Tag: M.W=450-500

Peng, Fang-liang published the artcileClinical observation of carboprost tromethamine and oxytocin in the treatment of postpartum hemorrhage, Application In Synthesis of 58551-69-2, the publication is Zhongguo Yaofang (2014), 25(32), 3015-3017, database is CAplus.

This paper is to observe clin. efficacy and safety of carboprost tromethamine and oxytocin in the treatment of postpartum hemorrhage. 60 Delivery women with postpartum hemorrhage were randomly divided into control group and observation group. In control group, women undergoing natural labor were given i.m. injection of oxytocin 20 u after delivery of fetus, and women undergoing caesarean section were given intrauterine injection of oxytocin 20 u after delivery of fetus; then all of them received i.v. dripping of oxytocin 20 u added into 5% glucose solution 500 mL, and i.v. injection of oxytocin was given repeatedly and oral dose of misoprostol was given 600 mg if necessary, qd. Observation group was addnl. given intrauterine injection of carboprost tromethamine 0.25 mg on the basis of control group, and repeated injection was given if necessary; total daily dose could not be more than 2.0 mg and medication interval was more than 15 min. The clin. efficacy, the intensity of uterine contraction, hemostatic rates of patients with different amount of bleeding at different time and ADR were observed in 2 groups. The total effective rate, the intensity of uterine contraction hemostatic rates of patients with different amount of bleeding 5, 10 and 15 min after medication in observation group were significantly higher than those in control group, and there were statistical significances(P<0.05); there was no statistical significance in the incidence of ADR between 2 groups(P>0.05). Carboprost tromethamine and oxytocin are more effective and safer than oxytocin alone in the treatment of postpartum hemorrhage.

Zhongguo Yaofang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application In Synthesis of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Kaisu published the artcileEffect of hypophysin combined with carboprost tromethamine in treatment of post-partum hemorrhage induced by uterine inertia, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Jianyan Yixue Yu Linchuang (2016), 13(20), 2872-2873, database is CAplus.

Objective: To investigate the effect of hypophysin combined with carboprost tromethamine in treatment of post-partum hemorrhage induced by uterine inertia. Methods: From Mar. 2014 to Aug. 2015, 92 patients with postpartum hemorrhage induced by uterine inertia were randomly divided into control group (46 cases), given combined treatment of hypophysin and oxytocin, and study group (46 cases), further given carboprost Tromethamine on the basis of control group. The postpartum bleeding time, amounts of postpartum blood loss, incidence rate of hysterectomy and fetal mortality rate were compared between the two groups. Results: The amounts of postpartum blood loss at 0.5, 2 and 24 h after delivery, postpartum bleeding time, incidence rate of hysterectomy and fetal mortality rate of study group were significantly lower than those of control group (P < 0.05). Conclusion: Hypophysin combined with carboprost tromethamine might be with significant curative effect in the treatment of post-partum hemorrhage induced by uterine inertia.

Jianyan Yixue Yu Linchuang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C14H31NO2, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Lan published the artcileClinical observation of uterine suture combining with carboprost tromethamine injection treatment for uterine atony postpartum hemorrhage, HPLC of Formula: 58551-69-2, the publication is Yixue Zongshu (2014), 20(10), 1901-1902, database is CAplus.

The clin. value of uterine suture combined with carboprost tromethamine on uterine atony postpartum hemorrhage was investigated. A total of 60 cases of uterine atony postpartum hemorrhage from Jiangyou Second People’s Hospital during Jun. 2012 and Aug. 2013 were randomly divided into two groups, control group (30 cases) received routine uterine suture, observation group (30 cases) received uterine suture combined with carboprost tromethamine treatment. The estradiol, FSH (FSH), hot flashes score, endometrial thickness and proportions of bleeding time (â‰?2 h, > 2 h), bleeding amount (500-1,000 mL, â‰?1,000 mL) of the two groups were observed The level of estradiol of the observation group was higher than the control group, the endometrial thickness bigger than the control group, FSH, hot flash scores were lower than the control group, with statistically significant differences. The proportion of bleeding time â‰?2 h and the bleeding amount of 500-1,000 mL of the observation group was significantly higher than the control group, with statistically significant difference. The use of uterine suture combined with carboprost tromethamine on uterine atony postpartum hemorrhage could effectively improve the clin. symptoms, and reduce the bleeding amount and time, further promotion of the treatment should be done to improve the medical service level.

Yixue Zongshu published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C7H6Cl2, HPLC of Formula: 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yongju published the artcileTreatment of atonic postpartum hemorrhage with carboprost tromethamine, SDS of cas: 58551-69-2, the publication is Sichuan Yixue (2014), 35(3), 356-358, database is CAplus.

Objective: To observe curative effect of carboprost tromethamine (Hemabate) for controlling atonic postpartum hemorrhage. Methods: A retrospective anal. was undertaken on 87 cases of atonic postpartum hemorrhage which were treated with Hemabate, and 87 cases which didn′t use Hemabate were regarded as controlled group. Results: The hemorrhage was successfully controlled immediately after administration of Hemabate in 69 of 87cases. The total effective rate was 96.5%, four cases failed and two were performed hysterectomy. Conclusion: Hemabate appeared very effective for treatment of severe atonic postpartum hemorrhage. It also has the characters of convenience, safety, quick and high performance. It should be used actively at the early stage of postpartum hemorrhage.

Sichuan Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H5F3N4, SDS of cas: 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhong, Wen-qu published the artcileComparison of efficacy of hemabate and oxytocin in prevention of high-risk cesarean section postpartum hemorrhage, COA of Formula: C25H47NO8, the publication is Xiandai Zhenduan Yu Zhiliao (2014), 25(19), 4421-4422, database is CAplus.

82 Cases of patients with high-risk cesarean section postpartum hemorrhage were divided into observation group and control group, 41 cases in each group. The observation group received i.m. injection of hemabate, and the control group received i.m. injection of oxytocin after cesarean section. The amount of bleeding 2 h after surgery, amount of bleeding 2 h after surgery and bleeding rate of observation group were 212.6 ± 57.8 mL, 298.6 ± 71.4 mL and 17.1%, and those of control group were 358.7 ± 62.5 mL, 459.7 ± 86.3ml and 41.5%. The incidence of adverse reactions of observation group was 4.88%, and that of control group was 19.51%. The differences of all the data between groups were statistically significant (P < 0.05 or P < 0.01). Compared with traditional drugs, hemabate can effectively control bleeding amount and bleeding rate in preventing high-risk cesarean section postpartum hemorrhage, has high drug safety and is recommended to be used in clinic.

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H15NO, COA of Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Xiao-yan published the artcileEffectiveness and safety of carboprost tromethamine in prevention and treatment of bleeding during cesarean section in high-risk parturients, Quality Control of 58551-69-2, the publication is Zhongguo Fuyou Baojian (2017), 32(22), 5539-5541, database is CAplus.

Objective: The article explored the effectiveness and safety of preventive intrauterine injection of carboprost tromethamine in the prevention and treatment of bleeding during cesarean section in high-risk parturients. Methods: The article selected 381 women with high-risk factors for postpartum hemorrhage during cesarean section admitted to the obstetrics department of Sichuan Provincial Maternity and Child Health Hospital from Jan. 2015 to Dec. 2016 as the research objects. They were divided according to the uterine body injection of uterine contraction drugs. 3 groups, each with 127 cases. Women in the control group were given 20 IU of oxytocin plus 500mL of compound sodium chloride i.v. infusion immediately after the fetus was delivered; study group 1 was given 20 IU of oxytocin plus 500mL of compound sodium chloride i.v. infusion immediately after the fetus was delivered 250 μg carprost tromethamine was injected into the uterus; study group 2 immediately after the fetus was delivered, 250 μg carprost tromethamine was injected into the uterus. The article compares the clin. treatment effect, operation time, intraoperative and postoperative blood loss, incidence of postpartum hemorrhage, hemostasis of postpartum hemorrhage and adverse reactions among the three groups of women. Results: The total effective rate of the control group was significantly lower than that of study group 1 and study group 2, and the difference was statistically significant (P < 0.05); the total effective rate of study group 1 and study group 2 was compared, and the difference was not statistically significant (P > 0.05). There was no statistically significant difference in the operation time between the three groups of women (P > 0.05). In the control group, the amount of bleeding and the incidence of postpartum hemorrhage during operation, 2h, 24h after operation were significantly higher than that of study group 1 and study group 2, and the differences were statistically significant (all P < 0.05); study group 1 during operation and 2h after operation Compared with study group 2, the amount of bleeding and the incidence of postpartum hemorrhage at 24h were not statistically significant (P > 0.05). The use of therapeutic uterine contractions in study group 1 and study group 2 was significantly less than that of control group, and the differences were statistically significant (P < 0.05). A total of 29 cases of adverse reactions occurred in all parturients, with an incidence of 22.83%. The incidence of adverse reactions in the control group, study group 1, and study group 2 were 3.94%, 11.18%, and 7.09%, resp. Conclusion: Carprost tromethamine was effective in preventing and treating high-risk parturientsâ€?bleeding during cesarean section, and it was worthy of clin. application.

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H15ClO3S, Quality Control of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Jin-ling published the artcileEvaluation and analysis of application of carboprost in obstetrics and gynecology, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xiandai Zhenduan Yu Zhiliao (2013), 24(9), 1993-1994, database is CAplus.

60 Placenta previa lying-in women receiving cesarean section in our hospital in 2012-2013 were randomly divided into observation group and control group. The women in the observation group were given carboprost before placental expulsion, and the women in the control group were given carboprost after placental expulsion. The cesarean operation time and blood loss of the patients of the two groups were comparatively analyzed. Results: The maternal operative time and blood loss of the patients in the observation group were significantly different from those of the control group (P < 0.05), and were statistically significant. Administration of carboprost tromethamine before placental expulsion can shorten operation time, reduce blood loss and has important application value in clin.

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C17H16O2, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Yu published the artcileClinical observation of oxytocin combined with hemabate in the treatment of postpartum hemorrhage after cesarean section, SDS of cas: 58551-69-2, the publication is Xiandai Zhenduan Yu Zhiliao (2021), 32(1), 28-29, database is CAplus.

This article discusses the clin. efficacy of oxytocin combined with hemabate in the treatment of post-cesarean hemorrhage. Oxytocin combined with hemabate treatment can improve the oxidative stress index and coagulation index in patients with post-cesarean hemorrhage, thereby improving the therapeutic effect.

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C18H28N2O7, SDS of cas: 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Miao published the artcileClinical research of carboprost tromethamine for preventing and treating postpartum hemorrhage of high risk puerpera undergoing cesarean, HPLC of Formula: 58551-69-2, the publication is Xiandai Zhongxiyi Jiehe Zazhi (2013), 22(2), 144-145, 205, database is CAplus.

The objective was to observe the effect and security of carboprost tromethamine for preventing and treating postpartum hemorrhage of high risk puerpera undergoing cesarean. The method includes dividing 397 puerpera undergoing cesarean with high risk of postpartum hemorrhage into 3 groups: oxytocin group (injection of 20 IU oxytocin into hyster and i.v. infusion of 20 IU oxytocin, n=131), oxytocin+carboprost tromethamine group (injection of 20 IU oxytocin 20 IU+carboprost tromethamine 250μg into hyster, n=152), and carboprost tromethamine group (injection of carboprost tromethamine 250μg into hyster, n=114), calculating bleeding amount during the cesarean and 2 h after cesarean and the total bleeding amount, and observing the untoward effects. The results show that carboprost tromethamine can significantly reduce the bleeding amount during the cesarean and after cesarean, and the combination of carboprost tromethamine and oxytocin has better effect, and the untoward effect is little.

Xiandai Zhongxiyi Jiehe Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, HPLC of Formula: 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Bai-zhu published the artcileComparison between Hemabate and oxytocin in preventing and treating postpartum hemorrhage in pregnant women with high-risk cesarean section, Related Products of alcohols-buliding-blocks, the publication is Xiandai Zhenduan Yu Zhiliao (2015), 26(20), 4646-4647, database is CAplus.

The clin. data of 106 pregnant women undergoing cesarean section were retrospectively analyzed, and they were randomly divided into control group and observation group with 53 cases each. The control group was given 20U i.v. infusion of oxytocin and 10U uterine muscle injection, and the observation group was given 20U i.v. infusion of oxytocin and 250 μg uterine muscle injection of Hemabate. The bleeding volume and urine volume of the two groups of pregnant women during operation, 2h and 24h postpartum were compared and recorded, and the occurrence of adverse reactions in the two groups was observed The bleeding amount of the control group during surgery, 2h and 24h postpartum was significantly higher than that of the observation group (P < 0.05), and the urine output was lower than that of the observation group (P < 0.05). There were no significant differences in common adverse reactions (such as nausea, vomiting, palpitations, headaches, etc.) between the two groups (P > 0.05). Hemabate has a significant clin. effect compared with oxytocin in preventing and treating postpartum hemorrhage of high-risk cesarean pregnant women, and has fewer adverse reactions and higher safety, which is suitable for clin. use.

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts