Tag: M.W=300-400

Related Products of 647-42-7 , The common heterocyclic compound, 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a stirred solution of the corresponding thiazoline 4a-c (2.0 mmol) in dry CH2Cl2 (8 mL) under N2 atmosphere at room temperature, were added subsequently the corresponding alcohol (2.0 mmol) EDCI (2.0 mmol) and catalytic amount of DMAP. After 16 h, the organic phase was transferred to an extraction funnel, washed with saturated NaHCO3 (2 × 10 mL), water (2 × 10 mL) and the organic layer was dried with Na2SO4. The solvent was evaporated and the remaining product was purified by chromatography (hexanes/AcOEt = 80:20).

The synthetic route of 647-42-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Schneider, Juliana M. F. M.; Sales, Eric S.; Livotto, Paolo R.; Schneider, Paulo H.; Merlo, Aloir A.; Journal of the Brazilian Chemical Society; vol. 25; 8; (2014); p. 1493 – 1503;,
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Electric Literature of 23377-40-4, Adding some certain compound to certain chemical reactions, such as: 23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol,molecular formula is C19H40O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23377-40-4.

Compound 2 (658 mg, 1.74 mmol) was added to the reaction flask.Add 10 ml of anhydrous dichloromethane to dissolve.Nitrogen protection drops to 0 C,Compound 1 (631 mg, 2.1 mmol) was slowly added dropwiseAnd pyridine (826 mg, 10.44 mmol)Anhydrous dichloromethane solution.After the addition, the reaction was carried out at a low temperature for 10 minutes, and then the reaction was continued to room temperature for 2 hours.MS monitors the reaction,The reaction was quenched by the addition of 1 M diluted hydrochloric acid (10 mL).Stir at room temperature overnight,After MS monitors the reaction, the organic phase is separated.The aqueous phase was extracted 2-3 times with dichloromethane.Combine the organic phase,Washed with saturated saline,Concentration and purification by silica gel column chromatography gave 815.3 g of product, yield: 82.3%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 23377-40-4, 3-(Hexadecyloxy)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Zhao Jiuyang; (46 pag.)CN109485676; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 59101-28-9, 16-Bromohexadecan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C16H33BrO, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C16H33BrO

11.1 Diethyl 2-[(tert-butoxycarbonyl)amino] -2-(1 6-hydroxyhexadecyl)malonate10461] Diethyl 2-(tert-butoxycarbonyl)amidomalonate 2 (1.18 g, 3.80 mmol, purity: 89% (GC), 1.1 eq.) obtained as in example 1.2, bromide 15 (1.11 g, 3.40 mmol) obtained as in example 4.2 and caesium carbonate (2.35 g, 7.20 mmol, 2.1 eq.) were suspended in acetonitrile (20 mE) and heated to reflux for 6 h. After cooling to tt. the mixture was adsorbed on silica gel (3 g) and the product was purified by column chromatography (21 x3 cm, cyclohexane/ethyl acetate, 4:1 – 100% ethyl acetate) and isolated as white solid. Yield:577 mg (33%).10462] M.p. 450 C.10463] ?H-NMR (300 MHz, CDC13) oe [ppm]: 1.22-1.32(m, 30H, 6-CR2 to 17-CR2, 21-CR3, 23-CR3), 1.43 (s, 9R,26-CR3, 27-CR3, 28-CR3), 1.49-1.60 (m, 4R, 5-CR2,18-CR2), 1.95 (brs, 1R, 19-OR), 2.25 (m, 2H, 4-CR2), 3.63(t, 3JHH=6.7 Hz, 2H, 19-CR2), 4.23 (m, 4H, 20-CR2,22-CR2), 5.95 (br s, 1R, 2-NH).10464] ?3C-NMR (75 MHz, CDC13) oe [ppm]: 14.1 (q, C-2 1,C-23), 23.3 (t, C-5), 25.8 (t, C-17), 28.3 (q, C-26, C-27,C-28), 29.3, 29.5, 29.7 (t, C-6 to C-16, C-18), 32.8 (t, C-4),62.3 (t, C-20, C-22), 63.0 (t, C-19), 66.6 (s, C-2), 80.1 (s,C-25), 153.8 (s, C-24), 168.4 (s, C-i, C-3).10465] Exact Mass (ESI): C28R53NO7+R: calcd. 516.3895, found 516.3879; C28R53NO7+Na: calcd. 538.3714,found 538.3713.

The synthetic route of 59101-28-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER; Haufe, Guenter; Levkau, Bodo; Schaefers, Michael; Schilson, Stefani Silke; Keul, Petra; US2014/170067; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, molecular weight is 364.1, as common compound, the synthetic route is as follows.HPLC of Formula: C8H5F13O

Weigh 2.2 g of succinic anhydride in a 250 ml dry anhydrous three-necked flask.After filling with nitrogen for 10 min, the air in the flask and a small amount of water in the reaction system were replaced.80 ml of anhydrous ethylene glycol dimethyl ether was added to the reaction system.After pyridine 0.15ml, the temperature was raised to 75 C, 7.28 g of trifluoro-n-octanol and 40 ml of ethylene glycol dimethyl ether were gradually added dropwise to the reaction system, and the addition process was carried out to ensure that the temperature of the reaction system was controlled at 65-75 C, and the addition was completed. Rear,The reaction was maintained at 75 C for 18 h, and the reaction was stopped after 18 h.After the reaction, a certain amount of saturated NaHCO3 was added to the reaction system, and the succinic acid monoester acid was converted into a sodium salt dissolved in water. Then, a certain amount of ethyl acetate is poured into the reaction system, and unreacted fluoroalcohol, succinic anhydride and the reaction to form a succinic acid diester are dissolved in the organic phase, and the monoester acid is dissolved in the aqueous phase, and the aqueous phase is separated.The obtained aqueous phase is placed in an ice water bath, acidified with concentrated hydrochloric acid, and extracted with a certain amount of ethyl acetate, and the extract is dried with a certain amount of anhydrous magnesium sulfate.Distillation under reduced pressure gave a purer succinic acid monoester acid. The synthetic route is as follows:

At the same time, in my other blogs, there are other synthetic methods of this type of compound,647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Han Tuo Optical Materials Co., Ltd.; Fu Zhiwei; Song Hongbo; Dai Junyan; Ran Ruicheng; Mao Guoping; (23 pag.)CN108997182; (2018); A;,
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Reference of 10535-17-8 , The common heterocyclic compound, 10535-17-8, name is 1-(3,4-Dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol, molecular formula is C18H22O6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The reaction was carried out in a glove box, and lignin dimer 3 (0.1 mmol, 33.4 mg) and photocatalyst lanthanum triflate (5 mol%) were weighed.Auxiliary tetrabutylammonium chloride (5mol%),Nitrogen source di-tert-butyl azodicarboxylate (1 mmol) and 2.0 mL of pyridine were placed in a 10 ml pressure-resistant tube.The reaction pressure tube is sealed and placed under a purple lamp at 380 nm.After stirring for 24 hours, after the lignin dimer 3 is completely converted,After separation by silica gel column chromatography (ethyl acetate: petroleum ether = 1:5, volume ratio), product 3,4-dimethoxybenzaldehyde (13.4 mg, yield 81%)And 1-[1-(2-methoxy)phenoxyethanol]-1,2-dicarboxylic acid diisopropyl ester-oxime(3) (28.3 mg, yield 71%).

The synthetic route of 10535-17-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jilin University; Zhang Yuetao; He Jianghua; Wang Yinling; (11 pag.)CN110156581; (2019); A;,
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Reference of 647-42-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctane-1-ol (20 g,55 mmol) and triphenylphosphine (15.7 g, 60 mmol) were dissolved in 110 ml of anhydrous acetonitrile and deoxygenated with argon. The mixture was heated at 60 C and bromine (9.6 g,60 mmol) was added dropwise. The mixture was stirred for 5 h at this temperature. After cooling down to room temperature, the reaction mixture was extracted with diethyl ether and the ether layers were washed with brine. After drying with Na2SO4, the ether was evaporated and the crude product was dissolved in 100 ml of dichloromethane. This solution was stirred with 50 g of silica gel for 2 h and then filtered and evaporated. The crude product was distilled at reduced pressure.

According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Luka?, Milo?; Garajova, Maria; Mrva, Martin; Devinsky, Ferdinand; Ondriska, Franti?ek; Kubincova, Janka; Journal of Fluorine Chemistry; vol. 164; (2014); p. 10 – 17;,
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Adding a certain compound to certain chemical reactions, such as: 23377-40-4, 3-(Hexadecyloxy)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 23377-40-4, blongs to alcohols-buliding-blocks compound. SDS of cas: 23377-40-4

Oxalylchloride (2.04 mL, 3 eq., 23.8 mmol) was added to a solution of dimethyl allylphosphonate (1 .19 g, 1 eq., 7.9 mmol) in dichloromethane (35 mL). This mixture was gently refluxed during 3 days at 45C. After evaporation of all volatiles, the crude compound was diluted in 35 mL of dichloromethane. Hexadecyloxypropyl alcohol (2.5 g, 1 .05 eq., 8.3mmol) and freshly distilled triethylamine (1 .6 mL, 1 .5 eq., 20 mmol) were then added subsequently and the resulting solution was refluxed during 3 days at 45C. The volatiles were removed under reduced pressure, and the residue was purified by flash column chromatography (eluting PE/EtOAc 9:1 – 6:4 – 0:1 ) to afford 209 as a white amorphous solid. (2.52 g, 76%) 1H NMR (400 MHz, CDCI3) d 5.75 (m, 1 H, CH=CH2), 5.23 (m, 2H, CH2-CH=CH2), 4.13 (dt, J = 6.5, 1 .7 Hz, 2H, He), 3.73 (d, J = 10.9 Hz, 3H, 0-CH3), 3.48 (t, J = 6.2 Hz, 2H, Ha), 3.38 (t, J = 6.7 Hz, 2H, CH2-0), 2.62 (ddt, J = 22.0, 7.4, 1 .1 Hz, 2H, CH2-P), 1 .91 (p, J = 6.3Hz, 2H, CH2-b), 1 .54 (p, J = 6.9 Hz, 2H, CH2-CH2-0), 1 .32-1 .22 (m, 26H, CH2), 0.87 (t, J= 6.8 Hz, 3H, CH3). 31P NMR (162 MHz, CDC ) d 28.3. CAS: 1258789-65- 9

At the same time, in my other blogs, there are other synthetic methods of this type of compound,23377-40-4, 3-(Hexadecyloxy)propan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE D’ORLEANS; NEOVIRTECH; AGROFOGLIO, Luigi; ROY, Vincent; DE SCHUTTER, Coralie; BESSIERES, Maxime; GALLARDO, Franck; (93 pag.)WO2019/206907; (2019); A1;,
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Synthetic Route of 647-42-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

C6F13-CH2CH2-O-CH2CH=CH2197.11g (488mmol) was dropped in 2 hours. It agitated at 110 degrees C after the end of dropping for 2 hours. Then, it lowered to 70 degrees C. NaOH solution 25.07g was added 0.1%, and it stirred for 2 hours. drying in 60 degrees C / 5KPa — after the end of drying, and the temperature — cull — bora — fin 3(made in Japanese Emba Illo Kem Carzou)2.51g was added, and it stirred for 2 hours. It filtered with the 0.1micrometer PTFE membrane filter, steam distillation of the filtrate was carried out using 100 degrees C / 5KPa, and the water 62.5g, and 206.3 g of object compounds (compound B1) were obtained (89% of yield).

According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KAO CORPORATION; WATARAI, ETSUKO; IGARASHI, TAKANORI; YAGO, YUKO; UEHARA, KOICHI; (20 pag.)JP2017/25048; (2017); A;,
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Application of 23377-40-4, Adding some certain compound to certain chemical reactions, such as: 23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol,molecular formula is C19H40O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23377-40-4.

General procedure: 4.1. General method A Bis isopropyl phosphonoethoxyethylchloride (1) (2.58 g,10.0 mmol) or bis isopropyl phosphonomethyltosylate (7) (3.50 g,10.0 mmol) in anhydrous acetonitrile (130 ml) was treated withbromotrimethylsilane (13 ml) overnight at room temperature.The mixture was then evaporated and codistilled with acetonitrile (3×25 mL), water (2×25 ml), ethanol (25 mL) and toluene (3 x 25 mL). The syrupy residue was dissolved in dichloromethane (50 ml) then DMF (0.1 ml) and oxalyl chloride (6.0 ml, 68.8 mmol) were added. The solution was gently refluxed (2 h), evaporated to dryness, and redissolved in dichloromethane (20 ml). The solution was cooled down to 0 C and treated slowly with pyridine (1.6 ml).The mixture was added to a cooled ( 30 C) solution of hexadecyloxypropanol (6.01 g, 20 mmol) in dichloromethane (100 ml) and triethylamine (8.7 ml). The mixture was allowed to reach 0C and kept at this temperature for3 h.The reactionmixturewas evaporated,codistilled with toluene (3 50 ml) and the residue was chromatographed on a silica gel column (400 g) in EtOAc/hexane (1:2/1:1). 4.1.1. Bis(hexadecyloxypropyl)phosphonoethoxyethylchloride (2) Yield 6.50 g of syrup (88%). The crude product was used without further purification procedures. ESI-MS, m/z: 753.6 (53) [M th H]th, 775.6 (100) [M th Na]th, 791.5 (22) [M th K]th, 812.7 (28); ESI-HRMS calcd for C42H87O6ClP 753.59233, found: 753.59185 [M th H]th.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 23377-40-4, 3-(Hexadecyloxy)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tichy, Tomas; Dracinsky, Martin; Krecmerova, Marcela; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 307 – 314,8;; ; Article; Tichy, Tomas; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; Dracinsky, Martin; Krecmerova, Marcela; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 307 – 314;,
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Electric Literature of 23377-40-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol, molecular formula is C19H40O2, molecular weight is 300.52, as common compound, the synthetic route is as follows.

To a tetrahydrofuran (THF) (1 mL/mmol) solution of l,3-bis(cyclcohexyl) imidazolium tetrafluoroborate (ICyHBF4) salt (0.05 eq.) and molecular sieves (0.5g/mmol), under argon, is added tBuOK (0.9 eq.) and stirred for 10 min. Lipophilic alcohol (1 eq.) and dialkyl H-phosphonate (2 eq.) are added and the reaction stirred at room temperature for 24h. The reaction is quenched with a saturated solution of ammonium chloride (5 mL/mmol) and filtrate on celite. Ethylacetate (AcOEt) (10 mL/mmol) is added to the solution then the organic and aqueous layers are separated. Aqueous phase is then extracted with AcOEt (10 mL/mmol) and the combinated organic layers are evaporated under vaccum. The corresponding alkyl/lipophilic chain H-phosphonate is finally purified by chromatography on silica gel.Example 2 : Synthesis of Bn/HDP H-phosphonateCompound 1 is synthesized according to procedure 1.4. from dibenzylphosphite as reported by the scheme 1. Scheme 11H NMR (400 MHz, CDCl3) delta = 7.74 (s, 0.5H, H-P), 7.41-7.33 (m, 5H, HA1), 5.99 (s, 0.5H, H-P), 5.11 (d, J = 9.5 Hz, 3H, OCH3), 4.20-4.07 (m, 2Eta, P-O-CH2-CH2-CH2-O), 3.46 (t, J = 6.1Hz, 2H, P-O-CH2-CH2-CH2-O), 3.37 (t, J = 6.7 Hz, 2H, 0-CH2-CH2-(CH2)I3-CH3), 1.90 ( p, J = 6.2 Hz, 2H, P-O-CH2-CH2-CH2-O), 1.53 (p, J = 6.9 Hz, 2H, 0-CH2-CH2-(CH2) ?- CH3), 1.35-1.19 (m, 26H, 0-CH2-CH2-(CH2)^-CH3), 0.87 (t, J = 6.4 Hz, 3H, 0-CH2-CH2- 13C NMR (100 MHz, CDCl3) delta = 136.6, 128.7, 128.6, 127.9, 126.9 (CA1), 71.2 (0-CH2-CH2- (CH2)I3-CH3), 67.2 (2C, CH2-Ph), 66.3 (P-O-CH2-CH2-CH2-O), 63.1, 63.0 (P-O-CH2-CH2- CH2-O), 31.9, 30.6 (2C), 29.7, 29.6 (2C), 29.5, 29.3, 26.1, 22.7 (CH2-P, P-O-CH2-CH2-CH2- O, 0-CH2-CH2-(CH2)^-CH3), 14.1 (O-CH2-CH2-(CH2)13-CH3).3 ’11P NMR (162 MHz, CDCl3): delta = 10.05.

The chemical industry reduces the impact on the environment during synthesis 23377-40-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE D’ORLEANS; AGROFOGLIO, Luigi A.; ROY, Vincent; PRADERE, Ugo; WO2010/146127; (2010); A1;,
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