Tag: M.W=450-500

Li, Wei published the artcileAnalysis of clinical efficacy of pituitrin combined with carboprost tromethamine in treatment of massive hemorrhage after placental abruption, Related Products of alcohols-buliding-blocks, the publication is Hebei Yixue (2016), 22(2), 221-223, database is CAplus.

Objective: To explore the clin. effect of pituitrin combined with carboprost tromethamine in the treatment of massive hemorrhage after placental abruption. Methods: A total of 116 patients with postpartum hemorrhage caused by premature abruption of placenta were selected and randomly divided into a control group and an observation group with 58 cases in each group. Both groups were treated with carboprost tromethamine, patients in the observation group were given pituitrin injection at the same time, and the time to hemostasis, total bleeding and the incidence of adverse events in the two groups were compared, and clin. summary and anal. were performed. Results: The observation group had bleeding volume 15min after delivery (224.7 ± 11.9) mL, bleeding volume 30min after delivery (254.8 ± 12.1) mL, bleeding volume 2h after delivery (275.2 ± 14.9) mL, bleeding volume 24h after delivery (291.7 ± 17.6) mL, postpartum hemostasis time (18.7 ± 5.9) min, hysterectomy rate 1.7%, neonatal asphyxia rate 6.9%, and no blood transfusion or death occurred, which were significantly better than the control group with statistical significance (P < 0.05). Conclusion: For patients with massive hemorrhage after premature abruption of placenta, the treatment of carboprost tromethamine combined with pituitrin can quickly inhibit the bleeding and improve the safety of mother and child.

Hebei Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yin, Yue published the artcileClinical analysis of Hemabate combined with oxytocin for prevention of postpartum hemorrhage after cesarean section in high-risk parturients, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xiandai Zhenduan Yu Zhiliao (2017), 28(8), 1407-1408, database is CAplus.

To observe the prevention and safety effect and safety of Hemabate combined with oxytocin on postpartum hemorrhage of cesarean women with high risk factors of postpartum hemorrhage. The 240 pregnant women undergoing cesarean section with high risk factors of postpartum hemorrhage, such as uterine weakness, placenta previa, twin pregnancy, giant fetus, polyhydramnios, scarred uterus, etc., were selected as the research subjects, and they were randomly divided into observation group and 120 cases in each control group. In the control group, oxytocin 20U was injected i.v. after the fetus was delivered to prevent postpartum hemorrhage, and the observation group was combined with the control group with 250 μg deep i.m. injection of Hemabate. We observed and compared the bleeding volume and the incidence of postpartum hemorrhage and adverse reactions during cesarean section, 2h postpartum and 24h postpartum between the two groups. In the observation group, the average blood loss at 2h and 24h after delivery was significantly lower than that in the control group (P < 0.05). The incidence of postpartum hemorrhage in the observation group was 1.67% significantly lower than 11.67% in the control group (P < 0.05). There were 16 cases of postpartum adverse reactions in the observation group, the symptoms were mild and alleviated spontaneously. For pregnant women undergoing cesarean section with high risk factors for postpartum hemorrhage. The preventive use of Hemabate significantly reduces the amount of intraoperative and postpartum hemorrhage, reduces the incidence of postpartum hemorrhage, and the medication is safe, convenient and effective.

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H10CoF6P, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Qiong-lin published the artcilePreventive efficacy of carboprost tromethamine on delivery woman having risk factors of postpartum hemorrhage, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xiandai Zhongxiyi Jiehe Zazhi (2013), 22(23), 2538-2540, database is CAplus.

The purpose is to investigate clin. efficacy and safety of carboprost tromethamine in prevention of postpartum hemorrhage after high-risk pregnancy cesarean section. 200 Cases of delivery primiparous mothers underwent cesarean section were selected, and randomly divided into observation group and control group, n=100. Patients in the observation group after the babies were delivered were immediately injected with oxytocin 20IU in uterine body, then were injected with carboprost tromethamine 250 μg in uterine body, patients in the control group after the babies were delivered were immediately injected with oxytocin 20IU in uterine body, meanwhile i.v. injected with oxytocin 10 IU. Operative time, bleeding in operation, postpartum hemorrhage, postpartum hemorrhage incidence, postpartum lochia duration time, postpartum anemia incidence and other conditions of delivery women in two groups were observed There were effective 95 cases and ineffective 5 cases in the observation group, the total effective rate was 95%; there were effective 89 cases and ineffective 13 cases in the control group, the total efficiency was 87%; there was a significant difference in clin. efficacy of two groups (P<0.05). The average operation time and average bleeding amount of the observation group were 37.86 min, and 300.35 mL; the average operation time and average bleeding amount of the control group were 48.19min and 415.66mL; and there were significant differences between two groups (P<0.05). The postpartum hemorrhage amount of delivery woman in the observation group was 368.41 mL, the incidence of postpartum hemorrhage was 5%, the postpartum lochia duration time was (17.32±5.01) d, the incidence of postpartum anemia was 6%; the postpartum hemorrhage amount of delivery woman in the control group was 473.55 mL, the incidence of postpartum hemorrhage was 13%, the postpartum lochia duration time was (23.29±7.91) d, the incidence of postpartum anemia was 15%; and there were significant differences between two groups (P<0.05). Carboprost tromethamine for prevention of postpartum hemorrhage in high-risk pregnancy cesarean section women, is safe and effective, has mild adverse reactions, and is worthy of clin. application.

Xiandai Zhongxiyi Jiehe Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C4H3Cl2NS, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jingyao published the artcileChIA-PET analysis of transcriptional chromatin interactions, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Methods (Amsterdam, Netherlands) (2012), 58(3), 289-299, database is CAplus and MEDLINE.

Long-range chromatin contacts between specific DNA regulatory elements play a pivotal role in gene expression regulation, and a global characterization of these interactions in the 3-dimensional (3D) chromatin structure is imperative in understanding signaling networks and cell states. Chromatin Interaction Anal. using Paired-End Tag sequencing (ChIA-PET) is a method which converts functional chromatin structure into millions of short tag sequences. Combining Chromatin Immunoprecipitation (ChIP), proximity ligation and high-throughput sequencing, ChIA-PET provides a global and unbiased interrogation of higher-order chromatin structures associated with specific protein factors. Here, we describe the detailed procedures of the ChIA-PET methodol., unraveling transcription-associated chromatin contacts in a model human cell line.

Methods (Amsterdam, Netherlands) published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C20H19NO4, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bojinova, S published the artcile[The use of prostaglandin F2alpha (Prostin 15M) for terminationof second trimester pregnancy]., Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Akusherstvo i ginekologiia (2013), 52(2), 53-5, database is MEDLINE.

The authors describe a case of terminating a second trimester pregnancy in 21 gestational weeks with use of Prostin 15 M. The patient come to the clinic in 21 gestational week with spontaneous rupture of the liquid amnii 72 hours ago, without any contractions and cervical dilatation. The foetus has breech presentation. From the ultrasound investment the fetal weight is measured to be around 380 grams and it has been confirmed that the liquid is less than normal. The woman refuse the use of Foley catheter. We induce the delivery with 10 E Oxytocin intravenously and with Cytotec by vaginal and per oral way (3 tablets equal to 600 micrograms) but there was no effect. There were no changes at the cervix and no contractions. Then we use 4 ampules of Prostin 15 M intramuscular through three hours and the pregnancy was successfully terminated.

Akusherstvo i ginekologiia published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pan, Haijuan published the artcileObservation on effect of carboprost tromethamine in prevention of postoperative bleeding during cesarean section with placenta previa, Quality Control of 58551-69-2, the publication is Guizhou Yiyao (2021), 45(7), 1064-1065, database is CAplus.

Objective: To investigate the effect of carboprost tromethamine in the prevention of postoperative bleeding during cesarean section with placenta previa. Methods: A controlled study was conducted on 88 puerperae with placenta previa who underwent cesarean section in our hospital from 2017.5 to 2019.5, and they were divided into observation group (carboprost tromethamine) and control group (oxytocin) 44 cases in each group, and the grouping method was random number table method to explore the effect of different treatments on postpartum hemorrhage and adverse reactions of puerperae. Results: The research objects in this paper were compared in terms of intraoperative blood loss, postoperative 12-h blood loss and postoperative 24-h blood loss. The observation group was significantly lower than the control group, and the difference was statistically significant (P < 0.05). Compared with the total effective rate, the observation group (97.73%) was significantly higher than the control group (86.36%), and the difference was statistically significant (P < 0.05). The observation group (2.27%, 9.09%) was significantly lower than the control group (15.91%, 27.27%), and the difference was statistically significant (P < 0.05). CONCLUSION: The application of carboprost tromethamine to pregnant women undergoing cesarean section with placenta previa could significantly reduce intraoperative and postoperative blood loss, with definite curative effect, less adverse reactions and high safety. This method was worthy of application and promotion.

Guizhou Yiyao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Quality Control of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xin-ni published the artcileEfficacy of preventive intrauterine injection of carboprost tromethamine in cesarean section of pregnant women with critical risk of postpartum hemorrhage, SDS of cas: 58551-69-2, the publication is Guangdong Yixue (2012), 33(5), 696-697, database is CAplus.

Objective: To observe the clin. efficacy of preventive intrauterine injection of carboprost tromethamine in cesarean section of pregnant women with critical risk of postpartum hemorrhage. Methods: Ninety-eight critical pregnant women receiving cesarean section with probability of postpartum hemorrhage were divided into an observation group (n=50) and a control group (n=48). The patients in the observation group were given conventional intrauterine injection of oxytocin and carboprost tromethamine for prevention of postpartum hemorrhage after parturition, and the patients in the control group were given oxytocin, misoprostol, pituitrin and calcium gluconate. The indexes of 2, 24 h hemorrhage volume, incidence of postpartum hemorrhage, hemostasis time, transfusion rate and complications in long or short term were compared between the two groups after parturition. Results: The 2, 24 h hemorrhage volume, incidence of postpartum hemorrhage, hemostasis time, transfusion rate and uterectomy rate in the observation group were significantly lower compared with the control group (P<0.05). Conclusion: Preventive intrauterine injection of carboprost tromethamine in cesarean section reduces hemorrhage volume, decreases the incidence of postpartum hemorrhage, transfusion rate and complications in long and short term for pregnant women with critical risk of postpartum hemorrhage, and the earlier of time selection, the better of the efficacy, which is valuable to popularize in basis hospitals.

Guangdong Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H10BNO3, SDS of cas: 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Qiu-hong published the artcileClinical effect of the combined application of carboprost tromethamine injection and gauze on patients with previa placenta underwent cesarean section, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Linchuang Yixue (2016), 36(2), 24-25, database is CAplus.

The aim of this paper is to investigate the clin. effects of combined application of Carboprost tromethamine injection and gauze on patients with previa placenta underwent cesarean section. From March 2013 to March 2015, forty-two patients with previa placenta underwent cesarean section were selected in the sixth people’s hospital of Nanhai district, all patients were randomly divided into observation group and control group. The patients in observation group were given Carboprost tromethamine injection and gauze to stop bleeding, while the patients in control group were managed with gauze only. The operation situations(bleeding volume, operation time, transfusion rate, and uterus resection rate), the bleeding volume after operation(2 h, 4 h, 8 h, 12 h), and adverse effects after operation of the two groups were observed The bleeding volume in operation of observation group and control group was resp.(361.3±69.9) ml vs. (552.0±59.6) ml, and there was significant difference(P<0.05). No significant difference was observed in operation time, transfusion rate, uterus resection rate or adverse effects after operation between the two groups(P>0.05). The effects of hemostasis of the combined application of carboprost tromethamine injection and gauze are better than gauze only on patients with previa placenta underwent cesarean section.

Linchuang Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patil, Ujwal S. published the artcileCleavable ester-linked magnetic nanoparticles for labeling of solvent-exposed primary amine groups of peptides/proteins, Quality Control of 70539-42-3, the publication is Analytical Biochemistry (2015), 18-20, database is CAplus and MEDLINE.

To study the solvent-exposed lysine residues of peptides/proteins, we previously reported disulfide-linked N-hydroxysuccinimide ester-modified silica-coated iron oxide magnetic nanoparticles (NHS-SS-SiO₂@Fe₃O₄ MNPs). The presence of a disulfide bond in the linker limits the use of disulfide reducing agent during protein digestion and allows unwanted disulfide formation between the MNPs and protein. In the current work, the disulfide bond was replaced with a cleavable ester group to synthesize NHS ester-modified SiO₂@Fe₃O₄ MNPs. Use of the cleavable ester group provides an improved method for protein labeling and allows the use of disulfide reducing agents during protein digestion.

Analytical Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Quality Control of 70539-42-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Chunfang published the artcileTo explore the best time of hemabate in prevention and treatment of postpartum hemorrhage, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Hebei Yixue (2017), 23(1), 52-54, database is CAplus.

Objective: To study the best time of hemabate in prevention and treatment of postpartum hemorrhage, to provide basis for clin. diagnosis and treatment. Methods: 114 cases of cesarean section with bleeding tendency from Feb. 2014 to Feb. 2016 in our hospital were selected, the patients were randomly divided into group I, group II and group III, 38 cases in each group, group I injection of oxytocin and hemabate immediately after fetal delivery, group II injection of the oxytocin immediately after fetal delivery, application of hemabate when uterine atony, group III injection of oxytocin immediately after fetal delivery, not using hemabate, the bleeding intraoperative, back to the ward to postoperative 2H and 2H to postpartum 24 h were compared between the three groups. Results: The bleeding during operation of group I significantly lower than II group and III group (P<0.05), there were no significant amount of intraoperative blood loss in group II and group III (P>0.05); back to the ward to postoperative 2H bleeding of group I and group II were significantly lower than those in the group III (P<0.05), group I and group II were not statistically significant (P>0.05), 2H to postpartum 24h bleeding of group I and group II were significantly lower than those in the group III (P<0.05), group I and group II were not statistically significant (P>0.05). Conclusion: Fetal delivery immediately injection of oxytocin and hemabate could effectively reduce the amount of postpartum hemorrhage, it is the best time to prevent postpartum hemorrhage.

Hebei Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H11BO2, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts