Tag: M.W=50-100

Vinogradov, M. G. published the artcileSelective method of 5-chloro-2-pentanone preparation, Synthetic Route of 20117-47-9, the publication is Izvestiya Akademii Nauk, Seriya Khimicheskaya (1995), 774-6, database is CAplus.

5-Chloro-2-pentanone (1) was prepared by reaction of 1-methylcyclobutanol (3) with Ca(OCl)₂, followed by decomposition of the 1-methylcyclobutyl hypochlorite in the presence of a Fe^II salt. The selectivity of 1 formation from 3 was 98%, and the conversion of 3 was 35-40%.

Izvestiya Akademii Nauk, Seriya Khimicheskaya published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C14H10N2O, Synthetic Route of 20117-47-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chakraborty, Shampa published the artcileRapid and efficient synthesis of 2,2-dimethylaminobenzazoles and 2,2-dimethylaminoazoles in a sustainable way, Synthetic Route of 96-20-8, the publication is Materials Research Innovations (2021), 25(2), 90-94, database is CAplus.

Reactions of 2-aminophenol, 2-aminobenzenethiol and other 2-substituted anilines, ethylene amines and amino acid containing 1,2 amino hydroxy groups with TBTU [2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumtetrafluoroborate], easily formed corresponding benzazoles (single crystal X-ray structure) and azoles attached with a di-Me amino group at 2-position via a guanidine intermediate which cyclizes and aromatizes by eliminating one dimethylamino group to afford benzazoles and azoles. The nobality of the synthesis is, single step and can occur at ambient temperature

Materials Research Innovations published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Synthetic Route of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barzagli, Francesco published the artcileScreening study of different amine-based solutions as sorbents for direct CO₂ capture from air, Product Details of C4H11NO, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(37), 14013-14021, database is CAplus.

Direct air capture (DAC) is an emerging technol. that can help limit the global temperature rises, as it has the potential to contrast the dispersed CO₂ emissions coming from transport and heating that cannot be captured with traditional CCS methods. Although recent improvements are bringing DAC closer to com. feasibility, an obstacle to its diffusion is the high regeneration energy required by the most common liquid sorbents, Na or K hydroxides. In order to develop efficient and more sustainable sorbents, in the present screening study several alkanolamines, particularly those already known for their utilization in CCS, were tested for DAC. The percentage of CO₂ absorbed from compressed air of their 1.5 mol dm^-3 aqueous solutions was evaluated in 24 h capture experiments and the species formed were identified and quantified by means of ¹³C-NMR spectroscopy. For selected amines, their performance in organic diluents was also evaluated. The correlations between aerial CO₂ absorption, chem. structures of the different amine and species formed in solution have shown that a high yield production of amine carbamate is the decisive factor for an effective CO₂ capture, and that aqueous primary unhindered amines are as efficient as aqueous alkali hydroxides, with the potential of a lower regeneration energy.

ACS Sustainable Chemistry & Engineering published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kuzniewski, Christian N. published the artcileSynthesis, Profiling, and Bioactive Conformation of trans-Cyclopropyl Epothilones, Application In Synthesis of 57044-25-4, the publication is Helvetica Chimica Acta (2019), 102(5), n/a, database is CAplus.

A series of new 3-deoxy-C(12),C(13)-trans-cyclopropyl-epothilones have been prepared, bearing benzothiazole, quinoline, thiazol-5-ylvinyl, or isoxazol-3-ylvinyl side chains (I – IV, resp.). For analogs with fused aromatic side chains, macrocyclic ring-closure was based on ring-closing olefin metathesis (RCM) of a precursor incorporating the fully elaborated heavy atom framework of the target structure (including the side chain moiety), while side chain attachment for the thiazole and isoxazole-containing 16-desmethyl analogs was performed only after establishment of the macrolactone core. Two approaches were elaborated for a macrocyclic aldehyde as the common precursor for the latter analogs that involved ring-closure either by RCM or by macrolactonization. Benzothiazole- and quinoline-based analogs were found to be highly potent antiproliferative agents; the two analogs with a thiazol-5-ylvinyl or an isoxazol-3-ylvinyl side chain likewise showed good antiproliferative activity but were significantly less potent than the parent epothilone A. Surprisingly, the desaturation of the C(10)-C(11) bond in these analogs was associated with a virtually complete loss in antiproliferative activity, which likely reflects a requirement for a ca. 60 ° C(10)-C(11) torsion angle in the tubulin-bound conformation of 12,13-trans-epothilones.

Helvetica Chimica Acta published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Application In Synthesis of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Krasniqi, Besir published the artcileGeneral Transition Metal-Free Synthesis of NH-Pyrroles from Secondary Alcohols and 2-Aminoalcohols, Name: 2-Aminobutan-1-ol, the publication is Journal of Organic Chemistry (2019), 84(9), 5027-5034, database is CAplus and MEDLINE.

A novel, transition metal-free and one-pot methodol. to synthesize various substituted NH-pyrroles from readily available building blocks such as secondary alcs. and 2-aminoalcs. is described. The process is based on the venerable Oppenauer-Woodward oxidation, which uses benzophenone as an inexpensive reagent to achieve oxidation of secondary alcs. under mild condition to ketones, further in situ condensation with aminoalc., and oxidative cyclization to the target pyrrole ring. The reaction occurs under basic conditions, and features a broad substrate scope combined with very good tolerance for sensitive functional groups. This method can be used to synthesize various substituted pyrroles useful as a starting material for broad applications.

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Name: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yuan-Yuan published the artcileProtective efficacy of phenoxyacetyl oxazolidine derivatives as safeners against nicosulfuron toxicity in maize, Application In Synthesis of 96-20-8, the publication is Pest Management Science (2021), 77(1), 177-183, database is CAplus and MEDLINE.

Herbicide safeners mitigate crop damage without reducing herbicide efficacy. Here, the protective effects of phenoxyacetyl oxazolidine derivatives as potential safeners were evaluated with a view toward reducing injury caused by sulfonylurea herbicide nicosulfuron to sensitive maize varieties. Growth indexes demonstrated that the bioactivity of compound 9 (N-phenoxyacety-2-methyl-2,4-diethyl-1,3-oxazolidine) was superior to that of R-28725 and all other compounds tested. Compound 9 induced endogenous glutathione and upregulated glutathione-S-transferase (GST) in maize. Thus, it could enhance maize tolerance to nicosulfuron. Compared with the untreated water control group, the maximum reaction rate of GST was increased by 37.62%, while the maximum velocity of GST was decreased by 61.93% after treatment with compound 9. Acetolactate synthase relative activity was significantly enhanced in the case of treatment with compound 9, indicating the excellent protective effects of compound 9 against nicosulfuron in maize. The present work demonstrates that phenoxyacetyl oxazolidine derivatives are potentially efficacious as herbicide safeners and merit further investigation.

Pest Management Science published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is CBF6K, Application In Synthesis of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cleveland, Alexander H. published the artcileSynthesis of Vicinal Dichlorides via Activation of Aliphatic Terminal Epoxides with Triphosgene and Pyridine, Recommanded Product: (R)-Oxiran-2-ylmethanol, the publication is Journal of Organic Chemistry (2018), 83(6), 3367-3377, database is CAplus and MEDLINE.

Herein we report a novel synthetic reaction to convert unactivated terminal aliphatic epoxide to alkyl vicinal dichloride based on triphosgene-pyridine activation. Our methodol. is operationally simple and readily tolerated by a broad of scope of substrates as well as protecting groups. Furthermore, these mild conditions generally yield clean reaction mixtures that are free of byproducts upon aqueous workup.

Journal of Organic Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Recommanded Product: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

De Mol, Eva published the artcileEPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor, COA of Formula: C3H6O2, the publication is ACS Chemical Biology (2016), 11(9), 2499-2505, database is CAplus and MEDLINE.

Castration-resistant prostate cancer is the lethal condition suffered by prostate cancer patients that become refractory to androgen deprivation therapy. EPI-001 is a recently identified compound active against this condition that modulates the activity of the androgen receptor, a nuclear receptor that is essential for disease progression. The mechanism by which this compound exerts its inhibitory activity is however not yet fully understood. Here we show, by using high resolution solution NMR spectroscopy, that EPI-001 selectively interacts with a partially folded region of the transactivation domain of the androgen receptor, known as transactivation unit 5, that is key for the ability of prostate cells to proliferate in the absence of androgens, a distinctive feature of castration-resistant prostate cancer. Our results can contribute to the development of more potent and less toxic novel androgen receptor antagonists for treating this disease.

ACS Chemical Biology published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, COA of Formula: C3H6O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pagola, G. I. published the artcileCould Electronic Anapolar Interactions Drive Enantioselective Syntheses in Strongly Nonuniform Magnetic Fields? A Computational Study, COA of Formula: C3H6O2, the publication is Journal of Chemical Theory and Computation, database is CAplus and MEDLINE.

It is shown that the anapolar interaction of the electrons of a mol. with an external uniform magnetic field B and a uniform curl C = ∇ × B′ determines different thermodn. stabilization of the ground state for the enantiomers and diastereoisomers of a chiral mol. A series of potential candidates for enantioselective syntheses have been investigated in a computational study via SCF-HF, B3LYP, and various coupled cluster approaches to determine the difference in energy between different enantiomers and diastereoisomers. The calculations show that these differences are very small for B and C presently available but approx. 3 orders of magnitude larger than those determined by parity violation effects. The chances that enantioselective synthesis may be attempted in the future are discussed. Recognition of anapolar interaction in chiral mols. via measurements of an induced magnetic dipole moment in the ordered phase may become possible in the presence of a nonuniform magnetic field with a strong gradient.

Journal of Chemical Theory and Computation published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, COA of Formula: C3H6O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Paul, Aparup published the artcileDouble μ₂-(phenoxido)-bridged dinuclear and polynuclear nickel(II) complexes: Magnetic properties and DNA/protein interaction, Category: alcohols-buliding-blocks, the publication is Polyhedron (2019), 39-48, database is CAplus.

One dinuclear and one 1-dimensional polymeric Ni(II) complex, {[Ni₂(HL)₂(pa)₂(H₂O)₂]·DMF} (1) and {[Ni₂(HL)₂(ppda)(H₂O)₂]·DMF·H₂O}_n (2) (H₂L = (E)-2-((1-hydroxybutan-2-ylimino)methyl)phenol, pa = 3-phenylacrylate, ppda = p-phenylenediacrylate) were synthesized and characterized by x-ray single crystal structure determination Complex 1 is double phenoxo-bridged dinuclear Ni(II) complex, whereas complex 2 is a 1-dimensional polynuclear chain where double phenoxo-bridged dinuclear units are connected through bridging ppda ligands. The variable temperature magnetic behavior of the complexes was studied using the Hamiltonian H = -JS₁S₂, S₁ = S₂ = S_Ni and confirms the presence of an overall antiferromagnetic interaction in both complexes. Good agreement between the exptl. and simulated curves were found using the parameters: g_Ni = 2.15, D_Ni = 4.0 cm^-1 and J_Ni-Ni = -0.60 cm^-1 for 1, and g_Ni = 2.15, D_Ni = 4.8 cm^-1 and J_Ni-Ni = -3 cm^-1 for 2. The interactions of the complexes with CT-DNA were studied using UV-visible absorption and fluorescence spectroscopic methods and both the complexes interact with CT-DNA. The intrinsic binding constants values for interaction with CT-DNA are 3.9(±0.10) × 10⁵ and 3.43(±0.09) × 10⁵ M^-1 for 1 and 2, resp. The interactions of the complexes with bovine serum albumins (BSA) and human serum albumins (HSA) were also studied using electronic absorption and fluorescence spectroscopic techniques and both complexes interact with the serum albumins via a ground state association process.

Polyhedron published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts