Tag: M.W=400-600

Zoetemelk, Marloes; Ramzy, George M.; Rausch, Magdalena; Koessler, Thibaud; van Beijnum, Judy R.; Weiss, Andrea; Mieville, Valentin; Piersma, Sander R.; de Haas, Richard R.; Delucinge-Vivier, Celine; Andres, Axel; Toso, Christian; Henneman, Alexander A.; Ragusa, Simone; Petrova, Tatiana V.; Docquier, Mylene; McKee, Thomas A.; Jimenez, Connie R.; Daali, Youssef; Griffioen, Arjan W.; Rubbia-Brandt, Laura; Dietrich, Pierre-Yves; Nowak-Sliwinska, Patrycja published the artcile< Optimized low-dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment>, Safety of Calcium folinate, the main research area is colorectal carcinoma drug treatment optimized low dose combinatorial; colorectal carcinoma; combination treatment; drug-drug interactions; drug-target interactions; phosphoproteomics; synergy.

The current standard of care for colorectal cancer (CRC) is a combination of chemotherapeutics, often supplemented with targeted biol. drugs. An urgent need exists for improved drug efficacy and minimized side effects, especially at late-stage disease. We employed the phenotypically driven therapeutically guided multidrug optimization (TGMO) technol. to identify optimized drug combinations (ODCs) in CRC. We identified low-dose synergistic and selective ODCs for a panel of six human CRC cell lines also active in heterotypic 3D co-culture models. Transcriptome sequencing and phosphoproteome analyses showed that the mechanisms of action of these ODCs converged toward MAP kinase signaling and cell cycle inhibition. Two cell-specific ODCs were translated to in vivo mouse models. The ODCs reduced tumor growth by ∼80%, outperforming standard chemotherapy (FOLFOX). No toxicity was observed for the ODCs, while significant side effects were induced in the group treated with FOLFOX therapy. Identified ODCs demonstrated significantly enhanced bioavailability of the individual components. Finally, ODCs were also active in primary cells from CRC patient tumor tissues. Taken together, we show that the TGMO technol. efficiently identifies selective and potent low-dose drug combinations, optimized regardless of tumor mutation status, outperforming conventional chemotherapy.

Molecular Oncology published new progress about Animal gene, c-kit Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Safety of Calcium folinate.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Mingming; Tang, Shuangmei; Yang, Xiaoqi; Xie, Xinyu; Luo, Yang; He, Shaojuan; Li, Xuezhong; Feng, Xin published the artcile< Identification of key genes and pathways in chronic rhinosinusitis with nasal polyps and asthma comorbidity using bioinformatics approaches>, Electric Literature of 1492-18-8, the main research area is gene expression nasal polyp bioinformatic chronic rhinosinusitis asthma comorbidity; asthma; bioinformatic; chronic rhinosinusitis with nasal polyps; enrichment analysis; hub genes.

Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma comorbidity (ACRSwNP) present severe symptoms and are more likely to relapse. However, the pathogenesis of ACRSwNP is not fully understood. The aim of this study was to explore the underlying pathogenesis of ACRSwNP using bioinformatics approaches. ACRSwNP-related differentially expressed genes (DEGs) were identified by the anal. of the GSE23552 dataset. The clusterProfiler R package was used to carry out functional and pathway enrichment anal. A protein-protein interaction (PPI) network was built using the STRING database to explore key genes in the pathogenesis of ACRSwNP. The bioinformatics anal. results were verified through qRTPCR. The Connectivity Map (CMap) database was used to predict potential drugs for the treatment of ACRSwNP. A total of 36 DEGs were identified, which were mainly enriched in terms of regulation of immune response and detection sensory perception of taste. Thirteen hub genes including AZGP1, AQP9, GAPT, PIP, and PRR4 were identified as potential hub genes in ACRSwNP from the PPI network. Anal. of the GSE41861 dataset showed that upregulation of CST1 in nasal mucosa was associated with asthma. qRT-PCR detection confirmed the bioinformatics anal. results. Tacrolimus and spaglumic acid were identified as potential drugs for the treatment of ACRSwNP from the CMap database. The findings of this study provide insights into the pathogenesis of ACRSwNP and may provide a basis for the discovery of effective therapeutic modalities for ACRSwNP.

Frontiers in Immunology published new progress about Adaptive immunity. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Electric Literature of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maneikyte, Juste; Bausys, Augustinas; Leber, Bettina; Feldbacher, Nicole; Hoefler, Gerald; Kolb-Lenz, Dagmar; Strupas, Kestutis; Stiegler, Philipp; Schemmer, Peter published the artcile< Dietary glycine prevents FOLFOXchemotherapy-induced heart injury: a colorectal cancer liver metastasis treatment model in rats>, Computed Properties of 1492-18-8, the main research area is colorectal cancer heart injury glycine collagen type I Hb; FOLFOX; cardiotoxicity; colorectal cancer; glycine.

This study tested the hypothesis of glycine being cardioprotective in a rat model of FOLFOX in combination with CRLM. Materials and Methods: The effect of glycine was tested in vitro on human cardiac myocytes (HCMs). To test glycine in vivo Wag/Rij rats with induced CRLM were treated with FOLFOX ±5% dietary glycine. Left ventricle ejection fraction (LVEF), myocardial fibrosis, and apoptosis, also heart fatty acid binding protein (h-FABP) and brain natriuretic peptide levels were monitored. PCR anal. for Collagen type I, II, and brain natriuretic peptide (BNP) in the heart muscle was performed. Results: In vitro glycine had no effect on HCM cell viability. Treatment with FOLFOX resulted in a significant increase of h-FABP levels, increased myocardial fibrosis, and apoptosis as well as increased expression of type I Collagen. Furthermore, FOLFOX caused a decrease of LVEF by 10% (p = 0.028). Dietary glycine prevented FOLFOX-induced myocardial injury by preserving the LVEF and reducing the levels of fibrosis (p = 0.012) and apoptosis (p = 0.015) in vivo. Conclusions: Data presented here demonstrate for the first time that dietary glycine protects the heart against FOLFOX-induced injury during treatment for CRLM.

Nutrients published new progress about Apoptosis. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Computed Properties of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yin, Shenyi; Xi, Ruibin; Wu, Aiwen; Wang, Shu; Li, Yingjie; Wang, Chaobin; Tang, Lei; Xia, Yuchao; Yang, Di; Li, Juan; Ye, Buqing; Yu, Ying; Wang, Junyi; Zhang, Hanshuo; Ren, Fei; Zhang, Yuanyuan; Shen, Danhua; Wang, Lin; Ying, Xiangji; Li, Zhongwu; Bu, Zhaode; Ji, Xin; Gao, Xiangyu; Jia, Yongning; Jia, Ziyu; Li, Nan; Li, Ziyu; Ji, Jia-Fu; Xi, Jianzhong Jeff published the artcile< Patient-derived tumor-like cell clusters for drug testing in cancer therapy>, Recommanded Product: Calcium folinate, the main research area is gastric colorectal breast cancer recurrence metastases.

Several patient-derived tumor models emerged recently as robust preclin. drug-testing platforms. However, their potential to guide clin. therapy remained unclear. Here, we report a model called patient-derived tumor-like cell clusters (PTCs). PTCs result from the self-assembly and proliferation of primary epithelial, fibroblast, and immune cells, which structurally and functionally recapitulate original tumors. PTCs enabled us to accomplish personalized drug testing within 2 wk after obtaining the tumor samples. The defined culture conditions and drug concentrations in the PTC model facilitate its clin. application in precision oncol. PTC tests of 59 patients with gastric, colorectal, or breast cancers revealed an overall accuracy of 93% in predicting their clin. outcomes. We implemented PTC to guide chemotherapy selection for a patient with mucinous rectal adenocarcinoma who experienced recurrence with metastases after conventional therapy. After three cycles of a nonconventional therapy identified by the PTC, the patient showed a pos. response. These findings need to be validated in larger clin. trials, but they suggest that the PTC model could be prospectively implemented in clin. decision-making for therapy selection.

Science Translational Medicine published new progress about Allele frequency. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Recommanded Product: Calcium folinate.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Klose, Johannes; Trefz, Stefan; Wagner, Tobias; Steffen, Luca; Preissendoerfer Charrier, Arsalie; Radhakrishnan, Praveen; Volz, Claudia; Schmidt, Thomas; Ulrich, Alexis; Dieter, Sebastian M.; Ball, Claudia; Glimm, Hanno; Schneider, Martin published the artcile< Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model>, SDS of cas: 1492-18-8, the main research area is colorectal cancer salinomycin fluorouracil oxaliplatin antitumoral combination therapy.

Objectives: Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Methods: Primary tumor-initiating cells isolated from human patients with colorectal liver metastases or from human primary colon carcinoma were exposed to salinomycin and compared to treatment with 5-FU and oxaliplatin. TICs were injected s.c. into NOD/SCID mice to induce a patient-derived mouse xenograft model of colorectal cancer. Animals were treated either with salinomycin, FOLFOX regimen, or salinomycin and FOLFOX. Results: Applying TICs isolated from human patients with colorectal liver metastases or from human primary colon carcinoma, we demonstrated that salinomycin exerts increased antiproliferative activity compared to 5-fluorouracil and oxaliplatin treatment. Consistently, salinomycin alone or in combination with FOLFOX exerts superior antitumor activity compared to FOLFOX therapy in a patient-derived mouse xenograft model of colorectal cancer. Salinomycin induces apoptosis of human colorectal cancer cells, accompanied by accumulation of dysfunctional mitochondria and reactive oxygen species. Conclusion: Collectively, the results of this pre-clin. study indicate that salinomycin alone or in combination with 5-fluorouracil and oxaliplatin exerts increased antitumoral activity compared to common chemotherapy.

PLoS One published new progress about Antitumor agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, SDS of cas: 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zou, Yuchen; Duan, Hanying; Li, Li; Chen, Xuju; Wang, Chao published the artcile< Quantification of polyglutamyl 5-methyltetrahydrofolate, monoglutamyl folate vitamers, and total folates in different berries and berry juice by UHPLC-MS/MS>, Formula: C20H21CaN7O7, the main research area is polyglutamyl methyltetrahydrofolate berry juice; 10-Formyldihydrofolate (PubChem CID: 168809); 10-Formylfolic acid (PubChem CID: 3080544); 10-Formyltetrahydrofolate (PubChem CID: 10); 5,10-Methenyltetrahydrofolate (PubChem CID: 439237); 5-Formyltetrahydrofolate (PubChem CID: 149436); 5-Methyltetrahydrofolate (PubChem CID: 439234); Berry; Deglutamylation; Folate vitamers; Folic acid (PubChem CID: 6037); Polyglutamyl 5-CH(3)THF; Recombinant γ-glutamyl hydrolase; Tetrahydrofolate (PubChem CID: 1129); Total folates.

Edible berries are good sources of several phytochems. However, the native folate levels in berries are not well known. The structure of native folates contains polyglutamyl chains, which reportedly jeopardize the bioavailability of native folates; further γ-glutamyl hydrolase (GGH) can deglutamylate polyglutamyl chains. In this study we use a validated ultra-high performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) method to determine the distribution of polyglutamyl 5-methyltetrahydrofolate (5-CH3THF-Glun), folate vitamers, and total folates in different berries and to monitor changes in their concentration during processing of berries into juice. The pre-boiling treatment was optimized during extraction to stabilize the native polyglutamyl folates profile and facilitate folate extraction, which can replace the traditional di-enzyme treatment process. Addnl., the efficiency of com. available human recombinant GGH was tested and it was found that a 10 μg GGH/mL extract at a pH of 6 could completely deconjugate polyglutamyl folates into monoglutamyl folates when incubated for 30 min. Pure human recombinant GGH with a higher catalytic efficiency and stable enzymic properties was better than traditional folate conjugase for this purpose. From exptl. anal., it could be inferred that strawberries and blackberries contained the highest amount of total folates (93-118 μg/100 g), while the total folate contents in blueberries were the lowest. Most of the investigated berries are good to excellent folate sources. This study is the first time that 5-CH3THF-Glun and distribution of folate vitamers in various berries are quantitated. Further, this is the first study to show the application of recombinant pure GGH for the deconjugation of polyglutamyl folates for folate vitamers and total folates anal.

Food Chemistry published new progress about Berry juice. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Formula: C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Zi-Bo; Fang, Hong-Bo; Feng, Quan-Kai; Li, Tao; Li, Jie published the artcile< Prognostic factors of recurrent intrahepatic cholangiocarcinoma after hepatectomy: A retrospective study>, Electric Literature of 1492-18-8, the main research area is intrahepatic cholangiocarcinoma hepatectomy cancer recurrence prognosis chemotherapy; Hepatectomy; Intrahepatic cholangiocarcinoma; Multimodality therapy; Prognosis; Recurrence.

Intrahepatic cholangiocarcinoma (ICC) is a highly malignant tumor. Hepatectomy is an effective treatment for early ICC, but postoperative recurrence greatly affects patient survival. Studies on recurrent ICC after hepatectomy are lacking. AIM To investigate the clin. characteristics of patients with recurrent ICC after hepatectomy, analyze prognostic factors and explore diagnosis and treatment strategies. A retrospective anal. was performed on all ICC patients undergoing hepatectomy from Jan. 2013 to August 2021. Patients with postoperative recurrence were selected according to the inclusion and exclusion criteria. Cumulative overall survival was plotted by the Kaplan-Meier method, and differences were assessed by univariate survival anal. using the log-rank test. Multivariate anal. of cumulative survival was performed using the Cox proportional risk model. During the 8-yr study period, 103 patients underwent ICC-related hepatectomy, and 54 exhibited postoperative recurrence. The median disease-free survival (DFS) was 6 mo, the median overall survival (OS) was 9 mo, and the cumulative OS rates at 1, 2 and 3 years after the operation were 40.7%, 14.8% and 7.4%, resp. The median OS after recurrence was 4 mo, and the cumulative OS rates at 1, 2 and 3 years after recurrence were 16.1%, 6.7% and 3.4%, resp. Multivariate anal. showed that alc. consumption [hazard ratio (HR) = 4.64, 95% confidence interval (CI): 1.53-14.04, P = 0.007] and DFS < 6 mo (HR = 3.47, 95%CI: 1.59-7.60, P = 0.002) were independent risk factors for the cumulative survival of patients with recurrence, while treatment after recurrence (HR = 0.21, 95%CI: 0.08-0.55, P = 0.001) was an independent protective factor. The median OS time of patients receiving multimodality therapy after recurrence of ICC was 7 mo, which was significantly higher than that of patients receiving only local therapy (3 mo), patients receiving systematic therapy (4 mo) and patients receiving the best supportive therapy (1 mo). Patients with recurrent ICC who received multimodality therapy had a significantly better long-term survival after recurrence than those who did not (P = 0.026). The prognosis of patients with recurrence after ICC-related hepatectomy is poor. Alc. consumption and DFS < 6 mo are independent risk factors in terms of the cumulative survival of patients with recurrence, while treatment after recurrence is an independent protective factor. Multimodality therapy can effectively improve the prognosis of patients. World Journal of Gastroenterology published new progress about Cancer antigen 19-9 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Electric Literature of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tian, Ning; Ma, Wanyun published the artcile< Antidotal effects of calcium folinate against high-dose methotrexate-induced damages to mouse matured oocytes>, Safety of Calcium folinate, the main research area is calcium folinate methotrexate matured oocyte damage antidotal effect.

Methotrexate (MTX) is a common folate antagonist and it blocks the dihydrofolate reductase, thereby causing tetrahydrofolate for mation disorder. Tetrahydrofolate is the active folate form and its related metabolic products are required for DNA synthesis and DNA methylation modification. The effects of MTX have been demonstrated by DNA methylation aberrations, DNA damage, and DNA synthesis obstruction, causing cell replication disorder and apoptosis. Calcium folinate (CF), a calcium salt of leucovorin, can easily be converted into tetrahydrofolate without dihydrofolate reductase involvement. CF supplement alleviates MTX-induced reduction in active folates and thus complements Me donor and the required components of DNA synthesis, Nevertheless, MTX also causes changes in proteins and their functions besides DNA-related side effects.

Acta Biochimica et Biophysica Sinica published new progress about Apoptosis. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Safety of Calcium folinate.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tanwar, Rajendra Kumar; Saxena, Bharti; Garg, Radha; Goyal, Harsh; Deepak, Des published the artcile< Gestational trophoblastic neoplasia: a retrospective study of 23 cases>, Name: Calcium folinate, the main research area is gestational trophoblastic neoplasia chemotherapy.

The aim of this study is to analyze the clinicopathol. features, diagnosis and appropriate treatment outcome of patients with gestational trophoblastic neoplasia (GTN), a heterogenous group of disorder in a government tertiary care hospital center. This is a retrospective study of 23 patients from 2002-2020 over 18 years. The patients were evaluated on the basis of their age, obstetric history and the treatment received. All the patients were scored according to Modified World Health Organization (WHO) prognostic scoring system as adapted by FIGO Year 2000. Low risk group patients were given injection Methotrexate + Calcium Leucovorin and high risk group were given EMACO regimen. After treatment, the patient follow up was till date or min. up to 2 years. The response to treatment was evaluated by regular clin. and radiol. examination and serum β-hCG level estimation Three out of 23 patients who relapsed after primary chemotherapy were given second line chemotherapy. All three patients achieved complete remission (CR) after salvage chemotherapy. Thus overall response rate is 100%. Proper diagnosis, close monitoring and follow up with β-hCG value is of utmost importance in the management of GTN, WHO/FIGO scoring should be done and managed with chemotherapy treatment according to the risk assessment.

Cancer Research Journal published new progress about Chemotherapy. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Name: Calcium folinate.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Johannesson, Jenny; Hansson, Paula; Bergstroem, Christel A. S.; Paulsson, Mattias published the artcile< Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: Need for personalized dosage forms>, HPLC of Formula: 1492-18-8, the main research area is pediatric oncol oral medications age Sweden; Age-appropriate; Drug manipulation; Oncology; Oral medication; Pediatric; Personalized dosage form.

Due to the lack of age-appropriate formulations for children, healthcare professionals and caregivers frequently manipulate dosage forms to facilitate oral administration and obtain the required dose. In this study, we investigated drug manipulation and age-appropriateness of oral medications for pediatric oncol. patients with the aim of identifying the therapeutic needs for personalized dosage forms. An observational study at a pediatric oncol. ward, combined with anal. of the age-appropriateness of the oral medications, was performed. Nurses frequently manipulated solid dosage forms to administer them via enteral feeding tubes. Of the active pharmaceutical ingredients (APIs) assessed for age-appropriateness, 74% (29 of 39) were identified to need personalization, either because of lack of child-friendly dosage form, suitable dosage strength, or both. Most APIs, due to limited solubility, were sensitive to formulation changes, such as drug manipulation. This study demonstrates problems and therapeutic needs regarding oral dosage forms in treatment of children with cancer. Expertise in formulation design, new manufacturing technologies, and patient-centered information are needed to address age-appropriate formulations for children.

Biomedicine & Pharmacotherapy published new progress about Aging, animal. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, HPLC of Formula: 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts