Meng, Xiangzhan’s team published research in Industrial & Engineering Chemistry Research in 58 | CAS: 96-20-8

Industrial & Engineering Chemistry Research published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Safety of 2-Aminobutan-1-ol.

Meng, Xiangzhan published the artcileSelective Oxidation of Amino Alcohols to Amino Acids over Au Supported on Monoclinic ZrO2: Dominant Active Sites and Kinetic Study, Safety of 2-Aminobutan-1-ol, the publication is Industrial & Engineering Chemistry Research (2019), 58(19), 8506-8516, database is CAplus.

Au supported on monoclinic ZrO2 (Au/m-ZrO2) prepared by deposition-precipitation method showed excellent catalytic performance in the aerobic oxidation of amino alcs. to amino acids, i.e., glycine, alanine, serine, β-alanine, and 2-aminobutyric acid. The Au particle size and valence distribution of the gold species were adjusted by calcination temperature, as demonstrated by XRD, TEM, UV-vis DRS, XPS, and H2-TPR, which significantly influenced the catalytic activity but not the selectivity of amino acids. Metallic gold atoms on the surface were shown to be the active sites by the correlation between reaction rate per mol of metallic Au and Au particle size. The kinetics of oxidation of monoethanolamine (MEA) was studied in detail, and the results indicated that MEA oxidation is a first-order reaction with an activation energy of 52.8 kJ·mol-1.

Industrial & Engineering Chemistry Research published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Safety of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Zuoyi’s team published research in International Journal of Food Science and Technology in 56 | CAS: 96-20-8

International Journal of Food Science and Technology published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C8H8O3, HPLC of Formula: 96-20-8.

Zhu, Zuoyi published the artcileStructural characterisation and antioxidant activity of melanoidins from high-temperature fermented apple, HPLC of Formula: 96-20-8, the publication is International Journal of Food Science and Technology (2021), 56(5), 2471-2480, database is CAplus.

Summary : High-temperature fermented apple is a new fermented product with characteristic black appearance, which is prepared through natural fermentation of whole fresh apple at controlled high temperature (60-90°C) and humidity (relative humidity of 50-90%). In this work, melanoidins from high-temperature fermented apple were obtained by ultrafiltration and subsequent diafiltration. The structural characterization of melanoidins was investigated in the present study. Results showed that the mol. weight of the obtained melanoidins was about 179 kDa and the melanoidins were comprised primarily of furans by pyrolysis-gas chromatog.-mass spectrometry. Antioxidant activities of the high-temperature fermented apple and its melanoidins were evaluated by ABTS, DPPH, hydroxyl radicals, ferric reducing antioxidant power and Fe2+-chelating assays. Both high-temperature fermented apple and its melanoidins showed extremely high antioxidant activities in scavenging hydroxyl radicals. High correlation between the antioxidant activity assayed methods and the physicochem. characteristics of melanoidins was obtained. The contribution of melanoidins to the total antioxidant capacity of high-temperature fermented apple was determined

International Journal of Food Science and Technology published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C8H8O3, HPLC of Formula: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hu, Bowen’s team published research in Youji Huaxue in 40 | CAS: 96-20-8

Youji Huaxue published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Quality Control of 96-20-8.

Hu, Bowen published the artcileHalf-sandwich ruthenium (II) complexes with bidentate NN ligands: active catalysts for synthesis of quinolines and pyrroles by acceptorless dehydrogenative cyclization, Quality Control of 96-20-8, the publication is Youji Huaxue (2020), 40(1), 53-60, database is CAplus.

Four (η6-p-cymene)Ru(II) complexes with bidentate NN ligands, (η6-p-cymene)Ru(C5H4N-C5H3N-OH), (η6-p-cymene)Ru(C5H4N-CH2-C5H4N), (η6-p-cymene)Ru(C5H4N-CH2-C5H3N-OH) and (η6-p-cymene)Ru(C5H4N-CH2-C5H3N-OCH3) were prepared These complexes were all characterized by 1H NMR, 13C NMR and elemental anal., and (η6-p-cymene)Ru(C5H4N-CH2-C5H4N) was further determined by single crystal crystallog. Complexes were treated as catalysts for cyclizations of amino alcs. with ketones, and (η6-p-cymene)Ru(C5H4N-CH2-C5H3N-OH) exhibited the highest activity. The cyclization reactions proceeded in toluene with 0.5 mol% catalyst loading, and a series of quinolines and pyrroles were synthesized.

Youji Huaxue published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Quality Control of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zak, Mark’s team published research in Journal of Medicinal Chemistry in 59 | CAS: 20117-47-9

Journal of Medicinal Chemistry published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C4H12ClNO, COA of Formula: C5H10O.

Zak, Mark published the artcileMinimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors, COA of Formula: C5H10O, the publication is Journal of Medicinal Chemistry (2016), 59(18), 8345-8368, database is CAplus and MEDLINE.

NAMPT inhibitors may show potential as therapeutics for oncol. Throughout our NAMPT inhibitor program, we found that exposed pyridines or related heterocyclic systems in the left-hand portion of the inhibitors are necessary pharmacophores for potent cellular NAMPT inhibition. However, when combined with a benzyl group in the center of the inhibitors, such pyridine-like moieties also led to consistent and potent inhibition of CYP2C9. In an attempt to reduce CYP2C9 inhibition, a parallel synthesis approach was used to identify central benzyl group replacements with increased Fsp3. A spirocyclic central motif was thus discovered that was combined with left-hand pyridines (or pyridine-like systems) to provide cellularly potent NAMPT inhibitors with minimal CYP2C9 inhibition. Further optimization of potency and ADME properties led to the discovery of compound 68, a highly potent NAMPT inhibitor with outstanding efficacy in a mouse tumor xenograft model and lacking measurable CYP2C9 inhibition at the concentrations tested.

Journal of Medicinal Chemistry published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C4H12ClNO, COA of Formula: C5H10O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Voller, Jiri’s team published research in Bioorganic Chemistry in 90 | CAS: 96-20-8

Bioorganic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C15H14Cl2S2, Application In Synthesis of 96-20-8.

Voller, Jiri published the artcile6-Substituted purines as ROCK inhibitors with anti-metastatic activity, Application In Synthesis of 96-20-8, the publication is Bioorganic Chemistry (2019), 103005, database is CAplus and MEDLINE.

Rho-associated serine/threonine kinases (ROCKs) are principal regulators of the actin cytoskeleton that regulate the contractility, shape, motility, and invasion of cells. We explored the relationships between structure and anti-ROCK2 activity in a group of purine derivatives substituted at the C6 atom by piperidin-1-yl or azepan-1-yl groups. Structure-activity relationship (SAR) analyses suggested that anti-ROCK activity is retained, and may be further increased, by substitution of the parent compounds at the C2 atom or by expansion of the C6 side chain. These inhibitors of ROCK can reach effective concentrations within cells, as demonstrated by a decrease in phosphorylation of the ROCK target MLC, and by inhibition of the ROCK-dependent invasion of melanoma cells in the collagen matrix. Our study may be useful for further optimization of C6-substituted purine inhibitors of ROCKs and of other sensitive kinases identified by the screening of a broad panel of protein kinases.

Bioorganic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C15H14Cl2S2, Application In Synthesis of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nageswara Rao, Desaboini’s team published research in Journal of Medicinal Chemistry in 64 | CAS: 20117-47-9

Journal of Medicinal Chemistry published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, Recommanded Product: 1-Methylcyclobutan-1-ol.

Nageswara Rao, Desaboini published the artcileDiscovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants, Recommanded Product: 1-Methylcyclobutan-1-ol, the publication is Journal of Medicinal Chemistry (2021), 64(16), 11972-11989, database is CAplus and MEDLINE.

The three pan-genotypic HCV NS3/4A protease inhibitors (PIs) currently in clin. use-grazoprevir, glecaprevir, and voxilaprevir-are quinoxaline-based P2-P4 macrocycles and thus exhibit similar resistance profiles. Using our quinoxaline-based P1-P3 macrocyclic lead compounds as an alternative chem. scaffold, we explored structure-activity relationships (SARs) at the P2 and P4 positions to develop pan-genotypic PIs that avoid drug resistance. A structure-guided strategy was used to design and synthesize two series of compounds with different P2 quinoxalines in combination with diverse P4 groups of varying sizes and shapes, with and without fluorine substitutions. Our SAR data and cocrystal structures revealed the interplay between the P2 and P4 groups, which influenced inhibitor binding and the overall resistance profile. Optimizing inhibitor interactions in the S4 pocket led to PIs with excellent antiviral activity against clin. relevant PI-resistant HCV variants and genotype 3, providing potential pan-genotypic inhibitors with improved resistance profiles.

Journal of Medicinal Chemistry published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, Recommanded Product: 1-Methylcyclobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khammas, A. J.’s team published research in Russian Journal of General Chemistry in 88 | CAS: 96-20-8

Russian Journal of General Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Application of 2-Aminobutan-1-ol.

Khammas, A. J. published the artcileSolvent Free Synthesis of N-Substituted Pyrrole Derivatives Catalyzed by Silica Sulfuric Acid, Application of 2-Aminobutan-1-ol, the publication is Russian Journal of General Chemistry (2018), 88(12), 2680-2683, database is CAplus.

Sulfuric acid immobilized on silica gel is used as an efficient catalyst in the synthesis of N-substituted pyrrole derivatives by the Clauson-Kaas pyrrole synthesis. The solvent free reaction mixture is stirred by grinding. Within very short reaction time the process leads to the corresponding products without any decomposition recorded.

Russian Journal of General Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Application of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Martin-Montero, Raul’s team published research in Organic Letters in 21 | CAS: 96-20-8

Organic Letters published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Quality Control of 96-20-8.

Martin-Montero, Raul published the artcileNi-catalyzed Reductive Deaminative Arylation at sp3 Carbon Centers, Quality Control of 96-20-8, the publication is Organic Letters (2019), 21(8), 2947-2951, database is CAplus and MEDLINE.

A Ni-catalyzed reductive deaminative arylation at unactivated sp3 carbon centers is described. This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp3 C-C linkages. These virtues have been assessed in the context of late-stage functionalization, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs.

Organic Letters published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Quality Control of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hayri-Senel, Tugba’s team published research in Journal of Coatings Technology and Research in | CAS: 96-20-8

Journal of Coatings Technology and Research published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, HPLC of Formula: 96-20-8.

Hayri-Senel, Tugba published the artcileThe use of poly(styrene-co-chloromethyl styrene) in the modification of triglyceride oils, HPLC of Formula: 96-20-8, the publication is Journal of Coatings Technology and Research, database is CAplus.

In this study, Poly(styrene-co-chloromethyl styrene) [Poly(St-co-CMS)] was prepared and used in the modification of triglyceride oils. The obtained modified triglyceride product was examined in view of oil-based binder. Nitroxide-mediated radical polymerization (NMRP) technique was applied for Poly(St-co-CMS) synthesis. Chloro groups on the Poly(St-co-CMS) backbone were reacted with 2-amino-1-butanol (2-AB) in order to obtain a polymer with hydroxyl ended side branches, [Poly(St-OH)], which were further combined with partial glycerides (PGs) through the reaction with toluene diisocyanate (TDI). The resulting product can also be considered as a polystyrene-modified urethane oil [Poly(St-OH)-SUO]. The structures of both intermediates, [Poly(St-co-CMS), Poly(St-OH)], and final products [Poly(St-OH)-SUO] were verified by using FTIR and 1H-NMR analyses. Addnl., thermal properties of the samples were determined The film properties of Poly(St-OH)-SUO samples prepared with different polymer/oil ratios and classic urethane oil were examined Poly(St-OH)-SUO-40 sample exhibited the best film properties among the others. In the end, the obtained results showed that Poly(St-OH)-SUO-40 could be utilized as an oil-based binder.

Journal of Coatings Technology and Research published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, HPLC of Formula: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, N. C.’s team published research in Journal of the American Chemical Society in 80 | CAS: 20117-47-9

Journal of the American Chemical Society published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C8H8O2, Formula: C5H10O.

Yang, N. C. published the artcilePhotochemical reactions of ketones in solution, Formula: C5H10O, the publication is Journal of the American Chemical Society (1958), 2913-14, database is CAplus.

The light-induced reactions of simple aliphatic ketones in saturated hydrocarbons were studied. Ketones with no γ-H atom gave the corresponding alc. and the addition product with the hydrocarbon. Ketones with γ-H atoms gave Me2CO, an olefin, and a cyclobutanol derivative These reactions differ markedly from those previously observed in the gas phase. The formation of cyclobutanols offers a route to a group of compounds otherwise difficult to prepare A 1:8 mixture of Me2CO and cyclohexane (I) irradiated in quartz yielded a small amount of CH4 and CO. Fractional distillation and gas chromatography yielded Me2CHOH 53, pinacol 15, MeCOCH2COMe 8, and cyclohexyldimethylcarbinol 12%; cyclohexylcyclohexene and hydrocarbon polymers were also obtained. The recovered I showed slight unsaturation Similarly, irradiation of 2-pentanone in I gave Me2CO, C2H4, and 1-methylcyclobutanol (phenylurethan m.p. 141°). Irradiation of 2-octanone in isoöctane gave equimol. amounts of Me2CO and CH2:CHPr (67%), and 17% 1-methyl-2-propylcyclobutanol b9 67-8°, nD20 1.4420, phenylurethan m. 78deg;. Irradiation of 2-nonanone in isoöctane yielded Me2CO, 1-hexene, and 1-methyl-2-butylcyclobutanol, b0.8 49-50°, nD20 1.4441, phenylurethan m.p. 91°. An intramol, mechanism is formulated for the formation of cyclobutanols.

Journal of the American Chemical Society published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C8H8O2, Formula: C5H10O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts