Tag: M.W=400-600

Larsen, Finn Ole; Jensen, Benny V.; Norgaard, Hans Henrik; Hermann, Helle Kirstine; Larsen, Peter N.; Markussen, Alice; Hogdall, Estrid; Nielsen, Dorte published the artcile< Intrahepatic Oxaliplatin and Systemic 5-FU +/- Cetuximab in Chemo-Naive Patients with Liver Metastases from Colorectal Cancer>, COA of Formula: C20H21CaN7O7, the main research area is oxaliplatin fluorouracil cetuximab anticancer agent liver metastasis colorectal cancer; Colorectal cancer; Intrahepatic infusion; Oxaliplatin; Transarterial chemoembolization.

In case of response to chemotherapy, unresectable liver metastases from colorectal cancer can be converted to resectable and thereby obtain a chance of cure. The primary aim of this trial was to evaluate the response rate with intrahepatic oxaliplatin in combination with systemic 5-FU +/- cetuximab. Secondary aims were to evaluate the conversion rate from unresectable to resectable liver metastases, median progression-free survival, median overall survival, and toxicity. Forty-five chemo-naive patients with liver metastases from colorectal cancer were treated in a prospective phase II trial. Calcium folinate and 5-FU were delivered systemically while oxaliplatin was delivered alternating between systemic and intrahepatic administration. When oxaliplatin was delivered intrahepatic-ally, infusion time was reduced to 10 min followed by embolic material. In patients with KRAS wild-type tumors, cetuximab was added. The treatment was well tolerated and only pain in the liver and a mild increase in liver enzymes were observed after intrahepatic oxaliplatin. The patients obtained a response rate of 82%. Further, 58% converted from having unresectable to resectable liver metastases. The median overall survival and progression-free survival were 38.7 mo (95% confidence interval [CI] 33.0-44.3) and 12.9 mo (95% CI 10.2-15.6), resp. Intrahepatic infusion of oxaliplatin in 10 min with systemic 5-FU to patients with chemo-naive colorectal cancer is feasible and with low toxicity. A high response rate and long median overall survival were obtained.

Oncology published new progress about Animal gene, N-ras Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, COA of Formula: C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Patel, Bhargavi J.; Patel, Chetna R. published the artcile< Assessment of causality, severity and preventability of adverse drug reactions of cancer chemotherapy in a tertiary care teaching hospital, Gujarat, India>, Recommanded Product: Calcium folinate, the main research area is adverse drug reaction causality cancer chemotherapy human.

To evaluate the various adverse drug reactions with different cancer chemotherapy regimens, severity, causality assessment and preventability. This cross-sectional, observational study was carried out in the oncol. department at a tertiary care teaching hospital over a period of one year. Data on Adverse Drug Reactions (ADRs) of anticancer drugs were collected of cancer patients diagnosed by a concerned clinician from the oncol. department. These ADRs were assessed for causality using Naranjo’s probability scale. The severity and preventability of the reported reactions were assessed using the modified Hartwig and Siegel scale and modified Schumock and Thornton scale, resp. Data were analyzed using Descriptive Statistics and Microsoft Excel. Out of 683 ADRs recorded from 198 patients, m/c ADRs were alopecia (21.08%), n/v (17.27%) & nail pigmentation (11.56%), etc. Taxanes, Platinum compounds, Nitrogen mustards, Antibiotics, and Antimetabolites were the most common group of drugs causing ADRs. On Causality Assessment showed highest ADRs were ‘possible’ (49.34%), ‘probable’ (47.58%) & few were ‘doubtful’ (3.07%). Severity Assessment showed a majority of the ADRs belonged to ‘mild’ grade (91.21%), then ‘moderate’ (8.05%) & ‘severe’ (0.73%). It was observed that most of the ADRs were ‘Not Preventable’ (57.83%), ‘Probably Preventable’ (24.3%) & lastly ‘Definitely Preventable’ (17.86%). The study shows that most of ADRs due to anticancer drugs belonged to ‘possible’ grade as per Causality assessment, ‘mild’ as per Severity Assessment, and ‘Not Preventable’ as per Preventability Assessment.

International Journal of Pharmaceutical Sciences and Research published new progress about Alopecia. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Recommanded Product: Calcium folinate.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts