Tag: M.W=400-600

Minhas, Muhammad Usman; Abdullah, Orva; Sohail, Muhammad; Khalid, Ikrima; Ahmad, Sarfaraz; Khan, Kifayat Ullah; Badshah, Syed Faisal published the artcile< Synthesis of novel combinatorial drug delivery system (nCDDS) for co-delivery of 5-fluorouracil and leucovorin calcium for colon targeting and controlled drug release>, Formula: C20H21CaN7O7, the main research area is drug delivery systems 5 fluorouracil leucovorin calcium; 5-fluorouracil; Combinatorial gel; colon targeting; controlled release; leucovorin calcium.

Purpose of the current study was to improve the oral effectiveness of 5-fluorouracil (5-FU) by developing novel controlled, combinatorial drug delivery system (nCDDS) for co-delivery of 5-FU and leucovorin calcium (LC) for colon targeting. SignificanceOn the basis of results obtained, novel controlled, combinatorial drug delivery system could be an effective strategy for the colon targeting of 5-FU and LC. Free radical polymerization method was tuned and used to fabricate this nCDDS. The nCDDS is synthesized in two steps, first synthesis of 5-FU/LC calcium loaded nanogels and second, pre-synthesized 5-FU and LC loaded nanogels were dispersed in pectin based polymerized matrix hard gel. The nanogels and nCDDS gels were characterized for network structure, thermal stability, and surface morphol. Swelling and in vitro release studies were carried out at different pH 1.2 and 7.4 both for naive nanogels and combined matrix gels. In vivo study of combinatorial gel was performed on rabbits by using HPLC method to estimate plasma drug concentration and pharmacokinetics parameters. Structure and thermal anal. confirmed the formation of stable polymeric network. SEM of nanogels and combinatorial gels showed that the spongy and rough edges particles and uniformly distributed in the combinatorial gel. The prepared nCDDS showed excellent water loving capacity and pH responsiveness. Combinatorial gel showed excellent characteristic for colonic delivery of drugs, which were confirmed by various in vitro and in vivo characterizations. Acute oral toxicity study of combinatorial gel confirmed the biocompatible and nontoxic characteristics of developed formulation. Conclusively, it can be found that nCDDS showed excellent properties regarding drug targeting in a controllable manner as compared to naive PEGylated nanogels.

Drug Development and Industrial Pharmacy published new progress about Blood. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Formula: C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Irene S.; Loree, Jonathan M. published the artcile< FOLFOXIRI plus Bevacizumab Versus FOLFOX plus Panitumumab for Metastatic Left-Sided RAS / BRAF Wild-Type Colorectal Cancer: Which ′′Side′′ Are You On?>, Product Details of C20H21CaN7O7, the main research area is review FOLFOXIRI bevacizumab FOLFOX panitumumab RAS BRAF colorectal cancer.

A review. This commentary focuses on the results of the study by Pietrantonio et al., which evaluated the clin. conundrum of triplet vs. doublet chemotherapy in combination with targeted therapy for metastatic left-sided RAS/BRAF wild-type colorectal cancer and appears in this issue. Both FOLFOXIRI [fluorouracil, leucovorin, oxaliplatin, and irinotecan] plus bevacizumab and FOLFOX [fluorouracil, leucovorin, and oxaliplatin] plus panitumumab have shown impressive activity in this population; however, the two have not been directly compared. The article by Pietrantonio et al. presents a propensity score-adjusted anal. using information from five previous randomized trials and provides best available evidence comparing these regimens. This commentary will discuss their results and how their findings fit in current treatment paradigms.

Oncologist published new progress about Antitumor agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Product Details of C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mollaei, Mahdi; Ghoreishi, Sayed Mehdi; Khoobi, Asma published the artcile< Multivariate optimization and validation of a new procedure for simultaneous determination of folic acid and folinic acid based on enhancement effect of n-dodecylpyridinium chloride>, Reference of 1492-18-8, the main research area is folinic acid dodecylpyridinium chloride optimization enhancement effect.

The present study is a first report about of an electrochem. sensor for simultaneous determination of folic acid (FA) and calcium folinate (CF). Also, the work is a first successful application of n-dodecylpyridinium chloride (DPC) as a modifier in simultaneous measurement of folates. This study is based on the adsorption of cationic surfactants at the surface of a carbon paste electrode (CPE) to improve the electrochem. response of the tow analytes. The enhancement effect of DPC is compared with CTAB by differential pulse voltammetry (DPV) technique and DPC shows the better results as a modifier. Other novelty of the work is application of multivariate optimization for optimization of effective parameters in the voltammetric peak current of the analytes. Under the optimized conditions, a peak separation of CF and FA is higher than 270 mV. CPE in the presence of DPC shows wide linear responses for CF and FA in the concentration ranges of 0.1-100.0μM and 0.05-10.0μM with detection limits of 24.0 nM and 7.5 nM (3s), resp. CPE in the presence of DPC exhibits good repeatability and stability for the two analytes. At the last, CPE in the presence of DPC was successfully applied to the simultaneous detection of FA and CF in urine real samples.

Microchemical Journal published new progress about Adsorption. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Reference of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Eissa, Ibrahim H.; Alesawy, Mohamed S.; Saleh, Abdulrahman M.; Elkaeed, Eslam B.; Alsfouk, Bshra A.; El-Attar, Abdul-Aziz M. M.; Metwaly, Ahmed M. published the artcile< Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2'-o-Methyltransferase Complex Inhibitors among 3009 FDA Approved Drugs>, Recommanded Product: Calcium folinate, the main research area is SARSCoV2 nsp16 nsp10 complex inhibitor in silico mol docking; FDA approved drugs; MD simulations; MMPBSA; SARS-CoV-2 nsp16-nsp10 2′-o-methyltransferase; molecular docking; molecular fingerprints; structural similarity.

As a continuation of our earlier work against SARS-CoV-2, seven FDA-approved drugs were designated as the best SARS-CoV-2 nsp16-nsp10 2′-o-methyltransferase (2’OMTase) inhibitors through 3009 compounds The in silico inhibitory potential of the examined compounds against SARS-CoV-2 nsp16-nsp10 2′-o-methyltransferase (PDB ID: (6W4H) was conducted through a multi-step screening approach. At the beginning, mol. fingerprints experiment with SAM (S-Adenosylmethionine), the co-crystallized ligand of the targeted enzyme, unveiled the resemblance of 147 drugs. Then, a structural similarity experiment recommended 26 compounds Therefore, the 26 compounds were docked against 2’OMTase to reveal the potential inhibitory effect of seven promising compounds (Protirelin, (1187), Calcium folinate (1913), Raltegravir (1995), Regadenoson (2176), Ertapenem (2396), Methylergometrine (2532), and Thiamine pyrophosphate hydrochloride (2612)). Out of the docked ligands, Ertapenem (2396) showed an ideal binding mode like that of the co-crystallized ligand (SAM). It occupied all sub-pockets of the active site and bound the crucial amino acids. Accordingly, some MD simulation experiments (RMSD, RMSF, Rg, SASA, and H-bonding) have been conducted for the 2’OMTase-Ertapenem complex over 100 ns. The performed MD experiments verified the correct binding mode of Ertapenem against 2’OMTase exhibiting low energy and optimal dynamics. Finally, MM-PBSA studies indicated that Ertapenem bonded advantageously to the targeted protein with a free energy value of -43 KJ/mol. Furthermore, the binding free energy anal. revealed the essential amino acids of 2’OMTase that served pos. to the binding. The achieved results bring hope to find a treatment for COVID-19 via in vitro and in vivo studies for the pointed compounds

Molecules published new progress about Antiviral agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Recommanded Product: Calcium folinate.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kirhan, Idris; Kas, Fehmi; Taskiran, Huseyin; Buyukhatipoglu, Hakan; Gonel, Ataman; Koyuncu, Ismail published the artcile< Evaluation of Micro-RNA Levels, Apoptosis and Oxidative Stress Markers in Patients Recieving Chemotherapy>, SDS of cas: 1492-18-8, the main research area is cancer microRNA apoptosis oxidative stress marker chemotherapy; DNA damage; Micro-RNA; apoptosis; cancer; chemotherapy; damage; injury; metastasis; miR-29a; miRNA; prognosis..

Objective: The primary objective of this study was to compare oxidative DNA damage markers, apoptosis markers and changes in miRNA levels in patients diagnosed with cancer and treated through chemotherapy. Our secondary objective was also to evaluate tumor responses that can be determined after post-chemotherapy clin. evaluations by phys. examinations, laboratory results and radiol. imagings, and to compare the clin. results to oxidative stress and apoptosis markers and micro RNA levels. Materials and Methods: To do that we designed a prospective observational cross-sectional study. A total of 34 cancer patients and 27 healthy controls were included in the study from the Harran University School of Medicine Department of Oncol. Newly diagnosed chemotherapy or radiotherapy naive patients without any chronic diseases were included into the study. Patients with a poor performance status (ECOG 2 and 3) and patients who did not meet the inclusion criteria were excluded. The cancer patients received chemotherapy according to their scheduled periods. Blood samples were taken from the patients before the first chemotherapy course and before the second chemotherapy round. Patients were called for toxicity control on the 10th day after the chemotherapy. However, there were subtle differences between pre-chemotherapy and post-chemotherapy levels. Mir-29a expressions were lower in cancer patients as compared to controls.

Combinatorial Chemistry & High Throughput Screening published new progress about Apoptosis. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, SDS of cas: 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wo, Jennifer Y.; Clark, Jeffrey W.; Eyler, Christine E.; Mino-Kenudson, Mari; Klempner, Samuel J.; Allen, Jill N.; Keane, Florence K.; Parikh, Aparna R.; Roeland, Eric; Drapek, Lorraine C.; Ryan, David P.; Corcoran, Ryan B.; Van Seventer, Emily; Fetter, Isobel J.; Shahzade, Heather A.; Khandekar, Melin J.; Lanuti, Michael; Morse, Christopher R.; Heist, Rebecca S.; Ulysse, Christine A.; Christopher, Benjamin; Baglini, Christian; Yeap, Beow Y.; Mullen, John T.; Hong, Theodore S. published the artcile< Results and molecular correlates from a pilot study of neoadjuvant induction FOLFIRINOX followed by chemoradiation and surgery for gastroesophageal adenocarcinomas>, Computed Properties of 1492-18-8, the main research area is FOLFIRINOX chemoradition gastroesophageal adenocarcinomas.

We performed a NCI-sponsored, prospective study of neoadjuvant FOLFIRINOX followed by chemoradiation with carboplatin/paclitaxel followed by surgery in patients with locally advanced gastric or gastroesophageal cancer. Patients and Methods: The primary objective was to determine completion rate of neoadjuvant FOLFIRINOX x 8 followed by chemoradiation. Secondary endpoints were toxicity and pathol. complete response (pCR) rate. Exploratory anal. was performed of circulating tumor DNA (ctDNA) to treatment response. From Oct. 2017 to June 2018, 25 patients were enrolled. All patients started FOLFIRINOX, 92% completed all eight planned cycles, and 88% completed chemoradiation. Twenty (80%) patients underwent surgical resection, and 7 had a pCR (35% in resected cohort, 28% intention to treat). Tumor-specific mutations were identified in 21 (84%) patients, of whom 4 and 17 patients had undetectable and detectable ctDNA at baseline, resp. Presence of detectable post-chemoradiation ctDNA (P = 0.004) and/or postoperative ctDNA (P = 0.045) were associated with disease recurrence. Here we show neoadjuvant FOLFIRINOX followed by chemoradiation for locally advanced gastroesophageal cancer is feasible and yields a high rate of pCR. ctDNA appears to be a promising predictor of postoperative recurrence.

Clinical Cancer Research published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (AKTl1). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Computed Properties of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Malekzadeh, Parisa; Cowan, Kenneth; Steinberg, Seth M.; Camphausen, Kevin A.; Shriver, Craig; Merino, Maria J.; Good, Meghan L.; Berman, Arlene; Danforth, David N. Jr published the artcile< Twenty-five-Year Follow-up of a Prospective Randomized Trial Comparing Preoperative Versus Postoperative FLAC/Granulocyte Colony-Stimulating Factor Chemotherapy for Stage II Breast Cancer>, Related Products of 1492-18-8, the main research area is breast cancer stimulating factor chemotherapy.

Patients and methods: We conducted a single-institution prospective randomized control trial comparing preoperative or postoperative fluorouracil, leucovorin calcium, doxorubicin, and cyclophosphamides/granulocyte colony-stimulating factor chemotherapy for women with untreated clin. stage II breast cancer. Long-term follow-up was conducted to define toxicities, recurrence patterns and RFS and OS. Results: Fifty-three women with clin. stage II breast cancer were randomized, 26 patients to receive preoperative chemotherapy and 27 to receive postoperative chemotherapy. Long-term follow-up, with a median of 25.3 years, was obtained. Local or systemic recurrence occurred in 8 women in the preoperative group and in 10 women in the postoperative group, and recurrences were predominantly within 10 years of treatment. Late toxicities included local upper extremity paresthesia’s, upper extremity edema and congestive heart failure in 1 patient each. Anal. revealed no difference in RFS (20-yr RFS probabilities; preoperative: 61.3%, postoperative: 54.7%, P=0.42), or in OS between the 2 treatment groups (20-yr probabilities, preoperative: 64.6%, postoperative: 62.2%, P=0.44). Twenty-five of 53 patients (47%) were alive and without disease at this follow-up.

American Journal of Clinical Oncology published new progress about Chemotherapy. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Related Products of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bumrungpert, Akkarach; Pavadhgul, Patcharanee; Piromsawasdi, Theera; Mozafari, M. R. published the artcile< Efficacy and Safety of Ferrous Bisglycinate and Folinic Acid in the Control of Iron Deficiency in Pregnant Women: A Randomized, Controlled Trial>, COA of Formula: C20H21CaN7O7, the main research area is ferrous bisglycinate folinic acid iron deficiency pregnancy; absorption; ferrous bisglycinate; folinic acid; iron deficiency; iron status; pregnant women; side effects.

Iron deficiency in pregnancy is a major public health problem that causes maternal complications. The objective of this randomized, controlled trial was to examine the bioavailability, efficacy, and safety of oral ferrous bisglycinate plus folinic acid supplementation in pregnant women with iron deficiency. Subjects (12-16 wk of gestation, n = 120) were randomly allocated to receive oral iron as ferrous bisglycinate (equivalent iron 24 mg) in supplement form with folinic acid and multivitamins (test group, n = 60) or as ferrous fumarate (equivalent iron 66 mg iron, control group, n = 60) after breakfast daily. Iron absorption was assessed by measuring fasted serum iron levels at 1 and 2 h immediately after supplementation. Hematol. biomarkers and iron status were assessed before intervention, and at 3 and 6 mo. Side effects were monitored throughout the intervention. A significant increase in serum iron was seen in both groups (p < 0.001) during the bioavailability assessment; however, the test group increases were comparatively higher than the control values at each timepoint (p < 0.001). Similarly, both test and control groups demonstrated a statistically significant increases in Hb (Hb) (p < 0.001), erythrocytes (p < 0.001), reticulocytes (p < 0.001), mean corpuscular volume (MCV) (p < 0.001), mean corpuscular Hb (MCH) (p < 0.001), mean corpuscular Hb concentration (MCHC) (p < 0.001), % transferrin saturation (p < 0.001), and ferritin (p < 0.001) at 3 and 6 mo after supplementation. However, in all cases, the test group increases were numerically larger than the control group increases at each timepoint. The test intervention was also associated with significantly fewer reports of nausea, abdominal pain, bloating, constipation, or metallic taste (p < 0.001). In conclusion, ferrous bisglycinate with folinic acid as a multivitamin nutraceutical format is comparable to standard ferrous fumarate for the clin. management of iron deficiency during pregnancy, with comparatively better absorption, tolerability, and efficacy and with a lower elemental iron dosage. Nutrients published new progress about Abdominal pain. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, COA of Formula: C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saeed, Mohamed E. M.; Kadioglu, Onat; Greten, Henry Johannes; Yildirim, Adem; Mayr, Katharina; Wenz, Frederik; Giordano, Frank A.; Efferth, Thomas published the artcile< Drug repurposing using transcriptome sequencing and virtual drug screening in a patient with glioblastoma>, Electric Literature of 1492-18-8, the main research area is aclarubicin idarubicin anticancer agent cytotoxicity BRAF PIK3R1 mutation glioblastoma; Drug repurposing; Precision medicine; Targeted chemotherapy; Virtual drug screening.

Precision medicine and drug repurposing are attractive strategies, especially for tumors with worse prognosis. Glioblastoma is a highly malignant brain tumor with limited treatment options and short survival times. We identified novel BRAF (47-438del) and PIK3R1 (G376R) mutations in a glioblastoma patient by RNA-sequencing. The protein expression of BRAF and PIK3R1 as well as the lack of EGFR expression as analyzed by immunohistochem. corroborated RNA-sequencing data. The expression of addnl. markers (AKT, SRC, mTOR, NF-κB, Ki-67) emphasized the aggressiveness of the tumor. Then, we screened a chem. library of > 1500 FDA-approved drugs and > 25,000 novel compounds in the ZINC database to find established drugs targeting BRAF47-438del and PIK3R1-G376R mutated proteins. Several compounds (including anthracyclines) bound with higher affinities than the control drugs (sorafenib and vemurafenib for BRAF and PI-103 and LY-294,002 for PIK3R1). Subsequent cytotoxicity analyses showed that anthracyclines might be suitable drug candidates. Aclarubicin revealed higher cytotoxicity than both sorafenib and vemurafenib, whereas idarubicin and daunorubicin revealed higher cytotoxicity than LY-294,002. Liposomal formulations of anthracyclines may be suitable to cross the blood brain barrier. In conclusion, we identified novel small mols. via a drug repurposing approach that could be effectively used for personalized glioblastoma therapy especially for patients carrying BRAF47-438del and PIK3R1-G376R mutations.

Investigational New Drugs published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (ABCA13). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Electric Literature of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Patel, Bhargavi J.; Patel, Chetna R. published the artcile< Assessment of causality, severity and preventability of adverse drug reactions of cancer chemotherapy in a tertiary care teaching hospital, Gujarat, India>, Recommanded Product: Calcium folinate, the main research area is adverse drug reaction causality cancer chemotherapy human.

To evaluate the various adverse drug reactions with different cancer chemotherapy regimens, severity, causality assessment and preventability. This cross-sectional, observational study was carried out in the oncol. department at a tertiary care teaching hospital over a period of one year. Data on Adverse Drug Reactions (ADRs) of anticancer drugs were collected of cancer patients diagnosed by a concerned clinician from the oncol. department. These ADRs were assessed for causality using Naranjo’s probability scale. The severity and preventability of the reported reactions were assessed using the modified Hartwig and Siegel scale and modified Schumock and Thornton scale, resp. Data were analyzed using Descriptive Statistics and Microsoft Excel. Out of 683 ADRs recorded from 198 patients, m/c ADRs were alopecia (21.08%), n/v (17.27%) & nail pigmentation (11.56%), etc. Taxanes, Platinum compounds, Nitrogen mustards, Antibiotics, and Antimetabolites were the most common group of drugs causing ADRs. On Causality Assessment showed highest ADRs were ‘possible’ (49.34%), ‘probable’ (47.58%) & few were ‘doubtful’ (3.07%). Severity Assessment showed a majority of the ADRs belonged to ‘mild’ grade (91.21%), then ‘moderate’ (8.05%) & ‘severe’ (0.73%). It was observed that most of the ADRs were ‘Not Preventable’ (57.83%), ‘Probably Preventable’ (24.3%) & lastly ‘Definitely Preventable’ (17.86%). The study shows that most of ADRs due to anticancer drugs belonged to ‘possible’ grade as per Causality assessment, ‘mild’ as per Severity Assessment, and ‘Not Preventable’ as per Preventability Assessment.

International Journal of Pharmaceutical Sciences and Research published new progress about Alopecia. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Recommanded Product: Calcium folinate.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts