Li, Yaowen’s team published research in Macromolecules (Washington, DC, United States) in 42 | CAS: 239075-02-6

Macromolecules (Washington, DC, United States) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Related Products of alcohols-buliding-blocks.

Li, Yaowen published the artcileEnergy level and molecular structure engineering of conjugated donor-acceptor copolymers for photovoltaic applications, Related Products of alcohols-buliding-blocks, the publication is Macromolecules (Washington, DC, United States) (2009), 42(13), 4491-4499, database is CAplus.

A series of novel soluble conjugated copolymers consisting of coplanar donor (bithiophenevinyl)-acceptor (2-pyran-4-ylidenemalononitrile) (TVM)-based unit coupled to different electron-donating ability moieties were synthesized by Suzuki coupling polymerization The structures of the copolymers were characterized, and their phys. properties were studied. High mol. weight (Mn up to 43.8 kg/mol) and thermostable copolymers were obtained. The combination of TVM unit building block with gradually increased electron-donating ability moieties results in enhanced π-π stacking in solid state and intramol. charge transfer (ICT) transition bands, which lead to an extension of their absorption spectral range. Cyclic voltammetry measurement displayed that the HOMO and LUMO energy levels of the copolymers can be fine-tuned. The resulting copolymers possessed relatively low HOMO energy levels promising good air stability and high open-circuit voltage (Voc) for photovoltaic application. Bulk heterojunction photovoltaic devices were fabricated by using the copolymers as donors and (6,6)-Ph C61-butyric acid Me ester (PCBM) as acceptor. The Voc reached 0.90 V, and the power conversion efficiencies (PCE) of the devices were measured between 0.04% and 0.99% under simulated AM 1.5 solar irradiation of 100 mW/cm2. The significant improvement of PCE indicates a novel concept for developing TVM-based donor-acceptor (D-A) conjugated copolymers with high photovoltaic performance by adjusting electron-donating ability and coplanarity.

Macromolecules (Washington, DC, United States) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kanakubo, Masashi’s team published research in Bulletin of the Chemical Society of Japan in 94 | CAS: 239075-02-6

Bulletin of the Chemical Society of Japan published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Computed Properties of 239075-02-6.

Kanakubo, Masashi published the artcileRoom-Temperature Phosphorescence of Thiophene Boronate Ester-Cross Linked Polyvinyl Alcohol; A Triplet-to-Singlet FRET-Induced Multi-Color Afterglow Luminescence with Sulforhodamine B, Computed Properties of 239075-02-6, the publication is Bulletin of the Chemical Society of Japan (2021), 94(4), 1204-1209, database is CAplus.

A thiophene-derived boronate ester-crosslinked polyvinyl alc., 1-PVA, has been prepared, which was found to exhibit room-temperature phosphorescence (RTP) at 475 nm upon UV irradiation (λem = 254 nm). The quantum yield (Fp) was determined to be 6.3% with a phosphorescence lifetime of 256 ms, the cyanish afterglow being visually detected after switching the UV lamp off. The emission properties were rationalized by El-Sayed’s rule, where introduction of a sulfur atom brings about n → π* transition in the T2 state to promote an ISC channel. Given that the phosphorescence spectrum at 77 K was consistent with that in the PVA film, the rigid environment of PVA-based matrix may stabilize the triplet state. In addition, the delayed emissive color was tuned by doping various amounts of sulforhodamine B (SRhoB) in the film; a triplet-to-singlet Forster-type resonance energy transfer process occurred from crosslinked thiophene boronate to SRhoB acceptor which modified the emission to a white-light afterglow. Given water-sensitivity of the resultant film, high-contrast water writing on the film was achieved, which would be profitable for a low-cost security film.

Bulletin of the Chemical Society of Japan published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wakioka, Masayuki’s team published research in Molecules in 23 | CAS: 239075-02-6

Molecules published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C8H6ClF3, Product Details of C20H28B2O4S2.

Wakioka, Masayuki published the artcileSynthesis of a 1,2-dithienylethene-containing donor-acceptor polymer via palladium-catalyzed direct arylation polymerization (DArP), Product Details of C20H28B2O4S2, the publication is Molecules (2018), 23(4), 981/1-981/10, database is CAplus and MEDLINE.

This paper reports the synthesis of D-A polymers containing 1,2-dithienylethene (DTE) units via palladium-catalyzed direct arylation polymerization (DArP). The reaction of dibromoisoindigo (1-Br) and DTE (2-H), in the presence of Pd2(dba)3·CHCl3 (0.5 mol%), P(2-MeOC6H4)3 (L1) (2 mol%), pivalic acid (1 equiv) as catalyst precursors, and Cs2CO3 (3 equiv) as a base affords poly(1-alt-2) with a high mol. weight (Mn up to 44,900). Although, it has been known that monomers, with plural C-H bonds, tend to form insoluble materials via direct arylation at undesirable C-H positions; the reaction of 1-Br and 2-H cleanly proceeds without insolubilization. The resulting polymer has a well-controlled structure and exhibits good charge transfer characteristics in an organic field-effect transistor (OFET), compared to the polymer produced by Migita-Kosugi-Stille cross-coupling polymerization The DArP product displays an ideal linear relationship in the current-voltage curve, whereas the Migita-Kosugi-Stille product shows a VG-dependent change in the charge mobility.

Molecules published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C8H6ClF3, Product Details of C20H28B2O4S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cai, Hongfeng’s team published research in Jianyan Yixue Yu Linchuang in 18 | CAS: 23828-92-4

Jianyan Yixue Yu Linchuang published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Cai, Hongfeng published the artcileEffects of dexamethasone combined with ambroxol hydrochloride therapy on myocardial enzymes, leukocytes and platelet levels in patients with severe pneumonia, Application In Synthesis of 23828-92-4, the publication is Jianyan Yixue Yu Linchuang (2021), 18(8), 1149-1151, database is CAplus.

Objective: To investigate the effect of dexamethasone combined with ambroxol hydrochloride on myocardial enzymes, leukocytes and platelet levels in patients with severe pneumonia. Methods: A total of 78 patients with severe pneumonia admitted to our hospital from Jan. 2018 to Jan. 2020 were selected and divided into a control group and a research group according to the method of drawing lots, with 39 cases in each group. The control group was treated with a single ambroxol hydrochloride , the study group was treated with dexamethasone on the basis of the control group. The myocardial enzymes [lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase (CK) before and after treatment ) and its isoenzyme (CK-MB)], leukocytes, platelets, inflammatory factors [interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α)] levels The clin. efficacy and lung function were compared. Results: Before treatment, there was no significant difference in the levels of myocardial enzymes, leukocytes and platelets between the two groups (P>0.05). After treatment, the levels of myocardial enzymes, leukocytes and platelets in the study group were lower than those in the control group (P<0.05). The clin. treatment effect of the patients in the study group was significantly better than that in the control group (P<0.05); there was no significant difference in the pulmonary function between the two groups before treatment (P>0.05), and the pulmonary function of the patients in the study group was better than that in the control group after the treatment (P>0.05). There was no significant difference in the levels of inflammatory factors between the two groups before treatment (P>0.05), and the levels of serum inflammatory factors in the study group were lower than those in the control group after treatment (P<0.05). Conclusion: Dexamethasone combined with ambroxol hydrochloride has a significant effect in the treatment of severe pneumonia, can effectively control the levels of myocardial enzymes, leukocytes and platelets, improve the lung function of patients, and reduce the level of inflammatory factors, which is worthy of clin. application.

Jianyan Yixue Yu Linchuang published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xiaoliang’s team published research in Jinri Yaoxue in 31 | CAS: 23828-92-4

Jinri Yaoxue published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C6H10O7, Category: alcohols-buliding-blocks.

Wang, Xiaoliang published the artcileDetermination of sucrose and sorbitol in ambroxol hydrochloride oral solution by HPLC-RID, Category: alcohols-buliding-blocks, the publication is Jinri Yaoxue (2021), 31(10), 756-760, database is CAplus.

OBJECTIVE To establish a method for determination of sucrose and sorbitol in ambroxol hydrochloride oral solution and investigated the addition among samples from 21 manufacturers all over the whole country. METHODS The HPLC determination was performed on a HYPERSIL amino column (250 mm×4.6 mm, 5 μm). The mobile phase was consisted of acetonitrile and water (80:20, V/V) at the flow rate of 1.0 mL·min-1. The column temperature was 35°C and the refractive index detector was used. RESULTS Sucrose and sorbitol could be well separated from ambroxol hydrochloride, and they had good linear relationship (n=6) at the range of 1-10 mg·mL-1 with sucrose (r=0.9996) and sorbitol (r=0.9999), resp. The limits of quantitation of sucrose and sorbitol were 8.03 and 8.04 μg resp. and the average recoveries (n=9) were 101.0% and 100.9% with the RSD 1.03% and 0.97% resp. The samples from 22 enterprises in the whole country were determined and the determinated results for few individual manufacturers were inconsistent with the production prescription. CONCLUSION The established method is simple, accurate and good repeatability which can lay the foundation for the determination of the addition and quality evaluation of flavor agents in oral solution

Jinri Yaoxue published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C6H10O7, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Ya-rui’s team published research in Xiandai Zhenduan Yu Zhiliao in 32 | CAS: 23828-92-4

Xiandai Zhenduan Yu Zhiliao published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C38H74Cl2N2O4, Formula: C13H19Br2ClN2O.

Zhu, Ya-rui published the artcileEffects of ambroxol hydrochloride combined with pulmicorin on changes of airway inflammation and allergic reaction EOS, ECP and IL-4 indexes in patients with bronchial asthma, Formula: C13H19Br2ClN2O, the publication is Xiandai Zhenduan Yu Zhiliao (2021), 32(5), 707-708, database is CAplus.

Objective: To investigate the effect of ambroxol hydrochloride combined with pulmicorin on airway inflammation and the changes of EOS, ECP and IL-4 indexes in patients with bronchial asthma. Methods: A total of 60 patients with bronchial asthma who were admitted to our hospital from Feb. 2019 to Dec. 2019 were selected and divided into a control group and an exptl. group with 30 cases in each group according to the method of tossing a coin. The control group was given routine treatment, and the exptl. group was given ambroxol hydrochloride combined with pulmicoride on this basis. The levels of eosinophils (EOS), eosinophil cationic protein (ECP), interleukin-4 (IL-4) and adverse reactions were observed in the two groups. Results: Before treatment, there was no significant difference in the levels of IL-4, ECP and EOS between the two groups (P>0.05). After treatment, the levels of IL-4, ECP and EOS in the two groups were lower than those before treatment, and the exptl. group was significantly lower than the control group (P<0.05). The incidence of adverse reactions in the exptl. group was significantly lower than that in the control group (P<0.05). Conclusion: Ambroxol hydrochloride combined with pulmicoride has pos. effect on airway inflammation and allergic reaction EOS, ECP and IL-4 levels in patients with bronchial asthma, with high safety, which is worthy of clin. application.

Xiandai Zhenduan Yu Zhiliao published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C38H74Cl2N2O4, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dong, Hui’s team published research in Latin American Journal of Pharmacy in 38 | CAS: 23828-92-4

Latin American Journal of Pharmacy published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Dong, Hui published the artcileClinical efficacy of atomizing inhalation of ambroxol hydrochloride in treatment of chronic bronchitis in elderly patients, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Latin American Journal of Pharmacy (2019), 38(7), 1284-1289, database is CAplus.

This study aimed to investigate the clin. efficacy of atomizing inhalation of ambroxol hydrochloride in treatment of chronic bronchitis in elderly patients. Four hundred elderly patients with chronic bronchitis were randomly divided into control and observation group, which received conventional treatment and atomizing inhalation of ambroxol hydrochloride based on conventional treatment, resp. After treatment, compared with control group, in observation group the disappearance time of clin. symptoms was decreased (P < 0.05), the total effective rate was increased (P < 0.01), the lung function, life quality and daily activity ability were improved (P < 0.05), the serum IL-2 level was increased (P < 0.05), and the serum IL-6 and TNF-α levels were decreased (P < 0.05). There was no significant difference of adverse reaction between two groups (P > 0.05). Atomizing inhalation of ambroxol hydrochloride can quickly and effectively alleviate the clin. symptoms of chronic bronchitis in elderly patients.

Latin American Journal of Pharmacy published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Weber, Lothar’s team published research in Dalton Transactions in | CAS: 239075-02-6

Dalton Transactions published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C5H9IO2, Safety of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Weber, Lothar published the artcileSynthetic, structural, photophysical and computational studies of π-conjugated bis- and tris-1,3,2-benzodiazaboroles and related bis(boryl) dithiophenes, Safety of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Dalton Transactions (2009), 1339-1351, database is CAplus and MEDLINE.

π-Conjugated systems with two and three 1,3-diethyl-1,3,2-benzodiazaborolyl end-groups were synthesized in 58-91% yields using established 1,3,2-diazaborole methodologies. The bis(diazaborolyl) compounds contain thiophene -2,5-C4H2S- (2a), dithiophene -5,5′-(2,2′-C4H2S)2– (2b), phenylene -1,4-C6H4– (2c), biphenylene -4,4′-(1,1′-(C6H4)2)- (2d) and dioctylfluorene -2,7-(9,9-(C8H7)2C11H6)- (2e) bridges. The three-way linkers in the tris(diazaborolyl) assemblies contain a central phenylene unit -1,3,5-C6H3– linked to the borolyl end groups via thiophene -2,5-C4H2S- (3a), directly bonded (3b) or via phenylene -1,4-C6H4– (3c) units. Mol. structures of 2a, 2b, 2c, 3a, 3b and 3c were determined by x-ray crystallog. studies. These borolylated systems show intense blue/violet luminescence with Stokes shifts of 6200-9500 cm-1 and quantum yields of 0.33 to 0.98. The absorption maxima (296-351 nm) of these assemblies are reproduced well by TD-DFT computations (B3LYP/6-31G*), and arise from strong, low energy HOMO-LUMO transitions. From MO computations on optimized geometries of these diazaborolyl systems, the LUMO is located mainly on the thiophene/benzene bridge (66-92%) while the HOMO is largely benzodiazaborolyl in character (53-83%). The S1←S0 absorption bands are thus assigned to π(diazaborolyl)-π*(thiophene/benzene) transitions. Computations on related bis(boryl) dithiophenes [with diarylboryl e.g. Ph2B, Mes2B, (C6F5)2B and FMes2B (Mes = 2,4,6-Me3C6H2; FMes = 2,4,6-(CF3)3C6H2), dioxaborolyl and other diazaborolyl groups] reveal strong, low energy UV-visible absorption bands arising from π(thiophene)-π*(thiophene) transitions, with increasing B participation in the LUMO of the diarylboryl and especially the highly fluorinated systems.

Dalton Transactions published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C5H9IO2, Safety of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Feng, Yi-chao’s team published research in Xiandai Zhenduan Yu Zhiliao in 32 | CAS: 23828-92-4

Xiandai Zhenduan Yu Zhiliao published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Formula: C13H19Br2ClN2O.

Feng, Yi-chao published the artcileApplication analysis of modified Zhike powder combined with ambroxol hydrochloride granules in treatment of chronic cough, Formula: C13H19Br2ClN2O, the publication is Xiandai Zhenduan Yu Zhiliao (2021), 32(6), 850-851, database is CAplus.

Objective: To investigate the application effect of Zhike powder combined with ambroxol hydrochloride granules in the treatment of chronic cough. Methods: A total of 80 patients with chronic cough who were admitted to our hospital from Apr. 2017 to March 2019 were selected and randomly divided into the control group and the observation group, 40 cases in each group. The control group was given ambroxol hydrochloride granules, the observation group was given modified Zhike powder, and both groups were treated for 14 d. The clin. efficacy, cough symptom scores and adverse reactions were compared between the two groups of patients after treatment. Results: After treatment, the total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The cough symptom scores of the two groups were lower than those before treatment, and the observation group was lower than the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Modified Zhike Powder combined with ambroxol hydrochloride granules can improve the clin. efficacy of patients with chronic cough and relieve cough symptoms, and the medication is safe and worthy of clin. use.

Xiandai Zhenduan Yu Zhiliao published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Hongbo’s team published research in Experimental and Therapeutic Medicine in 20 | CAS: 23828-92-4

Experimental and Therapeutic Medicine published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Computed Properties of 23828-92-4.

Liu, Hongbo published the artcileComparison of the efficacy of ambroxol hydrochloride and N-acetylcysteine in the treatment of children with bronchopneumonia and their influence on prognosis, Computed Properties of 23828-92-4, the publication is Experimental and Therapeutic Medicine (2020), 20(6), 130, database is CAplus and MEDLINE.

The aim of the present study was to compare the efficacy of ambroxol hydrochloride and N-acetylcysteine in the treatment of children with bronchial pneumonia and their influence on prognosis. A total of 120 children with bronchial pneumonia, admitted to The Affiliated Yantai Yuhuangding Hospital of Qingdao University from July 2015 to August 2018, were enrolled in the study. Among them, 58 children were treated with N-acetylcysteine and comprised the exptl. group, and 62 children were treated with ambroxol hydrochloride and comprised the control group. Children’s phys. signs (such as fever, short breath, cough and pulmonary rales) and the adverse reactions to treatment were observed, and the disappearance time of the signs was recorded. In addition, the cellular immune function indicators and the quality of life after treatment were investigated. There was no significant difference in clin. data between the two groups (P>0.05). The effective rate in the exptl. group was significantly higher than that in the control group (P<0.05). The disappearance time of symptoms, such as fever, cough, asthma and rales in the lung, was significantly shorter in the exptl. group than that in the control group (P<0.05). The hospitalization time of patients in the exptl. group was shorter than that in the control group (P<0.05). After treatment, IgA (IgA), IgG (IgG), IgM (IgM) and complement C3 were significantly increased in the exptl. group (P<0.01), and the IgA and IgG in the exptl. group were significantly higher than those in the control group (P<0.01). The incidence of adverse reactions in the exptl. group was significantly lower than that in the control group (P<0.05). In conclusion, N-acetylcysteine has a significant effect on the treatment of bronchopneumonia in children providing a quick relief from symptoms, such as lung rales, and therefore is worthy of use in clinic.

Experimental and Therapeutic Medicine published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Computed Properties of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts