Tag: M.W=400-450

Malviya, Yogendra published the artcileFormulation development and evaluation of gastroretentive floating tablets of ambroxol hydrochloride, Formula: C13H19Br2ClN2O, the publication is Journal of Drug Delivery and Therapeutics (2019), 9(4Suppl.), 1016-1021, database is CAplus.

The present study is focused on the development of gastroretentive floating drug delivery system of ambroxol hydrochloride, which acts as a mucolytic agent that is reported to be useful in gastric neoplasms which are designed to increase the gastric residence time, thus prolonging the drug release in the stomach. Gastro retentive floating tablets of ambroxol hydrochloride were prepared by direct compression method using altered concentrations of HPMC K4, HPMC K15 and PVP K30 as polymers. Sodium bicarbonate and citric acid was used as gas releasing agent. The prepared tablets of ambroxol hydrochloride were evaluated for hardness, thickness, friability, weight variation, drug content uniformity, buoyancy lag time, total floating time, in-vitro dissolution study, etc. All the compositions were resulted in adequate Pharmacopoeial limits. Compatibility studies was execution during FTIR shown that there was absence of probable chem. interaction between pure drug and excipients. The varying concentration of gas generating agent and polymers was found to affect on in-vitro drug release and floating lag time. In vitro drug release of floating gastro retentive tablet of ambroxol hydrochloride shown that the formulation F6 was found to be the best formulation as it releases 99.87% in a controlled manner for an extended period of time (up to 12 h). The release data was fitted to various math. models such as Higuchi, Korsmeyer-Peppas, First order and Zero order to evaluate the kinetics and mechanism of the drug release. The optimized formulation (F6) showed no significant change in phys. parameters such as, hardness, friability, weight variation and %drug content for accelerated stability condition at 40±2°C temperature and 75±5% relative humidity for a period 3 mo. Prepared floating tablets of ambroxol hydrochloride may prove to be a potential candidate for safe and effective controlled drug delivery over an extended period of time for gastro retentive drug delivery system.

Journal of Drug Delivery and Therapeutics published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Park, Hyeonjung published the artcileDisintegrable n-Type Electroactive Terpolymers for High-Performance, Transient Organic Electronics, Category: alcohols-buliding-blocks, the publication is Advanced Functional Materials (2022), 32(2), 2106977, database is CAplus.

Degradable organic semiconductors have significant potential for transient and biomedical organic electronics, but there have been only a few studies on fully degradable conjugated polymers (CPs) that achieve high elec. performance. In addition, these examples are limited to p-type CPs. In this study, a series of fully degradable n-type CPs, naphthalene diimide (NDI)-based terpolymer (PNDIT2/IM-f) are developed. The incorporation of an imine linker (IM) into the CP backbone affords the capability of facile hydrolysis degradation while maintaining efficient π-conjugations and excellent elec. properties. An addnl. benefit of this mol. design is the systematic tunability of the degradation characteristics and elec. performance depending on the IM content (f_IM). At the optimal point (f_IM = 0.45) that enables complete degradation of the polymer under acidic conditions, the resulting PNDIT2/IM-0.45 film exhibits high electron mobility (μ_e) of 0.04 cm² V^-1 s^-1 in organic field-effect transistors (OFETs), demonstrating excellent potential as transient OFETs. The high μe value is mainly attributed to the enlarged edge-on orientations and tighter stacking of PNDIT2/IM-f crystallites as increasing f_IM. Thus, this study provides useful guidelines for the design of fully degradable n-type CPs and establishes an important correlation between the mol. structure-electronic performance-transient properties.

Advanced Functional Materials published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jayakrishnan, S. S. published the artcileDrug utilization pattern in paediatric peritonitis, Quality Control of 23828-92-4, the publication is World Journal of Pharmacy and Pharmaceutical Sciences (2020), 9(10), 2159-2174, database is CAplus.

Peritonitis is defined as inflammation of a portion or all of the parietal and visceral peritoneum. In peritonitis, an infection can rapidly spread into the blood (sepsis) and then to other organs, carrying the risk of multiple organ failure and if left untreated death will occur. The objective of the study was to determine the drug utilization pattern of peritonitis among paediatric population. It was a Descriptive study for a period o6 mo with 115 patients. All paediatric patients diagnosed clin. with peritonitis reporting to the Department of Paediatric Surgery for undergoing treatment. A written informed consent was taken in a prescribed format from the patient/caregiver diagnosed with peritonitis. Patient who met the inclusion criteria were enrolled for the study. All the information relevant to the study was collected from case records and direct interview with the patient / caregiver by the help of a physician. In the study, majority of patients (43.5%) were in the age group of 7-10 years and were males. The drugs were classified into 9 classes, depending on the therapeutic indications. Majority of patients were given drugs belonging to Antibiotics in class I (100%), followed by Antiulcers in class -IV (97.4%). Drugs belonging to class- VI Antiemetics (18.3%) were the least used in the study population. Other categories of drugs in the study population included class – II used as Analgesics and Antipyretics (93.9%), class – VIII as Vitamins (45.2%), class – IX i.e, Miscellaneous drugs (32.2%), class V as Laxatives (29.6%), class VII (27.8%) used as Antiasthmatics and Antispasmodics class III (26.1%). The study is concluded by the demog. and drug utilization pattern in paediatric peritonitis. Drug utilization evaluation played a key role in helping health care system to understand, interrupt and improve the prescribing, administration and use of medications.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Quality Control of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tang, Weihua published the artcileIncorporating Perylene Moiety into Poly(phenothiazine-co-bithiophene) Backbone for Higher Charge Transport, SDS of cas: 239075-02-6, the publication is Journal of Physical Chemistry B (2008), 112(12), 3590-3596, database is CAplus and MEDLINE.

Low band gap π-conjugated polymers composed of phenothiazine, bithiophene, and perylene moieties were prepared in high yields by palladium-catalyzed Suzuki coupling reaction. The polymers were characterized by NMR, gel permeation chromatog., and elemental anal. The characterizations revealed that high-mol. weight (weight-average mol. weight up to 42 400 g/mol) polymers were thermally stable with a decomposition temperature at 338-354° and glass transition temperature (T_g) 124-136°. All polymers demonstrated broad optical absorption in the region of 300-550 nm with efficient blue-green light emission. The absorption was broadened further (for ca. 50 nm) when the perylene moiety was incorporated. Cyclic voltammograms displayed that the p- and n-doping processes of all the polymers were partially reversible and that electrochem. band gaps were as low as -2.30 eV with the incorporation of a perylene moiety. The hole mobility of polymers was evaluated by using the space-charge-limited current model with a PLED device structure of ITO/PEDOT:PSS/polymer/Ca. The incorporation of perylene is beneficial for improving the hole mobility of the conjugated polymers.

Journal of Physical Chemistry B published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C8H7NaO4S, SDS of cas: 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ahmad, Sufiyan published the artcileQuality by design approach to develop stability indicating reversed-phase high-performance liquid chromatography method development for ambroxol, Quality Control of 23828-92-4, the publication is Asian Journal of Pharmaceutical and Clinical Research (2021), 14(12), 44-49, database is CAplus.

As per requisition of current regulatory requirements, simple, rapid and sensitive method by 33 factorial quality by design approach was established and validated for Ambroxol (AMB) by reversed-phase high-performance liquid chromatog. (RP-HPLC). A simple RP-HPLC method has been developed and validated with different parameters such as linearity, precision, repeatability, limit of detection (LOD), limit of quantitation (LOQ), accuracy as per International Conference for Harmonisation guidelines (Q2R1). Statistical data anal. was done for data obtained from different aliquots Runs on Agilent Tech. Gradient System with Auto injector, UV diode-array detection and Gradient Detector. Equipped with Reverse Phase (Agilent) C18 column (4.6 mm x 100 mm; 2.5μm), a 20μl injection loop and UV730D Absorbance detector at 244 nm wave length and running chemstation 10.1 software and drugs along with degradants were separated via Methanol: (0.1% orthophosphoric acid) Water (75:25) of pH 3 as mobile phase setting flow rate 0.7 mL/min at ambient temperature the retention time of AMB were found to be 4.85 min. The industrialized method was found linear over the concentration range of 10-50μg/mL for AMB while the LOD and LOQ of AMB was found to be 0.5174-0.2739μg/mL, anal. method that concluded. There are no interfering peaks underperformed degradation conditions. Therefore, a sensitive, robust, accurate, and stability indicating method was developed with high degree of practical utility.

Asian Journal of Pharmaceutical and Clinical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Quality Control of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ochowiak, M. published the artcileThe thermostated medical jet nebulizer: Aerosol characteristics, Quality Control of 23828-92-4, the publication is International Journal of Pharmaceutics (Amsterdam, Netherlands) (2019), 118475, database is CAplus and MEDLINE.

The sudden expansion of gas at the outlet of the jet (pneumatic) nebulizer significantly reduces the temperature of the solution, which may provoke bronchospasm, therefore it is recommended to use modern pneumatic inhalers equipped with a thermostat or a universal thermal attachment that allow to obtain a higher temperature aerosol, i.e. thermo-aerosol. The research was carried out for model Newtonian fluids. The droplet diameters of the aerosol spray were investigated using a Spraytec aerosol particle size measurement system. Anal. of the obtained results showed that the increase in solution viscosity caused a decrease in mean droplet diameters and prolonged nebulization time. The anal. of exptl. data made it possible to propose a correlation equation describing the mean diameter of the droplets depending on the properties of the liquid and the flow conditions in the thermostated medical nebulizer. The obtained data contributes to a better understanding of the complex liquid atomization process and can be helpful in the design of medical nebulizers and pharmaceutical preparations

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Quality Control of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chandra, S. published the artcileDevelopment of sustained release matrix tablet formulation and evaluation of ambroxol hydrochloride, Related Products of alcohols-buliding-blocks, the publication is World Journal of Pharmaceutical Research (2020), 9(3), 295-308, database is CAplus.

A review. Ambroxyl is a Mucolytic expectorant. Ambroxyl has short half life (3- 4hrs) makes the development of sustained release forms extremely advantageous, Ambroxyl is a weak acidic pka 4.5 – 6, it has pH dependent solubility, characterized in low pH condition present in stomach, Which consequently delayed in onset of action, Formulation of SR tablet is effective approach for mucolytic expectorant it gives maximum action with prolong drug concentration due to sustained release from tablet matrix. Different formulation (F1 – F7) designed with HPMC K100, HPMC 5CPS, Povidone K30, MCCP. pre and post -compression parameters for all formulation were studied. Batch F7 selected as optimized batch on the basis of dissolution profile.

World Journal of Pharmaceutical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shahar, Or David published the artcileA high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair, Product Details of C28H29NO4, the publication is Nucleic Acids Research (2014), 42(9), 5689-5701, database is CAplus and MEDLINE.

DNA double-strand breaks (DSBs) are the most severe type of DNA damage. DSBs are repaired by non-homologous end-joining or homol. directed repair (HDR). Identifying novel small mols. that affect HDR is of great importance both for research use and therapy. Mols. that elevate HDR may improve gene targeting, whereas inhibiting mols. can be used for chemotherapy, since some of the cancers are more sensitive to repair impairment. Here, the authors performed a high-throughput chem. screen for FDA approved drugs, which affect HDR in cancer cells. The authors found that HDR frequencies are increased by retinoic acid and Idoxuridine and reduced by the antihypertensive drug Spironolactone. The authors further revealed that Spironolactone impairs Rad51 foci formation, sensitizes cancer cells to DNA damaging agents, to Poly (ADP-ribose) polymerase (PARP) inhibitors and crosslinking agents and inhibits tumor growth in xenografts, in mice. This study suggests Spironolactone as a new candidate for chemotherapy.

Nucleic Acids Research published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C7H7IN2O, Product Details of C28H29NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Xufeng published the artcileEfficacy and safety of ambroxol hydrochloride in the treatment of secretory otitis media: a systematic review and meta-analysis, COA of Formula: C13H19Br2ClN2O, the publication is Annals of Translational Medicine (2022), 10(3), 142, database is CAplus and MEDLINE.

Secretory otitis media is a very common nonsuppurative inflammatory disease in otorhinolaryngol. Ambroxol hydrochloride helps to improve ciliary movement in the ear canal and promote the dissolution and discharge of secretions. However, its effect still lacks systematic evaluation. We conducted a meta-anal. of clin. studies to systematically evaluate the application effect of ambroxol hydrochloride. A computer-based search of the Chinese Biomedical Database (CBM), China National Knowledge Infrastructure (CNKI), PubMed, and Web of Science databases was conducted using the keywords “Ambroxol hydrochloride” & “secretory otitis media”. Randomized controlled trials published after 2015 were selected and then screened and analyzed using RevMan 5.4 software. Ten studies involving a total of 998 patients were included. Meta-anal. showed that adding ambroxol hydrochloride to the original glucocorticoid treatment improved therapeutic efficacy [odds ratio (OR) = 4.95, 95% confidence interval (CI): 3.27, 7.50, P<0.00001], reduced tympanic pressure after treatment [mean difference (MD) = -19.04, 95% CI: -22.72, -15.36, P<0.00001], and increased the pure tone threshold (MD =6.37, 95% CI: 5.36, 7.37, P<0.00001), without increasing adverse reactions (OR = 0.51, 95% CI: 0.14, 1.85, P=0.30). On the basis of the original treatment of secretory otitis media, adding ambroxol hydrochloride treatment improved the therapeutic effect, reduced tympanic pressure after treatment, and improved the pure tone threshold (hearing), without increasing adverse reactions.

Annals of Translational Medicine published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C25H23NO4, COA of Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patel, Gopi published the artcileSimultaneous Estimation of azithromycin and ambroxol hydrochloride in combined dosage form by RP-HPLC method, Formula: C13H19Br2ClN2O, the publication is Journal of Chemical and Pharmaceutical Research (2018), 10(5), 142-147, database is CAplus.

A simple, accurate and precise RP-HPLC method was developed and subsequently validated for simultaneous determination of Azithromycin and Ambroxol Hydrochloride in combined dosage form. The Proposed HPLC method utilizes C18 (250 mm × 4.6 mm × 5 μm) column with mobile phase comprising of KH2PO4 (pH 5.0 adjusted with 1% Orthophosphoric acid: Methanol (60:40% volume/volume) at a flow rate of 1.0 mL/min. Selection of wavelength for determination of Azithromycin (50 μg/mL) and Ambroxol Hydrochloride (15 μg/mL) show reasonably good response at 215 nm. Quantitation was achieved based on peak area with linear calibration curves at concentration ranges 25 – 75 μg/mL for Azithromycin and 7.5 – 22.5 μg/mL for Ambroxol Hydrochloride with Correlation Coefficient of 0.999.The Retention times of Azithromycin and Ambroxol Hydrochloride were found to be 6.73 min and 4.17 min resp. The limit of detection (LOD) was 0.36 and 0.18 for Azithromycin and Ambroxol Hydrochloride resp. The limit of quantification (LOQ) was 1.09 and 0.56 for Azithromycin and Ambroxol Hydrochloride resp. The accuracy was found within the limit. The precision (inter – day, intra – day and repeatability) was found within the limit. The method was validated as per ICH guideline. The method can be successfully employed for simultaneous estimation of Azithromycin and Ambroxol Hydrochloride in combined dosage form.

Journal of Chemical and Pharmaceutical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts