Chowdhury, Amiya K. Roy’s team published research in Indian Medical Journal in 58 | CAS: 3818-50-6

Indian Medical Journal published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Chowdhury, Amiya K. Roy published the artcileR.S.(P), a new isolate from the root of Rauwolfia serpentina, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Indian Medical Journal (1964), 58(12), 241-52, database is CAplus.

The pharmacol. actions of a nonalkaloidal fraction isolated from the root of R. serpentina are given. This fraction, R.S.(P), was less potent than reserpine but equipotent to Rauwolfia total extract (1%) in lowering the blood pressure in anesthetized cats. In suitable doses it increased the pentobarbital sleeping time, reduced the spontaneous motility, postponed Metrazol convulsion and lethality, and affected the conditioned behavior in rats (maze test). Coordinated muscular movements were least affected, except when very high doses were used. Electroencephalogram studies in unanesthetized rabbits revealed considerable slowing of the brain wave pattern with the calming and quieting effect on the animals. Sometimes behavioral nonreactivity was seen. The drug appeared to have a central site of action. Its action differed from that of reserpine in many respects. It may possibly be used as an antihypertensive and anticonvulsant or sedative agent.

Indian Medical Journal published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Goulart, Enio G.’s team published research in Revista Brasileira de Medicina in 31 | CAS: 3818-50-6

Revista Brasileira de Medicina published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Category: alcohols-buliding-blocks.

Goulart, Enio G. published the artcileAnthemintic drugs. Their ovicidal and larvicidal actions, Category: alcohols-buliding-blocks, the publication is Revista Brasileira de Medicina (1974), 31(11), 791-4, database is CAplus.

Of 9 chemotherapeutic anthelmintics tested in vitro against eggs and larvae of Ascaris lumbricoides, Trichuris trichiura, and Ancylostoma caninum, pyrantel pamoate [22204-24-6] and tetrachloroethylene [127-18-4] (10 and 100 mg each) inhibited development of A. caninum; similar results were obtained with 1 mg tetramisole-HCl (I-HCl) [5086-74-8] and thiabendazole (II) [148-79-8]. Stilbazium iodide [3784-99-4], pyrvinium pamoate [3546-41-6], and bephenium hydroxynaphthoate [3818-50-6] showed anthelmintic activity which was directly related to the concentrations None of the compounds tested showed embryogenic blocking activity against A. lumbricoides or T. trichiura. Prophylactic treatments of contaminated soil or organic fertilizer are apparently ineffective.

Revista Brasileira de Medicina published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rajasekariah, G. R.’s team published research in Chemotherapy (Basel, Switzerland) in 32 | CAS: 3818-50-6

Chemotherapy (Basel, Switzerland) published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Rajasekariah, G. R. published the artcileResponse of preadult Necator americanus to some known anthelminthics in hamsters, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Chemotherapy (Basel, Switzerland) (1986), 32(1), 75-82, database is CAplus and MEDLINE.

Hamsters infected with laboratory-adapted preadult N. americanus were dosed with 6 reference anthelmintics; their efficacy was measured in terms of percentage cure of infected animals as well as percentage worm reduction following treatment. Mebendazole and pyrantel were equally effective in this system. Other anthelmintics, including the anti-hookworm compound, bephenium hydroxynaphthoate, were less effective. The comparative results revealed that the N. americanus model is sensitive and reliable for identifying and characterizing new anti-parasite preparations

Chemotherapy (Basel, Switzerland) published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Prabhu, Padmavathi P.’s team published research in International Journal of Pharmaceutical Sciences and Research in 9 | CAS: 23828-92-4

International Journal of Pharmaceutical Sciences and Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Category: alcohols-buliding-blocks.

Prabhu, Padmavathi P. published the artcileMethod development and validation for the estimation of ambroxol HCl in pharmaceutical dosage form, Category: alcohols-buliding-blocks, the publication is International Journal of Pharmaceutical Sciences and Research (2018), 9(6), 2550-2553, database is CAplus.

Rapid, sensitive, specific and validated colorimetric methods have been developed for the quant. estimation of ambroxol HCl in bulk and dosage form. The current method was developed based on oxidation of ambroxol with Gibb’s reagent (method I) and p-diethyl amino benzaldehyde in toluene (method II). The formed intense color complex was measured at 537.2 nm and 438.4 nm resp. Under optimized exptl. conditions, Beer’s law is obeyed in concentration range 5 – 30 μg/mL for both the methods with regression co-efficient 0.9994 and 0.9992. Recovery studies were conducted by standard addition method to confirm the accuracy of the method. The LOD and LOQ for the estimation of ambroxol were found as 0.0773, 0.2343 for method I and 0.0667, 0.2021 for method II resp. The proposed method was validated as per ICH guidelines.

International Journal of Pharmaceutical Sciences and Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wei, Bing’s team published research in Journal of International Medical Research in 46 | CAS: 23828-92-4

Journal of International Medical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C14H18BNO2, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Wei, Bing published the artcileChanges in Th1/Th2-producing cytokines during acute exacerbation chronic obstructive pulmonary disease, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Journal of International Medical Research (2018), 46(9), 3890-3902, database is CAplus and MEDLINE.

This study aimed to explore cytokine serum levels and the ratio of type 1 T helper (Th1)/Th2 cells in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total 245 patients diagnosed with AECOPD and 193 patients who progressed to stable COPD after the initiation of treatment in hospital were selected, while a further 50 healthy individuals served as controls. All patients with COPD were diagnosed using Global Initiative for Chronic Obstructive Lung Disease criteria. Serum concentrations of interleukin (IL)-2, interferon (IFN)-γ, IL-4, IL-10, IL-17, and Ig (Ig)E were measured using enzyme-linked immunosorbent assays. AECOPD patients had higher levels of IL-2, IFN-γ, IL-4, IL-10, IL-17, and IgE than those with stable COPD or controls. Intriguingly, the ratios of Th1/Th2 and IL-17/IgE were lower in AECOPD patients compared with the other two groups. These data suggest that AECOPD patients produce more IgE and have more differentiated Th2 cells than other groups. Ur findings suggest that an imbalance of circulating CD4+ T cell subsets correlates with AECOPD, and that a shift of Th1/Th2 and IL-17/IgE ratios may be caused by increased Th2 cell production

Journal of International Medical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C14H18BNO2, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lee, Jonghee’s team published research in Journal of Polymer Science, Part A: Polymer Chemistry in 44 | CAS: 239075-02-6

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Safety of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Lee, Jonghee published the artcileEnhanced efficiency of polyfluorene derivatives: organic-inorganic hybrid polymer light-emitting diodes, Safety of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2006), 44(9), 2943-2954, database is CAplus.

Two novel organic-inorganic hybrid polyfluorene derivatives, poly{(9,9′-dioctyl-2,7-fluorene)-co-(9,9′-di-POSS-2,7-fluorene)-co-[2,5-bis(octyloxy)-1,4-phenylene]} (PFDOPPOSS) and poly{(9,9′-dioctyl-2,7-fluorene)-co-(9,9′-di-POSS-2,7-fluorene)-co-bithiophene} (PFT2POSS), were synthesized by the Pd-catalyzed Suzuki reaction of polyhedral oligomeric silsesquioxane (POSS) appended fluorene, dioctyl phenylene, and bithiophene moieties. The synthesized polymers were characterized with 1H NMR spectroscopy and elemental anal. Photoluminescence (PL) studies showed that the incorporation of the POSS pendant into the polyfluorene derivatives significantly enhanced the fluorescence quantum yields of the polymer films, likely via a reduction in the degree of interchain interaction as well as keto formation. Addnl., the blue-light-emitting polyfluorene derivative PFDOPPOSS showed high thermal color stability in PL. Moreover, single-layer light-emitting diode devices of an indium tin oxide/poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate)/polymer/Ca/Al configuration fabricated with PFDOPPOSS and PFT2POSS showed much improved brightness, maximum luminescence intensity, and quantum efficiency in comparison with devices fabricated with the corresponding pristine polymers PFDOP and PFT2. In particular, the maximum external quantum efficiency of PFT2POSS was 0.13%, which was twice that of PFT2 (0.06%), and the maximum current efficiency of PFT2POSS was 0.38 cd/A, which again was twice that of PFT2 (0.19 cd/A).

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Safety of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chong, Curtis R.’s team published research in Nature Chemical Biology in 2 | CAS: 3818-50-6

Nature Chemical Biology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Chong, Curtis R. published the artcileA clinical drug library screen identifies astemizole as an antimalarial agent, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Nature Chemical Biology (2006), 2(8), 415-416, database is CAplus and MEDLINE.

The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases. To accelerate drug discovery the authors created a library of 2687 existing drugs and screened for inhibitors of the human malaria parasite Plasmodium falciparum. The antihistamine astemizole and its principal human metabolite are promising new inhibitors of chloroquine-sensitive and multidrug-resistant parasites, and they show efficacy in two mouse models of malaria.

Nature Chemical Biology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chu, Weiwei’s team published research in Guizhou Yiyao in 45 | CAS: 23828-92-4

Guizhou Yiyao published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Chu, Weiwei published the artcileEffects of Xuebijing injection combined with ambroxol hydrochloride in the treatment of elderly patients with severe pneumonia on serum DAO, D-Lac, ET levels and arterial blood gas, Application In Synthesis of 23828-92-4, the publication is Guizhou Yiyao (2021), 45(10), 1525-1527, database is CAplus.

Objective To investigate the effect of Xuebijing injection combined with ambroxol hydrochloride in the treatment of elderly patients with severe pneumonia on serum DAO, D-Lac, ET levels and arterial blood gas. Methods A total of 118 elderly patients with severe pneumonia admitted to the department of respiratory medicine of our hospital were selected and divided into the control group and the observation group by random numbers table method, with 59 cases in each group. Both groups were treated with conventional treatment, the control group was given ambroxol hydrochloride on the basis of conventional treatment, and the observation group was given Xuebijing injection on the basis of the control group. Both groups were treated for 14 d. Arterial blood gas, T lymphocyte subsets, intestinal mucosal barrier function and respiratory mechanics indexes were compared between the two groups before and after treatment. Results After treatment, the levels of SaO2, PaO2, CD3+, CD4+, CD4+/CD8+ in whole blood of the observation group were higher than before treatment, and the observation group were higher than the control group (P<0.05); Pplat, PIP, mRaw, Paw, PaCO2, whole blood CD8+, serum DAO, D-Lac and ET levels were lower than before treatment, the observation group were lower than the control group (P<0.05). Conclusion Xuebijing injection combined with ambroxol hydrochloride in the treatment of elderly patients with severe pneumonia can reduce serum DAO, D-Lac, ET levels, improve intestinal mucosal barrier function and arterial blood gas, respiratory mechanics indexes, with accurately effect.

Guizhou Yiyao published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gallaher, Joseph K.’s team published research in Journal of Physical Chemistry Letters in 7 | CAS: 239075-02-6

Journal of Physical Chemistry Letters published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Quality Control of 239075-02-6.

Gallaher, Joseph K. published the artcileEvolution of Nonmirror Image Fluorescence Spectra in Conjugated Polymers and Oligomers, Quality Control of 239075-02-6, the publication is Journal of Physical Chemistry Letters (2016), 7(17), 3307-3312, database is CAplus and MEDLINE.

The nonmirror image relation between absorption and fluorescence spectra of conjugated polymers contrasts with most organic chromophores and is widely considered a signature of interchromopohore energy funneling. The authors apply broad-band ultrafast fluorescence spectroscopy to resolve the evolution of fluorescence spectra for dilute solutions of conjugated oligothiophenes, where no energy transfer is possible. Fluorescence spectra evolve from a mirror image of absorption, which lacks vibronic structure, toward a spectrally narrower and vibronically structured species on the hundreds of femtosecond to early picosecond time scale. The authors’ anal. of this fluorescence spectral evolution shows that a broad distribution of torsional conformers is driven to rapidly planarize in the excited state, including in solid films, which is supported by Raman spectroscopy and quantum chem. modeling. The authors’ data have important implications for understanding different energy-transfer regimes that are delineated by structural relaxation.

Journal of Physical Chemistry Letters published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Quality Control of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rout, Kanhu Charan’s team published research in Inorganica Chimica Acta in 437 | CAS: 5941-07-1

Inorganica Chimica Acta published new progress about 5941-07-1. 5941-07-1 belongs to alcohols-buliding-blocks, auxiliary class Salt,Benzene,Naphthalene,Phenol,Inhibitor, name is 8-Hydroxy-1-(salicylideneamino)naphthalene-3,6-disulfonic acid monosodium Salt, and the molecular formula is C17H12NNaO8S2, Category: alcohols-buliding-blocks.

Rout, Kanhu Charan published the artcileA copper(II) complex as selective turn-on fluorosensor for nitric oxide and its intracellular application, Category: alcohols-buliding-blocks, the publication is Inorganica Chimica Acta (2015), 201-206, database is CAplus.

A highly water soluble copper(II) complex, 1 of a fluorophore ligand 4-(2-hydroxybenzylamino)-5-hydroxynaphthalene-2,7-disulfonic acid (FL1) was synthesized and characterized. In the complex, the fluorescence intensity of the ligand was found to quench due to the presence of paramagnetic Cu(II) center. In degassed methanol solution of complex 1, the Cu(II) center was found to undergo reduction in presence of nitric oxide. This resulted in the simultaneous formation of N-nitrosated ligand. In the process, the quenched fluorescence intensity of the ligand restored. The selective turn on fluorogenic nature of the complex 1 was used to study the endogenously produced NO in living cells.

Inorganica Chimica Acta published new progress about 5941-07-1. 5941-07-1 belongs to alcohols-buliding-blocks, auxiliary class Salt,Benzene,Naphthalene,Phenol,Inhibitor, name is 8-Hydroxy-1-(salicylideneamino)naphthalene-3,6-disulfonic acid monosodium Salt, and the molecular formula is C17H12NNaO8S2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts