Tag: M.W=400-500

Post, Wouter published the artcileSelf-healing glass fiber reinforced polymer composites based on montmorillonite reinforced compartmented alginate fibers, Computed Properties of 7575-23-7, the main research area is self healing glass fiber epoxy composite montmorillonite alginate fiber; healing agent carrier mech property.

This study shows the feasibility of clay-reinforced alginate-based compartmented fibers as healing agent carriers for the autonomous healing of glass fiber-reinforced polymer composites. First we report on the effect of montmorillonite (MMT) clay on the fiber tensile and vacuole lateral compression properties. It is found that the fiber tensile properties are enhanced with increasing MMT concentration, while the effects on the vacuole lateral compression properties are seemingly negligible. The second part of this work shows the proof of concept of healing by compartmented fibers in glass fiber-reinforced polymer (GFRP) composites. A single- and a double-healing agent configuration, both based on epoxy-thiol chem., were compared in these model GFRP composites. The healing phenomena were quantified by mech. characterization (interlaminar fracture and flexural testing) and nondestructive testing techniques (X-ray microtomog. and air-coupled ultrasonic C-scanning). It is found that a configuration with one healing agent is favorable over a system with two sep. agents and that further exploitation of the compartmented fiber concept should focus on the healing of matrix damage as the loss of mech. integrity because of glass fiber fracture cannot be overcome.

Polymer Composites published new progress about Bending strength. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Computed Properties of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sadeghi, Sayed Ali Mirmohammad published the artcileSelf-healing performance of hybrid core-shell nanofibers mat containing epoxy-mercaptan at subroom temperature, Formula: C17H28O8S4, the main research area is epoxy mercaptan core shell nanofiber mat self healing performance.

Self-healing epoxy composite working at subroom temperature could be useful in aerospace industry and wind turbine blades. In this research, hybrid core-shell nanofibers mat containing epoxy resin and mercaptan was embedded in epoxy matrix to investigate repeated self-healing ability of the fabricated composite at subroom temperature (10°C). The results of three-point bending test illustrated that the release of epoxy resin and mercaptan into cracks and curing reaction between them could restore flexural properties of the composite. In fourth bending cycle, flexural modulus of composite reinforced by hybrid mat and unreinforced epoxy (without nanofiber) was reduced 6% and 24%, resp. In addition, hybrid mat reinforced composite was broken at fifth bending cycle, whereas for unreinforced epoxy specimen occurred at fourth bending cycle. Non-isothermal differential scanning calorimetry thermograms after each three-point bending cycle of hybrid mat reinforced composite showed an exothermic peak centered about 64°C. This peak is related to epoxy and mercaptan reaction that could confirm self-healing ability of hybrid core-shell nanofibers mat. Extraction results, FTIR anal., and three-point bending test showed the stability of epoxy and mercaptan into nanofibers during 8 mo.

Polymer Composites published new progress about Bending strength. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Formula: C17H28O8S4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Feng published the artcileA comparison study of hyaluronic acid hydrogel exquisite micropatterns with photolithography and light-cured inkjet printing methods, SDS of cas: 7575-23-7, the main research area is hyaluronic acid hydrogel photolithog inkjet printing.

The microstructure design of hydrogel materials offers a broad range of practical applications and is extensively used in flexible sensors, polymer microneedles, microfluidic chips, and other biomedical engineering fields. Among the bio-sourced hydrogels, oligomeric hyaluronic acid (HA) possesses wound healing, anti-tumor, and angiogenesis properties. However, micropatterning soft hydrogels, such as HA-relative hydrogels containing 90% water by weight, continue to pose difficulties for both high precision and micro-scale lithog. The purpose of this study was to compare the photolithog. and light-cured inkjet printing methods of methacryloyl HA hydrogel (HAMA-gel) to those for synthetic light-curable polymer resins. Photolithog. and light-cured inkjet printing methods with designed scale, high resolution, and little processing times were used to effectively prepare micropatterns of HAMA-gel. The well-shaped micropatterns consisted of parallel channels in tens of micrometers and strip/grid lines in the hundreds of micrometers. Human vein endothelial cells cultured on the material′s surface demonstrated that HAMA-gel had good biocompatibility. The width of the flow channel (10 and 20 μm) was regulated on the surface of the microstructure to allow for simultaneous control of cell growth along the flow channel and groove directions.

e-Polymers published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, SDS of cas: 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Xiaorong published the artcileThiol-branched graphene oxide and polydopamine-induced nanofibrillated cellulose to strengthen protein-based nanocomposite films, Application In Synthesis of 7575-23-7, the main research area is thiol graphene oxide polydopamine nanofibrillated cellulose strengthen protein.

Soy protein isolate (SPI)-based composite materials possess a variety of excellent properties including biodegradability, biocompatibility, low cost, and easy availability, which have great potential for replacing petroleum-based materials. However, the inferior mech. properties and high moisture sensitivity severely restrict their practical applications. In this study, novel integrated ternary hybrid nanocomposite films with multiple network structures were fabricated through introducing functionalized building blocks [graphene oxide (GO) sheets and nanofibrillated cellulose (NFC)] in a SPI matrix, in which, the interface interactions and building blocks worked synergistically to result in excellent integrated mech. properties. First, the functionalized GO (SGO) sheets were successfully prepared via the thiol-ene click reaction with four-armed HS-terminated compound pentaerythritol tetra (3-mercaptopropionate) (PETMP) and were thus covalently cross-linked with catechol moieties of polydopamine layers on NFC (PNFC) by the Michael addition reaction. Then, the catechol moieties of PNFC covalently cross-linked to form the other crosslinked network with amino-containing SPI chains through Michael addition and/or Schiff base reactions. Moreover, H-bonding and π-π interactions also formed in such cross-linked networks. The resultant ternary SPI/SGO/PNFC films exhibited an optimal tensile strength of 11.10 MPa, which was nearly 2.81-fold higher than that of the neat SPI film. These films had the lowest water vapor permeability value of 3.91, which was 64.70% less than that of the neat SPI film. This work provides an effective and scalable design strategy for combining the synergistic effects of multiple building blocks and interfacial interactions and may show promise for various biomass applications.

Cellulose (Dordrecht, Netherlands) published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application In Synthesis of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Elkassih, Sussana A. published the artcileDegradable redox-responsive disulfide-based nanogel drug carriers via dithiol oxidation polymerization, SDS of cas: 7575-23-7, the main research area is drug carrier nanogel oxidative radical polymerization.

Stimuli-responsive nanogels are important drug and gene carriers that mediate the controlled release of therapeutic mols. Herein, we report the synthesis of fully degradable disulfide cross-linked nanogel drug carriers formed by oxidative radical polymerization of 2,2′-(ethylenedioxy)diethanethiol (EDDET) as a monomer with different cross-linkers, including pentaerythritol tetramercaptoacetate (PETMA). Because the poly(EDDET) backbone repeat structure and crosslinking junctions are composed entirely of disulfide bonds, these nanogels specifically degrade to small mol. dithiols intracellularly in response to the reducing agent glutathione present inside of cells. Cross-linked nanogels were synthesized using controlled microfluidic mixing in the presence of a nonionic Pluronic surfactant PLU-127 to increase the nanogel stability. Adjusting the monomer to cross-linker ratio from 5 : 1 to 100 : 1 (mol/mol) tuned the crosslinking d., resulting in swelling ratios from 1.65 to >3. Increasing the amount of stabilizing Pluronic surfactant resulted in a decrease of nanogel diameter, as expected due to increased surface area of the resulting nanogels. The monomer to cross-linker ratio in the feed had no effect on the formed nanogel diameter, providing a way to control crosslinking d. with constant nanogel size but tunable drug release kinetics. Nanogels exhibited an entrapment efficiency of up to 75% for loading of Rhodamine B dye. In vitro studies showed low cytotoxicity, quick uptake, and fast degradation kinetics. Due to the ease of synthesis, rapid gelation times, and tunable functionality, these non-toxic and fully degradable nanogels offer potential for use in a variety of drug delivery applications.

Biomaterials Science published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, SDS of cas: 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Chang published the artcileGlucose and H2O2 dual-sensitive nanogels for enhanced glucose-responsive insulin delivery, Application In Synthesis of 7575-23-7, the main research area is diabetes glucose hydrogen peroxide nanogel insulin delivery polyethylene glycol.

Diabetes is a chronic metabolic disorder disease characterized by high blood glucose levels and has become one of the most serious threats to human health. In recent decades, a number of insulin delivery systems, including bulk gels, nanogels, and polymeric micelles, have been developed for the treatment of diabetes. Herein, a kind of glucose and H2O2 dual-responsive polymeric nanogel was designed for enhanced glucose-responsive insulin delivery. The polymeric nanogels composed of poly(ethylene glycol) and poly(cyclic phenylboronic ester) (glucose and H2O2 dual-sensitive groups) were synthesized by a one-pot thiol-ene click chem. approach. The nanogels displayed glucose-responsive release of insulin and the release rate could be promoted by the incorporation of glucose oxidase (GOx), which generated H2O2 at high glucose levels and H2O2 further oxidizes and hydrolyzes the phenylboronic ester group. The nanogels have characteristics of long blood circulation time, a fast response to glucose, and excellent biocompatibility. Moreover, s.c. delivery of insulin to diabetic mice with the insulin/GOx-loaded nanogels presented an effective hypoglycemic effect compared to that of injection of insulin or insulin-loaded nanogels. This kind of nanogel would be a promising candidate for the delivery of insulin in the future.

Nanoscale published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application In Synthesis of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tao, Yangchun published the artcilePseudo target release behavior of simvastatin through pH-responsive polymer based on dynamic imine bonds: Promotes rapid proliferation of osteoblasts, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate), the main research area is simvastatin release polymer pH osteoblast cell proliferation; Controlled release; Simvastatin; Stimuli-responsive polymer; pH-responsive polymer.

In this article, a simvastatin loaded pentaerythritol tetra(3-mercaptopropionate)-allylurea-poly(ethylene glycol) (SIM-loaded PETMP-AU-PEG) polymer with excellent biocompatibility by means of in-situ loading method was synthesized. The presence of the imine bonds has given the polymer system an excellent response performance to weak acidic environment. Specifically, for the SIM-loaded polymer, the simvastatin cumulative release dose is only 2.2% in the first 2 h, and the first 32 h of the cumulative release dose is less than 10% in pH 7.4; However, in pH 6.0, the first 2 h of the cumulative release dose is 65.2%, and the first 32 h of the cumulative release dose is almost 100%. MC3T3-E1 osteoblast cell culture experiments show that the SIM-loaded polymer at pH 6.0 can accelerate the proliferation of osteoblasts significantly, which is expected to promote the rapid proliferation of bone cells in clin. applications and accelerate the healing of the lesion region.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Kai published the artcilePhoto-Cross-Linked Polycarbonate Coating with Surface-Erosion Behavior for Corrosion Resistance and Cytocompatibility Enhancement of Magnesium Alloy, Synthetic Route of 7575-23-7, the main research area is magnesium alloy photocrosslinking polycarbonate coating corrosion resistance; corrosion resistance; cytocompatibility; magnesium alloy; surface-eroding coating; thiol−ene photo-cross-linking.

Absorbable magnesium (Mg) materials are promising for medical implant applications. However, their corrosion rate and potential toxicity remain a challenge. Herein, a photo-cross-linked coating with suitable durability and unique surface-eroding behavior for enhancement of anticorrosion property and cytocompatibility of AZ31 Mg alloy was developed. The biodegradable allyl-functional polycarbonate, poly[(5-methyl-5-allyloxycarbonyl-1,3-propanediol carbonate)-co-(trimethylene carbonate)] [P(MAC-co-TMC), PMT], was first synthesized by ring-opening copolymerization The PMT copolymer, pentaerythritol tetrakis(3-mercaptopropionate), and a photoinitiator were then applied on AZ31 Mg alloy by dip coating, and these films were cross-linked via the subsequent photoinitiated thiol-ene click reaction. The poly(L-lactide) (PLLA) and poly(1,3-trimethylene carbonate) (PTMC) coatings without crosslinking were prepared and used as control. Our results show that the cross-linked PMT coatings exhibited superior mech. properties compared with PLLA and PTMC coatings. Meanwhile, the surface-erosion behavior of the cross-linked PMT coatings remained, as confirmed by SEM anal. As a result, the cross-linked PMT-coated Mg alloy showed lower corrosion rates, better in vitro corrosion resistance, and much lower cytotoxicity, compared with bare Mg and ones coated with PLLA and PTMC coatings. Results indicate that the cross-linked PMT coatings with unique surface-erosion behavior and good cytocompatibility might be promising to improve the safety and success rate of Mg-based devices and implants.

ACS Applied Bio Materials published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Synthetic Route of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shaha, Rajib K. published the artcileBiocompatible liquid-crystal elastomers mimic the intervertebral disc, Quality Control of 7575-23-7, the main research area is liquid crystalline elastomer tension compression biocompatibility intervertebral disk implant; Annulus fibrosus; Biocompatibility; Biomaterial; Intervertebral disc implant; Liquid crystal elastomer; Nucleus pulposus; Porous LCE; Wettability.

The hierarchical and anisotropic mech. behavior requirement of load-bearing soft tissues limits the utility of conventional elastomeric materials as a replacement for soft-tissue materials. Liquid-crystal elastomers (LCEs) have the potential to excel in this regard owing to its unique combination of mesogenic order in an elastomeric network. In this study, the mech. behavior of the LCEs relevant to load-bearing biomedical applications was explored. LCEs with different network orientations (i.e., mesogen alignments) were investigated by fabricating the LCEs with polydomain and monodomain configurations. The polydomain and monodomain LCEs with the same degree of network crosslinking demonstrated diverse mech. behavior, ranging from highly stiff and elastic nature to high damping capacity, depending on the loading direction with respect to the network alignment. The LCEs were also capable of matching the anisotropic mech. behavior of an intervertebral disk. Addnl. studies were conducted on the in vivo biol. response of LCEs upon s.c. implantation, as well as on the effect of the exposure to an in vitro simulated physiol. environment on the mech. behavior. The LCEs mech. response was negligibly affected when exposed to biomedically relevant conditions. Furthermore, the solid and porous LCEs did not show any adverse effect on the surrounding tissues when implanted s.c. in rats. The biol. response allows for tissue ingrowth and helps illustrate their utility in implantable biol. devices. Finally, the utility of LCEs to mimic the mech. function of biol. tissue such as intervertebral disk was demonstrated by fabricating a proof of concept total disk replacement device.

Journal of the Mechanical Behavior of Biomedical Materials published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Quality Control of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thijssen, Quinten published the artcileFrom Chain Growth to Step Growth Polymerization of Photoreactive Poly-ε-Caprolactone: The Network Topology of Bioresorbable Networks as Tool in Tissue Engineering, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate), the main research area is photoreactive polycaprolactone step growth polymerization thermal mech biol property.

Control of the network topol. by selection of an appropriate crosslinking chem. is introduced as a new strategy to improve the elasticity and toughness of bioresorbable networks. The development of novel photocrosslinkable and bioresorbable oligomers is essential for the application of light-based 3D-printing techniques in the context of tissue engineering. Although light-based 3D-printing techniques are characterized by an increased resolution and manufacturing speed as compared to extrusion-based 3D-printing, their application remains limited. Via chem. modification, poly-ε-caprolactone (PCL) is functionalized with photoreactive end groups such as acrylates, alkenes, and alkynes. Based on these precursors, networks with different topologies are designed via chain growth polymerization, step growth polymerization, or a combination thereof. The influence of the network topol. and the concomitant crosslinking chem. on the thermal, mech., and biol. properties are elucidated together with their applicability in digital light processing (DLP). Photocrosslinkable PCL with an elongation at break of 736.3 ± 47% and an ultimate strength of 21.3 ± 0.8 MPa is realized, which is approx. tenfold higher compared to the current state-of-the-art. Finally, extremely elastic DLP-printed dog bones are developed which can fully retrieve their initial length upon stress relieve at an elongation of 1000%.

Advanced Functional Materials published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts