Tag: M.W=400-450

Botero, David published the artcileComparative study of pyrantel pamoate, bephenium hydroxynaphthoate, and tetrachloroethylene in the treatment of Necator americanus infections, HPLC of Formula: 3818-50-6, the publication is American Journal of Tropical Medicine and Hygiene (1972), 22(1), 45-52, database is CAplus and MEDLINE.

A study of 105 patients with the hookworm N. americanus infections was undertaken to compare the new anthelmintic pyrantel pamoate (I-pamoate) [22204-24-6] and 2 commonly used drugs bephenium hydroxynaphthoate [3818-50-6] and tetrachloroethylene [127-18-4]. I, in a dose of 10 mg/day, orally, for 3 days, had action comparable or superior to the other drugs against the hookworm. In addition, I caused an almost 100% cure rate in patients infected with Ascaris lumbricoides, and caused a slight decrease in egg count in patients infected with Trichuris trichiura. I was tolerated well and no toxic effects were observed by hematol. and biochem. examination

American Journal of Tropical Medicine and Hygiene published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, HPLC of Formula: 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sapleva, V. T. published the artcileDetermination of naphthamon using rhodamine 6G, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Farmatsiya (Moscow, Russian Federation) (1974), 23(1), 39-42, database is CAplus and MEDLINE.

The reaction of naphthamon (2-phenoxyethyldimethylbenzylammonium β-hydroxynaphthoate) (I) with rhodamine 6G was used for the quant. determination of I. The resulting complex compound was extracted with benzene and the optical d. of the extract was determined at 512 nm. The relative error of the determination is ±2.2%.

Farmatsiya (Moscow, Russian Federation) published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Kang published the artcileExploring functionalized polythiophene derivatives based on thiophene-linker-thiophene platform, analysis of prototype monomer crystal for C-Br/C-H bulk polycondensation and its application for acid detection, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Polymer (2019), 70-76, database is CAplus.

Ten thiophene derivatives monomers were designed based on thiophene-linker-thiophene platform and were subjected to C-Br/C-H bulk polycondensation. All of them were converted to corresponding polythiophene derivatives smoothly, indicating that up to three-building-blocks of thiophene monomers can be successfully constructed. Detailed characterizations of the obtained polymers were carried out by regular measurements, including Cyclic Voltammetry (CV), IR spectrum (IR), UV-Vis absorbance spectroscopy, TGA and so on. In addition, the obtained poly{phenyl-bis-(4-thiophen-2-yl-phenyl)-amine} was employed as acid sensor and the results showed that HNO₃ acid could be recognized and distinguished successfully. Furthermore, a prototype monomer crystal of 2-bromo-3-(9,9-dimethyl-9H-fluoren-2-yl)-thiophene is obtained and its effective reaction points distance (4.197 Å) is longer (37.6%) than the van der Waals radius (rw) of reaction points (sum of rw of bromine and hydrogen atoms 3.05 Å).

Polymer published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Colella, L. published the artcileOutside rules inside: the role of electron-active substituents in thiophene-based heterophenoquinones, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Physical Chemistry Chemical Physics (2015), 17(16), 10426-10437, database is CAplus and MEDLINE.

The biradicaloid vs. quinoidal character of the ground state of thiophene-based heterophenoquinones bearing donor or acceptor groups is investigated. Keeping the conjugation length fixed, namely, the 5,5′-bis(3,5-di-tert-butyl-4-oxo-2,5-cyclohexadiene-1-ylidene)-2,2′-dihydroxy bithiophene backbone, an opposite effect occurs depending on the donating or withdrawing nature of the substituents. The character of the ground state depends not only on the electronic nature of the substituents but also on their position on the mol. skeleton: donor groups on the 3,3′-positions of the bithiophene central core stabilize a quinoidal ground state, whereas a biradicaloid electronic structure results from the introduction of the same donor groups onto the lateral phenones. Withdrawing groups behave similar to donors, but in the opposite direction.

Physical Chemistry Chemical Physics published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Naykodi, Pradnya S. published the artcileTaste masking of bitter drugs by using ion exchange resin method, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is World Journal of Pharmaceutical Research (2020), 9(2), 562-597, database is CAplus.

The various organoleptic properties such as taste, smell, texture also these are important factor in development of oral dosage forms. The taste is the major factor that affect the patient compliance and product quality. Acceptability of any dosage form mainly depends over its taste i.e. mouth feel. Drug mol. interact with taste receptor on the tongue to give bitter, sweet or other taste sensation, when they dissolve in saliva. The taste buds shows the sensation of taste by signal transduction from the receptor organs. Now a days most of the potent drugs that are cardiac, analgesic, anti-inflammatory, anti-tubercular, antibacterial, anthalmetics, antimalarial, antiepileptics, anticoagulants, histamine receptor agonist, antithyroids, antineoplastic, antiprotozoal, diuretics, nutritional agents, opioid analgesic, sex hormones, vaccines most of them are bitter in taste. So it become a necessary to develop such a dosage form that is acceptable for its taste by patients especially children or geriatrics. It becomes a challenge for pharmacist to make palatable formulation by masking the bitter taste of the drug.

World Journal of Pharmaceutical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Roy, Niloy published the artcileProbing Host-Guest inclusion complexes of Ambroxol Hydrochloride with α- & β-Cyclodextrins by physicochemical contrivance subsequently optimized by molecular modeling simulations, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Chemical Physics Letters (2020), 137372, database is CAplus.

Herein, we report the inclusion of AMB in cyclodextrins leading to host-guest assemblies. The inclusion complexes comprised of Ambroxol Hydrochloride (AMB) with α-cyclodextrin (αCD) and β-cyclodextrin (βCD) have been confirmed by exptl. (UV-vis titration, FTIR, ESI-MS, ¹NMR, 2D-NMR) and computational studies (mol. docking, mol. mechanics calculation). The mol. docking studies demonstrate a better insight into geometry and inclusion mode of AMB inside αCD as well as βCD cavity. Formation of inclusion complexes with different cyclodextrins causes some structural changes of guest mols. during the encapsulation process confirmed by bond length, dihedral angle changes and dynamic simulations.

Chemical Physics Letters published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sharma, Kamna published the artcileDevelopment and Validation of UV-Spectrophotometric and RP-HPLC Methods for Simultaneous Estimation of Fexofenadine Hydrochloride, Montelukast Sodium and Ambroxol Hydrochloride in Tablet Dosage Form, Related Products of alcohols-buliding-blocks, the publication is Analytical Chemistry Letters (2018), 8(6), 829-843, database is CAplus.

A UV-spectrophotometric and RP-HPLC method was developed and validated for concurrent estimation of fexofenadine hydrochloride (FEX), montelukast sodium (MLK) and ambroxol hydrochloride (AMB). In RP-HPLC chromatog., the retention time for FEX, MLK and AMB was 2.775 min, 9.529 min and 5.261 min, resp. and detection at _max 210 nm for all three of drugs (overlain spectra). Linear regression anal. shows a good linear relationship; in the concentration range of 10-30, 10-50 and 5-25μg/mL; for FEX, MLK and AMB with r² > 0.999. The UV-spectrophotometric estimation was done by two methods; zero order and first derivative method. These methods were based on the measurement of absorbance at 220.20, 283.42 and 245.84 nm in zero order; 221, 287.52 and 262.25 nm in first order derivative method. In both UV methods, the drugs follow the Beer-Lambert’s law in the concentration range of 6-26, 4-24 and 8-28μg/mL, resp. showing correlation coefficient r² > 0.999. The RP-HPLC and UV methods showed good reproducibility and recovery with the percent relative standard deviation (RSD) less than 5%. These methods were successfully applied for reliable quantification of FEX, MLK and AMB in a com. and routine anal. in combined dosage form.

Analytical Chemistry Letters published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C4H6O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gomes, Raimundo Nonato S. published the artcileAdverse effects of respiratory disease medicaments and tooth brushing on teeth: A scanning electron microscopy, X-ray fluorescence and infrared spectroscopy study, Synthetic Route of 23828-92-4, the publication is Microscopy Research and Technique (2019), 82(9), 1489-1499, database is CAplus and MEDLINE.

The present study aims to evaluate the effect of brushing with fluoride dentifrice on teeth severely affected by erosion due to respiratory medicaments. Enamel (n = 50) and dentin (n = 50) bovine specimens were prepared and treated with artificial saliva (S-control), acebrofilin hydrochloride (AC), ambroxol hydrochloride (AM), bromhexine hydrochloride (BR), and salbutamol sulfate (SS) and subjected to cycles of demineralization (immersing in 3 mL, 1 min, three times a day at intervals of 1 h, for 5 days) followed by remineralization (saliva, 37°C, 1 h). Simulated brushing with fluoridated toothpaste was performed using 810 strokes in a reciprocal-action brushing simulator. SEM, micro energy dispersive X-ray fluorescence (μ-EDXRF) spectroscopy and attenuated total reflection Fourier transform IR (ATR FTIR) spectroscopy were then performed. μ-EDXRF images showed extensive erosion after treatment with all medicaments. SEM images showed enamel erosion in order SS > BR > AC = AM > S after brushing and fluoridation. FTIR results were in agreement. In case of dentin, μ-EDXRF measurements showed significant difference in mineral content (percent weight of calcium and phosphate) in SS + brushing + fluoridation treated enamel compared to control, while μ-EDXRF images showed erosive effects in the order SS > AM>BR > AC = S post brushing + fluoridation. SEM images showed erosion in the order SS > AM = BR > AC > S post brushing + fluoridation. Again, FTIR multivariate results were in agreement. Overall, our study shows that proper oral care is critical when taking certain medication. The study also demonstrates the possible use of FTIR for rapid clin. monitoring of tooth erosion in clinics.

Microscopy Research and Technique published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Synthetic Route of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gomes, Raimundo Nonato Silva published the artcileATR-FTIR spectroscopy and μ-EDXRF spectrometry monitoring of enamel erosion caused by medicaments used in the treatment of respiratory diseases, Quality Control of 23828-92-4, the publication is Microscopy Research and Technique (2018), 81(2), 220-227, database is CAplus and MEDLINE.

Medicaments essential for alleviation of diseases may sometime adversely affect dental health by eroding the enamel, owing to their acidic nature. It is therefore highly desirable to be able to detect these effects quickly and reliably. In this study, we evaluated the erosive capacity of four most commonly prescribed respiratory disease syrup medicaments on enamel using micro-energy-dispersive X-ray fluorescence spectrometry (μ-EDXRF) and attenuated total reflection Fourier transform IR spectroscopy (ATR-FTIR). Fifty-five enamel fragments obtained from 30 bovine teeth were treated with artificial saliva (S), acebrofilin hydrochloride (AC), ambroxol hydrochloride (AM), bromhexine hydrochloride (BR), and salbutamol sulfate (SS); by immersing in 3 mL of resp. solutions for 1 min, three times a day at intervals of 1 h, for 5 days. μ-EDXRF anal. of enamel surface did not reveal significant erosion caused by the medications. However, ATR-FTIR showed a detectable shift in the phosphate (PO4) antisym. stretching mode (ν3) at ~985 cm^-1 for AM, BR, and SS, indicating erosion. Multivariate statistical anal. showed that AC, AM, SS, and BR could be classified with 70%, 80%, 100%, and 100% efficiency from S (control), further highlighting the ability of ATR-FTIR to identify degree of erosion. This suggests ATR-FTIR may be used to rapidly and nondestructively investigate erosive effects of medicaments.

Microscopy Research and Technique published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Quality Control of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Li published the artcileTopical administration of ambroxol eye drops augments tear secretion in rabbits, Computed Properties of 23828-92-4, the publication is Graefe’s Archive for Clinical and Experimental Ophthalmology (2021), 259(6), 1529-1538, database is CAplus and MEDLINE.

To investigate if topical administration of ambroxol promotes tear secretion and to compare with Diquas ophthalmic eye drop. Two consecutive studies were conducted using sixteen (32 eyes) New Zealand White rabbits. The first study compared the efficacy of ambroxol hydrochloride (0.05%, 0.2%, and 1.0%) on tear and mucin secretion when administered twice daily. Tear secretion was assessed by Schirmer test I and mucin production by conjunctival impression cytol. and PAS stain. The second study compared 0.2% ambroxol hydrochloride with Diquas. A human goblet cell line and human conjunctival tissue were used to test the effect of ambroxol hydrochloride on the expression of aquaporin 5 (AQP5) and MUC5AC, using reverse transcriptase-quant. polymerase chain reaction and immunoblotting. All three concentrations of ambroxol hydrochloride demonstrated significant efficacy on tear stimulation within 2 wk of treatment and total mucin component appeared increased. When administered topically twice daily, 0.2% ambroxol hydrochloride was more effective in augmenting tear secretion than Diquas. With 24 h of treatment, 5μM of ambroxol hydrochloride upregulated AQP5 and MU5AC mRNA and MUC5AC protein in a goblet cell line. When tested on preserved human conjunctiva tissue, a trend of increased production of MUC5AC protein was seen (P = 0.26). Ambroxol is effective in augmenting tear secretion at the ocular surface in rabbits. With actions desirable of a candidate dry eye drug, further investigation of ambroxol and related compounds is warranted to explore their value toward clin. application.

Graefe’s Archive for Clinical and Experimental Ophthalmology published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C20H28B2O4S2, Computed Properties of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts