Tag: M.W=400-450

Panchale, Wrushali A. published the artcileConcurrent analysis of ambroxol HCl and salbutamol sulphate from tablet formulation by RP-HPLC, HPLC of Formula: 23828-92-4, the publication is GSC Biological and Pharmaceutical Sciences (2020), 13(3), 197-202, database is CAplus.

RP-HPLC method was developed for concurrent anal. of ambroxol HCl and salbutamol sulfate from tablet formulation. Analytes were separated with mobile phase consisting of mixture of methanol and water (0.1% triethylamine) in the ratio 50: 50 at a flow rate of 0.7 mL/min with Nucleosil (4.6 mm I.D x 250 mm) C18 column. The retention time of ambroxol HCl and salbutamol sulfate was found to be 3.61 and 6.20 min, resp. The detection was carried out at 224 nm. The dynamic range for ambroxol HCl and salbutamol sulfate observed was 15-75μg/mL and 1-5μg/mL, resp. The percent recovery obtained for ambroxol HCl and salbutamol sulfate were close to 100%. Obtained statistical data of results was found to satisfactorily.

GSC Biological and Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, HPLC of Formula: 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gupta, P. C. published the artcileEffect of certain factors on the activities of phosphatases in trematodes, Gastrothylax crumenifer and Cotylophoron orientale, Computed Properties of 3818-50-6, the publication is Indian Veterinary Medical Journal (1984), 8(3), 164-70, database is CAplus.

The effects of temperature variation, period of incubation, anthelmintics, SH blocking reagents, thiols, and EDTA  [60-00-4] on the activities of acid (EC 3.1.3.2) [9001-77-8] and alk. (EC 3.1.3.1) phosphatase [9001-78-9] in the trematodes, G. crumenifer and C. orientale were studied at pH 5.0 and 2.0, resp. Temperature variation had greater effect on alk. phosphatase than on acid phosphatase. Maximum activity was observed at 60 and 15 min for acid and alk. phosphatases, resp. After which it became linear. Anthelmintics, Vermisol-150  [14769-73-4] and Besantin  [31431-39-7] were inhibitory while Alcopar  [3818-50-6] and Helmacid  [96697-24-4] were strong activators. Sulfhydryl blocking reagents, HgCl₂, AgNO₃, Cd acetate and Pb acetate were inhibitory. Thiols (cysteine  [52-90-4] and 2-mercaptoethanol  [60-24-2]) and EDTA enhanced the activities of both enzymes.

Indian Veterinary Medical Journal published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Computed Properties of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Heeney, Martin published the artcileOrganic field effect transistors fabricated from polymerizable liquid crystals, Safety of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) (2003), 44(2), 340-341, database is CAplus.

The synthesis and phase behavior of reactive mesogens based on phenylnaphthalene and quaterthiophenes are described. End groups compatible with free-radical polymerization were compared. The phase behavior was studied with DSC.

Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Safety of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Panchale, Wrushali A. published the artcileFirst-order derivative spectrophotometric estimation of gemifloxacin mesylate and ambroxol HCl in tablet dosage form, Category: alcohols-buliding-blocks, the publication is GSC Biological and Pharmaceutical Sciences (2021), 14(2), 29-36, database is CAplus.

Aim of present work was to develop and validate a simple, precise and accurate uv-vis spectrophotometric method for the simultaneous estimation of gemifloxacin mesylate (GEMI) and ambroxol HCl (AMB) in their combined tablet dosage form. The method is based on first-order derivative spectroscopy. For determination of sampling wavelengths, each of GEMI and AMB were scanned in the wavelength range of 200-400 nm in the spectrum mode and sampling wavelengths were selected at 360 nm (zero crossing of GEMI) where AMB showed considerable absorbance and at 221.6 nm (zero crossing of AMB) where GEMI showed considerable absorbance. The linearity was obtained in the concentration range of 32-192μg/mL for GEMI and 7.5-45μg/mL for AMB. The correlation coefficients were found to be 0.9987 and 0.9992 for GEMI and AMB, resp. The method was validated as per ICH guidelines. Mean recoveries were found satisfactory. All the data of validation study was found to be satisfactorily. The proposed method can be applied for simultaneous estimation of both the drugs.

GSC Biological and Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Singh, Bharpoor published the artcileMouth dissolving tablets: an innovative deviation in drug delivery system, Quality Control of 3818-50-6, the publication is Journal of Pharmaceutical Sciences and Research (2019), 11(4), 1186-1194, database is CAplus.

The main aim of novel drug delivery system is to develop a dosage form which is easy to administer, free from side effects, exhibit immediate release and offer enhanced bioavailability for better patient compliance. To achieve such results oral drug delivery system, preferably, tablets are the most widely accepted dosage forms which offer numerous advantages. Beside those advantages, Dysphagia is the most common disadvantage of conventional tablets which is associated with number of conditions like sudden exposure of allergies, mental disability, motion sickness, unconsciousness, unavailability of water etc. To get rid from these problems several innovative drug delivery systems have been developed like Mouth Dissolving Tablets (MDT′s) which dissolve in saliva within a few seconds, when put on tongue. These tablets can be administered anywhere and anytime, without the need of water and are thus quite suitable for children, elderly and mentally disabled patients.

Journal of Pharmaceutical Sciences and Research published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C19H14Cl2, Quality Control of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Espinosa-Aguirre, J. J. published the artcileGenotoxicity of amebicide and anthelmintic drugs in Escherichia coli pol A⁺/pol A^–, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Mutation Research, Genetic Toxicology Testing (1987), 188(2), 111-20, database is CAplus and MEDLINE.

The amebicides dehydroemetine and chloroquine and the anthelmintic pyrvinium pamoate, previously reported to be mutagenic in Salmonella typhimurium were clearly genotoxic in the Escherichia coli pol A⁺/pol A^– assay. Two other antiparasitic drugs, diiodohydroxyquin and 4-hexylresorcinol, were also genotoxic in E. coli, while iodochlorhydroxyquin preferentially inhibited the pol A⁺ strain. From the 3 alternative testing methods employed, the liquid suspension succeeded in detecting 5 antiparasitic drugs as genotoxic; the microsuspension identified 2, and the disk diffusion method only 1. However, the metabolic activation system could only be coupled successfully and in a reproducible way to the microsuspension assay.

Mutation Research, Genetic Toxicology Testing published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sastry, C. S. P. published the artcileSpectrophotometric determination of bephenium hydroxynaphthoate, diiodohydroxyquinoline and iodochlorohydroxyquinoline with diazotized dapsone, COA of Formula: C28H29NO4, the publication is Indian Drugs (1989), 26(10), 567-9, database is CAplus.

Bephenium hydroxynaphthoate (I) diiodohydroxyquinoline (II), and iodochlorohydroxyquinoline (III) were determined in pharmaceuticals by a spectrophotometric method based on the drug reaction with the diazonium salt from dapsone and measurement of absorbances at 500 nm for I and 430 nm for II and III. Beer’s law limits, molar extinction coefficients, and Sandell’s sensitivities for these drugs were determined The relative standard deviations for I, II, and III were 1.17, 0.78 and 1.05%, resp.

Indian Drugs published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, COA of Formula: C28H29NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sastry, C. S. P. published the artcileExtractive spectrophotometric determination of some anthelmintics using Fast green FCF or Orange II, SDS of cas: 3818-50-6, the publication is Indian Journal of Pharmaceutical Sciences (1988), 50(2), 140-2, database is CAplus.

Two sensitive methods for the determination of diethylcarbamazine citrate, bephenium hydroxynaphthoate, tetramisole and levamisole based on the formation of colored complexes of the drug with reagents such as Fast Green FCF at pH 5.0 or Orange II in presence of 0.1N HCl are described in bulk samples and pharmaceutical preparations The ion-pair complexes formed are quant. extracted into CHCl₃ under the exptl. conditions. The methods are sensitive, accurate, precise and reproducible with recoveries 96.6-99.1%. Beer’s law limits are given.

Indian Journal of Pharmaceutical Sciences published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, SDS of cas: 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sastry, C. S. P. published the artcileSpectrophotometric determination of some anthelmintics and antiamebic agents with 3-methyl-2-benzothiazolinone hydrazone hydrochloride, Formula: C28H29NO4, the publication is Pharmazie (1988), 43(5), 361, database is CAplus and MEDLINE.

A spectrophotometric method for determination of anthelmintics and antiamebic drugs using 3-methyl-2-benzothiazolinone hydrazone (I) as a chromogenic agent was developed. The maximum absorbance (λ_max) for the drug-I systems and Beer’s law limits for 8 drugs studied are presented. The relative standard deviations were 0.66-1.26%. The method is simple and sensitive with reasonable precision and accuracy.

Pharmazie published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Formula: C28H29NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Przybylak, Katarzyna R. published the artcileHow Does the Quality of Phospholipidosis Data Influence the Predictivity of Structural Alerts?, Name: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Journal of Chemical Information and Modeling (2014), 54(8), 2224-2232, database is CAplus and MEDLINE.

The ability of drugs to induce phospholipidosis (PLD) is linked directly to their mol. substructures: hydrophobic, cyclic moieties with hydrophilic, peripheral amine groups. These structural properties can be captured and coded into SMILES arbitrary target specification (SMARTS) patterns. Such structural alerts, which are capable of identifying potential PLD inducers, should ideally be developed on a relatively large but reliable data set. We had previously developed a model based on SMARTS patterns consisting of 32 structural fragments using information from 450 chems. In the present study, addnl. PLD structural alerts have been developed based on a newer and larger data set combining two data sets published recently by the United States Food and Drug Administration (US FDA). To assess the predictive performance of the updated SMARTS model, two publicly available data sets were considered. These data sets were constructed using different criteria and hence represent different standards for overall quality. In the first data set high quality was assured as all neg. chems. were confirmed by the gold standard method for the detection of PLD-transmission electron microscopy (EM). The second data set was constructed from seven previously published data sets and then curated by removing compounds where conflicting results were found for PLD activity. Evaluation of the updated SMARTS model showed a strong, pos. correlation between predictive performance of the alerts and the quality of the data set used for the assessment. The results of this study confirm the importance of using high quality data for modeling and evaluation, especially in the case of PLD, where species, tissue, and dose dependence of results are addnl. confounding factors.

Journal of Chemical Information and Modeling published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Name: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts