Tag: M.W=300-400

HPLC of Formula: 12080-32-9. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Platinum(II) Complexes of Tridentate N N- N -Coordinating Ligands Based on Imides, Amides, and Hydrazides: Synthesis and Luminescence Properties. Author is Puttock, Emma V.; Sturala, Jiri; Kistemaker, Jos C. M.; Williams, J. A. Gareth.

Five Pt(II) complexes are described in which the metal ion is bound to anionic N N N-coordinating ligands. The central, deprotonated N atom is derived from an imide Ar-C(:O)-NH-C(:O)-Ar {PtL1-2Cl; Ar = pyridine or pyrimidine}, an amide py-C(:O)-NH-CH2-py {PtL3Cl}, or a hydrazide py-C(:O)-NH-N:CH-py {PtL4Cl}. The imide complexes PtL1-2Cl show no significant emission in solution but are modestly bright green/yellow phosphors in the solid state. PtL3Cl is weakly phosphorescent. PtL4Cl is formed as a mixture of isomers, bound through either the amido or imino nitrogen, the latter converting to the former upon absorption of light. Remarkably, the imino form displays fluorescence in solution, λ0,0=535 nm, whereas the amido shows phosphorescence, λ0,0=624 nm, τ=440 ns. It is highly unusual for two isomeric compounds to display emission from states of different spin multiplicity. The amido-bound PtL4Cl can act as a bidentate O N-coordinating ligand, demonstrated by the formation of bimetallic complexes with iridium(III) or ruthenium(II).

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Name: Dichloro(1,5-cyclooctadiene)platinum(II). The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Platinum(II) complexes containing hydrazide-based aminophosphine ligands: Synthesis, molecular structures, computational investigation and evaluation as antitumour agents. Author is Gholivand, Khodayar; Maghsoud, Yazdan; Kahnouji, Mohammad; Hosseini, Mahdieh; Satari, Mohammad; Abdolmaleki, Parviz; Roe, Stephen Mark.

Four new N,N-bis(diphenylphosphino)amine ligands (amine = 1-amino-4-methylpiperazine (L1), N-aminophthalimide (L2), 4-aminomorpholine (L3) and hydrazine dihydrochloride (L4)) and their Pt(II) complexes C1, C2, C3 and C4 were synthesized and characterized using IR and NMR spectroscopies. The crystal structures of C1, C2 and C3 were determined using single-crystal x-ray diffraction techniques. The antitumor activities of the synthesized complexes determined using MTT assay on MDA-MB-231 cell line revealed that the studied complexes, especially C2, significantly suppressed the proliferation of these cancer cells in a dose- and time-dependent manner (e.g. at a complex concentration of 100 μg ml-1, in 24 h, the reduction of the cell viability was 88.00, 38.89, 83.35 and 64.28% for C1-C4, resp.). Theor. approaches were also used to investigate the energy and the nature of metal-ligand and metal-chlorine interactions in the complexes, which could explain their biol. activities. The interaction between ligand and Pt is stronger in C2, while the Pt-Cl interaction is weaker in this complex in comparison with the other complexes.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Novel tetranuclear PdII and PtII anticancer complexes derived from pyrene thiosemicarbazones, the main research direction is tetranuclear palladium platinum cyclometalated pyrene thiosemicarbazone preparation antitumor activity; crystal mol structure cyclometalated pyrene thiosemicarbazone platinum tetranuclear complex.HPLC of Formula: 12080-32-9.

Cyclometalated palladium(II) and platinum(II) pyrenyl-derived thiosemicarbazone (H2PrR) complexes of the type [M4(μ-S-PrR-κ3-C,N,S)4] (M = PdII, PtII; R = Et, cyclohexyl) have been synthesized in good yields and fully characterized. X-ray crystallog. showed that the tetranuclear complex [Pt4(μ-S-PrCh-κ3-C,N,S)4](CH3)2COCHCl3 contains an eight-membered ring of alternating M-S atoms. The Et derivatives [M4(μ-S-PrEt-κ3-C,N,S)4] exhibit potent antiproliferative activity towards A2780 human ovarian cancer cells, with IC50 values of 1.27μM (for M = PdII) and 0.37μM (for M = PtII), the latter being an order of magnitude more potent than the anticancer drug cisplatin (IC50 1.20μM). These promising complexes had low toxicity towards non-cancerous human MRC5 cells, which points towards an early indication of differential toxicity between cancer and normal cells. Experiments that investigated the effects of these tetranuclear complexes on the cell cycle, integrity of the cell membrane, and induction of apoptosis, suggested that their mechanism of action of does not involve DNA targeting, unlike cisplatin, and therefore could be promising for combating cisplatin resistance.

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Category: alcohols-buliding-blocks. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about pH-mediated colorimetric and luminescent sensing of aqueous nitrate anions by a platinum(II) luminophore@mesoporous silica composite. Author is Norton, Amie E.; Sharma, Malvika; Cashen, Christina; Dourges, Marie-Anne; Toupance, Thierry; Krause, Jeanette A.; Motkuri, Radha Kishan; Connick, William B.; Chatterjee, Sayandev.

Increased levels of nitrate (NO3-) in the environment can be detrimental to human health. Herein, we report a robust, cost-effective, and scalable, hybrid material-based colorimetric/luminescent sensor technol. for rapid, selective, sensitive, and interference-free in situ NO3- detection. These hybrid materials are based on a square-planar platinum(II) salt [Pt(tpy)Cl]PF6 (tpy = 2,2′;6′,2′′-terpyridine) supported on mesoporous silica. The platinum salt undergoes a vivid change in color and luminescence upon exposure to aqueous NO3- anions at pH ≤ 0 caused by substitution of the PF6- anions by aqueous NO3-. This change in photophysics of the platinum salt is induced by a rearrangement of its crystal lattice that leads to an extended Pt···Pt···Pt interaction, along with a concomitant change in its electronic structure. Furthermore, incorporating the material into mesoporous silica enhances the surface area and increases the detection sensitivity. A NO3- detection limit of 0.05 mM (3.1 ppm) is achieved, which is sufficiently lower than the ambient water quality limit of 0.16 mM (10 ppm) set by the United States Environmental Protection Agency. The colorimetric/luminescence of the hybrid material is highly selective to aqueous NO3- anions in the presence of other interfering anions, suggesting that this material is a promising candidate for the rapid NO3- detection and quantification in practical samples without separation, concentration, or other pretreatment steps.

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Category: alcohols-buliding-blocks. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Platinum(II) Complexes of Tridentate N N- N -Coordinating Ligands Based on Imides, Amides, and Hydrazides: Synthesis and Luminescence Properties. Author is Puttock, Emma V.; Sturala, Jiri; Kistemaker, Jos C. M.; Williams, J. A. Gareth.

Five Pt(II) complexes are described in which the metal ion is bound to anionic N N N-coordinating ligands. The central, deprotonated N atom is derived from an imide Ar-C(:O)-NH-C(:O)-Ar {PtL1-2Cl; Ar = pyridine or pyrimidine}, an amide py-C(:O)-NH-CH2-py {PtL3Cl}, or a hydrazide py-C(:O)-NH-N:CH-py {PtL4Cl}. The imide complexes PtL1-2Cl show no significant emission in solution but are modestly bright green/yellow phosphors in the solid state. PtL3Cl is weakly phosphorescent. PtL4Cl is formed as a mixture of isomers, bound through either the amido or imino nitrogen, the latter converting to the former upon absorption of light. Remarkably, the imino form displays fluorescence in solution, λ0,0=535 nm, whereas the amido shows phosphorescence, λ0,0=624 nm, τ=440 ns. It is highly unusual for two isomeric compounds to display emission from states of different spin multiplicity. The amido-bound PtL4Cl can act as a bidentate O N-coordinating ligand, demonstrated by the formation of bimetallic complexes with iridium(III) or ruthenium(II).

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called The importance of intramolecular conductivity in three dimensional molecular solids, published in 2019, which mentions a compound: 12080-32-9, Name is Dichloro(1,5-cyclooctadiene)platinum(II), Molecular C8H12Cl2Pt, Formula: C8H12Cl2Pt.

Recent years have seen tremendous progress towards understanding the relation between the mol. structure and function of organic field effect transistors. The metrics for organic field effect transistors, which are characterized by mobility and the on/off ratio, are known to be enhanced when the intermol. interaction is strong and the intramol. reorganization energy is low. While these requirements are adequate when describing organic field effect transistors with simple and planar aromatic mol. components, they are insufficient for complex building blocks, which have the potential to localize a carrier on the mol. Here, we show that intramol. conductivity can play a role in controlling device characteristics of organic field effect transistors made with macrocycle building blocks. We use two isomeric macrocyclic semiconductors that consist of perylene diimides linked with bithiophenes and find that the trans-linked macrocycle has a higher mobility than the cis-based device. Through a combination of single mol. junction conductance measurements of the components of the macrocycles, control experiments with acyclic counterparts to the macrocycles, and analyses of each of the materials using spectroscopy, electrochem., and d. functional theory, we attribute the difference in electron mobility of the OFETs created with the two isomers to the difference in intramol. conductivity of the two macrocycles.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Photochemistry of 1,5-Cyclooctadiene Platinum Complexes for Photoassisted Chemical Vapor Deposition》. Authors are Liu, Hanwen; Brewer, Christopher R.; Walker, Amy V.; McElwee-White, Lisa.The article about the compound:Dichloro(1,5-cyclooctadiene)platinum(II)cas:12080-32-9,SMILESS:C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-]).Recommanded Product: Dichloro(1,5-cyclooctadiene)platinum(II). Through the article, more information about this compound (cas:12080-32-9) is conveyed.

Quantum yields for disappearance of (COD)PtMe2 (1a) and (COD)PtMeCl (1b) were determined at 334 nm in C6D6 solvent. Chain reactions initiated by formation of a Me radical were proposed to be the cause of quantum yields higher than unity (Φ = 5.52 ± 0.40 for 1a) when the reaction mixtures included C4F9I. The chain reactions were suppressed in the presence of the radical trap 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO), which resulted in measured disappearance quantum yields of Φ = 0.037 ± 0.003 for (COD)PtMe2 and Φ = 0.44 ± 0.02 for (COD)PtMeCl at 334 nm. Weak luminescence was observed for 1a and 1b, and it was determined that emissive decay is not competitive with Pt-CH3 bond homolysis. DFT studies enabled assignment of both SBLCT and MLCT transitions in the UV/vis spectra of 1a, while 1b only exhibits MLCT transitions. These effects can be attributed to the symmetry of the mol. and its electronic structure.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Photocytotoxic Pt(IV) complexes as prospective anticancer agents.COA of Formula: C8H12Cl2Pt.

The use of Pt(IV) complexes as potential anticancer drugs is attractive, because they have higher stability and less side effects than Pt(II) compounds Moreover, some Pt(IV) complexes can also be activated with light, opening an avenue to photochemotherapy. Our purpose is to widen the library of photoactivatable Pt(II)-based prodrugs and here we report on the oxidation of the Pt(II) compound [PtCl(4′-phenyl-2,2′:6′,2”-terpyridine)][CF3SO3] (1) with PhICl2 or H2O2. The synthetic procedure avoids the formation of multiple species: the treatment with PhICl2 produces the Pt(IV) complex with axial chlorides, [PtCl3(4′-phenyl-2,2′:6′,2”-terpyridine)][CF3SO3] (2), while H2O2 oxidation and post-synthesis carboxylation produce [Pt(OCOCH3)2Cl(4′-phenyl-2,2′:6′,2”-terpyridine)][CF3SO3] (3), bearing acetates in the axial positions. 2 and 3 are stable in physiol.-like buffers and in DMSO in the dark, but undergo photoreduction to 1 upon irradiation at 365 nm. Their stability toward reduction is a fundamental parameter to consider: cyclic voltammetry experiments show that the 2 electron reduction Pt(IV) → Pt(II) occurs at a more neg. potential for 3, because of the greater stabilization provided by the acetate axial groups; noteworthily, 3 is stable for hours also in the presence of mM concentration of glutathione. The cytotoxicity of 2 and 3 toward A2780 and A2780cis cell lines reveals that 3 is the least toxic in the dark, but is able to produce cytotoxic effects far higher than cisplatin when irradiated. To shed light on the mechanistic aspects, the interaction with protein and DNA models has been explored through high-resolution mass spectrometry revealing that 2 and 3 behave as prodrugs, but are able to bind to biol. targets only after irradiation

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mastrocinque, Francesco; Anderson, Craig M.; Elkafas, Adel M.; Ballard, Isabel V.; Tanski, Joseph M. researched the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ).Safety of Dichloro(1,5-cyclooctadiene)platinum(II).They published the article 《Synthesis, characterization, and photophysical properties of cyclometalated N-Heterocyclic carbene Platinum(II) complexes》 about this compound( cas:12080-32-9 ) in Journal of Organometallic Chemistry. Keywords: platinum cyclometalated thienyl benzothienyl imidazolylidene benzimidazolylidene complex preparation photoluminescence; crystal structure platinum cyclometalated thienyl benzothienyl imidazolylidene benzimidazolylidene complex; mol structure platinum cyclometalated thienyl benzothienyl imidazolylidene benzimidazolylidene complex. We’ll tell you more about this compound (cas:12080-32-9).

Cyclometalated platinum complexes I (R = Me, 3-thienylmethyl; X1, X2 = H, benzo) were prepared by a two-step, one-pot procedure and characterized; the complexes showed photoluminescence at 450-550 nm. Thiophene and benzothiophene ligands containing N-heterocyclic carbene (NHC) moieties were used to synthesize five and six-membered Pt(II) metallacycles. Ligand scaffolding was synthesized using two methods. The ligands were synthesized using a coupling reaction, utilizing Cu2O as the catalyst or were synthesized using a nucleophilic substitution reaction. The ligands were then metalated by chelate-assisted C-H activation. The synthesis, characterization, reactivity, and photophys. properties of these NHC-functionalized, cyclometalated products are reported.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Bright Luminescent Platinum(II)-Biaryl Emitters Synthesized Without Air-Sensitive Reagents, published in 2020-04-28, which mentions a compound: 12080-32-9, mainly applied to platinum biaryl emitter synthesis photoluminescence photophys property; ligand design; ligand effects; luminescence; metallacycles; photophysics; platinum, Recommanded Product: Dichloro(1,5-cyclooctadiene)platinum(II).

Transition-metal complexes bearing biaryl-2,2′-diyl ligands tend to show intense luminescence. However, difficulties in synthesis have prevented their further functionalization and practical applications. Herein, a series of platinum(II) complexes bearing biaryl-2,2′-diyl ligands, which have never been prepared in air, were synthesized through transmetalation and successive cyclometalation of biarylboronic acids. This approach does not require any air- or moisture-sensitive reagents and features a simple synthesis even in air. The resulting (Et4N)2[Pt(m,n-F2bph)(CN)2] (m,n-F2bph=m,n-difluorobiphenyl-2,2′-diyl) complexes exhibit intense green emissions with high quantum efficiencies of up to 0.80 at 298 K. The emission spectral fitting and variable-temperature emission lifetime measurements indicate that the high quantum efficiency was achieved because of the tight packing structure and strong σ-donating ability of bph.

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