Obstetrics & Gynecology (Philadelphia, PA, United States) published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Computed Properties of 58551-69-2.
Govindappagari, Shravya published the artcileMild Thrombocytopenia and Postpartum Hemorrhage in Nulliparous Women With Term, Singleton, Vertex Deliveries, Computed Properties of 58551-69-2, the publication is Obstetrics & Gynecology (Philadelphia, PA, United States) (2020), 135(6), 1338-1344, database is CAplus and MEDLINE.
Objective: To assess whether mild thrombocytopenia (platelet count 100-149 k/μL) is associated with an increased risk of postpartum hemorrhage. Methods: Nulliparous women with term, singleton, vertex pregnancies undergoing labor at our institution between August 2016 and Sept. 2017 were included. The primary exposure was mild thrombocytopenia, defined as platelet count 100-149 k/μL, and the comparator was normal platelet count (150 k/μL or greater). Those with severe thrombocytopenia (platelet count less than 100 k/μL) were excluded from anal. The primary outcome was postpartum hemorrhage, determined by International Classification of Diseases, Tenth Revision codes and the hospital discharge problem list. Secondary outcomes included use of uterotonic agents (methylergonovine maleate or carboprost tromethamine), total blood loss 1,000 mL or greater, and blood transfusion. Data were analyzed by t test, χ or Fisher exact test, and multivariable logistic regression, with significance at α <0.05. Results: We evaluated 2,845 eligible women, of whom 2,579 (90.2%) had normal platelet count 150 k/μL or greater, 266 (9.3%) had platelet count 100-149 k/μL (mild thrombocytopenia), and 13 (0.5%) had platelet count less than 100 k/μL (severe thrombocytopenia). Compared with women with normal platelet count, those with mild thrombocytopenia had a higher rate of postpartum hemorrhage (16.9% vs 8.5%, P<.001) and were more likely to have total blood loss 1,000 mL or greater (4.5% vs 1.7%, P=.002) and receive methylergonovine maleate (10.5% vs 5.9%, P=.003) or carboprost tromethamine (6.0% vs 1.6%, P<.001) or both (3.8% vs 1.0%, P<.001), but rates of blood transfusion were no different (1.9% vs 1.5%, P=.59). The association between mild thrombocytopenia and postpartum hemorrhage persisted after multivariable adjustment for potential confounders (adjusted odds ratio 2.2, 95% CI 1.5-3.2, P<.001). Conclusion: Among nulliparous women with term, singleton, vertex pregnancies undergoing labor, those with mild thrombocytopenia (platelet count 100-149 k/μL) had a twofold greater likelihood of postpartum hemorrhage compared with those with normal platelet count.
Obstetrics & Gynecology (Philadelphia, PA, United States) published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Computed Properties of 58551-69-2.
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