Tag: M.W=400-450

Itagimatha, N. published the artcileRP-HPLC-UV method development and validation for simultaneous determination of terbutaline sulphate, ambroxol HCl and guaifenesin in pure and dosage forms, COA of Formula: C13H19Br2ClN2O, the publication is Annales Pharmaceutiques Francaises (2019), 77(4), 295-301, database is CAplus and MEDLINE.

The objective of the present work was to develop and validate a simple, sensitive, rapid and stable reverse-phase high performance liquid chromatog. (RP-HPLC) method for a combination of Terbutaline sulfate (TSL), Ambroxol hydrochloride (AML) and Guaifenesin (GFN).The combination of these drugs was analyzed by using Shimadzu LC 2010 CHT high performance liquid chromatog. (HPLC). Successful separation was achieved by isocratic elution on a reverse-phase C₁₈ column (sun fire) (250 mm, 4.6 mm, 5μg), using a mobile phase consisting of buffer: acetonitrile in the ratio 80: 20 (buffer – 0.1% volume/volume triethyleamine pH-3.0) followed by 1.0 mL/min flow rate. The wavelength of detection was at 220 nm.The chromatog. retention times were consistent at 3.0, 10.5 and 13.8 min for TSL, AML and GFN resp. For these three compounds, the lower limit of detection was 1.0, 1.25, and 1.5μg/mL and lower limit of quantification was 3.3, 4.1 and 5.0μg/mL resp. The linearity concentrations established for TSL, AML and GFN were 1.0-7.0, 1.5-7.5 and 4.0-14.0μg/mL resp. The correlation coefficients for all the drugs were found to be greater than 0.999. The relative standard deviation of inter- and intra-day were less than 2.0%.This method provides a necessary tool for quantification of the selected drugs for their assay. The proposed method is simple, accurate, reproducible and applied successfully to analyze three compounds in pure as well dosage form. This method provides a necessary tool for quantification of the selected drugs for their assay.

Annales Pharmaceutiques Francaises published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, COA of Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Horie, Masaki published the artcileCyclopentadithiophene based polymers; a comparison of optical, electrochemical and organic field-effect transistor characteristics, SDS of cas: 239075-02-6, the publication is Journal of Materials Chemistry (2010), 20(21), 4347-4355, database is CAplus.

A series of cyclopentadithiophene based polymers have been synthesized by oxidative polymerization or palladium-catalyzed coupling reactions. Polymers have been prepared with backbones containing benzothiadiazole, benzoxadiazole, 2,2′-bithiophene, Ph and fluorene units. The backbone structure is shown to have a large effect on the film morphol., and the optical and electrochem. properties in solution and the solid state. We show that the polymer composition can be used to tune the band gap over the entire visible spectrum. Spin-coated films of these polymers have been used as the active layer of organic field effect transistors and hole mobilities up to 3.7 × 10^-3 cm² V^-1 s^-1 have been measured under ambient conditions.

Journal of Materials Chemistry published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, SDS of cas: 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Min, Jie published the artcileA star-shaped D-π-A small molecule based on a tris(2-methoxyphenyl)amine core for highly efficient solution-processed organic solar cells, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2014), 2(36), 7614-7620, database is CAplus.

A new star-shaped D-π-A small mol., 2,2′,2”-{nitrilotris[(3-methoxy-4,1-phenylene)-2,2′-bithiene-5′,5-diyleth-1-yl-1-ylidene]}tri-malononitrile N(Ph(OMe)-2T-DCN-Me)₃, with high efficiency potential for photovoltaic applications was synthesized. Introducing a soluble tris(2-methoxyphenyl)amine (TPA-MeO) core unit can significantly improve the solubility of star-shaped small mols. without neg. impacting intramol. conjugation and intermol. solid state arrangements. Solution-processed organic solar cells based on a blend of N(Ph(OMe)-2T-DCN-Me)₃ and PC₇₀BM show an initially high power conversion efficiency of over 4% under simulated AM 1.5.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zasosov, R. V. published the artcileExcretion of naphthamon in the bile of white rats, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1973), 42(5), 557-60, database is CAplus and MEDLINE.

Naphthamon (I) [3818-50-6] (50-1250 mg/kg) was detected in the bile 10 min after it was introduced into the duodenum of rats. The total amount of I excreted in the bile for 24-48 hr was <1% of the dose applied.

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C5H11BrO, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Usta, Hakan published the artcileDithienosilole- and Dibenzosilole-Thiophene Copolymers as Semiconductors for Organic Thin-Film Transistors, Computed Properties of 239075-02-6, the publication is Journal of the American Chemical Society (2006), 128(28), 9034-9035, database is CAplus and MEDLINE.

The synthesis and physicochem. properties of a new class of thiophene/arenesilole-containing π-conjugated polymers are reported. Examples of this new polymer class include the following: poly(2,5-bis(3′,3”-dihexylsilylene-2′,2”-bithieno)thiophene) (TS6T1), poly(2,5′-bis(3”,3”’-dihexylsilylene-2”,2”’-bithieno)bithiophene) (TS6T2), poly(2,5′-bis(2”,2”’-dioctylsilylene-1”,1”’-biphenyl)thiophene) (BS8T1), and poly(2,5′-bis(2”,2”’-dioctylsilylene-1”,1”’-biphenyl)bithiophene) (BS8T2). Organic field-effect transistors (OFETs) with hole mobilities as high as 0.02-0.06 cm²/V s in air, low turn-on voltages, and current on/off ratios >10⁵-10⁶ are fabricated using solution processing techniques with the above polymers as the active channel layer. OFETs based on this polymer class exhibit excellent ambient operational stability.

Journal of the American Chemical Society published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C13H17BF3NO2, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Usta, Hakan published the artcileSilole-based polymeric semiconductors for organic thin film transistors, Related Products of alcohols-buliding-blocks, the publication is PMSE Preprints (2007), 337-338, database is CAplus.

Four new silolearene-thiophene copolymers were synthesized and their properties in organic field-effect transistors (OFETs) were studied. Carrier mobilities ≤0.06 cm²/Vs and current on/off ratios of 10⁵-10⁶ for unaligned films were measured in devices functioning in ambient conditions. The silole-based systems can be synthesized in high yields, are environmentally stable, and yield solution-processable films which act as efficient hole transporters in FET devices.

PMSE Preprints published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C10H12O5, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xin Rui published the artcileA photochromic thin film based on salicylideneaniline derivatives intercalated layered double hydroxide, COA of Formula: C17H12NNaO8S2, the publication is Chemical Physics Letters (2010), 493(4-6), 333-339, database is CAplus.

Optically transparent thin films with photochromic properties were fabricated by co-intercalation of azomethine-H anions (AMH) and 1-pentanesulfonate (PS) with different molar ratios into the galleries of a ZnAl layered double hydroxide (LDH). The photochromism of AMH occurred in a 2D confined inorganic matrix was studied by steady state and transient UV-visible spectroscopy. The AMH anion undergoes an excited-state intramol. proton transfer from the enol tautomer to trans-keto tautomer after UV excitation, and the relaxed back-isomerization to the ground state of enol tautomer was studied by transient UV-visible spectroscopy.

Chemical Physics Letters published new progress about 5941-07-1. 5941-07-1 belongs to alcohols-buliding-blocks, auxiliary class Salt,Benzene,Naphthalene,Phenol,Inhibitor, name is 8-Hydroxy-1-(salicylideneamino)naphthalene-3,6-disulfonic acid monosodium Salt, and the molecular formula is C8H10O2, COA of Formula: C17H12NNaO8S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Varkuti, Boglarka H. published the artcileHigh-Throughput Small Molecule Screen Identifies Modulators of Mitochondrial Function in Neurons, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is iScience (2020), 23(3), 100931, database is CAplus and MEDLINE.

We developed a high-throughput assay for modulators of mitochondrial function in neurons measuring inner mitochondrial membrane potential (ΔΨ_m) and ATP production The assay was used to screen a library of small mols., which led to the identification of structural/functional classes of mitochondrial modulators such as local anesthetics, isoflavones, COXII inhibitors, adrenergic receptor blockers, and neurotransmitter system effectors. Our results show that some of the isolated compounds promote mitochondrial health, enhance oxygen consumption rate, and protect neurons against toxic insults found in the cellular environment of Alzheimer disease. These studies offer a set of compounds that may provide efficacy in protecting the mitochondrial system in neurodegenerative disorders.

iScience published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C23H28N2O4, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hau, King In published the artcileSynthesis of Metallo-conjugated Copolymer with Electron Deficient Main Chain and the Formation of Polymer-Carbon Nanotube Hybrids, Application In Synthesis of 239075-02-6, the publication is Journal of Inorganic and Organometallic Polymers and Materials (2020), 30(1), 243-253, database is CAplus.

The authors report the synthesis of a conjugated polymer incorporated with electron-deficient dipyrridophenanzine units and pendant ruthenium complexes. The electronic transition and photophys. properties of the polymer were thoroughly studied. Due to the presence of an extended conjugated system, polymer main chain was able to interact strongly with carbon nanotube (CNT) surface by π-π interaction, resulting in the formation of a dispersion in organic solvents. The polymer-nanotube hybrid was characterized by different microscopic and spectroscopic experiments Raman spectroscopic results suggested that the electron d. of the CNT decreased after the formation of polymer/nanotube hybrids, which suggests there is an electronic interaction between the polymer main chain and CNT.

Journal of Inorganic and Organometallic Polymers and Materials published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Application In Synthesis of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Yong published the artcileAchieving the low interfacial tension by balancing crystallization and film-forming ability of the cathode interlayer for organic solar cells, HPLC of Formula: 239075-02-6, the publication is Journal of Colloid and Interface Science (2022), 880-890, database is CAplus and MEDLINE.

A series of mols. with imide units bridged by the core of thiophene-based groups, namely N-dimethylaminopropyl-4-thiophene-1,8- naphthalimide (NT), bis(N-dimethylaminopropyl)-4-thiophene-1,8-naphthalimide (NTN), and bis(N-dimethylaminopropyl)-4-bithiophene-1,8-naphthalimide (N2TN), have been reported as cathode interfacial materials (CIMs) to realize low interfacial tension with the blend in organic solar cells (OSCs). We evaluated the Ohmic contact between the active layer and these cathode interlayers based on various characterizations, which is of great significance for further understanding these imide-based interlayers. It turned out that the homogeneous and continuous NTN interlayer as a CIM balanced the factors of crystallization and film-forming property, and broke through the limitation of poor conductivity and high aggregation in our previous work. Moreover, compared with NT and N2TN, the NTN interlayer achieve a combination of good solubility in methanol, efficient electron mobility, and aligned work function. These advantages of NTN are conducive to the realization of high-efficient interfacial electron collection and transfer, thus improving the short-circuit c.d. (JSC) and filling factor (FF) of devices. Therefore, the binary OSCs (PM6:Y6) based on NTN engineered aluminum-cathode with excellent stability demonstrate a maximum power conversion efficiency (PCE) of 16.56 %, which is higher than NT (PCE = 1.34 %) and N2TN (PCE = 13.90 %). The enhanced performance is ascribed to the improvement of JSC and FF, which is originated from the outstanding conductivity and high-quality interface of NTN. Surprisingly, the PM6:Y6-based semitransparent device with NTN obtain a PCE of 13.43 % with an average visible transmittance of 17.79 %, which is better than traditional PDINO. This study highlights a potential strategy for enhancing the performance of OSCs by the interface engineering via decreasing the interfacial intension.

Journal of Colloid and Interface Science published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C11H8O3, HPLC of Formula: 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts