Tag: M.W=300-400

Reference of 23377-40-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol, molecular formula is C19H40O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of adefovir (1.36 g, 5 mmol) and 3-hexadecyloxy-l-propanol (1.8 g, 6 nunol) in dry pyridine was added DCC (2.06 g, 10 mmol). The mixture was heated to reflux and stirred 18 h then cooled and filtered. The filtrate was concentrated under reduced pressure and the residue was applied to a short column of silica gel. Elution of the column with 9:1 dichloromethane/methanol yielded hexadecyloxypropyl-adefovir (HDP-ADV) as a white powder.

According to the analysis of related databases, 23377-40-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHIMERIX, INC.; WO2006/110656; (2006); A2;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol

(3) In a 4-liter reactor equipped with electromagnetic stirring, a rectification column, a thermometer, a constant pressure dropping funnel, a separator, a condenser, etc., 2500 g of an intermediate product obtained by (2) (6.05 mol of a fluorine-containing alcohol) is added. 20 g of p-toluenesulfonic acid and 13 g of hydroquinone. StirThe temperature was raised to 90 C, and 413 g (5.74 mol) of acrylic acid was added dropwise thereto for 2 hours.At the end of the reaction, no significant water droplets were produced after 5 hours of continuous reaction.The fluorine-containing olefin and the unreacted fluoroalcohol are distilled off.Refining 2133 g of perfluorohexylethyl acrylate, the purity is 99.02%,The yield was 88.8%.

With the rapid development of chemical substances, we look forward to future research findings about 647-42-7.

Reference:
Patent; Jinan Qifu New Materials Co., Ltd.; Shandong Chemical Institute; Li Haijing; Zhang Liting; (6 pag.)CN108911983; (2018); A;,
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Electric Literature of 647-42-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, molecular weight is 364.1, as common compound, the synthetic route is as follows.

Toluene (2 L), 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctane-1-ol (2.18 kg, 6.0 mol), 2-methyl-2-propenic acid (methacrylic acid) (567 g, 6.6 mol) and 1,4-dihydroxybenzene (hydroquinone) (6.59 g, 60 mmol) were added and then p-toluenesulfonic acid monohydrate (148.06 g, 0.78 mol) was added thereto. The obtained solution was heated and subjected to reflux dehydration at 115 C. for 5 hours. After reflux dehydration, the obtained reaction solution was cooled to around room temperature and added with triethylamine (151.5 g, 1.50 mol) was added thereto, stirred for 0.5 hours and then added with 150 g of silica gel. After stirring for 0.5 hours, the silica gel was filtered off and the obtained filtrate was added with 1,4-dihydroxybenzene (hydroquinone) (1.32 g, 12.0 mmol), and the solvent was removed in vacuum distillation and then was purified in distillation to obtain 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctane 2-methyl-2-propenic acid ester (2.44 kg, 94%).

The chemical industry reduces the impact on the environment during synthesis 647-42-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; WAKO PURE CHEMICAL INDUSTRIES, LTD.; US2010/324314; (2010); A1;,
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Synthetic Route of 23377-40-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol, molecular formula is C19H40O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

l-O-Hexadecyl^-deoxy-S-O-iS’^’-O-diacetyl^’-N-phthalimido-S’-azido-Z e’- dideoxy- -D-glucopyranosyl)-sn-glycerol (35)Compound 30 (0.4 mmol) and the previously reported lipid compound 34 (168 mg, 0.48mmol) were dissolved in anhydrous DCM (10 ml) under argon atmosphere. NIS (180 mg, 0.8 mmol) and silver triflate (20 mg, 0.08 mmol) were added. The reaction mixture was left under vigorous stirring for 3 hrs. At the completion of reaction (TLC monitoring), the reaction mixture was diluted by DCM (20 ml) and then filtered over Celite. The resulting organic layer was washed with saturated sodium thiosulphate solution (2 times), saturated sodium bicarbonate (3 times) and water (2 times). The organic layer was then dried over anhydrous Na2S04 and then concentrated under vacuum to give a brownish gel residue. The residue was then purified by flash chromatography (Hexane/Ethyl acetate, 4:6) to give compound 35 as a white solid. Yield 51%. (0265) 1H NMR (300 MHz, Chloroform-d) delta = 7.85 (dd, J=5.5, 3.1 , 2H, phthalimido aromatic protons), 7.73 (dd, J=5.5, 3.1 , 2H, phthalimido aromatic protons), 5.79 (dd, J=10.8, 9.0, 1 H, H-3), 5.38 (d, J=8.5, 1 H, H-1), 5.05 (dd, J=10.1 , 9.0, 1 H, H-4), 4.30 (dd, J=10.8, 8.5, H, H-2), 3.96 – 3.81 (m, 2H), 3.63 – 3.52 (m, 1 H), 3.43 (dt, J-13.6, 6.9, 1 H), 3.28 – 3.16 (m, 3H), 3.15 – 2.99 (m, 2H), 2.03 (s, 3H, Acetate CH3), 1.85 (s, 3H, Acetate CH3), 1.76 – 1.58 (m, 2H), 1.26 (s, 26H, Lipid tail), 0.89 (t, J = 6.6 Hz, 3H, lipid terminal -CH3).13C NMR (75 MHz, CDC13) delta = 170.12, 169.62, 134.27, 123.57, 97.99, 73.60, 71.82, 71.00, 70.53, 70.37, 67.04, 66.96, 54.68, 51.24, 31.91 , 29.73, 29.68, 29.59, 29.48, 29.34, 26.07, 22.67, 14.10.ES-MS: calcd: m/z: 723.4, found [M+Na]+ m/z: 723.5.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 23377-40-4, 3-(Hexadecyloxy)propan-1-ol.

Reference:
Patent; THE UNIVERSITY OF MANITOBA; OGUNSINA, Makanjuola; SAMADDER, Pranati; SCHWEIZER, Frank; ARTHUR, Gilbert; IDOWU, Temilolu; (119 pag.)WO2015/179983; (2015); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol. A new synthetic method of this compound is introduced below., Safety of 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol

To a solution of the perfluoroalkyl alcohol (10 mmol) in 10 mLof dry THF, was added sodium hydride (60% 1.4 equiv. dissolved in 2 mL of dry THF in oil) at 0 C under nitrogen atmosphere. The mixture was stirred for 30 min. Then 1.35 g (10 mmol) of henylisothiocyanate was added. The reaction mixture was allowed to warm to room temperature and stirred for 3 h. The mixture was quenched with saturated aqueous ammonium chloride. The aqueous layer was washed with diethyl ether and the combined organic layers were dried over Na2SO4. The solvent was removed by vacuum evaporation and the crude products were purified with column chromatography on silica gel (70-230 meshes) using petroleum ether/diethyl ether (8:2) as eluent or recrystallized in cyclohexane to give the corresponding O-perfluoroalkyl thiocarbamate.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol.

Reference:
Article; Chniti, Ines; Sanhoury; Chehidi; Journal of Fluorine Chemistry; vol. 156; (2013); p. 101 – 105;,
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Electric Literature of 647-42-7, Adding some certain compound to certain chemical reactions, such as: 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol,molecular formula is C8H5F13O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 647-42-7.

To a mixture of 2-(perfluorohexyl)ethanol (33.3 g, 46 mmol) and succinic anhydride (9.7 g, 49 mmol) and 10ml tetrahydrofuranand stirred at 100C And allowed to react for 60 minutes.Thereafter, the mixture was cooled to 30 DEG C, 100 mL of water was added, and the mixture was further cooled to 15 DEG C, and the precipitated crystals were collected by filtration to obtain carboxylic acid (1-2a). (39.7 g, 94%).

According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Fuji Photo Film Co., Ltd.; Kato, Syunya; Yoshikawa, Masaru; (58 pag.)KR101634475; (2016); B1;,
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Application of 647-42-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A succinic anhydride (9.7 g, 49 mmol), tetrahydrofuran (10 ml), and triethylamine (0.2 mL) were added to 2-(perfluorohexyl)ethanol (33.3 g, 46 mmol). A reaction was allowed for 60 min at an increased temperature of 100C while stirring the mixture. Water (100 mL) was added after cooling the mixture to 30C, and the precipitated crystals formed upon further cooling to 15C were filtered off to obtain carboxylic acid (5a; 39.7 g, 94%).

According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FUJIFILM Corporation; MIZUMURA Masatoshi; KATOH Shunya; UEMURA Minoru; ISHIWATAYasuhiro; YOSHIKAWA Masaru; MATSUYAMA Hiroshi; EP2738155; (2014); A1;,
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Application of 23377-40-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol, molecular formula is C19H40O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A suspension of 3-hexadecyloxypropan-1-ol (2.02 g, 6.72 mmol) and DIPEA (4.7 mL, 26.9mmol) in anhydrous methylene chloride (45 mL) was treated dropwise over a 10 minute period with 3-((chloro(diisopropylamino)phosphino)oxy)propanenitrile (3 mL, 13.45 mmol). After 18hours at room temperature, the mixture was quenched with saturated sodium bicarbonate solution (15 mL) and extracted with ethyl acetate (2 x 100 mL). Combined organic phases were concentrated to dryness, and the resulting crude residue purified by chromatography over silica gel (25 mm x 140 mm) using a solvent gradient from 10 to 20% ethyl acetate in hexanes to give hexadecyloxypropyl-(2-cyanoethyl) diisopropylphosphoramidite (2.1 g, 65%) as a white solid. 1H NMR (400 MHz, Chloroform-d) delta 3.89 – 3.54 (m, 6H), 3.49 (t, J= 6.3 Hz, 2H), 3.39 (t, J= 6.7 Hz, 2H), 2.64 (t, J= 6.6 Hz, 2H), 1.87 (p, J = 6.3 Hz, 2H), 1.57 (p, J= 6.3 Hz, 2H), 1.25 (s, 26H), 1.18 (dd, J = 6.8, 3.5 Hz, 12H), 0.87 (t, J= 6.6 Hz, 3H). 31P NMR (162 MHz,Chloroform-d) delta 147.40.

According to the analysis of related databases, 23377-40-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; EMORY UNIVERSITY; PAINTER, George; BLUEMLING, Gregory R.; DE LA ROSA, Abel; LIOTTA, Dennis C.; (124 pag.)WO2017/106710; (2017); A1;,
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Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 135261-74-4, Name is 1-(Dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-ol hydrochloride, molecular formula is C20H28ClNO3, belongs to alcohols-buliding-blocks compound. In a document, author is Fajin, Jose L. C., introduce the new discover, Product Details of 135261-74-4.

Light alcohols reforming towards renewable hydrogen production on multicomponent catalysts

Fuel cells (FC) produce electricity in a continuous mode through a catalytic reaction and have many possible applications, as for example, in the transportation sector substituting the combustion engines. These devices can be regarded as a free emission technology if the fuel used in them is obtained in a renewable mode, such as hydrogen from the reforming of light alcohols obtained from biomass fermentation or gasification. In fact, proton exchange membrane fuel cells (PEMFC) use hydrogen as fuel that, in turn, has to be free of carbon monoxide (CO) since the later chemical species poisons the platinum based catalyst applied in the electrochemical process. This review aims at clarifying how multicomponent catalysts can be used in the hydrogen production from light alcohols reforming to overcome the limitations of current catalysts. Specifically, their low thermal stability, the CO formation that is not suitable for FC use, the carbon (coke) production that poisons the reforming catalyst, or byproducts (i.e. CH4) generation that reduces the hydrogen amount produced. Special emphasis is paid to the applicability of theoretical methods for the study and development of improved multicomponent catalysts for light alcohols reforming.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 135261-74-4. Product Details of 135261-74-4.

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 135261-74-4, Name is 1-(Dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-ol hydrochloride, molecular formula is C20H28ClNO3. In an article, author is Shekarsaraee, S.,once mentioned of 135261-74-4, Safety of 1-(Dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-ol hydrochloride.

Measurement, Correlation and Prediction of LLE Data for the Ternary System Water

In this study, tie-line points and solubility data were experimentally measured for the ternary mixture (water + lactic acid + diethyl ether) at T = 293.2 K and atmospheric pressure. UNIFAC calculations predicted that lactic acid and diethyl ether do not form an azeotrope. The mass fractions of organic and aqueous layers were determined by acid-base and the Karl Fisher titrations. Cloud point method verified that the LLE behavior of the studied system is Type-1. The reliability of the tie-line points was demonstrated by the Othmer-Tobias and Hand plots. Thermodynamic correlation of tie-line data was done by NRTL model and the obtained binary interaction parameters were tested after validation. The experimental and correlated data had very good accordance (rmsd = 0.88%). Extraction quality of diethyl ether was investigated using the calculation of distribution coefficients and separation factors over the immiscibility area. Separation factors decreased from 1.93 to 1.13 when aqueous mass fraction of lactic acid increased from 0.070 to 0.305. However, distribution coefficient increased from 0.07 to 0.12 in the same region. The study shows that the extraction of lactic acid is possible in all investigated feeds at 293.2 K.

Interested yet? Keep reading other articles of 135261-74-4, you can contact me at any time and look forward to more communication. Safety of 1-(Dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-ol hydrochloride.

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