Chowdhury, Amiya K. Roy published the artcileR.S.(P), a new isolate from the root of Rauwolfia serpentina, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Indian Medical Journal (1964), 58(12), 241-52, database is CAplus.
The pharmacol. actions of a nonalkaloidal fraction isolated from the root of R. serpentina are given. This fraction, R.S.(P), was less potent than reserpine but equipotent to Rauwolfia total extract (1%) in lowering the blood pressure in anesthetized cats. In suitable doses it increased the pentobarbital sleeping time, reduced the spontaneous motility, postponed Metrazol convulsion and lethality, and affected the conditioned behavior in rats (maze test). Coordinated muscular movements were least affected, except when very high doses were used. Electroencephalogram studies in unanesthetized rabbits revealed considerable slowing of the brain wave pattern with the calming and quieting effect on the animals. Sometimes behavioral nonreactivity was seen. The drug appeared to have a central site of action. Its action differed from that of reserpine in many respects. It may possibly be used as an antihypertensive and anticonvulsant or sedative agent.
Indian Medical Journal published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.
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