Rodriguez-Alba, Efrain’s team published research in Journal of Molecular Structure in 1183 | CAS: 239075-02-6

Journal of Molecular Structure published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Quality Control of 239075-02-6.

Rodriguez-Alba, Efrain published the artcileDesign of novel well-defined oligothiophenes bearing donor-acceptor groups (pyrene-porphyrin): Synthesis, characterization, optical properties and energy transfer, Quality Control of 239075-02-6, the publication is Journal of Molecular Structure (2019), 28-36, database is CAplus.

Novel thiophene monomers containing porphyrin units attached via di(ethylene glycol) and tetra(ethylene glycol) spacers were synthesized: 3-methyl-4-(4-(1-(5-phenyl-10,15,20-triphenylporphyrin)) diethoxy) thiophene (M2PPh) and 3-methyl-4-(4-(1-(5-phenyl-10,15,20-triphenylporphyrin)) tetraethoxy) thiophene (M4PPh). These monomers and other co-monomers with pyrene units 3-methyl-4-(diethoxy) thiophene (M2) and 3-methyl-4-(tetraethoxy) thiophene (M4) previously reported by us, were linked to thiophene and bithiophene via a Suzuki coupling reaction to give the corresponding terthiophenes and quaterthiophenes: [3-diethoxypyrene, 3-diethoxyporphyrin, 4,4”’ di-Me – 2,2:5’2″- terthiophene (TT2PY-PPh)], [3-tetraethoxypyrene, 3-tetraethoxyporphyrin, 4, 4”’dimethyl-2,2:5’2″-terthiophene (TT4PY-PPh)], [3′-diethoxypyrene, 3′-diethoxyporphyrin, 4,4”’methyl-2,2′:5′:2”:5”,2”’-quaterthiophene (QT2PY-PPh)], and [3′-tetraethoxypyrene, 3′-tetraethoxyporphyrin,4,4”’methyl-2,2′:5′:2”:5”,2”’-quaterthiophene (QT4PY-PPh)]. The synthesized compounds were characterized by 1H NMR, 13C NMR and MALDI-TOF mass spectrometry; their optical properties were studied by absorption and fluorescence spectroscopy. The emission spectra of the oligothiophenes bearing pyrene-porphyrin units showed a significant decrease in the pyrene monomer emission and the appearance of a new emission band at 650 nm, arising from the porphyrin, which revealed that a FRET phenomenon is occurring from the excited pyrene to the porphyrin. The obtained FRET efficiencies were between 93 and 98% depending on the oligomer structure.

Journal of Molecular Structure published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Quality Control of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Michinobu, Tsuyoshi’s team published research in Polymers (Basel, Switzerland) in 2 | CAS: 239075-02-6

Polymers (Basel, Switzerland) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Michinobu, Tsuyoshi published the artcileSynthesis and properties of 1,8-carbazole-based conjugated copolymers, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Polymers (Basel, Switzerland) (2010), 2(3), 159-173, database is CAplus.

A new series of conjugated carbazole polymers based on the 1,8-carbazolylene unit was synthesized by the Pd-catalyzed polycondensation between the 1,8-diiodocarbazole derivative and various bifunctional counter comonomers. An alkyne spacer was found to be a key to increasing the mol. weight of the resulting polymers. All the obtained polymers showed good solubilities in the common organic solvents, and they were fully characterized by Gel permeation chromatog. (GPC), and 1H NMR and IR spectroscopies. The UV-vis absorption and fluorescence spectra revealed the relationship between the chem. structure and effective conjugation length. The efficiency order of the carbazole connectivity was 2,7-carbazolylene > 1,8-carbazolylene > 3,6-carbazolylene. The electrochem. properties of these polymers suggested the relatively facile oxidation at ca. +0.5-0.7 V vs. Fc/Fc+ or a high potential as p-type semiconductors. The combination of the electrochem. oxidation potentials and the optical band gaps allowed us to estimate the HOMO and LUMO levels of the polymers. It was shown that the energy levels of the 1,8-carbazole-based conjugated polymers can be tunable by selecting the appropriate comonomer structures.

Polymers (Basel, Switzerland) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Okunlola, Adenike’s team published research in Progress in Biomaterials in 9 | CAS: 23828-92-4

Progress in Biomaterials published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, SDS of cas: 23828-92-4.

Okunlola, Adenike published the artcileMicrosphere formulations of ambroxol hydrochloride: influence of Okra (Abelmoschus esculentus) mucilage as a sustained release polymer, SDS of cas: 23828-92-4, the publication is Progress in Biomaterials (2020), 9(1-2), 65-80, database is CAplus and MEDLINE.

Ambroxol hydrochloride (AH), a secretion-releasing expectorant, is a good candidate for sustained delivery. Mucilages are biodegradable, inexpensive carriers in microsphere formulations. The study aimed to prepare microspheres of AH using Okra mucilage obtained from pods of Abelmoschus esculentus combined with sodium alginate at various polymer/drug ratios. Okra mucilage was characterized for morphol., swelling, viscosity and flow properties. AH microspheres were prepared by ionic emulsification method and characterized using size, entrapment efficiency, swelling index and dissolution time (t50). A full 2 by 3 factorial exptl. design using three factors (Okra mucilage/alginate ratio X1; drug/polymer ratio X2; and polymer concentration X3), each at two levels, was used to determine the effects of formulation variables on the responses. Optimized formulations of AH microspheres had sizes ranging from 250.91 ± 16.22 to 462.10 ± 23.85μm; swelling index 1.35 ± 0.05 and 3.20 ± 0.03 and entrapment 55.70 ± 3.55-94.11 ± 4.50%. The microspheres exhibited sustained release of AH over a prolonged period as revealed by the dissolution time (t50) 2.85 ± 1.03-7.50 ± 0.96 h. Drug release kinetics generally followed zero order, implying that the process is constant and independent of the initial concentration of drug. Polymer concentration had the highest influence on microsphere size, entrapment efficiency and dissolution time while Okra/alginate ratio had the highest influence on swelling. Okra mucilage was a suitable polymer that could serve as an alternative to synthetic polymers in sustaining the release of ambroxol hydrochloride.

Progress in Biomaterials published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, SDS of cas: 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zheng, Yijun’s team published research in Synthetic Metals in 181 | CAS: 239075-02-6

Synthetic Metals published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C5H6BNO3, Application In Synthesis of 239075-02-6.

Zheng, Yijun published the artcileOptical and redox properties of phenyl-capped cyclohexa[c]-oligothiophenes, Application In Synthesis of 239075-02-6, the publication is Synthetic Metals (2013), 1-9, database is CAplus.

A series of phenyl-capped cyclohexa[c]thiophene derivatives (nCHT-TEG, n = 2, 4, or 6) have been synthesized. NCHT-TEG are well-soluble in common organic solvents. The absorption spectra of neutral nCHT-TEG oligomers indicated a shorter effective conjugation length than conventional oligothiophenes based on the non-coplanarity of the thiophene rings. NCHT-TEG can be oxidized/reduced reversibly. The results of cyclic voltammetry and UV-Vis-NIR spectroscopy of the oxidized nCHT-TEG revealed that the effective conjugation length increases at the higher oxidation state. D. functional theory (DFT) calculations indicate that the quinoidal structure of the oxidized nCHT contributes to the improved effective conjugation length. NCHT-TEG radical cations and dications were characterized by ESR and NMR spectroscopies, resp. NMR results of nCHT-TEG dication revealed that 2CHT-TEG2+ have closed-shell bipolaron structure, while 4CHT-TEG2+ and 6CHT-TEG2+ are the mixture of closed-shell bipolaron and open-shell two-polaron structures.

Synthetic Metals published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C5H6BNO3, Application In Synthesis of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Okamoto, Sentaro’s team published research in Polymer in 230 | CAS: 239075-02-6

Polymer published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Category: alcohols-buliding-blocks.

Okamoto, Sentaro published the artcileSynthesis of folded H-stacking skipped π polymers consisting of different 2-substituted trimethylene tethering units and their optical and conductive property, Category: alcohols-buliding-blocks, the publication is Polymer (2021), 124037, database is CAplus.

A series of polymers P1-P4 ([-CH2CH(Z)CH2-(π conjugated unit)-]n, where Z = a bulky substituent) were synthesized via the Suzuki-Miyaura coupling polymerization and predominantly existed in their folded H-stacking form in the solution and film, which was evidenced by UV absorption, fluorescent behavior, and X-ray diffraction anal. The morphol. of the polymers in the solid states was dependent on the structure of the Z group present. The conductive nature of P1-P4 was preliminarily demonstrated on hole-only devices. Moreover, a similar onset voltage was observed for P1-P3, which all contained the same π units; however, their current-voltage characteristics were highly dependent on the Z structure. P4, which contained cross-conjugated π units, exhibited a relatively high conductivity with a lower onset requirement.

Polymer published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Moriai, Ryota’s team published research in Tetrahedron Letters in 55 | CAS: 239075-02-6

Tetrahedron Letters published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Formula: C20H28B2O4S2.

Moriai, Ryota published the artcileDesign and synthesis of 2-(1,3-dialkoxy-2-methylpropan-2-yl)-1,3-diarylpropanes as tethering units for folded H-stacking polymers, Formula: C20H28B2O4S2, the publication is Tetrahedron Letters (2014), 55(16), 2649-2653, database is CAplus.

1,3-Diarylpropenes 9 having a 1,3-dialkoxy-2-methylpropan-2-yl group were designed as tethering monomers for folded H-stacking polymers, and were readily synthesized from 2-ethoxymethylidene malonate in four- or five-steps, including a facile sequential addition-elimination-addition reaction of benzyl zinc reagents. The preference for the closed (stacked) conformation in the resulting 2-substituted 1,3-diarylpropanes 9 was evaluated using MM2 calculations, 1H NMR analyses, and fluorescence measurements. Copolymerization of the resulting monomers 9 with compounds containing π-units provided polymers with blue-shifted UV-absorptions both in solution and as films, compared with that of a model compound containing a single π-unit. This optical property is unique to H-aggregated π-units.

Tetrahedron Letters published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Formula: C20H28B2O4S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Matsui, Kazuki’s team published research in European Journal of Pharmaceutical Sciences in 165 | CAS: 23828-92-4

European Journal of Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Matsui, Kazuki published the artcilePotential pharmacokinetic interaction between orally administered drug and osmotically active excipients in pediatric polypharmacy, Application In Synthesis of 23828-92-4, the publication is European Journal of Pharmaceutical Sciences (2021), 105934, database is CAplus and MEDLINE.

Poorly absorbable sugar alcs. (e.g., mannitol, sorbitol, and maltitol) are the excipients frequently contained in pediatric dosage forms. Due to their osmotically active properties, certain amount of sugar alcs. reportedly reduces oral bioavailability of concomitant drugs. This fact implies the possible pharmacokinetic interaction between orally administered drug and sugar alcs. which are present in other concomitant medications. The purpose of this study was to identify the possibility and likeliness of the osmotically active excipient-induced pharmacokinetic interaction in pediatric polypharmacy. Previously developed in silico model that captured the osmotic effect of sugar alcs. in adults was expanded to pediatric population. This math. model successfully explained the impaired bioavailability of lamivudine by the co-administered sorbitol in other dosage forms. In the meantime, sugar alc. contents in marketed pediatric dosage forms were investigated by reverse engineering technol. Considering the critical administration dose of sugar alcs. estimated by in silico model, it was revealed that 25 out of 153 pediatric dosage forms were identified as possible perpetrators even under the approved administration and dosage in Japan. This study shed light on the potential pharmacokinetic interaction that cannot be dismissed throughout the pediatric pharmaceutical dosage form design and development.

European Journal of Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Blagov, N. A.’s team published research in Meditsinskaya Parazitologiya i Parazitarnye Bolezni in | CAS: 3818-50-6

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Blagov, N. A. published the artcileMorphological changes in the gastric and intestinal mucosa after mebendazole treatment of rats, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1991), 41-4, database is CAplus and MEDLINE.

The effect of mebendazole on the gastric and intestinal mucosa was studied in intact white rats. The drug caused significant damage to the mucosa, especially to goblet cells of villi and crypts and interfered with mucoid secretion. The alterations after mebendazole administration were more severe than those caused by naphthamon. On the 13-15th day after treatment, a complete restoration of the damage was not yet seen.

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hermoso, R.’s team published research in Revista Iberica de Parasitologia in 30 | CAS: 3818-50-6

Revista Iberica de Parasitologia published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Hermoso, R. published the artcileSurvival study of parasitic helminths. III. Effects of antihelminthic and other drugs on survival of Ascaris lumbricoides, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Revista Iberica de Parasitologia (1970), 30(4), 567-85, database is CAplus.

The metabolism of A. lumbricoides from pigs was studied in media with the addition of anthelmintics and other drugs; intake of glucose, NH3 production, dry residue, and final glycogen were also determined The action of these substances was observed on the worm’s mobility, the elapsed time until inhibition, and recuperation (if any). Santonin, dimethoate, Sevin, piperazine, NaF, bephenium, hydroxynaphthoate, pyrvinium pamoate, arecoline bromide, hexylresorcinol, dithiazanine iodide, and dithiocarbo(bisethylenediamine) totally inhibited Ascaris activity. Naphthalophos, thiabendazole, phenothiazine, diethylcarbamazine, and Na N1-(2-quinoxalinyl)sulfanilamide partially inhibited muscular activity.

Revista Iberica de Parasitologia published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tsuchiya, Tomoaki’s team published research in RSC Advances in 11 | CAS: 239075-02-6

RSC Advances published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C22H12F6O6S2, HPLC of Formula: 239075-02-6.

Tsuchiya, Tomoaki published the artcileThe factors that govern the allosteric chemical sensing of polythiophene chemosensors: scope and limitation toward signal-amplification sensing, HPLC of Formula: 239075-02-6, the publication is RSC Advances (2021), 11(48), 30472-30478, database is CAplus and MEDLINE.

The newly designed polythiophene chemosensors (PT1 and PT2) were synthesized via the Suzuki-Miyaura polymerization with appropriate yields. The photophys. properties of PTs thus obtained were examined by means of UV/vis, fluorescence, excitation spectroscopy, and time-correlated single-photon-counting method. The π-π* transitions around 400-600 nm and the emissions in the range of 400-650 nm were observed The binding behavior of PTs was also investigated upon the interaction of tetrabutylammonium or tetrabutylphosphonium isophthalate, affording the binding constants (K) of 5790-8310 M-1, which were quite smaller than those observed in the corresponding repeating unit. The comprehensive analyses of the UV/vis data and theor. calculation supports revealed the origins of scope and limitation toward signal-amplification sensing. The present results obtained herein will guide the development of new amplification chemosensors.

RSC Advances published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C22H12F6O6S2, HPLC of Formula: 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts