Tag: M.W=400-450

Ray, D. K. published the artcileEfficacy of seven anthelmintics against Ancylostoma ceylanicum in the golden hamster, Mesocricetus auratus, Related Products of alcohols-buliding-blocks, the publication is Annals of Tropical Medicine & Parasitology (1978), 72(1), 55-8, database is CAplus and MEDLINE.

The infection of A. ceylanicum in hamsters was treated with 7 anthelmintics: bephenium hydroxynaphthoate [3818-50-6], tetramisole [5036-02-2], tetrachlorethylene [127-18-4], phenylene 1,4-diisothiocyanate [4044-65-9],thiabendazole [148-79-8],parbendazole [14255-87-9], and mebendazole [31431-39-7]. Mebendazole was most effective, whereas tetrachlorethylene and tetramisole were least effective.

Annals of Tropical Medicine & Parasitology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Braude, M. B. published the artcileChemical structure and anthelmintic activity. V. Analogs of the anthelmintics neftamon and difezil, SDS of cas: 3818-50-6, the publication is Khimiko-Farmatsevticheskii Zhurnal (1975), 9(10), 12-14, database is CAplus.

I (R = H, 4-Cl, 2-MeCO2, 4-Me; X = CO2, OCH2CO2, CO; R1 = Ph, 2,3,5-HO(Ac)(Cl)C6H2, CH2COPh; A = Cl, p-ClC6H4SO3, iodo, hydroxynaphthoate) were prepared in 56.5-100% yield by standard methods. RCO2CH2CH2NMe2 (R = Ph, p-ClC6H4, p-ClC6H4OCH2) were prepared in 88-95% yield. I (R = H, X = CO2, R1 = Ph, 2,3,5-HO(Ac)(Cl)C6H2) at 0.4-0.6 g/kg in mice infected with Trichocephalus muris were less effective and more toxic than neftamon and difezil. The introduction of an acetoxy group in position 2 and a halo group in position 4 lowered the toxicity and effectiveness.

Khimiko-Farmatsevticheskii Zhurnal published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, SDS of cas: 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Debbarma, Bimal published the artcileFormulation and in-vitro evaluation of taste masked fast dissolving tablets of Ambroxol hydrochloride, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is World Journal of Pharmacy and Pharmaceutical Sciences (2021), 10(2), 1528-1550, database is CAplus.

The purpose of the present work was to mask the taste of Ambroxol hydrochloride and to formulate its patient-friendly dosage form. Complexation technique using KYRON -T-114 an ion-exchange resin was used to mask the bitter taste and the drug loading onto the ion-exchange resin was optimized for ratio of drug to resin, effect of pH and effect on soaking time. The resinate was evaluated for taste masking and characterized by FT-IR and DSC. Then the taste-masked drug was formulated into a fast dissolving tablet (FDT). The developed tablets were evaluated for hardness, friability, drug content, weight variation, content uniformity, friability, water absorption ratio, in-vitro disintegration time and in-vitro drug release studies. IR and DSC spectra revealed that there were no possible interactions between the drug and polymer. Maximum loading was obtained at drug- resin ratio 1:2, pH 7, and soaking time 30 min. A successful taste masking of resinate was confirmed by time intensity method. The values of pre-compression parameters evaluated and were within prescribed limits and indicated good free flowing properties. The data obtained of post-compression parameters found superior over conventional formulation. The F3 batch with disintegration time 30.4±0.64 s and dissolution 98.4±2.69 was selected as optimized formulation, This was compared with conventional marketed formulation and was found superior. The obtained results revealed that Ambroxol hydrochloride has been successfully taste masked and formulated into an FDT as a suitable alternative to the conventional tablets.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Melukhova, A. G. published the artcileKinetics of choline esterase activity in Ascaris suum, Safety of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1971), 40(6), 672-4, database is CAplus.

Bephenium (I) [7181-73-9], naphthamon [3818-50-6], and preparation 397 were 8, 6, and 22 times more inhibitive toward the cholinesterase [9001-08-5] of the ascarid A. suum than toward the cholinesterase of rat brain. This may account for the selective activity of these antihelminthic preparations against the worm in mammalian bodies.

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Safety of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kiran Kumar, A. published the artcileReverse phase-UPLC method of analysis for simultaneous estimation of Levosalbutamol sulphate, Guaiphenesin and Ambroxol hydrochloride in pharmaceutical cough, cold liquid dosage forms, Application In Synthesis of 23828-92-4, the publication is International Journal of Research in Pharmaceutical Sciences (Madurai, India) (2019), 10(2), 927-934, database is CAplus.

The three most drug combinations for cough, cold are widely used worldwide now a day. The purpose of the study was to build up an innovative RP-UPLC technique for simultaneous estimation of Levosalbutamol Sulfate (LEV), Guaiphenesin (GUA) and Ambroxol Hydrochloride (AMB) in liquid dosage forms. Chromatog. was carried out on UHPLC (WATERS)⊕MMETRY C18 4.6mm × 1000mm, 3.5μm, (Agilent – Zorbax Eclipse Plus C18 – Rapid Resolution) with an isocratic mobile phase with pH 3.0 composed of buffer, methanol and Acetonitrile (60:20:20) with a flow rate of 0.8mL/min. The detection was carried out with column temperature at 25°C using a UV detector at 276nm. Validation parameters like linearity, specificity, precision, accuracy, limit of detection (LOD), limit of quantification (LOQ), system suitability, Solutions stability and robustness were considered as affirmed in the ICH guidelines. Retention times for LEV, GUA & AMB were 1.07 min, 1.99 min & 3.55 min resp. The assay of syrups with the relative standard deviation found to be less than 2%. The parameters values were found, and the method was found to be satisfactory. This validated UHPLC method is cost-effective, receptive and precise than other chromatog. methods.

International Journal of Research in Pharmaceutical Sciences (Madurai, India) published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Stas, Sara published the artcileStraightforward access to diketopyrrolopyrrole (DPP) dimers, Formula: C20H28B2O4S2, the publication is Dyes and Pigments (2013), 97(1), 198-208, database is CAplus.

Synthesis, isolation and characterization of diketopyrrolopyrrole (DPP) dimers are described. These derivatives were prepared starting from sym. or asym. diketopyrrolopyrrole monomers through Pd-catalyzed homocoupling, Yamamoto coupling or Suzuki coupling. The spectroscopic properties of these newly synthesized DPP dimers were investigated and were supported by quantum-chem. calculations

Dyes and Pigments published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C11H21BF4N2O2, Formula: C20H28B2O4S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dey, Piyali published the artcileDesign and evaluation of anti-fibrosis drug engineered resealed erythrocytes for targeted delivery, Formula: C13H19Br2ClN2O, the publication is Drug Delivery and Translational Research (2019), 9(5), 997-1007, database is CAplus and MEDLINE.

Resealed erythrocytes (RSE) are potential, site-specific carrier system for drug delivery with prolonged drug release activity. In this study, erythrocytes obtained from Wistar albino rats were loaded with ambroxol hydrochloride (AH) with the focus to convenience the lung targeting possibility of the carrier erythrocytes. AH loading in erythrocytes using preswell dilution technique with glutaraldehyde (GA) as a crosslinking agent was evaluated and validated. Drug-loaded erythrocyte was characterized in terms of in vitro drug release followed by osmotic fragility study which showed amplified drug entrapment efficiency (DEE) and Hb content values as well. In vivo lung fibrosis study, rats were sensitized to egg albumin by i.p. (i.p.) injection and then inhalation in a whole body inhalation chamber. A sign of inflammation, airway sub-mucosal fibrosis, hypertrophy, and hyperplasia was observed A series of in vivo studies were carried out to describe the effect of AH-loaded RSE including measurement of cytokines in Bronchoalveolar Lavage (BAL) fluid and histopathol. study. AH showed a stepwise reduced level of cytokines in BAL at a different time interval after being injected of AH-loaded RSE. Furthermore, in vivo lung distribution experiments were performed for optimized formulation, and degree of distribution of the drugs inside the targeted organ was found to be satisfactory.

Drug Delivery and Translational Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kumar, Rakesh published the artcileDevelopment and validation of RP-HPLC method for the simultaneous estimation of salbutamol sulphate and ambroxol hydrochloride in oral liquid dosage form, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Asian Journal of Pharmaceutical Research and Development (2021), 9(1), 84-94, database is CAplus.

Pharmaceutical anal. is imported branch of science deals with to check the identity, strength, quality and purity of chem. and herbal compounds Qual. anal. of drugs and pharmaceutical compounds Quant. anal. is of much importance and done by various methods. One of the most accurate and precise methods is spectrophotometry which comprises the measurement of intensity of electromagnetic radiation emitted or absorbed by the compound Another most popular method of for quant. anal. is high performance liquid chromatog. (HPLC). In the present article a RP-HPLC method was developed for the simultaneous determination of salbutamol sulfate and ambroxol hydrochloride in oral liquid doses form and validation of the developed method. Developed methods include selection of mobile phase, chromatog. method, and wavelength whereas validation involves the system suitability, accuracy, precision, linearity, reproducibility, robustness, specificity and solution stability of the developed method. The result showed that the developed method is the best suited to the simultaneous determination of salbutamol sulfate and ambroxol hydrochloride and validated as per the standards

Asian Journal of Pharmaceutical Research and Development published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Melucci, Manuela published the artcileSolvent-Free, Microwave-Assisted Synthesis of Thiophene Oligomers via Suzuki Coupling, Quality Control of 239075-02-6, the publication is Journal of Organic Chemistry (2002), 67(25), 8877-8884, database is CAplus and MEDLINE.

The purpose of this study was to obtain a rapid, efficient, and environmentally friendly methodol. for the synthesis of highly pure thiophene oligomers. The solvent-free, microwave-assisted coupling of thienyl boronic acids and esters with thienyl bromides, using aluminum oxide as the solid support, allowed us to rapidly check the reaction trends on changing times, temperature, catalyst, and base and easily optimize the exptl. conditions to obtain the targeted product in fair amounts This procedure offers a novel, general, and very rapid route to the preparation of soluble thiophene oligomers. Thus, for example, quaterthiophene was obtained in 6 min by reaction of 2-bromo-2,2′-bithiophene with bis(pinacolato)diboron (isolated yield 65%), whereas quinquethiophene was obtained in 11 min by reaction of dibromoterthiophene with thienylboronic acid (isolated yield 74%). The synthesis of new chiral 2,2′-bithiophenes is reported. The detailed anal. of the byproducts of some reactions allowed us to elucidate a few aspects of reaction mechanisms. While the use of microwaves proved to be very convenient for the coupling between conventional thienyl moieties, the same was not true for the coupling of thienyl rings to thienyl-S,S-dioxide moieties. Indeed, in this case, the targeted product was obtained in low yields because of the competitive, accelerated, Diels-Alder reaction that affords a variety of condensation products.

Journal of Organic Chemistry published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Quality Control of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hassan Omar, Omar published the artcileSynthesis of D-glucose and L-phenylalanine substituted phenylene-thiophene oligomers, Computed Properties of 239075-02-6, the publication is Tetrahedron (2011), 67(2), 486-494, database is CAplus.

Phenylene-thiophene oligomers bearing peracetylated β-D-glucose or Boc-L-phenylalanine as chiral substituents were synthesized in good yields by a versatile protocol based on the Suzuki-Miyaura cross-coupling reaction. Aryl iodides bearing the chiral biomols. as substituents efficiently reacted with pinacol boronates of bi- or terthiophenes leading to the bio-functionalized oligomers in good yields.

Tetrahedron published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts