Morisaki, Yasuhiro’s team published research in Polymer Journal (Tokyo, Japan) in 42 | CAS: 239075-02-6

Polymer Journal (Tokyo, Japan) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Product Details of C20H28B2O4S2.

Morisaki, Yasuhiro published the artcileNaphthalene-based oligothiophene-stacked polymers, Product Details of C20H28B2O4S2, the publication is Polymer Journal (Tokyo, Japan) (2010), 42(12), 928-934, database is CAplus.

We report the synthesis and properties of π-stacked polymers consisting of oligothiophene and naphthalene as the stacked π-system and the scaffold, resp. The titled polymers were obtained by the Suzuki-Miyaura coupling reaction. Oligothiophene units were layered in proximity, ∼3.0 Å from each other. Contribution of the quinoidal structure of the oligothiophene units involving the naphthalene scaffolds in the excited state resulted in relatively high photoluminescence quantum efficiencies. The polymers have potential application to optoelectronic devices such as hole-transporting materials. Polymer Journal (2010) 42, 928-934; doi:10.1038/pj.2010.101; published online 27 Oct. 2010.

Polymer Journal (Tokyo, Japan) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Product Details of C20H28B2O4S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Morisaki, Yasuhiro’s team published research in Macromolecular Chemistry and Physics in 211 | CAS: 239075-02-6

Macromolecular Chemistry and Physics published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, SDS of cas: 239075-02-6.

Morisaki, Yasuhiro published the artcileXanthene-Based Oligothiophene-Layered Polymers, SDS of cas: 239075-02-6, the publication is Macromolecular Chemistry and Physics (2010), 211(22), 2407-2415, database is CAplus.

We synthesized xanthene-based oligothiophene-layered polymers containing bithiophenes, terthiophenes, quaterthiophenes and quinquethiophenes by the Suzuki-Miyaura coupling reaction. The polymers were characterized by various spectroscopic and electrochem. methods. They were well soluble in common organic solvents and thermally stable. Effective π-π interactions among the layered oligothiophene units in the polymer backbone were not observed in the ground state as well as in the excited state. A possible application of the polymers in opto-electronic devices such as hole transporting materials is expected.

Macromolecular Chemistry and Physics published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, SDS of cas: 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mitini-Nkhoma, Steven C.’s team published research in Journal of Immunology Research in | CAS: 23828-92-4

Journal of Immunology Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Mitini-Nkhoma, Steven C. published the artcileIon transport modulators differentially modulate inflammatory responses in THP-1-derived macrophages, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Journal of Immunology Research (2021), 8832586, database is CAplus and MEDLINE.

Ion transport modulators are most commonly used to treat various noncommunicable diseases including diabetes and hypertension. They are also known to bind to receptors on various immune cells, but the immunomodulatory properties of most ion transport modulators have not been fully elucidated. We assessed the effects of thirteen FDA-approved ion transport modulators, namely, ambroxol HCl, amiloride HCl, diazoxide, digoxin, furosemide, hydrochlorothiazide, metformin, omeprazole, pantoprazole, phenytoin, verapamil, drug X, and drug Y on superoxide production, nitric oxide production, and cytokine expression by THP-1-derived macrophages that had been stimulated with ethanol-inactivated Mycobacterium bovis BCG. Ambroxol HCl, diazoxide, digoxin, furosemide, hydrochlorothiazide, metformin, pantoprazole, phenytoin, verapamil, and drug Y had an inhibitory effect on nitric oxide production, while all the test drugs had an inhibitory effect on superoxide production Amiloride HCl, diazoxide, digoxin, furosemide, phenytoin, verapamil, drug X, and drug Y enhanced the expression of IL-1β and TNF-α. Unlike most immunomodulatory compounds currently in clin. use, most of the test drugs inhibited some inflammatory processes while promoting others. Ion pumps and ion channels could therefore serve as targets for more selective immunomodulatory agents which do not cause overt immunosuppression.

Journal of Immunology Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boltia, Shereen A.’s team published research in Journal of Pharmacy Research (Mohali, India) in 12 | CAS: 23828-92-4

Journal of Pharmacy Research (Mohali, India) published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Boltia, Shereen A. published the artcileFour validated spectrophotometric methods for determination of ambroxol, guaifenesin, and theophylline in their ternary mixture in bulk powder and dosage form, Application In Synthesis of 23828-92-4, the publication is Journal of Pharmacy Research (Mohali, India) (2018), 12(4), 446-454, database is CAplus.

The purpose of the present study was to develop and validate spectrophotometric methods for simultaneous determination of a ternary mixture of ambroxol HCl (AMB), guaifenesin (GUA) and theophylline (THEO) in pharmaceutical dosage forms. (a) Direct spectrophotometry (DS), (b) dual wavelength (DW), (c) first derivative of ratio spectra (1DD), and (d) absorption correction (AC). DS method was applied to determine AMB at its λmax (309.0 nm) without any interference of THEO and GUA. Both THEO and GUA were determined as a binary mixture after removal of AMB contribution from the ternary mixture by ratio subtraction technique. DW method was applied to determine GUA by measuring the difference in absorbance at 224.5 nm and 255.0 nm. 1DD was used to determine THEO at 295.4 nm and GUA at 236.5 nm using 14.0μg/mL GUA and 14.5μg/mL THEO as divisors, resp. AC was applied after the second derivative for determination of GUA at 239.5 nm and THEO at 239.5 nm and 266.0 nm. The methods were accurate, specific, and successfully applied for the determination of the three drugs in laboratory prepared mixtures and their combined dosage form.

Journal of Pharmacy Research (Mohali, India) published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Donnelly, Liam J.’s team published research in ACS Catalysis in 11 | CAS: 239075-02-6

ACS Catalysis published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Donnelly, Liam J. published the artcileC-H Borylation Catalysis of Heteroaromatics by a Rhenium Boryl Polyhydride, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is ACS Catalysis (2021), 11(12), 7394-7400, database is CAplus.

Transition metal complexes bearing metal-boron bonds are of particular relevance to catalytic C-H borylation reactions, with iridium polyboryl and polyhydrido-boryl complexes the current benchmark catalysts for these transformations. Herein, we demonstrate that polyhydride boryl phosphine rhenium complexes are accessible and catalyze the C-H borylation of heteroaromatic substrates. Reaction of [K(DME)(18-c-6)][ReH4(Bpin)(η2-HBpin)(κ2-H2Bpin)] 1 with 1,3-bis(diphenylphosphino)propane (dppp) produced [K(18-c-6)][ReH42-HBpin)(dppp)] 2 through substitution of two equivalent of HBpin, and protonation of 2 formed the neutral complex [ReH6(Bpin)(dppp)] 3. Combined X-ray crystallog. and DFT studies show that 2 is best described as a σ-borane complex, whereas 3 is a boryl complex. Significantly, the boryl complex 3 acted as a catalyst for the C(sp2)-H borylation of a variety of heteroarenes (14 examples including furan, thiophene, pyrrole and indole derivatives) and displayed similar reactivity to the iridium analogs.

ACS Catalysis published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Koohmareh, Gholam Ali’s team published research in Designed Monomers and Polymers in 17 | CAS: 239075-02-6

Designed Monomers and Polymers published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Related Products of alcohols-buliding-blocks.

Koohmareh, Gholam Ali published the artcileSynthesis, characterization, and optical properties of poly[2-(4-(2,2′-bithiophen-5-yl)phenyl)-4-(4-alkoxyphenyl)-6-phenylpyridine|s, Related Products of alcohols-buliding-blocks, the publication is Designed Monomers and Polymers (2014), 17(5), 401-415, database is CAplus.

Two new copolymers, P1 and P2, composed of 4[4-(alkoxy)phenyl]-2, 6-bis(4-bromophenyl)pyridine and bithiophene units, have been synthesized via Suzuki cross-coupling reactions. 4[4-(alkoxy)phenyl]-2, 6-bis(4-bromophenyl)pyridines were synthesized starting from condensation reaction of 4-bromoacetophenone and 4-hydroxy benzaldehyde, and subsequent alkoxylation of hydroxyl groups. All of the polymers and intermediates were characterized using FTIR and NMR spectroscopies. The synthesized polymers exhibit good solubility in common organic solvents. The maximum absorption peak for P1 and P2 was 430 and 420 nm, resp. The optical band gap energy of the polymers was determined by absorption onset and found to be 2.17 eV for P1 and 2.13 eV for P2.

Designed Monomers and Polymers published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

El-Sayed, A.’s team published research in Annales Pharmaceutiques Francaises in | CAS: 23828-92-4

Annales Pharmaceutiques Francaises published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

El-Sayed, A. published the artcileFacile approaches for determination of Bromhexine Hydrochloride and its active metabolite Ambroxol Hydrochloride using Eosin Y, Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Annales Pharmaceutiques Francaises, database is CAplus and MEDLINE.

New validated Spectroscopic methods were developed to assay Bromhexine Hydrochloride and its active metabolite Ambroxol Hydrochloride sep. in pure form and pharmaceutical formulations. The spectrophotometric assay (method I) shows complex formation between each of the drugs and Eosin Y at 540 nm at pH 3.6 and 3.4 mL of 4 x 10-4M Eosin for Bromhexine and Ambroxol. The Spectrofluorimetric assay (method II) depends on quenching eosin native fluorescence by the studied drugs, which measured at 540 nm after excitation at 302 nm. The spectrophotometric absorbance-concentration plot is rectilinear over the ranges (1.0-5.0) and (1.0-10.0) μg/mL for bromhexine and ambroxol with LOD of 0.31 and 0.14 μg/mL and LOQ of 0.94 and 0.42 μg/mL for the two drugs resp. The fluorometric-concentration plot is linear along the range (1.0-5.0) μg/mL and (1-10) μg/mL for the two drugs resp. with LOD of 0.13 μg/mL and 0.22 μg/mL and LOQ of 0.4 μg/mL and 0.65 μg/mL for the two drugs, resp. Developed assays have been validated in agreement with ICH recommendations and they were used in the anal. of com. drug formulations containing the two mucolytic drugs and the results were matching with those obtained by the comparison method.De nouvelles methodes spectroscopiques validees ont etedeveloppes pour doser le chlorhydrate de bromhexine et son metabolite actif, le chlorhydrate d′Ambroxol, sous forme pure et dans des formulations pharmaceutiques. Le dosage spectrophotometrique (methode I) montre la formation d′un complexe entre chacun des medicaments et l′eosine Y a540 nm a pH 3,6 et 3,4 mL d′eosine 4 x 10-4M pour la bromhexine et l′ambroxol. Le dosage spectrofluorimetrique (methode II) depend de l′extinction de la fluorescence native de l′eosine par les medicaments etudies, qui a ete mesuree a 540 nm apres excitation a 302 nm. Le trace spectrophotometrique. Le trace spectrophotometrique absorbance-concentration est lineaire sur les plages (1,0-5,0) et (1,0-10,0) μg/mL pour la bromhexine et l′ambroxol avec LOD de 0,31 et 0,14 μg/mL et LOQ de 0,94 et 0,42 μg/mL pour les deux medicaments respectivement. Le trace de la concentration fluorometrique est lineaire le long de la plage (1,0-5,0) μg/mL et (1-10) μg/mL pour les deux medicaments respectivement avec LOD de 0,13 μg/mL et 0,22 μg/mL et LOQ de 0,4 μg/ mL et 0,65 μg/mL pour les deux medicaments, respectivement. Les tests developpes ont ete valides en accord avec les recommandations de l′ICH et ils ont ete utilizes dans l′analyze des formulations de medicaments commerciaux contenant les deux medicaments mucolytiques et les resultats correspondaient a ceux obtenus par la methode de comparaison.

Annales Pharmaceutiques Francaises published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brody, Gerald’s team published research in Journal of Parasitology in 57 | CAS: 3818-50-6

Journal of Parasitology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Brody, Gerald published the artcileComparative activity of 29 known anthelmintics under standarized drug-diet and gavage medication regimens against four helminth species in mice, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Journal of Parasitology (1971), 57(5), 1068-77, database is CAplus and MEDLINE.

Of 29 reference anthelmintics (21 aromatic-heterocyclic and 8 organophosphate compounds) tested at an initial concentration of 1000 ppm in the diet of mice for 18 days against 4 mouse helminths, parbendazole (I) [14255-87-9] was the only compound exhibiting activity against all 4 helminths and the effectiveness of I was .sim.100% against the 4 helminths. However, in experiments using the 29 compounds at an initial dose of 200 mg/kg/day by gavage for 3 days, significant differences were observed in the effectiveness of a number of the anthelmintics in the 2 different medication regimens. The data below refers to the effectiveness of the compounds when given in the diet. Against Nematospiroides dubius, I, pyrantel (II) [15686-83-6], dl-tetramisole [5036-02-2], l-tetramisole (III) [14769-73-4], and thiabendazole (IV) [148-79-8] were the most effective. Against Hymenolepis nana (tapeworm), I and Ro-2-9009 (1,4-bis(2-diethylaminoethoxy)anthraquinone-2HCl (V) [18272-48-5] were the most effective. Against Syphacia obvelata, I, II, III, IV, V, dithiazanine (VI) [7187-55-5] (at 250 ppm), pyrvinium (VII) [7187-62-4], stilbazium (VIII) [3784-99-4], coumaphos (IX) [56-72-4], haloxon (X) [321-55-1], mercaptophos (XI) [55-38-9], and Ruelene (XII) [299-86-5] were the most effective. Against Aspiculuris tetraptera, I, II, VI, VII, VIII, IX, X, XI, XII, and dichlorvos [62-73-7] were the most effective.

Journal of Parasitology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wasin, Tuchinda’s team published research in ACS Sensors in 1 | CAS: 239075-02-6

ACS Sensors published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C6H8O3, Related Products of alcohols-buliding-blocks.

Wasin, Tuchinda published the artcileFabrication of “Clickable” Polyfluorene Nanowires with High Aspect Ratio as Biological Sensing Platforms, Related Products of alcohols-buliding-blocks, the publication is ACS Sensors (2016), 1(6), 766-774, database is CAplus.

“Clickable” nanowires with well-defined and uniform structures made of conjugated polyfluorene polymers were successfully fabricated by single particle nanofabrication technique (SPNT). Poly[(9,9-dihex-5-yn-1-ylfluorenyl-2,7-diyl)-co-(9,9′-di-n-octylfluorenyl-2,7-diyl)] (F6E8) and poly[(9,9-dihex-5-yn-1-ylfluorenyl-2,7-diyl)-co-(2,2′-bithiophene)] (F6E2T) underwent an efficient crosslinking reaction upon irradiation, resulting in formation of one-dimensional nanostructures with high and desired aspect ratio reaching up to 200. Alkyne groups on the surface of nanowires were functionalized effectively by click reaction with fluorescent 5-TAMRA-PEG3-azide, which was confirmed by confocal microscopy. Substrates functionalized with the nanowires provide dramatic expansion of “clickable” surface area immobilized directly with TAMRA, and the fluorescence resonance energy transfer (FRET) processes between TAMRA and nanowire backbones are demonstrated as biol. sensing platforms.

ACS Sensors published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C6H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arriaga Alba, M.’s team published research in Environmental and Molecular Mutagenesis in 14 | CAS: 3818-50-6

Environmental and Molecular Mutagenesis published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Arriaga Alba, M. published the artcileMutagenicity of urine from mice exposed orally to nitrite and various aminated antiparasitic drugs, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Environmental and Molecular Mutagenesis (1989), 14(1), 13-19, database is CAplus and MEDLINE.

The mutagenic activity of mouse urine was determined after oral administration of sodium nutrite and pyrantel pamoate, chloroquine, piperazine, dehydroemetine, iodochlorhydroxyquin, and bephenium hydroxynaphthoate. The simultaneous administration of piperazine or chloroquine with sodium nitrite produced urinary mutagens that appeared conjugated as glucuronides, whereas pyrantel pamoate and dehydroemetine in the presence of nitrite caused only slight mutagenic urine. No mutagenic activity was detected in the urine of mice to which halogenated derivatives of tertiary amines (iodochlorhydroxyquin) or quaternary ammonium salts (bephenium hydroxynaphthoate) were administered together with nitrite.

Environmental and Molecular Mutagenesis published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts