Tag: M.W=50-100

In general, the hydroxyl group makes alcohols polar. 16545-68-9, formula is C3H6O, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Category: alcohols-buliding-blocks

Lin, Wenwei;Yang, Lei;Chai, Sergio C.;Lu, Yan;Chen, Taosheng research published 《 Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor》, the research content is summarized as follows. Constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) are master regulators of endobiotic and xenobiotic metabolism and disposition. Because CAR is constitutively active in certain cellular contexts, inhibiting CAR might reduce drug-induced hepatotoxicity and resensitize drug-resistant cancer cells to chemotherapeutic drugs. We recently reported a novel CAR inhibitor/inverse agonist CINPA1 (11). Here, we have obtained or designed 54 analogs of CINPA1 and used a time-resolved fluorescence resonance energy transfer (TR-FRET) assay to evaluate their CAR inhibition potency. Many of the 54 analogs showed CAR inverse agonistic activities higher than those of CINPA1, which has an IC₅₀ value of 687 nM. Among them, 72 has an IC₅₀ value of 11.7 nM, which is about 59-fold more potent than CINPA1 and over 10-fold more potent than clotrimazole (an IC₅₀ value of 126.9 nM), the most potent CAR inverse agonist in a biochem. assay previously reported by others. Docking studies provide a mol. explanation of the structure-activity relationship (SAR) observed exptl. To our knowledge, this effort is the first chem. endeavor in designing and identifying potent CAR inverse agonists based on a novel chem. scaffold, leading to 72 as the most potent CAR inverse agonist so far. The 54 chems. presented are novel and unique tools for characterizing CAR’s function, and the SAR information gained from these 54 analogs could guide future efforts to develop improved CAR inverse agonists.

16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , SDS of cas: 16545-68-9

Liu, Bo;Lu, Chong-Dao research published 《 Asymmetric synthesis of cis-2-aminocyclopropanols by intramolecular Mannich addition of silyloxy benzyl carbanions》, the research content is summarized as follows. An efficient, highly diastereoselective method for the preparation of protected cis-2-aminocyclopropanols from N-tert-butanesulfinyl ketimines and various aryl acylsilanes is described. A tandem process for carbon-carbon bond formation via nucleophilic addition to acylsilanes, Brook rearrangement, and intramol. Mannich reaction has been developed.

16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., SDS of cas: 16545-68-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 16545-68-9, formula is C3H6O, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Related Products of 16545-68-9

Liu, Chunliang;Steere, Luke;McGregor, Cari;Frederick, Brittany H.;Pastoor, Timothy;Zhou, Yasheen;Liu, C. Tony;Cai, Yan;Zhou, Haibo;Xu, Musheng;Wang, Jiangong;Kim, Sang Hu;Whitesell, Luke;Cowen, Leah E.;Zhang, Yong-Kang research published 《 Exploring boron applications in modern agriculture: A structure-activity relationship study of a novel series of multi-substitution benzoxaboroles for identification of potential fungicides》, the research content is summarized as follows. Several boron-containing small mols. have been approved by the US FDA to treat human diseases. We explored potential applications of boron-containing compounds in modern agriculture by pursuing multiple research and development programs. Here, we report a novel series of 36 multi-substitution benzoxaboroles (I) wherein R¹ is t-Bu, Me, Et, etc.; Z is O, SH, or N; W is O or S; R² is H; X is H or Cl; Y is H, Me, F or Cl; and R³ is H or Me; a compound class that we recently reported as targeting geranylgeranyl transferase I (GGTase I) and thereby inhibiting protein prenylation (Kim et al., 2020). These compounds were designed, synthesized, and tested against the agriculturally important fungal pathogens Mycosphaerella fijiensis and Colletotrichum sublineolum in a structure-activity relationship study. Compounds Pr (7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)carbamate, benzyl (7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)carbamate, 4-chlorobenzyl (7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)carbamate, O-(4-chlorobenzyl) (7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)carbamothioate and O-(4-fluorobenzyl) (7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)carbamothioate were identified as active leads with excellent antifungal MIC₉₅ values in the range of 1.56-3.13 ppm against M. fijiensis and 0.78-3.13 ppm against C. sublineolum.

Related Products of 16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 16545-68-9, formula is C3H6O, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Safety of Cyclopropanol

Liu, Jidan;Jiang, Jinyuan;Yang, Zhenke;Zeng, Qiaohai;Zheng, Jieying;Zhang, Siying;Zheng, Liyao;Zhang, Shang-Shi;Liu, Zhao-Qing research published 《 Rhodium(III)-catalyzed oxidative alkylation of N-aryl-7-azaindoles with cyclopropanols》, the research content is summarized as follows. An efficient Rh(III)-catalyzed C-H oxidative alkylation of N-aryl-7-azaindoles with cyclopropanols by merging tandem C-H and C-C cleavage was developed. This transformation features mild reaction conditions, high regioselectivity, and excellent functional group compatibility. The resulting β-aryl ketone derivatives can be readily transformed into 7-azaindole-containing π-extended polycyclic heteroarenes.

Safety of Cyclopropanol, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 16545-68-9, formula is C3H6O, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Formula: C3H6O

Liu, Ruiting;Tzounopoulos, Thanos;Wipf, Peter research published 《 Synthesis and Optimization of K_v7 (KCNQ) Potassium Channel Agonists: The Role of Fluorines in Potency and Selectivity》, the research content is summarized as follows. Based on the potent K_v7 agonist RL-81, we prepared new lead structures with greatly improved selectivity for K_v7.2/K_v7.3 over related potassium channels, i.e., K_v7.3/K_v7.5, K_v7.4, and K_v7.4/7.5. RL-36 and RL-12 maintain an agonist EC_2x of ca. 1 μM on K_v7.2/K_v7.3 in a high-throughput assay on an automated electrophysiol. platform in HEK293 cells but lack activity on K_v7.3/K_v7.5, K_v7.4, and K_v7.4/7.5, resulting in a selectivity index SI > 10. RL-56 is remarkably potent, EC_2x 0.11 ± 0.02 μM, and still shows an SI = 2.5. We also identified analogs with significant selectivity for K_v7.4/K_v7.5 over K_v7.2/K_v7.3. The extensive use of fluorine in iterative core structure modifications highlights the versatility of these substituents, including F, CF₃, and SF₅, to span orders of magnitude of potency and selectivity in medicinal chem. lead optimizations.

Formula: C3H6O, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of Cyclopropanol, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 16545-68-9, name is Cyclopropanol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Liu, Tong-Xin;Zhu, Xue;Xia, Shilu;Wang, Xin;Zhang, Pengling;Zhang, Guisheng research published 《 NHC-Catalyzed Three-Component Hydroalkylation Reactions of [60]Fullerene: An Umpolung Approach to Diverse Monoalkylated Hydrofullerenes》, the research content is summarized as follows. A novel N-heterocyclic carbene-catalyzed three-component umpolung hydroalkylation of [60]fullerene with 4-(chloromethyl)benzaldehydes/α,β-unsaturated aldehydes and alcs./thiols has been developed for the flexible and efficient preparation of diverse monoalkylated hydrofullerenes. Organic catalysis, broad substrate scope, excellent functional group tolerance, and products with high diversity and complexity levels are attractive features of this protocol.

16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., Safety of Cyclopropanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Product Details of C3H6O

Liu, Yafei;Ling, Yijing;Ge, Hangming;Lu, Long;Shen, Qilong research published 《 Rational Design and Development of Low-Price, Scalable, Shelf-Stable and Broadly Applicable Electrophilic Sulfonium Ylide-Based Trifluoromethylating Reagents》, the research content is summarized as follows. The development of two highly reactive electrophilic trifluoromethylating reagents (trifluoromethyl)(4-nitrophenyl)bis(carbomethoxy)methylide I and (trifluoromethyl)(3-chlorophenyl)bis(carbomethoxy)methylide II through structure-activity study was described. Under mild conditions, reagent I reacted with β-ketoesters and silyl enol ethers to give α-trifluoromethylated-β-ketoesters or α-trifluoromethylated ketones in high yields. In addition, reagent I could serve as a trifluoromethyl radical for a variety of trifluoromethylative transformations under visible light irradiation, including radical trifluoromethylation of electron-rich indoles and pyrroles and sodium aryl sulfinates as well as trifluoromethylative difunctionalization with styrene derivatives On the other hand, as a complimentary, under reductive coupling conditions, reagent II reacted with a variety of (hetero)aryl iodides for the formation of trifluoromethylated (hetero)arenes.

Product Details of C3H6O, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Synthetic Route of 16545-68-9

Li, Guanguan;Stephen, Michael R.;Kodali, Revathi;Zahn, Nicolas M.;Poe, Michael M.;Tiruveedhula, V. V. N. Phani Babu;Huber, Alec T.;Schussman, Melissa K.;Qualmann, Krista;Panhans, Cristina M.;Raddatz, Nicholas J.;Baker, David A.;Prevot, Thomas D.;Banasr, Mounira;Sibille, Etienne;Arnold, Leggy A.;Cook, James M. research published 《 Synthesis of chiral GABAA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression》, the research content is summarized as follows. A series of novel imidazobenzodiazepine analogs of the lead chiral ligand SH-053-2’F-S-CH₃ (2), an α2/α3/α5 (Bz)GABA (A)ergic receptor subtype selective ligand, which reverses PCP-induced prepulse inhibition (PPI) of acoustic startle, were synthesized. These chiral (S)-CH₃ ligands are targeted for the treatment of schizophrenia and depression. These new ligands were designed by modifying the labile ester functionality in 2 to improve the metabolic stability, cytotoxicity, and activity as compared to 2. Based on the data to date, the most promising ligands are the N-cyclopropyl amide GL-I-55 (8c) and the Me bioisostere GL-I-65 (9a). The in vitro metabolic stability, cytotoxicity and in vivo locomotor effects are described in this report. Based on these results, 8c and 9a are the most promising for further in vivo pharmacol.

16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., Synthetic Route of 16545-68-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 7748-36-9, formula is C3H6O2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Category: alcohols-buliding-blocks

Li, Peijun;Zbieg, Jason R.;Terrett, Jack A. research published 《 A Platform for Decarboxylative Couplings via Photoredox Catalysis: Direct Access to Carbocations from Carboxylic Acids for Carbon-Oxygen Bond Formation》, the research content is summarized as follows. Within the past decade, photoredox catalysis has enabled numerous decarboxylative transformations to couple carboxylic acids with a variety of partners primarily through carbon-centered radical intermediates. Herein, we describe a method for the construction of carbon-oxygen bonds using a dual photoredox/iodine(III) platform directly from simple carboxylic acids and alcs. This activation platform enables the direct utilization of readily available acids and alcs. without the need for prefunctionalization and works broadly across primary, secondary, and tertiary carboxylic acid substrates. We propose that this transformation proceeds via a radical-polar crossover event to generate a discrete carbocation intermediate which is intercepted by a nucleophilic coupling partner, thereby overcoming the electronically mismatched nature inherent in previous radical-based decarboxylative couplings. The application of this mechanistic approach toward addnl. nucleophiles is also demonstrated using water, enabling a direct decarboxylative-hydroxylation reaction. Finally, we demonstrated that the decarboxylative etherification can be applied to a peptide substrate, selectively functionalizing serine over other nucleophilic residues, providing support for future potential bioconjugation applications.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 16545-68-9, formula is C3H6O, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Category: alcohols-buliding-blocks

Li, Yong;Ye, Zhishi;Bellman, Tabitha M.;Chi, Teng;Dai, Mingji research published 《 Efficient Synthesis of β-CF₃/SCF₃-Substituted Carbonyls via Copper-Catalyzed Electrophilic Ring-Opening Cross-Coupling of Cyclopropanols》, the research content is summarized as follows. The first copper-catalyzed ring-opening electrophilic trifluoromethylation and trifluoromethylthiolation of cyclopropanols to form C_sp3-CF₃ and C_sp3-SCF₃ bonds have been realized. These transformations are efficient for the synthesis of β-CF₃– and β-SCF₃-substituted carbonyl compounds that are otherwise challenging to access. The reaction conditions are mild and tolerate a wide range of functional groups. Application to a concise synthesis of LY2409021, a glucagon receptor antagonist that is used in clin. trials for type 2 diabetes mellitus, is reported as well.

16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts