Tag: M.W=400-600

Goto, Emi; Yamaguchi, Toshifumi; Hattori, Nobuhiro; Goto, Masahiro; Nishihara, Masami; Uchiyama, Kazuhisa; Rikitake, Yoshiyuki published the artcile< Safety of Ramucirumab regimen without H1-antihistamine premedication in patients with solid cancers>, Reference of 1492-18-8, the main research area is ramucirumab H1antihistamine solid cancer; H1-antihistamines; Ramucirumab; infusion-related reactions; monoclonal antibodies.

Background/Aim: To prevent infusion-related reactions (IRRs), H1-antihistamines (H1AT) are recommended as a premedication for monoclonal antibodies, such as Ramucirumab (RAM), even though there are H1AT-related side effects, such as drowsiness and dizziness. Here, we investigated the safety of H1AT-free RAM regimens in patients with solid cancer. Patients and Methods: We retrospectively reviewed the patients with solid cancer receiving RAM without H1AT at Osaka Medical College Hospital between 2015 and 2019. Results: Among the 123 registered patients, 58 were identified as eligible. The total number of RAM infusions was 291, and the median number of RAM administration was 4 cycles (range = 1-23 cycles). IRRs were not observed in any patient. Conclusion: Although our data are preliminary and limited, H1AT-free RAM regimens may be a treatment option for cancer patients having a significant risk of developing H1AT-related side effects. Further studies are needed to confirm the safety of H1AT-free RAM regimens.

In Vivo published new progress about Colon neoplasm. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Reference of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hubbard, Joleen M.; Toke, Eniko R.; Moretto, Roberto; Graham, Rondell P.; Youssoufian, Hagop; Lorincz, Orsolya; Molnar, Levente; Csiszovszki, Zsolt; Mitchell, Jessica L.; Wessling, Jaclynn; Toth, Jozsef; Cremolini, Chiara published the artcile< Safety and activity of PolyPEPI1018 combined with maintenance therapy in metastatic colorectal cancer: an open-label, multicenter, phase Ib study>, Application In Synthesis of 1492-18-8, the main research area is PolyPEPI1018 tumor associated antigen metastatic colorectal cancer.

Although chemotherapy is standard of care for metastatic colorectal cancer (mCRC), immunotherapy has no role in microsatellite stable (MSS) mCRC, a “”cold”” tumor. PolyPEPI1018 is an off-the-shelf, multi-peptide vaccine derived from 7 tumor-associated antigens (TAA) frequently expressed in mCRC. This study assessed PoIyPEPI1018 combined with first-line maintenance therapy in patients with MSS mCRC. Patients and Methods: Eleven patients with MSS mCRC received PolyPEPI1018 and Montanide ISA51VG adjuvant s.c., combined with tluoropyrimidine/biol. following first-line induction with chemotherapy and a biol. (NCT03391232). In Part A of the study, 5 patients received a single dose; in Part B, 6 patients received up to three doses of Poly- PEPI1018 every 12 wk. The primary objective was safety; secondary objectives were preliminary efficacy, immunogenicity at peripheral and tumor level, and immune correlates. PolyPEPI1018 vaccination was safe and well tolerated. No vaccine-related serious adverse event occurred. Eighty percent of patients had CD8+ T-cell responses against ≥3 TAAs. Increased d. of tumor-infiltrating lymphocytes were detected post-treatment for 3 of 4 patients’ liver biopsies, combined with increased expression of immune-related gene signatures. Three patients had objective response according to REClSTv1.1, and 2 patients qualified for curative surgery. Longer median progression-free survival for patients receiving multiple doses compared with a single dose (12.5 vs. 4.6 mo; P = 0.017) suggested a dose-efficacy correlation. The host HLA genotype predicted multi-antigen specific T-cell responses (P = 0.01) indicative of clin. outcome. PolyPEPI1018 added to maintenance chemotherapy for patients with unresectable, MSS mCRC was safe and associated with specific immune responses and antitumor activity warranting further confirmation in a randomized, controlled setting.

Clinical Cancer Research published new progress about Adenocarcinoma. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Application In Synthesis of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saveliev, Anatoly A.; Galeeva, Ekaterina V.; Semanov, Dmitry A.; Galeev, Roman R.; Aryslanov, Ilshat R.; Falaleeva, Tatyana S.; Davletshin, Rustam R. published the artcile< Adaptive noise model based iteratively reweighted penalized least squares for fluorescence background subtraction from Raman spectra>, Reference of 1492-18-8, the main research area is ANM IRPLS math model fluorescence Raman spectroscopy.

The spectral anal. depends heavily on unwanted signals, such as the fluorescent background from the samples or other interfering components. A number of math. algorithms have been proposed to remove the background of Raman spectra. However, these methods require the selection of appropriate parameters to correct the of Raman spectra baseline. In this paper, we propose a method of adaptive noise model based on iteratively reweighted penalized least squares (ANM-IRPLS) for Raman spectrum baseline correction. The algorithm was applied to various artificial spectra containing real forms of baselines and characteristic Raman peaks and then to the spectra of real drug samples with fluorescence obtained on a device equipped with a 532-nm laser with a resolution of 15 cm-1. The modeling results showed that the proposed ANM-IRPLS baseline correction method allows for better results in background removal than the airPLS. For real Raman spectra processed by the ANM-IRPLS method, it is shown that the algorithm handles a complex background well, while maintaining the characteristic Raman signal features, such as a wide water peak for aqueous solutions

Journal of Raman Spectroscopy published new progress about Algorithm. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Reference of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kasper, Stefan; Foch, Caroline; Messinger, Diethelm; Esser, Regina; Lamy, Francois-Xavier; Rothe, Vivien; Chen, Wenfeng; Cheng, Ann-Lii; Rouyer, Magali; Brodowicz, Thomas; Zielinski, Christoph published the artcile< Noninferiority of cetuximab every-2-weeks versus standard once-weekly administration schedule for the first-line treatment of RAS wild-type metastatic colorectal cancer>, Recommanded Product: Calcium folinate, the main research area is cetuximab anticancer agent RAS metastatic colorectal cancer; Administration schedule; Cetuximab; Metastatic colorectal cancer; Noninferiority; Overall survival; Pooled analysis.

This study assessed whether cetuximab 500 mg/m2 administered every 2 wk (Q2W), when combined with chemotherapy as a first-line (1L) treatment, was noninferior to the approved dose (400 mg/m2 followed by 250 mg/m2 once weekly [Q1W]) for overall survival (OS) in adults with RAS wild-type metastatic colorectal cancer (mCRC).This pooled anal. included patients receiving 1L treatment with cetuximab Q1W or Q2W in combination with chemotherapy from post-authorisation studies with patient-level data available to the sponsor. Baseline characteristics were adjusted with a propensity score using inverse probability of treatment weighting (IPTW). Noninferiority in terms of OS was tested with a noninferiority margin for the hazard ratio (HR) of 1.25 using a Cox proportional hazards regression model. Secondary outcomes were progression-free survival (PFS), overall response rate (ORR) and rates of lung/liver metastases resection and serious adverse events.OS time was noninferior in the Q2W cohort (n = 554) compared to the Q1W cohort (n = 763), with a HR after IPTW (95% confidence interval) of 0.827 (0.715-0.956) and median OS times of 24.7 (Q1W) and 27.9 (Q2W) months. There were no major differences in PFS (HR: 0.915 [0.804-1.042]). The odds ratios (ORs) after IPTW for ORR (1.292 [1.031-1.617]) and the rates of lung/liver metastases resection (1.419 [1.043-1.932]) favored the Q2W regimen. No differences were noted in the occurrence rate of any SAE between groups; the OR after IPTW was 1.089 (0.858-1.382). The cetuximab Q2W regimen was noninferior to the Q1W regimen for OS in the 1L treatment of mCRC.

European Journal of Cancer published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (BRAF). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Recommanded Product: Calcium folinate.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ozkan, Ilknur; Taylan, Secil; Eroglu, Nermin; Kolac, Nurcan published the artcile< The Relationship between Malnutrition and Subjective Taste Change Experienced by Patients with Cancer Receiving Outpatient Chemotherapy Treatment>, Related Products of 1492-18-8, the main research area is human malnutrition taste change cancer chemotherapy.

Taste changes and malnutrition are two important problems in patients with different types of cancer. This study was conducted to evaluate the relationship between malnutrition and subjective taste changes experienced by cancer patients receiving outpatient chemotherapy. The study used a cross-sectional design and was carried out with 1382 patients with cancer receiving outpatient chemotherapy. Of the patients, 63.1% experienced taste changes. It was determined that 8.8% of patients had malnutrition according to the Mini Nutritional Assessment. The mean scores of patients experiencing malnutrition and being at risk for malnutrition from all sub-dimensions of The Chemotherapy-induced Taste Alteration Scale (CiTAS) were found to be higher than the patient group evaluated to have normal nutrition. It was determined that a unit increase in the scores of the parageusia and phantogeusia subscales of the CiTAS increased the risk of malnutrition by 3.36 times (%95CI = 2.68-4.02). In line with these results, we recommend that patients with cancer receiving chemotherapy should be routinely evaluated in terms of taste changes in clin. practice and that they should be followed up in terms of malnutrition in the presence of taste changes.

Nutrition and Cancer published new progress about Bladder neoplasm. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Related Products of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abdullah, Orva; Usman Minhas, Muhammad; Ahmad, Mahmood; Ahmad, Sarfaraz; Ahmad, Aousaf published the artcile< Synthesis of hydrogels for combinatorial delivery of 5-fluorouracil and leucovorin calcium in colon cancer: optimization, in vitro characterization and its toxicological evaluation>, Computed Properties of 1492-18-8, the main research area is leucovorin calcium 5fluorouracil drug delivery hydrogel colon cancer.

Chem. crosslinking of monomers methacrylic acid (MAA) and itaconic acid (IA) through ethylene glycol dimethacrylate (EGDMA) was carried out for synthesizing robust hydrogel system for oral administration and tuned for targeted release of 5-fluorouracil (5-FU) and leucovorin calcium (LV) at colonic site. Aqueous-based free radical polymerization method was optimized first, and then a series of batches were prepared Various in vitro tests were performed to probe the characteristics of synthesized hydrogels such as the presence of functional groups, surface morphol., crystalline/amorphous properties and thermal stability which confirms the crosslinking and stability of hydrogels. Swelling, drug loading and drug release evaluations were carried out at two different pH levels of 1.2 and pH 7.4. pH responsiveness was observed in synthesized hydrogels. Co-polymeric hydrogels exhibited higher swelling and release at higher pH 7.4 as compared to lower pH 1.2. Moreover, an increased trend in swelling and drug release was observed for formulations with higher content of IA. Co-polymeric hydrogels were biocompatible and non-toxic to biol. system as investigated by acute oral toxicity study on rabbits.

Polymer Bulletin (Heidelberg, Germany) published new progress about Antitumor agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Computed Properties of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Joshi, Tanuja; Joshi, Tushar; Pundir, Hemlata; Sharma, Priyanka; Mathpal, Shalini; Chandra, Subhash published the artcile< Predictive modeling by deep learning, virtual screening and molecular dynamics study of natural compounds against SARS-CoV-2 main protease>, COA of Formula: C20H21CaN7O7, the main research area is SARSCoV2 main protease virtual screening natural compound; COVID-19; deep learning; main protease (MPro); molecular docking; natural compounds.

The whole world is facing a great challenging time due to Coronavirus disease (COVID-19) caused by SARS-CoV-2. Globally, more than 14.6 M people have been diagnosed and more than 595 K deaths are reported. Currently, no effective vaccine or drugs are available to combat COVID-19. Therefore, the whole world is looking for new drug candidates that can treat the COVID-19. In this study, we conducted a virtual screening of natural compounds using a deep-learning method. A deep-learning algorithm was used for the predictive modeling of a CHEMBL3927 dataset of inhibitors of Main protease (Mpro). Several predictive models were developed and evaluated based on R2, MAE MSE, RMSE, and Loss. The best model with R2=0.83, MAE = 1.06, MSE = 1.5, RMSE = 1.2, and loss = 1.5 was deployed on the Selleck database containing 1611 natural compounds for virtual screening. The model predicted 500 hits showing the value score between 6.9 and 3.8. The screened compounds were further enriched by mol. docking resulting in 39 compounds based on comparison with the reference (X77). Out of them, only four compounds were found to be drug-like and three were non-toxic. The complexes of compounds and Mpro were finally subjected to Mol. dynamic (MD) simulation for 100 ns. The MMPBSA result showed that two compounds Palmatine and Sauchinone formed very stable complex with Mpro and had free energy of -71.47 kJ mol-1 and -71.68 kJ mol-1 resp. as compared to X77 (-69.58 kJ mol-1). From this study, we can suggest that the identified natural compounds may be considered for therapeutic development against the SARS-CoV-2.

Journal of Biomolecular Structure and Dynamics published new progress about Antiviral agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, COA of Formula: C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nastyukha, Yuliya; Kostyana, Kateryna; Maksymovych, Maria; Boretska, Olga published the artcile< The role of the state drug formulary of Ukraine in providing rational pharmacotherapy for elderly patients>, Application of C20H21CaN7O7, the main research area is drug formulary pharmaceutical care pharmacotherapy human.

Applying the Classification for Drug-Related Problems (DRPs) of the Pharmaceutical Care Network Europe (V 9.00, 2019) allowed to systematize the information on the use of drugs in elderly patients given in the Annex of the State Drug Formulary of Ukraine. As a result of this work, special warnings and recommendations of the State Drug Formulary were presented together with the possible causes for potential DRPs, which they allow to prevent. The lists of potentially inappropriate medications (PIMs) for the elderly (n = 98), drugs the dosage of which in patients of this age group should be adjusted (n = 127), and drugs that need monitoring (n = 108) were formed. The obtained results can serve as a basis for the development of a specialized geriatric tool to ensure rational pharmacotherapy, in particular in the provision of pharmaceutical care.

Pharmacia (Sofia, Bulgaria) published new progress about Antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Application of C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Joshi, Tanuja; Joshi, Tushar; Pundir, Hemlata; Sharma, Priyanka; Mathpal, Shalini; Chandra, Subhash published the artcile< Predictive modeling by deep learning, virtual screening and molecular dynamics study of natural compounds against SARS-CoV-2 main protease>, COA of Formula: C20H21CaN7O7, the main research area is SARSCoV2 main protease virtual screening natural compound; COVID-19; deep learning; main protease (MPro); molecular docking; natural compounds.

The whole world is facing a great challenging time due to Coronavirus disease (COVID-19) caused by SARS-CoV-2. Globally, more than 14.6 M people have been diagnosed and more than 595 K deaths are reported. Currently, no effective vaccine or drugs are available to combat COVID-19. Therefore, the whole world is looking for new drug candidates that can treat the COVID-19. In this study, we conducted a virtual screening of natural compounds using a deep-learning method. A deep-learning algorithm was used for the predictive modeling of a CHEMBL3927 dataset of inhibitors of Main protease (Mpro). Several predictive models were developed and evaluated based on R2, MAE MSE, RMSE, and Loss. The best model with R2=0.83, MAE = 1.06, MSE = 1.5, RMSE = 1.2, and loss = 1.5 was deployed on the Selleck database containing 1611 natural compounds for virtual screening. The model predicted 500 hits showing the value score between 6.9 and 3.8. The screened compounds were further enriched by mol. docking resulting in 39 compounds based on comparison with the reference (X77). Out of them, only four compounds were found to be drug-like and three were non-toxic. The complexes of compounds and Mpro were finally subjected to Mol. dynamic (MD) simulation for 100 ns. The MMPBSA result showed that two compounds Palmatine and Sauchinone formed very stable complex with Mpro and had free energy of -71.47 kJ mol-1 and -71.68 kJ mol-1 resp. as compared to X77 (-69.58 kJ mol-1). From this study, we can suggest that the identified natural compounds may be considered for therapeutic development against the SARS-CoV-2.

Journal of Biomolecular Structure and Dynamics published new progress about Antiviral agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, COA of Formula: C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nastyukha, Yuliya; Kostyana, Kateryna; Maksymovych, Maria; Boretska, Olga published the artcile< The role of the state drug formulary of Ukraine in providing rational pharmacotherapy for elderly patients>, Application of C20H21CaN7O7, the main research area is drug formulary pharmaceutical care pharmacotherapy human.

Applying the Classification for Drug-Related Problems (DRPs) of the Pharmaceutical Care Network Europe (V 9.00, 2019) allowed to systematize the information on the use of drugs in elderly patients given in the Annex of the State Drug Formulary of Ukraine. As a result of this work, special warnings and recommendations of the State Drug Formulary were presented together with the possible causes for potential DRPs, which they allow to prevent. The lists of potentially inappropriate medications (PIMs) for the elderly (n = 98), drugs the dosage of which in patients of this age group should be adjusted (n = 127), and drugs that need monitoring (n = 108) were formed. The obtained results can serve as a basis for the development of a specialized geriatric tool to ensure rational pharmacotherapy, in particular in the provision of pharmaceutical care.

Pharmacia (Sofia, Bulgaria) published new progress about Antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Application of C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts