Tag: M.W=400-450

Arriaga Alba, M. published the artcileMutagenicity of products generated by the reaction between several antiparasitic drugs and nitrite, HPLC of Formula: 3818-50-6, the publication is Environmental and Molecular Mutagenesis (1988), 12(1), 65-73, database is CAplus and MEDLINE.

Drugs containing secondary aliphatic amines, heterocyclic N, or secondary aliphatic amido groups (chloroquine, dihydroemetine, mebendazole, and piperazine) and pyrimidine derivatives such as pyrantel pamoate were reacted in vitro with NaNO₂ at pH 3.7 and became mutagenic for Salmonella typhimurium strain TA1535. The products derived from the nitrosation of chloroquine and dehydroemetine required metabolic activation by mammalian hepatic S9 to be mutagenic. The N-nitroso derivatives of mebendazole, piperazine, and pyrantel pamoate were mutagenic with and without S9, although more activity was noted in the presence of S9 with the nitrosated compounds formed from mebendazole and piperazine. Under identical conditions, no mutagenic products were detected from quaternary ammonium salts such as bephenium hydroxynaphthoate or drugs containing tertiary heterocyclic amino groups, such as iodochlorhydroxyquin.

Environmental and Molecular Mutagenesis published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, HPLC of Formula: 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cortinas de Nava, C. published the artcileMutagenicity of antiamebic and anthelmintic drugs in the Salmonella typhimurium microsomal test system, Product Details of C28H29NO4, the publication is Mutation Research, Genetic Toxicology Testing (1983), 117(1-2), 79-91, database is CAplus and MEDLINE.

Amebicides (chloroquine (I) [54-05-7], diiodohydroxyquin  [83-73-8], iodochlorohydroxyquin  [130-26-7] and dehydroemetine  [4914-30-1]) and anthelmintics (bephenium hydroxynaphthoate  [3818-50-6], 4-hexylresorcinol  [136-77-6], mebendazole  [31431-39-7], niclosamide  [50-65-7], pyrantel pamoate  [22204-24-6] and pyrvinium pamoate  [3546-41-6]) were tested for mutagenicity in the S. typhimurium microsomal test system. Frameshift mutations were induced by dehydroemetine and niclosamide following activation by microsomal enzymes, while pyrvinium pamoate induced both frameshift and base-pair substitution mutations with or without metabolic activation. The urine of mice treated with dehydroemetine or pyrvinium pamoate showed no mutagenic activity. However, urine obtained from mice treated with niclosamide was mutagenic in strains TA98 and TA1538. The fluctuation assay showed I to be mutagenic in TA1537, a strain which detects frameshift mutations.

Mutation Research, Genetic Toxicology Testing published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Product Details of C28H29NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Coles, G. C. published the artcileMechanism of action of the anthelmintic levamisole, SDS of cas: 3818-50-6, the publication is General Pharmacology (1975), 6(4), 309-13, database is CAplus.

In a solution of levamisole-HCl (I) [16595-80-5], the small round worm Nippostrongylus brasiliensis became paralyzed, but recovered on being left in the solution Both the rates of paralysis and recovery increased with increasing concentration of I. A small percentage of Ascaris suum also resumed movement in I, and were then protected against the effects of the anthelmintics bephenium hydroxynaphthoate [3818-50-6], methyridine [114-91-0], and pyrantel tartrate [33401-94-4]. The autonomic blocking agents mecamylamine and pempidine blocked I contractions in normal A. suum, and the results suggested that all 4 anthelmintics acted in a similar way.

General Pharmacology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, SDS of cas: 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ji, Lei published the artcileExperimental and Theoretical Studies of Quadrupolar Oligothiophene-Cored Chromophores Containing Dimesitylboryl Moieties as π-Accepting End-Groups: Syntheses, Structures, Fluorescence, and One- and Two-Photon Absorption, Computed Properties of 239075-02-6, the publication is Chemistry – A European Journal (2014), 20(42), 13618-13635, database is CAplus and MEDLINE.

Quadrupolar oligothiophene chromophores composed of four to five thiophene rings with two terminal (E)-dimesitylborylvinyl groups (4 V-5 V), and five thiophene rings with two terminal aryldimesitylboryl groups (5 B), and an analog of 5 V with a central EDOT ring (5 VE), were synthesized via Pd-catalyzed cross-coupling reactions in high yields (66-89 %). Crystal structures of 4 V, 5 B, bithiophene 2 V, and five thiophene-derived intermediates are reported. Chromophores 4 V, 5 V, 5 B and 5 VE have photoluminescence quantum yields of 0.26-0.29, which are higher than those of the shorter analogs 1 V-3 V (0.01-0.20), and short fluorescence lifetimes (0.50-1.05 ns). Two-photon absorption (TPA) spectra were measured for 2 V-5 V, 5 B and 5 VE in the range 750-920 nm. The measured TPA cross-sections for the series 2 V-5 V increase steadily with length up to a maximum of 1930 GM. We compare the TPA properties of 2 V-5 V with the related compounds 5 B and 5 VE, giving insight into the structure-property relation for this class of chromophore. DFT and TD-DFT results, including calculated TPA spectra, complement the exptl. findings and contribute to their interpretation. A comparison to other related thiophene and dimesitylboryl compounds indicates that our design strategy is promising for the synthesis of efficient dyes for two-photon-excited fluorescence applications.

Chemistry – A European Journal published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Busev, A. I. published the artcileSpectroscopic study of the reaction products of Rhodamine 6Zh with naftamon during extraction by benzene, Product Details of C28H29NO4, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (1974), 17(9), 1367-70, database is CAplus.

Reaction products of the dye Rhodamine 6Zh (I) [7325-85-1] with Naftamon (II) [3818-50-6], and the dye itself were extracted with C6H6, and the spectra obtained from the extracts in the region 17,000-22,000 cm-1 were split into gauss constituents. Four gauss peaks were found in the extract corresponding to monomeric and dimeric forms of ionic associates of I with II and traces of the dye.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Product Details of C28H29NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Su, Weiwei published the artcileStudy on the efficacy and safety of ambroxol combined with methylprednisolone in patients with acute lung injury, Product Details of C13H19Br2ClN2O, the publication is BioMed Research International (2021), 5771101, database is CAplus and MEDLINE.

There is no better treatment method towards paraquat-induced acute lung injury (ALI) at present. Ambroxol combined with methylprednisolone exhibits a significant improvement effect on ALI treatment, whereas their mechanism in ALI is still unclear. 64 Patients with ALI caused by paraquat poisoning brought to author’s hospital from Jan. 2015 to Jan. 2018 were selected. They were separated into a combined treatment group (CTG) and a routine treatment group (RTG) on the basis of different treatment methods. The survival of patients was observed after 7 days of treatment. Arterial blood gas, oxygen partial pressure (PaO₂), partial pressure of carbon dioxide (PaCO₂), oxygenation index (PaO₂/FiO₂), patient’s spontaneous respiratory rate (RR), tidal volume (VT), and pos. end-expiratory pressure (PEEP) were observed before and after treatment for 7 days. Interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) were analyzed. The differences of indexes between the dead patients and the survivors were observed, and the potential predictive value of death was analyzed. After treatment, the indexes of patients were significantly improved in both groups compared with those before therapy. Further comparison showed that the improvement of PaO₂, PaCO₂, and PaO₂/FiO₂ in CTG was obviously higher than that in RTG (p < 0.05). The improvement of RR, PEEP, and VT in CTG was obviously higher than that in RTG (p < 0.05). The decreased degree of IL-6 and TNF-α in CTG was higher than that in RTG (p < 0.05). The 7-day mortality rate of 64 patients was 39.06%, and there was no obvious difference in the 7-day survival rate in both groups (p = 0.649). IL-6 and TNF-α were expected to be potential prediction indexes of paraquat-induced ALI. Ambroxol combined with methylprednisolone significantly improved the oxygen partial pressure and oxygenation index of patients with paraquat-induced ALI and inhibited the inflammatory response of patients.

BioMed Research International published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C14H26O2, Product Details of C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Poddar, S. N. published the artcileSpectrophotometric determination of thorium(IV) with the Schiff base derived from 1-amino-8-naphthol-3,6-disulfonic acid and salicylaldehyde, Name: 8-Hydroxy-1-(salicylideneamino)naphthalene-3,6-disulfonic acid monosodium Salt, the publication is Indian Journal of Chemistry (1965), 3(9), 407-8, database is CAplus.

A spectrophotometric method for the determination of 0.0003913 g. Th/ml. solution is described. Th⁴⁺ gives a red color with the Schiff base (I) derived from ο-HOC₆H₄CHO and 1-amino-8-naphtnol-3,6-disulfonic acid (mono-Na salt) at pH 3.2-5.2. The color (450 mμ; sensitivity 0.032 γ Th/cm.²) of the complex is stable and obeys Beer’s law over 1 to 95 ppm. Th. A mixture of 10 ml. 10% aqueous Th(NO₃)₄ and 15 ml. 10% I was heated to give a red solution This on treatment with a few drops of aqueous KOH produced a bright red precipitate of the Th-I complex (II), which was filtered, washed with aqueous alc. and dried. II was soluble in H₂O, but insoluble in EtOH, Me₂CO, CHCl₃, and Et₂O. On heating with alk. solution, II decomposed to form hydrated ThO₂. The composition of II was Th(SB)₂, where SBH₂ is a mol. of I. Cl^–, Br^–, I^–, NO₃^–, Na⁺, K⁺, alk. earth metals, Cu(II), Co(II), Hg(II), Pd(II), Zn(II), Al(III), Mn(II), Cr(III), and U have no effect on the color system. SO₄^— tungstate, citrate, PO₄^—, Ac^–, OAc^–, and C₂O₄^— do not interfere when present in small quantities but lower the intensity of the color when present in large excess. Fe(III) interferes due to the formation of a violet color but Fe(II) does not. Interference due to Fe(III) can be avoided by reducing it by passing the solution through a Jones reductor and then developing the color with Th. F^– bleaches the Th-reagent color quant. VO₃^–, CrO₄^—, and Fe(III) form colored products with the reagent and should be removed beforehand.

Indian Journal of Chemistry published new progress about 5941-07-1. 5941-07-1 belongs to alcohols-buliding-blocks, auxiliary class Salt,Benzene,Naphthalene,Phenol,Inhibitor, name is 8-Hydroxy-1-(salicylideneamino)naphthalene-3,6-disulfonic acid monosodium Salt, and the molecular formula is C17H12NNaO8S2, Name: 8-Hydroxy-1-(salicylideneamino)naphthalene-3,6-disulfonic acid monosodium Salt.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Poddar, Sailendra N. published the artcileSpectrophotometric determination of vanadium with Schiff’s base derived from 1-amino-8-hydroxynaphth-3,6-disulfonic acid and salicylaldehyde, SDS of cas: 5941-07-1, the publication is Indian Journal of Chemistry (1966), 4(8), 371-2, database is CAplus.

A spectrophotometric method for the determination of 0.000168 g. V/ml. is described. The method is based on the formation of a reddish yellow-colored complex when a solution containing VO3- is added to an aqueous solution of Schiff’s base (I) derived from o-HOC6H4-CHO and mono-Na 1-amino-2-hydroxynaphthalene-3,6-disulfonate (II) at pH 4.22-9.1. The color [λmax. 420 mμ and sensitivity 0.0048 γ V/cm.2] of the complex is quite stable and obeyed Beer’s law over a wide range (1.34-13.40 ppm.) of VO3- concentration By using Job’s method of continuous variation, a metal-ligand ratio of 1:2 is found. Halides, NO3-, NO2-, SO42-, WO42-, MoO42-, PO43-, citrate, OAc-, C2O42-, F-, alkali metals, and alk. earth metals do not interfere with the estimation when present at ±550 ppm. I was prepared by refluxing a mixture of II and o-OHC6H4CHO on water-bath for 2 hrs.; the mixture is left over night and the separated I is washed with dilute EtOH and dried (CaCl2).

Indian Journal of Chemistry published new progress about 5941-07-1. 5941-07-1 belongs to alcohols-buliding-blocks, auxiliary class Salt,Benzene,Naphthalene,Phenol,Inhibitor, name is 8-Hydroxy-1-(salicylideneamino)naphthalene-3,6-disulfonic acid monosodium Salt, and the molecular formula is C17H12NNaO8S2, SDS of cas: 5941-07-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bagutski, Viktor published the artcileMechanistic studies into amine-mediated electrophilic arene borylation and its application in MIDA boronate synthesis, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Journal of the American Chemical Society (2013), 135(1), 474-487, database is CAplus and MEDLINE.

Direct electrophilic borylation using Y₂BCl (Y₂ = Cl₂ or o-catecholato) with equimolar AlCl₃ and a tertiary amine has been applied to a wide range of arenes and heteroarenes, yielding aryl and heterocyclic boronates in a regioselective way. In situ functionalization of the ArBCl₂ products is possible with Me₃SiOCOCH₂NMeCH₂CO₂SiMe₃ (TMS₂MIDA), to afford bench-stable and easily isolable MIDA-boronates in moderate to good yields; pinacol and neopentylglycol esters were also prepared According to a combined exptl. and computational study, the borylation of activated arenes at 20° proceeds through an S_EAr mechanism with borenium cations, [Y₂B(amine)]⁺, the key electrophiles. For catecholato-borocations, two amine dependent reaction pathways were identified: with [CatB(NEt₃)]⁺, an addnl. base is necessary to accomplish rapid borylation by deprotonation of the borylated arenium cation (σ complex), which otherwise would rather decompose to the starting materials than liberate the free amine to effect deprotonation. Apart from amines, the addnl. base may also be the arene itself when it is sufficiently basic (e.g., N-Me-indole). When the amine component of the borocation is less nucleophilic (e.g., 2,6-lutidine), no addnl. base is required due to more facile amine dissociation from the boron center in the borylated arenium cation intermediate. Borenium cations do not borylate poorly activated arenes (e.g., toluene) even at high temperatures; instead, the key electrophile in this case involves the product from interaction of AlCl₃ with Y₂BCl. When an extremely bulky amine is used, borylation again does not proceed via a borenium cation; instead, a number of mechanisms are feasible including via a boron electrophile generated by coordination of AlCl₃ to Y₂BCl, or by initial (heteroarene)AlCl₃ adduct formation followed by deprotonation and transmetalation.

Journal of the American Chemical Society published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Porzio, William published the artcileClose Packing in Crystals of Cyanophenylene/Thienylene Derivatives, COA of Formula: C20H28B2O4S2, the publication is Crystal Growth & Design (2006), 6(6), 1497-1503, database is CAplus.

A new mol., designed as a potential active material in field effect transistor (FET) devices and constituted by p-cyanophenylene and -thienylene residues, was synthesized and characterized by electrochem., photophys., and structural points of view. Its crystal structure, derived from powder XRD data, displays higher close packing as compared with mol. crystals constituted by similar residues. The crystallization aptness was demonstrated by growing solid films, from 15 nm to 2 μm thick, using high vacuum depositions, casting, and spin coating techniques. AFM study shows well formed needles, univocally oriented with respect to the substrate. The HOMO/LUMO levels, matching the electrode working function, the film orientation, and the close packing, suggest its promising use as an active layer in FET devices.

Crystal Growth & Design published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, COA of Formula: C20H28B2O4S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts