Tag: M.W=50-100

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Quality Control of 7748-36-9

Ogawa, Hiroshi;Kodera, Yasutake;Kanoh, Shigeyoshi;Ueyama, Akihiko;Motoi, Masatoshi research published 《 Preparation and Characterization of Side-Chain Liquid-Crystalline Polyoxetanes Anchoring a Pendant Spacer-Separated Mesogen at the Tertiary-Like C-3 Carbon of the Oxetane Unit》, the research content is summarized as follows. Polyoxetanes anchoring a pendant spacer-separated mesogen at the tertiary-like C-3 carbon of the oxetane unit were prepared by cationic ring-opening polymerization of the corresponding oxetane derivatives The resulting polymers were liquid-crystalline substances showing textures assignable to the nematic or smectic mesophase over a wide temperature range from about 260 °C to room temperature These mesogens also behaved in the manner similar to that of the mesogens in the analogous polyoxetanes attached by a Me side chain at the quaternary C-3 carbon, although the less bulky polymer backbone in the present work indicated a somewhat higher isotropic phase-transition temperature than that of the methyl-substituted analogs. In both types of the polyoxetanes, their mesophase patterns were influenced by the core structure and alkoxy tail length in the pendant mesogen, but not by the bulkiness of the second side chains, H and CH₃, attached at the C-3 carbon of the polyoxetane unit.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Quality Control of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Formula: C3H6O

Meng, Wei;Pi, Zulan;Brigance, Robert;Rossi, Karen A.;Schumacher, William A.;Bostwick, Jeffrey S.;Gargalovic, Peter S.;Onorato, Joelle M.;Luk, Chiuwa E.;Generaux, Claudia N.;Wang, Tao;Wexler, Ruth R.;Finlay, Heather J. research published 《 Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure》, the research content is summarized as follows. This paper describes our continued efforts in the area of small-mol. apelin receptor agonists. Recently disclosed compound 2 showed an acceptable metabolic stability but demonstrated monodemethylation of the dimethoxyphenyl group to generate atropisomer metabolites in vitro. In this article, we extended the structure-activity relationship at the C2 position that led to the identification of potent pyrazole analogs with excellent metabolic stability. Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. Compound 21 (I) displayed excellent pharmacokinetic profiles in rat, monkey, and dog models and robust pharmacodynamic efficacy in the rodent heart failure model. Compound 21 also showed an acceptable safety profile in preclin. toxicol. studies and was selected as a backup development candidate for the program.

16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., Formula: C3H6O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Product Details of C3H6O2, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Merrill, G. N. research published 《 The gas-phase reactivity of epichlorohydrin with hydroxide》, the research content is summarized as follows. The reaction of hydroxide with epichlorohydrin in the gas phase was studied with ab initio calculations Three mechanisms were examined, each corresponding to nucleophilic attack at a different carbon atom of the substrate. Through attack at the ring methylene position was favored, whereas attacks at the alkyl methylene or ring methine positions have larger activation energies. These results are consistent with exptl. results found in the literature.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Product Details of C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Name: Oxetan-3-ol

Merrill, G. N. research published 《 A computational study into the reactivity of epichlorohydrin and epibromohydrin under basic conditions in the gas phase and solution》, the research content is summarized as follows. Ab initio MO calculations were carried out on epibromohydrin (EBH) and epichlorohydrin (ECH) in an attempt to elucidate their reactivity with respect to a hard nucleophile, hydroxide. These systems were modeled in both the gas phase and a polar solvent under basic conditions. In the gas phase, a direct displacement mechanism (nucleophilic attack at the C1 position) was operative for EBH, while an indirect pathway (nucleophilic attack at the C3 position and subsequent intramol. displacement) was followed for ECH. In an acetone solution, only the indirect displacement mechanism occurs. An electrostatic argument is advanced to account for this behavior in polar solution

Name: Oxetan-3-ol, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Recommanded Product: Cyclopropanol

Muthukrishnan, Sivaramakrishnan;Shete, Vivekanand S.;Sanan, Toby T.;Vyas, Shubham;Oottikkal, Shameema;Porter, Lauren M.;Magliery, Thomas J.;Hadad, Christopher M. research published 《 Mechanistic insights into the hydrolysis of organophosphorus compounds by paraoxonase-1: exploring the limits of substrate tolerance in a promiscuous enzyme》, the research content is summarized as follows. We designed, synthesized, and screened a library of analogs of the organophosphate pesticide metabolite paraoxon against a recombinant variant of human serum paraoxonase-1 (PON1). Alterations of both the aryloxy leaving group and the retained alkyl chains of paraoxon analogs resulted in substantial changes to binding and hydrolysis, as measured directly by spectrophotometric methods or in competition experiments with paraoxon. Increases or decreases in the steric bulk of the retained groups generally reduced the rate of hydrolysis, while modifications of the leaving group modulated both binding and turnover. Studies on the hydrolysis of phosphoryl azide analogs as well as amino-modified paraoxon analogs, the former being developed as photoaffinity labels, found enhanced tolerance of structural modifications when compared with O-alkyl-substituted mols. Results from computational modeling predict a predominant active site binding mode for these mols., which is consistent with several proposed catalytic mechanisms in the literature and from which a mol.-level explanation of the exptl. trends is attempted. Overall, the results of this study suggest that while paraoxonase-1 is a promiscuous enzyme, there are substantial constraints in the active site pocket, which may relate to both the leaving group and the retained portion of paraoxon analogs. Copyright © 2012 John Wiley & Sons, Ltd.

Recommanded Product: Cyclopropanol, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 16545-68-9, formula is C3H6O, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Category: alcohols-buliding-blocks

Nageswara Rao, Desaboini;Zephyr, Jacqueto;Henes, Mina;Chan, Elise T.;Matthew, Ashley N.;Hedger, Adam K.;Conway, Hasahn L.;Saeed, Mohsan;Newton, Alicia;Petropoulos, Christos J.;Huang, Wei;Kurt Yilmaz, Nese;Schiffer, Celia A.;Ali, Akbar research published 《 Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants》, the research content is summarized as follows. The three pan-genotypic HCV NS3/4A protease inhibitors (PIs) currently in clin. use-grazoprevir, glecaprevir, and voxilaprevir-are quinoxaline-based P2-P4 macrocycles and thus exhibit similar resistance profiles. Using our quinoxaline-based P1-P3 macrocyclic lead compounds as an alternative chem. scaffold, we explored structure-activity relationships (SARs) at the P2 and P4 positions to develop pan-genotypic PIs that avoid drug resistance. A structure-guided strategy was used to design and synthesize two series of compounds with different P2 quinoxalines in combination with diverse P4 groups of varying sizes and shapes, with and without fluorine substitutions. Our SAR data and cocrystal structures revealed the interplay between the P2 and P4 groups, which influenced inhibitor binding and the overall resistance profile. Optimizing inhibitor interactions in the S4 pocket led to PIs with excellent antiviral activity against clin. relevant PI-resistant HCV variants and genotype 3, providing potential pan-genotypic inhibitors with improved resistance profiles.

Category: alcohols-buliding-blocks, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 7748-36-9, formula is C3H6O2, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Formula: C3H6O2

MacQueen, Preston M.;Tassone, Joseph P.;Diaz, Carlos;Stradiotto, Mark research published 《 Exploiting Ancillary Ligation To Enable Nickel-Catalyzed C-O Cross-Couplings of Aryl Electrophiles with Aliphatic Alcohols》, the research content is summarized as follows. The use of (L)Ni(o-tolyl)Cl precatalysts (L = PAd-DalPhos or CyPAd-DalPhos, I or II, resp.) enables the C(sp²)-O cross-coupling of primary, secondary, or tertiary aliphatic alcs. with (hetero)aryl electrophiles, including unprecedented examples of such nickel-catalyzed transformations employing (hetero)aryl chlorides, sulfonates, and pivalates. In addition to offering a competitive alternative to palladium catalysis, this work establishes the feasibility of utilizing ancillary ligation as a complementary means of promoting challenging nickel-catalyzed C(sp²)-O cross-couplings, without recourse to precious-metal photoredox catalytic methods.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Formula: C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of 16545-68-9, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 16545-68-9, name is Cyclopropanol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Mane, Baliram B.;Waghmode, Suresh B. research published 《 Iron-Catalyzed Ring Opening of Cyclopropanols and Their 1,6-Conjugate Addition to p-Quinone Methides》, the research content is summarized as follows. A novel iron-catalyzed ring opening of cyclopropanols and their 1,6-conjugate addition to p-quinone methides for accessing substituted phenols was disclosed. In this protocol, various cyclopropanols were converted to alkyl radicals and underwent 1,6-conjugate addition to p-quinone methides toward C-C bond formation. The salient features of this methodol. include operationally simple and mild reaction conditions, environmentally benign protocol, high efficiency, inexpensive catalyst, good to excellent yield and a wide range of substrate scope.

Application In Synthesis of 16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 16545-68-9, formula is C3H6O, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Category: alcohols-buliding-blocks

Liu, Yongfeng;Sheng, Yuqi;Wei, Ping;Zhang, Lu;Yao, Shengzhuo;Liu, Haifeng;Sun, Hua research published 《 The Third Body Effect of Carbon Dioxide on N-heptane Ignition Delay Characteristics under O₂/CO₂ Conditions》, the research content is summarized as follows. In order to study the impact of CO₂ during n-heptane ignition delay under O₂/CO₂ conditions, this study presents a numerical and exptl. study in four cases (40 mol.% O₂/60 mol.% CO₂, 50 mol.% O₂/50 mol.% CO₂, 57 mol.% O₂/43 mol.% CO₂ and 65 mol.% O₂/35 mol.% CO₂). Firstly, a third body effect (TBE) model is presented, which considers the third body efficiency of CO₂. Secondly, the TBE model adds the third body efficiency into a one-step global mechanism and obtains an ignition delay time formula according to the auto-ignition theory. Thirdly, experiments are carried out in a constant volume combustion chamber (CVCC) test system. Furthermore, the experiment and simulation results are compared and discussed. In addition, two parameters (α and β) are defined to study the third body effect and the chem. effect of CO₂ resp. Finally, chem. kinetic analyses are used to study the CO₂ effect. The results show that the TBE model is in agreement with the experiment and the maximum difference is 8.94% under the 57 mol.% O₂/43 mol.% CO₂ condition. The third body effect is the main effect of CO₂ and it can decrease small mol. intermediates and radicals. Besides, C₃H₆O is the most affected species by the third body effect of CO₂ among four prominent intermediate species. Furthermore, the third body effect of CO₂ inhibits most paths of OH production H+ O₂→O+ OH (R11) is the most affected pathway whose peak rate of production (ROP) decreases by 51.5%.

Category: alcohols-buliding-blocks, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Safety of Oxetan-3-ol

Lu, Hongfu;Yang, Ting;Xu, Zhongmiao;Lin, Xichen;Ding, Qian;Zhang, Yueting;Cai, Xin;Dong, Kelly;Gong, Sophie;Zhang, Wei;Patel, Metul;Copley, Royston C. B.;Xiang, Jianing;Guan, Xiaoming;Wren, Paul;Ren, Feng research published 《 Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists》, the research content is summarized as follows. CXCR2 has emerged as a therapeutic target for not only peripheral inflammatory diseases but also neurol. abnormalities in the central nervous system (CNS). Herein, we describe the discovery of a novel 1-cyclopentenyl-3-phenylurea series as potent and CNS penetrant CXCR2 antagonists. Extensive SAR studies, wherein mols.’ property forecast index (PFI) was carefully optimized for overall balanced developability profiles, led to the discovery of the advanced lead compound I with a desirable PFI. Compound I demonstrated good in vitro pharmacol. with excellent selectivity over CXCR1 and other chemokine receptors. Rat and dog pharmacokinetics (PK) revealed good oral bioavailability, high oral exposure, and desirable elimination half-life of the compound in both species. In addition, the compound demonstrated dose-dependent efficacy in the in vivo pharmacol. neutrophil infiltration “air pouch” model in rodents after oral administration. Further, compound I is a CNS penetrant mol. with high unbound fraction in brain tissue.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Safety of Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts