyclopropane; of the heteroanalogous oxirane, thiirane, and aziridine; and of various substituted mono-, dis-, and tris-cyclic analogs were computed by the GIAO perturbation method employing the nucleus independent chem. shift (NICS) concept and visualized as iso-chem.-shielding surfaces (ICSSs) of various size and direction. The TSNMRS values, thus obtained, can be employed to visualize the anisotropy (ring current) effect of the cyclopropane ring moiety. This approach was employed to qualify and quantify substituent influences and contributions of appropriate ring heteroatoms O, NH, and S on the anisotropy (ring current) effect of three-membered ring moieties, and to assign the stereochem. of mono-, bis-, and tris-cyclic structures containing cyclopropane as a structural element. Characteristic examples are included.

16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., Reference of 16545-68-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Computed Properties of 7748-36-9

Klug, Dana M.;Tschiegg, Laura;Diaz, Rosario;Rojas-Barros, Domingo;Perez-Moreno, Guiomar;Ceballos, Gloria;Garcia-Hernandez, Raquel;Martinez-Martinez, Maria Santos;Manzano, Pilar;Ruiz, Luis Miguel;Caffrey, Conor R.;Gamarro, Francisco;Pacanowska, Dolores Gonzalez;Ferrins, Lori;Navarro, Miguel;Pollastri, Michael P. research published 《 Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics》, the research content is summarized as follows. Human African trypanosomiasis (HAT) is a neglected tropical disease caused by infection with either of two subspecies of the parasite Trypanosoma brucei. Due to a lack of economic incentive to develop new drugs, current treatments have severe limitations in terms of safety, efficacy, and ease of administration.In an effort to develop new HAT therapeutics, author report the structure-activity relationships around T. brucei for a series of benzoxazepinoindazoles previously identified through a high-throughput screen of human kinase inhibitors, and the subsequent in vivo experiments for HAT. Author identified compound I (R¹ = H; R² = Me; R³ = NH₂) , which showed an improved kinase selectivity profile and acceptable pharmacokinetic parameters, as a promising lead. Although treatment with I (R¹ = H; R² = Me; R³ = NH₂) cured 60% of mice in a systemic model of HAT, the compound was unable to clear parasitemia in a CNS model of the disease. Author also report the results of cross-screening these compounds against T. cruzi, L. donovani, and S. mansoni.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Computed Properties of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Application of C3H6O2

Kozikowski, Alan P.;Fauq, Abdul H. research published 《 Synthesis of novel four-membered ring amino acids as modulators of the N-methyl-D-aspartate (NMDA) receptor complex》, the research content is summarized as follows. The first syntheses of three novel four-membered ring amino acids (3-aminooxetane-3-carboxylic acid, 3-aminoazetidine-3-carboxylic acid and 3-aminotheitane-3-carboxylic acid) (I; X = O, NH, S), starting from 1-chloro-2,3-epoxypropane, are reported together with a summary of their biol. actions at the NMDA receptor-ion channel complex.

Application of C3H6O2, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Synthetic Route of 7748-36-9

Lai, Junshan;Fianchini, Mauro;Pericas, Miquel A. research published 《 Development of Immobilized SPINOL-Derived Chiral Phosphoric Acids for Catalytic Continuous Flow Processes. Use in the Catalytic Desymmetrization of 3,3-Disubstituted Oxetanes》, the research content is summarized as follows. A family of C₂-sym. 1,1′-spirobiindane-7,7′-diol (SPINOL) derivatives containing polymerizable styryl units has been prepared through a highly convergent approach. Radical copolymerization of these monomers with styrene has allowed the synthesis of a family of immobilized SPINOL-derived chiral phosphoric acids (SPAs) where the combination of the restricted axial flexibility of the SPINOL units and the existence of extended and adaptable chiral walls adjacent to them leads to enhanced stereocontrol in catalytic processes. The optimal immobilized species (Cat f) brings about the catalytic desymmetrization of 3,3-disubstituted oxetanes in up to 90% yield with up to >99% enantioselectivity, exhibiting a very high recyclability (no decrease in conversion or enantioselectivity after 16, 16-h runs). To exploit these characteristics, a continuous flow process has been implemented and operated for the sequential preparation of 17 diverse enantioenriched products. The suitability of the flow setup for gram scale preparations (20 mmol scale), the stability of Cat f for long periods of time with intermittent use in flow, and its deactivation/reactivation by treatment with pyridine/hydrochloric acid in dioxane have been demonstrated. D. functional theory has been employed to provide a rational justification of the deep effect on enantioselectivity arising from the presence of sterically bulky substituents at the 6,6′-positions of the SPINOL unit. The main structural features of Cat f have subsequently been incorporated to the design of a simplified homogeneous analog available in a straightforward manner (Cat g) that performs the benchmark desymmetrization reaction with similar yields and enantioselectivities as Cat f, providing a convenient alternative for cases when single use in solution is sought.

Synthetic Route of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 16545-68-9, formula is C3H6O, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. HPLC of Formula: 16545-68-9

Johnson, Kerr;Castro-Marin, Pablo;Farrell, Carl;Davidson, Ian A.;Fu, Qiang;Jasion, Gregory T.;Wheeler, Natalie V.;Poletti, Francesco;Richardson, David J.;Reid, Derryck T. research published 《 Hollow-core fiber delivery of broadband mid-infrared light for remote spectroscopy》, the research content is summarized as follows. High-resolution multi-species spectroscopy is achieved by delivering broadband 3-4-μm mid-IR light through a 4.5-m-long silica-based hollow-core optical fiber. Absorptions from H³⁷Cl, H³⁵Cl, H₂O and CH₄ present in the gas within the fiber core are observed, and the corresponding gas concentrations are obtained to 5-ppb precision using a highresoln. Fourier-transform spectrometer and a full-spectrum multi-species fitting algorithm. We show that by fully fitting the narrow absorption features of these light mols. their contributions can be nulled, enabling further spectroscopy of C₃H₆O and C₃H₈O contained in a Herriott cell after the fiber. As a demonstration of the potential to extend fiber-delivered broadband mid-IR spectroscopy to significant distances, we present a high-resolution characterization of the transmission of a 63-m length of hollow-core fiber, fully fitting the input and output spectra to obtain the intra-fiber gas concentrations We show that, despite the fiber not having been purged, useful spectroscopic windows are still preserved which have the potential to enable hydrocarbon spectroscopy at the distal end of fibers with lengths of tens or even hundreds of meters.

HPLC of Formula: 16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts