Tag: M.W=400-600

Liu, Ying; Chen, Liuxi; Zhang, Ruonan; Chen, Bi; Xiang, Yu; Zhang, Mingming; Huang, Xingxing; Zhang, Wenzheng; Chen, Xiaying; Pan, Ting; Yan, Lili; Jin, Ting; Liu, Shuiping; Feng, Jiao; Duan, Ting; Xie, Tian; Lin, Shuang; Sui, Xinbing published the artcile< Efficacy and safety of elemene combined with chemotherapy in advanced gastric cancer: A Meta-analysis>, Quality Control of 1492-18-8, the main research area is elemene 5fluorouracil doxorubicin anticancer agent gastric cancer.

Elemene is a natural compound extracted from Zingiberaceae plants, and is used in various cancer. However, the efficacy and safety elemene combined with chemotherapy in advanced gastric cancer (GC) are lack of systematic assessment. We searched the PubMed, EMBASE, Web of Science, Cochrane Library, China Academic Journals (CNKI), Chinese Science and Technol. Journals (CQVIP) and Chinese Biomedical Literature databases. Randomized controlled trials (RCTs) comparing elemene plus chemotherapy with chemotherapy alone in participants with advanced GC and reporting at least one of the following outcomes were selected and assessed for inclusion. JADAD scale was used to assess the quality. Data was screened and extracted by two independent investigators. The primary clin. outcome was overall response rate (ORR); the secondary outcomes were quality of life (QOL) and adverse events (AEs). Anal. was performed using Review Manager 5.3. Sixteen RCTs matched the selection criteria, which reported on 969 subjects. Risk ratios (RR) and corresponding 95% confidence intervals (CIs) were pooled for ORR, life quality based on KPS, and risk of AEs. Compared to chemotherapy alone, elemene combined with chemotherapy in the treatment of GC may increase the efficiency of ORR(RR: 1.41; 95% CI: 1.23-1.60; P<.0001), improve their life quality based on KPS (RR: 1.84; 95% CI: 1.45-2.34; P<.00001), and reduce the adverse reactions, including leukopenia(RR: 0.73; 95% CI: 0.62-0.85; P<.00001), neutropenia (RR: 0.75; 95% CI: 0.60-0.95; P=.02), anemia (RR: 0.76; 95% CI: 0.60-0.95; P=.02), thrombocytopenia (RR: 0.56; 95% CI: 0.43-0.73; P<.00001). Nausea and vomiting (RR: 0.84; 95% CI: 0.84-1.07; P=.39), diarrhea (RR: 0.69; 95% CI: 0.41-1.15; P=.15), neurotoxicity (RR: 0.77; 95% CI: 0.59-1.00; P=.05) and hepatic dysfunction (RR: 0.95; 95% CI: 0.58-1.54; P=.83) were similar between two groups. Elemene may have the potential to improve the efficacy and reduce the AEs of chemotherapy for gastric cancer. However, the long-term, high-quality researches with a large sample size in different populations are required. Medicine (Philadelphia, PA, United States) published new progress about Antitumor agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Quality Control of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Yiyun; Xi, Yixin; Zhao, Jiulong; Zhao, Jiayan; Li, Jincan; Huang, Guoqi; Li, Junqiang; Fang, Fei; Gu, Lingling; Wang, Shige published the artcile< Preparation of therapeutic-laden konjac hydrogel for tumor combination therapy>, Related Products of 1492-18-8, the main research area is therapeutic laden konjac hydrogel tumor combination therapy.

Featured with three-dimensional network structure, polymer hydrogels have found tremendous applications in biomedical fields. In this study, therapeutic-laden Konjac glucomannan (KGM) hydrogel was prepared by injecting polydopamine (PDA)/5-fluorouracil (5-FU)/calcium folinate (CF)/KGM alk. solution to the target area, for the synergistic tumor photothermal and chemotherapy. In alk. solution, dopamine can be synchronously polymerized to form PDA, while KGM can be hydrolyzed and transformed into a thermally irreversible KGM hydrogel. Besides, the alk. condition can increase the solubility of 5-FU. The hydrogel matrix can control the release of 5-FU and cf. PDA renders the composite hydrogel excellent tumor photothermal therapy ability. Moreover, CF can be used as a synergist to enhance the tumor chemotherapy efficiency of 5-FU. With convenient handling, excellent photothermal conversion ability and high biocompatibility, the multifunctional hydrogel system is anticipated to find a promising translational potential in clin. therapeutic applications.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Antitumor agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Related Products of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mao, Jie; Du, Peng; Yang, Han-teng; Hu, Huan; Wang, Shi-Yao; Wu, Xia; Cheng, Zhi-Bin published the artcile< Prognostic value of carbohydrate antigen125 and carcino embryonic antigen expression in patients with colorectal carcinoma and its guiding significance for chemotherapy>, Application of C20H21CaN7O7, the main research area is carcino embryonic antigen expression chemotherapy.

The aim of this study is to evaluate the predictive value of carbohydrate antigen125 (CA125) and carcino embryonic antigen (CEA) expression and its guiding role of choosing chemotherapy regimen in post-operation patients with colorectal carcinoma.The clin. data of all patients, including laboratory data and pathol. data, were collected from the electronic medical records. Kaplan-Meier Log rank test, COX regression model and subgroup analyses were employed to assess the correlation between the expression of CA125 and CEA in patients with colorectal carcinoma and the survival, and the effect on chemotherapy efficacy.Kaplan-Meier showed that CA125 expression is neg. related to the progression-free survival (PFS) of the post-operative patients, Median PFS was 1140 days in the patients with high expression, and Median PFS was 1387 days in the patients with low expression (Χ=4.715, P = .030); CEA expression is also neg. associated with the PFS of the post-operative patients, Median PFS was 1197 days in the patients with high expression, and Median PFS was 1424 days in the patients with low expression (Χ=4.992, P = .025). Subgroup anal. also showed that the patients with normal CA125 and CEA had better prognosis, median PFS was 1505 days, and the patients with CA125 and (or) CEA high expression had poor prognosis and median PFS was 1162 days (Χ=13.346, P = .001), and found that there was no statistical difference in patients with oxaliplatin plus capecitabine (XELOX) and oxaliplatin, 5-fluorouracil and Calcium folinate (FOLFOX) chemotherapy in patients with CA125 and CEA low expression. However, in these patients with CA125 or (and) CEA high expression, the median PFS of patients treated with XELOX was 1082 days, and the median PFS of patients treated with FOLFOX chemotherapy was 1335 (Χ=4.547, P = .033).Expression of CA125 and CEA associated with the survival of patients, and have some guiding significance for chemotherapy in patients with colorectal cancer after operation; Compared with XELOX, FOLFOX chemotherapy is more effective for CA125 or (and) CEA high expression patients with colorectal carcinoma.

Medicine (Philadelphia, PA, United States) published new progress about Analysis. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Application of C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khorana, Alok A.; McKernin, Shannon E.; Berlin, Jordan; Hong, Theodore S.; Maitra, Anirban; Moravek, Cassadie; Mumber, Matthew; Schulick, Richard; Zeh, Herbert J.; Katz, Matthew H. G. published the artcile< Potentially curable pancreatic adenocarcinoma: ASCO clinical practice guideline update>, Product Details of C20H21CaN7O7, the main research area is pancreatic adenocarcinoma adjuvant chemotherapy.

The purpose of this guideline update is to incorporate recently reported practice-changing evidence into ASCO’s recommendations on potentially curable pancreatic adenocarcinoma. ASCO convened an Expert Panel to evaluate data from PRODIGE 24/CCTG PA.6, a phase III, multicenter, randomized clin. trial of postoperative leucovorin calcium, fluorouracil, irinotecan hydrochloride, and oxaliplatin (FOLFIRINOX) vs. gemcitabine alone, presented at the 2018 ASCO Annual Meeting. In addition, PubMed was searched for addnl. papers that may influence the existing recommendations. The Expert Panel only updated Recommendation 4.1 as a result of the practice-changing data. Recommendation 4.1 states that all patients with resected pancreatic adenocarcinoma who did not receive preoperative therapy should be offered 6 mo of adjuvant chemotherapy in the absence of medical or surgical contraindications. The modified combination regimen of 5-fluorouracil, oxaliplatin, and irinotecan (mFOLFIRINOX; oxaliplatin 85 mg/m2, leucovorin 400 mg/m2, irinotecan 150 mg/m2 D1, and 5-fluorouracil 2.4 g/m2 over 46 h every 14 days for 12 cycles) is now preferred in the absence of concerns for toxicity or tolerance; alternatively, doublet therapy with gemcitabine and capecitabine or monotherapy with gemcitabine alone or fluorouracil plus folinic acid alone can be offered.

Journal of Clinical Oncology published new progress about Chemotherapy. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Product Details of C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lin, Jamie S.; Mamlouk, Omar; Selamet, Umut; Tchakarov, Amanda; Glass, William F.; Sheth, Rahul A.; Layman, Rachel M.; Dadu, Ramona; Abdelwahab, Noha; Abdelrahim, Maen; Diab, Adi; Yee, Cassian; Abudayyeh, Ala published the artcile< Infliximab for the treatment of patients with checkpoint inhibitor-associated acute tubular interstitial nephritis>, Application In Synthesis of 1492-18-8, the main research area is infliximab checkpoint inhibitor acute tubular interstitial nephritis patient treatment; Checkpoint inhibitors; acute interstitial nephritis; immune-related adverse event.

Acute tubular interstitial nephritis (ATIN) is the most frequently reported pathol. in patients with checkpoint inhibitor (CPI) induced acute kidney injury (AKI). Glucocorticoid (GC) therapy and discontinuation of CPI are the mainstay of treatment to prevent permanent renal dysfunction and dialysis. However, less than 50% of patients have complete kidney recovery and relapse of ATIN can occur. Infliximab is effective in treating other immune-related adverse events but its use for the treatment of CPI-ATIN is not well established. We report the first retrospective study examining the steroid-sparing potential of infliximab in achieving durable and complete renal recovery for patients with CPI-ATIN. Data were collected from medical records of patients diagnosed with CPI-AKI with a kidney biopsy or clin. diagnosis of ATIN that was managed with GC and infliximab. Infliximab-containing regimens were used to treat 10 patients with CPI-ATIN. Four patients relapsing after GC therapy achieved durable and complete renal recovery, four patients experienced partial renal recovery, and two patients showed no improvement in kidney function. This is the first study evaluating clin. outcomes using an infliximab-containing regimen for treatment of relapsed CPI-ATIN in patients or patients failing to achieve complete response after primary therapy. Our data suggest that infliximab may be a treatment option for achieving durable and complete renal recovery in this patient population and represents a potential steroid-sparing strategy in challenging cases of CPI-ATIN. Rigorous clin. studies are warranted to evaluate the risk-benefit anal. for infliximab usage in CPI-ATIN patients.

OncoImmunology published new progress about Acute kidney injury. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Application In Synthesis of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shimada, Kazuyo; Hasegawa, Shiori; Nakao, Satoshi; Mukai, Ririka; Matsumoto, Kiyoka; Tanaka, Mizuki; Uranishi, Hiroaki; Masuta, Mayuko; Nishida, Shohei; Shimizu, Shinya; Hayashi, Yuichi; Suzuki, Akio; Nakamura, Mitsuhiro published the artcile< Adverse event profiles of ifosfamide-induced encephalopathy analyzed using the Food and Drug Administration Adverse Event Reporting System and the Japanese Adverse Drug Event Report databases>, HPLC of Formula: 1492-18-8, the main research area is ifosfamide alkylating agent encephalopathy; Encephalopathy; FAERS; FDA Adverse Event Reporting System; Ifosfamide; JADER; Japanese Adverse Drug Event Report.

Ifosfamide is extensively used to treat several malignant conditions. Administration of ifosfamide can cause encephalopathy and other neurotoxic effects. The aim of this study was to obtain novel information on the onset profiles of ifosfamide-induced encephalopathy (IIE) considering other associated clin. factors using the US Food and Drug Administration Adverse Event Reporting System (FAERS) and the Japanese Adverse Drug Event Report (JADER) databases. We analyzed the reports of encephalopathy between 2004 and 2018 from the FAERS and JADER databases. To define IIE, we used the Medical Dictionary for Regulatory Activities (MedDRA) preferred terms and standardized queries. The reporting odds ratios (ROR) at 95% confidence interval (CI) was used to detect the signal for IIE and adjusted for covariates using a multivariate logistic regression technique. We evaluated the time-to-onset profile of IIE and used the association rule mining technique to discover undetected associations, such as potential risk factors. In the FAERS database, the ROR (CI) for encephalopathy (preferred term, PT) and encephalopathy (standardized MedDRA queries, SMQ) was 56.58 (51.69-61.93) and 1.57 (1.48-1.67), resp. In the JADER database, the ROR (95% CI) for encephalopathy (PT) and encephalopathy (SMQ) was 13.54 (9.91-18.50) and 1.24 (1.01-1.53), resp. The multivariate logistic regression anal. showed a significant contribution in IIE signal in the ≥ 60 yr group (p = 0.00094; vs. < 60 yr group) and ≥ 2000 mg/m2 dosage group (p = 0.00045; vs. < 2000 mg/m2 dosage group). The association rules of {ifosfamide, aprepitant} → {encephalopathy (SMQ)} demonstrated high lift values. The average dose of ifosfamide in patients with encephalopathy (PT) and without encephalopathy (PT) was 2022.8 ± 592.8 (mean ± standard deviation) and 1568.5 ± 703.2 mg/m2, resp. (p < 0.05). Encephalopathy within the first 7 days of ifosfamide administration was 94.1% for encephalopathy (PT) and 87.7% for encephalopathy (SMQ), resp. The present anal. demonstrated that the incidence of encephalopathy with ifosfamide should be closely monitored for a short onset (within 7 days). The patients who are administered a high dose of ifosfamide or co-administrated aprepitant should be carefully monitored for the development of encephalopathy. Cancer Chemotherapy and Pharmacology published new progress about Alkylating agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, HPLC of Formula: 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Le-Niculescu, H.; Roseberry, K.; Levey, D. F.; Rogers, J.; Kosary, K.; Prabha, S.; Jones, T.; Judd, S.; McCormick, M. A.; Wessel, A. R.; Williams, A.; Phalen, P. L.; Mamdani, F.; Sequeira, A.; Kurian, S. M.; Niculescu, A. B. published the artcile< Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs>, Formula: C20H21CaN7O7, the main research area is gene expression betulin neuroprotectant FKBP5 biomarker diagnosis stress disorder.

The biol. fingerprint of environmental adversity may be key to understanding health and disease, as it encompasses the damage induced as well as the compensatory reactions of the organism. Metabolic and hormonal changes may be an informative but incomplete window into the underlying biol. We endeavored to identify objective blood gene expression biomarkers for psychol. stress, a subjective sensation with biol. roots. To quantify the stress perception at a particular moment in time, we used a simple visual analog scale for life stress in psychiatric patients, a high-risk group. Then, using a stepwise discovery, prioritization, validation, and testing in independent cohort design, we were successful in identifying gene expression biomarkers that were predictive of high-stress states and of future psychiatric hospitalizations related to stress, more so when personalized by gender and diagnosis. One of the top biomarkers that survived discovery, prioritization, validation, and testing was FKBP5, a well-known gene involved in stress response, which serves as a de facto reassuring pos. control. We also compared our biomarker findings with telomere length (TL), another well-established biol. marker of psychol. stress and show that newly identified predictive biomarkers such as NUB1, APOL3, MAD1L1, or NKTR are comparable or better state or trait predictors of stress than TL or FKBP5. Over half of the top predictive biomarkers for stress also had prior evidence of involvement in suicide, and the majority of them had evidence in other psychiatric disorders, providing a mol. underpinning for the effects of stress in those disorders. Some of the biomarkers are targets of existing drugs, of potential utility in patient stratification, and pharmacogenomics approaches. Based on our studies and analyses, the biomarkers with the best overall convergent functional evidence (CFE) for involvement in stress were FKBP5, DDX6, B2M, LAIR1, RTN4, and NUB1. Moreover, the biomarker gene expression signatures yielded leads for possible new drug candidates and natural compounds upon bioinformatics drug repurposing analyses, such as calcium folinate and betulin. Our work may lead to improved diagnosis and treatment for stress disorders such as PTSD, that result in decreased quality of life and adverse outcomes, including addictions, violence, and suicide.

Molecular Psychiatry published new progress about Actin-related protein 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (type A). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Formula: C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Feng, Guanping; Zou, Wenying; Zhong, Yihui published the artcile< Sulfonamides repress cell division in the root apical meristem by inhibiting folates synthesis>, Synthetic Route of 1492-18-8, the main research area is sulfonamide folic acid synthesis cell division root apical meristem.

Sulfonamides, as broad-spectrum antibiotics, are widely used to protect against bacterial infections in livestock production A large number of sulfa antibiotics are discharged into soil and water system, which poses a great threat to the safety of organisms. The antibacterial mechanism of sulfonamides is to prevent folate biosynthesis by competitively inhibiting bacterial dihydropteroate synthetase (DHPS). The inhibitory effect of sulfanilamide on root growth has been reported, but the mechanism has not been determined Here, we used high performance liquid chromatog. with UV detector (HPLC-UV) and transgenic technol. to study the effect of sulfonamides on folate synthesis in plants. The results showed that the application of sulfonamide sharply reduced the content of folic acid in plants, resulting in strong inhibition of cell division in the root apical meristem. The inhibition of sulfonamide on cell division can be relieved by supplementing synthetic folic acid and folinic calcium salt hydrate. The transgenic plants expressing the bacterial antibiotic resistance genes (ARGs) Sul1 or Sul2 showed obvious antibiotic resistance. Taking these results together, we suggest that sulfonamides repress cell proliferation in the root apical meristem by competitively inhibiting the biosynthesis of folic acid in plants.

Journal of Hazardous Materials Advances published new progress about Antibiotic resistance. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Synthetic Route of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Feng, Guanping; Zou, Wenying; Zhong, Yihui published the artcile< Sulfonamides repress cell division in the root apical meristem by inhibiting folates synthesis>, Synthetic Route of 1492-18-8, the main research area is sulfonamide folic acid synthesis cell division root apical meristem.

Sulfonamides, as broad-spectrum antibiotics, are widely used to protect against bacterial infections in livestock production A large number of sulfa antibiotics are discharged into soil and water system, which poses a great threat to the safety of organisms. The antibacterial mechanism of sulfonamides is to prevent folate biosynthesis by competitively inhibiting bacterial dihydropteroate synthetase (DHPS). The inhibitory effect of sulfanilamide on root growth has been reported, but the mechanism has not been determined Here, we used high performance liquid chromatog. with UV detector (HPLC-UV) and transgenic technol. to study the effect of sulfonamides on folate synthesis in plants. The results showed that the application of sulfonamide sharply reduced the content of folic acid in plants, resulting in strong inhibition of cell division in the root apical meristem. The inhibition of sulfonamide on cell division can be relieved by supplementing synthetic folic acid and folinic calcium salt hydrate. The transgenic plants expressing the bacterial antibiotic resistance genes (ARGs) Sul1 or Sul2 showed obvious antibiotic resistance. Taking these results together, we suggest that sulfonamides repress cell proliferation in the root apical meristem by competitively inhibiting the biosynthesis of folic acid in plants.

Journal of Hazardous Materials Advances published new progress about Antibiotic resistance. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Synthetic Route of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cheng, Yuan; Qin, Shu-kui; Li, Jin; Dai, Guang-hai; Shen, Bai-yong; Ying, Jie-er; Ba, Yi; Liang, Han; Wang, Xin-bo; Xu, Ye; Zhou, Lin; Ding, Ke-feng; Qin, Yan-ru; Yang, Shu-jun; Guan, Wen-xian; Zheng, Hui; Wang, Qian; Song, Hang; Zhu, Yan-ping published the artcile< A multicenter clinical study: personalized medication for advanced gastrointestinal carcinomas with the guidance of patient-derived tumor xenograft (PDTX)>, Formula: C20H21CaN7O7, the main research area is medication gastrointestinal carcinoma human tumor xenograft clin study; Advanced gastrointestinal carcinomas; Clinical study; Patient-derived tumor xenograft; Personalized medication.

Establish patient-derived tumor xenograft (PDTX) from advanced GICs and assess the clin. value and applicability of PDTX for the treatment of advanced gastrointestinal cancers. Patients with advanced GICs were enrolled in a registered multi-center clin. study (ChiCTR-OOC-17012731). The performance of PDTX was evaluated by analyzing factors that affect the engraftment rate, comparing the histol. consistency between primary tumors and tumorgrafts, examining the concordance between the drug effectiveness in PDTXs and clin. responses, and identifying genetic variants and other factors associated with prognosis. Thirty-three patients were enrolled in the study with the engraftment rate of 75.8% (25/33). The success of engraftment was independent of age, cancer types, pathol. stages of tumors, and particularly sampling methods. Tumorgrafts retained the same histopathol. characteristics as primary tumors. Forty-nine regimens involving 28 drugs were tested in seventeen tumorgrafts. The median time for drug testing was 134.5 days. Follow-up information was obtained about 10 regimens from 9 patients. The concordance of drug effectiveness between PDTXs and clin. responses was 100%. The tumor mutation burden (TMB) was correlated with the effectiveness of single drug regimens, while the outgrowth time of tumorgrafts was associated with the effectiveness of combined regimens. The engraftment rate in advanced GICs was higher than that of other cancers and meets the acceptable standard for applying personalized therapeutic strategies. Tumorgrafts from PDTX kept attributes of the primary tumor. Predictions from PDTX modeling closely agreed with clin. drug responses. PDTX may already be clin. applicable for personalized medication in advanced GICs.

Journal of Cancer Research and Clinical Oncology published new progress about Aging, animal. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Formula: C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts