Ito, Motoki’s team published research in Angewandte Chemie, International Edition in 51 | CAS: 239075-02-6

Angewandte Chemie, International Edition published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Ito, Motoki published the artcileSynthesis of Boron-Substituted Diaryliodonium Salts and Selective Transformation into Functionalized Aryl Boronates, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Angewandte Chemie, International Edition (2012), 51(50), 12555-12558, database is CAplus and MEDLINE.

Diaryliodonium salts were synthesized from aryl boronate derivatives according to two alternative general methods with hypervalent iodine(III) reagents and fluoroalc. solvents: transformation of an aryl C-H bond and boron-iodine(III) exchange. The salts could be functionalized by both catalyst-free and metal-catalyzed reactions without loss of the boron functionality.

Angewandte Chemie, International Edition published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Maegawa, Yoshifumi’s team published research in Dalton Transactions in 44 | CAS: 239075-02-6

Dalton Transactions published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Maegawa, Yoshifumi published the artcileIridium-bipyridine periodic mesoporous organosilica catalyzed direct C-H borylation using a pinacolborane, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Dalton Transactions (2015), 44(29), 13007-13016, database is CAplus and MEDLINE.

Heterogeneous catalysis for direct C-H borylation of arenes and heteroarenes in the combination of iridium (Ir) complex fixed on periodic mesoporous organosilica containing bipyridine ligands within the framework (Ir-BPy-PMO) and pinacolborane (HBpin) is reported. Ir-BPy-PMO showed higher catalytic activity toward the borylation of benzene with inexpensive HBpin compared to expensive bis(pinacolato)diboron (B2pin2). The precatalyst could be handled without the use of a glove box. The catalyst was easily recovered from reaction mixtures by simple filtration under air. The recovered catalyst still showed good catalytic activity for at least three more times for the borylation of benzene. A variety of arenes and heteroarenes were successfully borylated with high boron efficiency by Ir-BPy-PMO using HBpin, whereas almost no activity was observed for borylation of some heteroarenes with B2pin2. The system using Ir-BPy-PMO and HBpin was also utilized in syntheses of multi-boronated thiophene-based building blocks containing ladder-, acenefused-, and fused-thiophene skeletons. The combination of a stable and reusable solid catalyst and inexpensive HBpin is expected to be superior to conventional approaches for the development of industrial applications.

Dalton Transactions published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Watanabe, Jun-ichi’s team published research in Macromolecules (Washington, DC, United States) in 43 | CAS: 239075-02-6

Macromolecules (Washington, DC, United States) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C8H10S, Synthetic Route of 239075-02-6.

Watanabe, Jun-ichi published the artcileFolded H-Stacking Polymers by Conformational Control with 2-Substituted Trimethylene Tethers, Synthetic Route of 239075-02-6, the publication is Macromolecules (Washington, DC, United States) (2010), 43(16), 6562-6569, database is CAplus.

Oligomers and polymers of type [-CH2CHRCH2-(π)-]n comprising aryl units tethered by 2-substituted trimethylene were found to exist as a folding H-stacking structure in polar solvents such as CH3CN and in film, which was evidenced by their blue-shifted UV absorption compared to that of the parent aryl compounds, and exhibited predominantly excimer-like emission. In addition, annealing of the films resulted in a unique layered structure, which may arise from the folded polymer form.

Macromolecules (Washington, DC, United States) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C8H10S, Synthetic Route of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chang, Gung-Pei’s team published research in Thin Solid Films in 527 | CAS: 239075-02-6

Thin Solid Films published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Chang, Gung-Pei published the artcileHigh-performance semiconductors based on oligocarbazole-thiophene derivatives for solution-fabricated organic field-effect transistors, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Thin Solid Films (2013), 291-298, database is CAplus.

Oligocarbazole-thiophenes based on a constant conjugate backbone (carbazole-bithiophene-carbazole) with various n-alkyl chain lengths were prepared for application to organic field-effect transistors (OFETs). The lengths of the n-alkyl substitutions attached on 9-position of carbazole moieties were Me (CCzT2), hexyl (C6CzT2), dodecyl (C12CzT2), and octadecyl (C18CzT2), called CxCzT2. Variations of n-alkyl chain lengths probably figure out the optimization of OFET performance via solution fabrication of the active layer. Before fabricating OFET devices, the thermal, optical, and electrochem. properties of CxCzT2 were fully characterized with TGA, DSC, UV-visible spectroscopy, and cyclic voltammetry to realize the relations of the structure to the properties. After fabricating CxCzT2 on Si/SiO2 substrates via solution casting, the thin film morphologies were also studied with polarizing optical microscopy, at. force microscopy, and x-ray diffraction to study the structural relation to OFET performance. A higher hole mobility was observed with C12CzT2 (3.6 × 10-2 cm2 V-1 s-1) due to its liquid crystal properties, and the hole mobility could be further improved to 1.2 × 10-1 cm2 V-1 s-1 by the introduction of a phenyl-self-assembled monolayer on the Si/SiO2 substrates. The excellent OFET performances of C12CzT2 by solution-fabrication could be considered as a promising candidate for high-end OFET application.

Thin Solid Films published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wollenburg, Marco’s team published research in ACS Catalysis in 10 | CAS: 23828-92-4

ACS Catalysis published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C12H10N2O5, COA of Formula: C13H19Br2ClN2O.

Wollenburg, Marco published the artcileTrans-Selective and Switchable Arene Hydrogenation of Phenol Derivatives, COA of Formula: C13H19Br2ClN2O, the publication is ACS Catalysis (2020), 10(19), 11365-11370, database is CAplus and MEDLINE.

A trans-selective arene hydrogenation of abundant phenol derivatives catalyzed by a com. available heterogeneous palladium catalyst was reported. The described method tolerates a variety of functional groups and provides access to a broad scope of trans-configurated cyclohexanols as potential building blocks for life sciences and beyond in a one-step procedure. The transformation is strategically important because arene hydrogenation preferentially delivers the opposite cis-isomers. The diastereoselectivity of the phenol hydrogenation can be switched to the cis-isomers by employing rhodium-based catalysts. Moreover, a protocol for the chemoselective hydrogenation of phenols to cyclohexanones was developed.

ACS Catalysis published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C12H10N2O5, COA of Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mannanovna, Yunusova Kholida’s team published research in International Journal of Pharmacy and Pharmaceutical Research in 20 | CAS: 23828-92-4

International Journal of Pharmacy and Pharmaceutical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Mannanovna, Yunusova Kholida published the artcileResearch on the selection of a certain content of “Ambronat” juice syrup, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is International Journal of Pharmacy and Pharmaceutical Research (2021), 20(4), 62-71, database is CAplus.

This article presents several experiments on the selection of a specific composition of Ambronat syrup. These selected several excipients in the selection of the sweetness and consistency and consistency of the syrup, based on which the ingredients were considered, and the result was the result of the selection of a moderate content.

International Journal of Pharmacy and Pharmaceutical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ijitsu, Shin’s team published research in Chemical & Pharmaceutical Bulletin in 69 | CAS: 23828-92-4

Chemical & Pharmaceutical Bulletin published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Ijitsu, Shin published the artcilePreparation of novel functional drug particles embedded in a gelling-swelling layer (PEGS) for taste masking and subsequent rapid drug release, Application In Synthesis of 23828-92-4, the publication is Chemical & Pharmaceutical Bulletin (2021), 69(4), 383-390, database is CAplus.

The purpose of this research was to develop novel functional drug particles embedded in a gelling-swelling layer (PEGS) which are capable of achieving both taste-masking of unpalatable drugs and rapid drug elution. The functional particles had a three-layer structure consisting of a core drug layer, a gelling-swelling layer and an outer water-penetration control layer containing a water-insoluble polymer. The concept of formulation design was as follows: when water reaches the gelling-swelling layer, pulverized fine gelling-swelling particles gellate and swell from water absorption to form a rigid layer, thereby preventing drug release. After a defined lag time, the increased volume of the gelling-swelling layer breaks down the outer water-penetration control layer, leading to rapid drug release. In order to adapt this system for use in orally disintegrating tablets, PEGS were prepared at a size of about 250μm using a fine particle-coating method. Ambroxol hydrochloride was used as a model drug for bitterness and the effects of different gelling-swelling agents and water-insoluble polymers on drug release characteristics from PEGS were examined In in vitro dissolution tests, it was shown that the drug dissolution rate from PEGS could be suppressed to about 5% after 2 min and increased to more than 85% after 30 min by adjusting the composition and thickness of the outer layer. The PEGS expanded about 1.5-fold and the outer layer was ruptured after 5 min in water.

Chemical & Pharmaceutical Bulletin published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sun, Shuzhou’s team published research in Jinri Yaoxue in 31 | CAS: 23828-92-4

Jinri Yaoxue published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C12H15ClO3, Quality Control of 23828-92-4.

Sun, Shuzhou published the artcileDetermination of 26 chemical drugs for the treatment of cough and asthma added illegally in herbal tea by high performance liquid chromatography-tandem mass spectrometry, Quality Control of 23828-92-4, the publication is Jinri Yaoxue (2021), 31(3), 195-199, database is CAplus.

OBJECTIVE To establish a rapid screening method for determination of 26 chem. drugs for the treatment of cough and asthma added illegally in herbal tea. METHODS This method involved liquid chromatog.-tandem mass spectrometry. The samples were extracted with methanol, filtrated by 0.22 μm microporous filters and finally separated on a C18 column (2.1 mm×150 mm, 3.5 μm) by using acetonitrile and water (containing 5 mmol·L-1 ammonium formate and 0.1% formic acid) as mobile phase. Qual. and quant. anal. were carried out in multiple reaction monitoring (MRM) model. RESULTS The correlative coefficient of 26 chem. drugs were above 0.995. The average recoveries were 61.2% ∼ 115.6%, the relative standard deviations ranged from 1.0% to 2.0% (n=6). CONCLUSION The method is simple, rapid and sensitive. It is suitable for the determination of 26 chem. drugs for the treatment of cough and asthma added illegally in herbal tea.

Jinri Yaoxue published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C12H15ClO3, Quality Control of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Shi-yun’s team published research in Huaxue Shiji in 41 | CAS: 23828-92-4

Huaxue Shiji published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Category: alcohols-buliding-blocks.

Chen, Shi-yun published the artcileSynthesis of related substances for ambroxol hydrochloride glucose injection, Category: alcohols-buliding-blocks, the publication is Huaxue Shiji (2019), 41(10), 1098-1100, database is CAplus.

To perform the quality control of ambroxol hydrochloride glucose injection, related substance 4-(6, 8-dibromo-3, 4-dihydroquinazoline-3-yl)-cyclohexanol was prepared 4-(6, 8-Dibromo-3, 4-dihydroquinazoline-3-yl)-cyclohexanol was synthesized from ambroxol hydrochloride and formaldehyde by cyclization and oxidation reactions. The structure of 4-(6, 8-dibromo-3, 4-dihydroquinazoline-3-yl)-cyclohexanol was confirmed by IR, 1HNMR, 13CNMR and ESI-MS. The synthetic route designed in this work is simple and the post-processing is convenient, can be used to provide the material foundation for ambroxol hydrochloride related substances 4-(6,8-dibromo-3,4-dihydroquinazoline-3-yl)-cyclohexanol reference substance preparation

Huaxue Shiji published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Peay, Miya A.’s team published research in Organometallics in 30 | CAS: 239075-02-6

Organometallics published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Related Products of alcohols-buliding-blocks.

Peay, Miya A. published the artcileRed-Shifts upon Metal Binding: A Di-Gold(I)-Substituted Bithiophene, Related Products of alcohols-buliding-blocks, the publication is Organometallics (2011), 30(18), 5071-5074, database is CAplus.

5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene was metalated with (triphenylphosphine)gold(I) at the 5,5′-positions to yield a di-gold(I)-substituted bithiophene. The resulting complex was characterized by X-ray diffraction crystallog., optical spectroscopy, and elemental anal. The digold bithiophene complex emits green, structured luminescence in chloroform. Its absorption profile is red-shifted from those of 2,2′-bithiophene or the boronate ester starting material. D.-functional theory (DFT) calculations indicate that the frontier orbitals of the digold complex concentrate on the bithienyl bridge. Time-dependent DFT calculations find that the LUMO-HOMO promotion mostly accounts for the absorption onset in all three compounds and that CI with vacant orbitals on gold modulates this transition. This interaction contributes to red-shifted absorption profiles of σ-aurated gold(I) organometallics.

Organometallics published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts