Tag: M.W=400-450

Xiang, Jiajun published the artcileEfficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome, Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Experimental and Therapeutic Medicine (2019), 18(1), 654-658, database is CAplus and MEDLINE.

Clin. efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome (NRDS) was investigated. One hundred child patients with NRDS in Linyi Central Hospital were collected according to the diagnostic criteria for RDS in the Pediatrics, and randomly divided into the treatment group (n=50) and the control group (n=50) based on different therapeutic methods. Patients in the control group were treated with basic treatment and high-dose ambroxol hydrochloride injection, while those in the treatment group were addnl. administered with pulmonary surfactant Curosurf based on conventional therapy in the control group. The chest X-rays were collected before the treatment and at 12 h after the drug administration, the degree of respiratory distress in child patients was observed and evaluated via Silverman grading, and changes in blood gas indexes were recorded before treatment and at 2, 6 and 12 h after the drug administration. The chest X-ray grade, Silverman grade and blood gas anal. results had no differences between the two groups before the treatment (P>0.05). In the treatment group, partial pressure of oxygen (PaO₂) and PH were increased and partial pressure of carbon dioxide (PaCO₂) was decreased compared with those in the control group at 2, 6 and 12 h after the drug administration (P<0.05). At 12 h after the drug administration, chest X-ray grade and Silverman grade in both groups were improved, which were significantly superior in the treatment group to those in the control group (P<0.01). Moreover, the efficacy in the treatment group was remarkably better than that in the control group at 12 h after drug administration (P<0.01). Pulmonary surfactant combined with high-dose ambroxol hydrochloride has definite efficacy in the treatment of NRDS, which can significantly improve the pulmonary infection, respiratory distress and blood gas indexes of child patients.

Experimental and Therapeutic Medicine published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C26H26N4O7, Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Montes, Victor A. published the artcileUltrafast Dynamics of Triplet Excitons in Alq₃-Bridge-Pt(II)porphyrin Electroluminescent Materials, Formula: C20H28B2O4S2, the publication is Journal of the American Chemical Society (2007), 129(42), 12598-12599, database is CAplus and MEDLINE.

Excited-state dynamics are crucial for maximizing the performance of organic light-emitting diodes (OLEDs). Because electron-hole recombination yields singlet and triplet excited states in a 3:1 ratio, it is important to harvest the energy of triplets in light-emitting processes. Self-assembled multichromophore electroluminescent materials consisting of a trisquinolinolate Al(III) (Alq₃) donor, fluorene-based conjugated oligomers as a bridge, and Pt(II) tetraphenylporphyrin as an acceptor and phosphorescent emitter are described. In these materials, the energy of singlet as well as triplet states is harvested and emitted as red phosphorescence from the porphyrin acceptor. Attention was devoted to the triplet exciton dynamics, which was studied by ultrafast transient spectroscopy, and the observations are compared with phosphorescence in thin films and with electroluminescence from OLEDs. Exothermicity of the forward Alq₃-to-fluorene bridge triplet transfer appears to be a less stringent requirement for triplet transfer electroluminescence. In contradistinction, the energy alignment between the bridge and Pt(II)porphyrin emitter is of crucial importance. The triplet exciton dynamics has a dominant effect on the electroluminescence properties of conjugated donor-bridge-acceptor materials. The triplet-energy transfer operates on an ultrafast time scale (k_TTET = (4-6) × 10¹⁰ s^-1) and requires careful energy alignment of the components (³ΔE_D-B ≈ ³ΔE_B-A ≥ 0.1 eV) to prevent endothermic energy transfer and severe quenching of the electroluminescence. This is the 1st time triplet dynamics was directly observed in donor-acceptor electroluminescent materials and direct connection to device efficiency was established.

Journal of the American Chemical Society published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Formula: C20H28B2O4S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kochansky, Jan published the artcileScreening additional antibiotics for efficacy against American foulbrood, Category: alcohols-buliding-blocks, the publication is Journal of Apicultural Research (2005), 44(1), 24-28, database is CAplus.

The sensitivity of Paenibacillus larvae larvae (American foulbrood, AFB) to 35 antibiotics and synthetic antimicrobials, including two previously reported, was investigated. All compounds but one are currently approved by the US Food and Drug Administration for agricultural uses. The most active approved antibiotics screened were pirlimycin, tiamulin, and the polyether ionophores, particularly narasin, lasalocid, salinomycin, laidlomycin, and maduramicin. Pirlimycin and tiamulin show high activity in vitro, but share the mode of action of tylosin and lincomycin (inhibition of ribosomal peptide synthesis), and therefore have no advantage over it. While the ionophores have high in vitro activity and a completely different mode of action (interference with cation transport across cell membranes) and therefore seemed to represent potential alternative treatments for AFB, they were inactive in the field.

Journal of Apicultural Research published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patel, Rashmin B. published the artcileBox-Behnken Experimental Design Aided Optimization of Stability Indicating HPTLC-Based Assay Method: Application in Pharmaceutical Dosage form Containing Model Drugs-Roxithromycin and Ambroxol Hydrochloride, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Analytical Chemistry Letters (2019), 9(6), 816-834, database is CAplus.

The objective of this study was to apply Design of Experiment (DoE) concept for development of stability indicating high-performance thin-layer chromatog. (HPTLC) method for assay of model drugs (Roxithromycin (ROXTM) and Ambroxol hydrochloride (AMBRX)) in marketed tablet formulations followed by validation of developed HPTLC method as per ICHQ2(R1). Box-Behnken exptl. design was applied to optimize chromatog. conditions and their effects on retardation factor (Rf) value. The developed HPTLC method was validated for specificity, linearity, accuracy, precision, and robustness. The ROXTM (Rf 0.42) and AMBRX (Rf 0.75) were well separated (Rs 2.06) from each other and from their resp. degradation products on HPTLC plate using optimized chromatog. conditions. The developed method was successfully validated and statistical anal. proved that the method is sensitive, specific (peak purity > 0.9999 for both ROXTM and AMBRX), accurate (98.59-101.14% and 99.96-101.76%, ROXTM and AMBRX, resp.) and precise (% RSD >1.0 for both ROXTM and AMBRX). The developed HPTLC method have advantages over reported methods in being robust and able to determine the model drugs and degradation products with sensitivity, selectivity and short anal. time using simple mobile phase.

Analytical Chemistry Letters published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gershbein, Leon L. published the artcileAction of drugs and chemical agents on rat liver regeneration, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Drug and Chemical Toxicology (1977) (1985), 8(3), 125-43, database is CAplus and MEDLINE.

A large number (> 270) of drugs, chems., and other agents were tested for their effects on the regeneration of liver in hepatectomized rats. Seven anticonvulsants, 4 antiinflammatory drugs, 4 sedatives-hypnotics, the antipyretic-analgesic aminopyrine  [58-15-1], the antifungal griseofulvin  [126-07-8], a uricosuric, a muscle relaxant, a hydrocholeretic, an antihypertensive, and a thyroid inhibitor were hepatotrophic. Most the remaining drugs were inactive in this screening, whereas a few suppressed liver regeneration.

Drug and Chemical Toxicology (1977) published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bolis, Serena published the artcileUltrafast study of inter- and intrachain energy transfer in a core-polymer, Formula: C20H28B2O4S2, the publication is Journal of Polymer Science, Part B: Polymer Physics (2018), 56(13), 965-969, database is CAplus.

Interchain interactions can play a pos. role in reaching amplified spontaneous emission in an interesting core-polymer system where the donor (side chains) and the acceptor (core) are chem. linked together. Different degree of interchain interactions modifies the photophys. characteristics of the polymer. By means of transient absorption spectroscopy we show that the stimulated emission from the core decreases passing from solid state to concentrated solution and it is almost absent in the diluted solution The conformational rearrangements of the core-polymer chain in solution limits the efficiency of the intrachain Foerster energy transfer mechanism. The free chain rotations decrease the exciton hopping along the conjugated chains, the ratio between donor and acceptor moieties in the polymer, and change the relative orientation of the transition dipoles of the donor and acceptor causing a strong decrease of energy transfer efficiency and subsequently of the gain. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018.

Journal of Polymer Science, Part B: Polymer Physics published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Formula: C20H28B2O4S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bolis, Serena published the artcileA core copolymer approach to improve the gain properties of a red-emitting molecule, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(100), 11761-11763, database is CAplus and MEDLINE.

The authors report a new approach to improve the gain characteristics of a red-emitting based mol. The insertion of the active dye between two polymeric arms prevents the inter-mol. interactions deleterious for the gain. By the ultra-fast pump-probe technique the authors found an efficient energy transfer between the polymer and dye. High gain in the nanosecond timescale regime was proved.

Chemical Communications (Cambridge, United Kingdom) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shiraki, Tadashi published the artcileMass treatment of trichuriasis with several anthelmintics, especially on the statistical criteria for the evaluation of egg-diminishing effects of the drug, Product Details of C28H29NO4, the publication is Acta Medica et Biologica (Niigata, Japan) (1973), 21(1), 11-27, database is CAplus.

A single oral dose of paromomycin sulfate [1263-89-4] (3g), tetrachlorethylene [127-18-4] (1.5 g), bithional [97-18-7] (1.5 g), biphenium hydroxynaphthoate [3818-50-6] (1.4 g), 1-bromo-2-naphthol [573-97-7] (4 g), piperazine [110-85-0] (3 g), and a santonin-kainic acid mixture [51990-05-7] (50 mg-5 mg) given to whipworm (Trichuris trichiura) infested school children gave a 60.0, 52.6, 42.9, 42.9, 33.4, 28.6, and 0% decrease, resp., in the number of eggs in stool samples. Tetrachloroethylene and 1-bromo-2-naphthol completely eliminated eggs from, respectively, 26.3 and 16.7% of the children treated.

Acta Medica et Biologica (Niigata, Japan) published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C4H4N2O2, Product Details of C28H29NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Yao published the artcileFinely Tuned Polymer Interlayers Enhance Solar Cell Efficiency, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Angewandte Chemie, International Edition (2015), 54(39), 11485-11489, database is CAplus and MEDLINE.

Three conjugated polymer zwitterions (CPZs), containing thiophene-, diketopyrrolopyrrole- (DPP), and naphthalene diimide (NDI) backbones, were synthesized with pendant zwitterions, specifically sulfobetaine groups. Diboronate-ester-functionalized bithiophene and benzothiadiazole monomers were copolymerized with zwitterion-substituted dibromothiophene, DPP, and NDI monomers by A₂+B₂ Suzuki polymerization The CPZs were incorporated into polymer solar cells (PSCs) as interlayers between the photoactive layer and Ag cathode. The thiophene-based CPZs gave power conversion efficiencies (PCEs) of about 5 %, while the narrow-energy-gap DPP- and NDI-based CPZs performed exceptionally well, giving PCEs of 9.49 % and 10.19 %, resp. The interlayer thickness had only a minor impact on the device performance for the DPP- and NDI-CPZs, a finding attributed to their electron-transport properties. UV photoelectron and reflectance spectroscopies, combined with external quantum efficiency measurements, provided structure-property relationships that lend insight into the function of CPZ interlayers in PSCs. NDI-based CPZ interlayers provide some of the best performing organic solar cells reported to date, and prove useful in conjunction with high-performing polymer-active layers and stable, high-work-function, metal cathodes.

Angewandte Chemie, International Edition published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rodriguez-Alba, Efrain published the artcileSynthesis, characterization and optical properties of novel oligothiophenes bearing pyrene units attached via well defined oligo(ethylene glycol) spacers, Quality Control of 239075-02-6, the publication is Synthetic Metals (2015), 92-105, database is CAplus.

Two new thiophene monomers bearing pyrene units attached via di(ethylene glycol) and tetra(ethylene glycol) spacers were synthesized, 3-methyl-4-(diethoxy) thiophene (M2) and 3-methyl-4-(tetraethoxy) thiophene (M4). These monomers were linked to thiophene and bithiophene via a Suzuki coupling reaction to give the corresponding terthiophenes and quaterthiophenes: [3,3-(di (diethoxypyrene)), 4,4”’dimethyl-2,2: 5#14-15#-terthiophene (TT2)], [3,3-(di(tetraethoxypyrene)), 4,4”’dimethyl-2,2:5#14-15#-terthiophene (TT4)], [3,3”’-di(diethoxypyrene), 4,4”’methyl-2,2′:5′: 2”:5”,2”’-quaterthiophene (QT2)], and [3,3”’-di(tetraethoxypyrene), 4,4”’methyl -2,2′:5′:2”:5”,2”’-quaterthiophene (QT4)]. The obtained oligothiophenes were characterized by ¹H, ¹³C NMR spectroscopies and MALDI-TOF mass spectrometry. The optical properties of these compounds were studied by absorption and fluorescence spectroscopy. The absorption spectra of these compounds exhibited a broad absorption band at λ_max = 350 nm arising from the S₀ → S₂ transition of the pyrene group. This broadening is an indication of the presence of pyrene-pyrene interactions in the ground state. A discrete band at ca λ = 385 due to the S₀ → S₁ transition (n-π*) of the oligothiophene backbone was also observed The emission spectra of oligomers TT2, TT4, QT2 and QT4 showed a “monomer emission” band at λ_M = 379-450 nm followed by an intense excimer emission band at λ_E = 570 nm due to intramol. pyrene-pyrene interactions. The effect of the flexible spacer length and that of the oligomer backbone influences significantly the formation of pyrene-pyrene complexes.

Synthetic Metals published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Quality Control of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts