Tag: M.W=300-400

Eriksson, A.; Nyholm, L. published the artcile< Coulometric and spectroscopic investigations of the oxidation and reduction of some azosalicylic acids at glassy carbon electrodes>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is coulometry spectroscopy oxidation reduction azosalicylic acid glassy carbon electrode.

Constant potential coulometry in combination with cyclic voltammetry, UV-visible, 1H and 13C NMR spectroscopy were used to identify the oxidation and reduction products for some structurally similar azosalicylic acids, including the azosalicylic drugs Sulfasalazine and Olsalazine. The experiments were carried out in aqueous solutions at pH 4.5 to 10.0. Voltammetric and UV-visible spectroscopic comparisons involving standard substances confirm that all compounds studied, except 4,4′-azobis[2-hydroxybenzoic acid], are reduced in an overall four-electron process to their corresponding amines. For 4,4′-azobis[2-hydroxybenzoic acid], the reduction involves only two electrons and most likely gives rise to the corresponding hydrazo compound The oxidations of 3,3′-azobis[6-hydroxybenzoic acid] (Olsalazine), 3,3′-azoxybis[6-hydroxybenzoic acid] and 2-hydroxy-5-[(3′-carboxy-2′-hydroxyphenyl)azo]benzoic acid involve an initial two-electron step. Based on UV and NMR spectroscopic data, probably the oxidation of 3,3′-azobis-[6-hydroxybenzoic acid] gives rise to a 2,2′-dicarboxy-1,4-dibenzoquinone azine.

Electrochimica Acta published new progress about Coulometry. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Niu, Yanfen; Li, Hongjian; Gao, Lihui; Lin, Hua; Kung, Hsiangfu; Lin, Marie Chia-mi; Leung, Kwong-Sak; Wong, Man-Hon; Xiong, Wenyong; Li, Ling published the artcile< old drug, new indication: olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity>, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is olsalazine sodium xanthine oxidase dehydrogenase inhibitor hyperuricemia; Hyperuricemia; Olsalazine sodium; Uric acid; Xanthine oxidase.

Hyperuricemia, a long-term purine metabolic disorder, is a well-known risk factor for gout, hypertension and diabetes. In maintaining normal whole-body purine levels, xanthine oxidase (XOD) is a key enzyme in the purine metabolic pathway, as it catalyzes the oxidation of hypoxanthine to xanthine and finally to uric acid. Here we used the protein-ligand docking software idock to virtually screen potential XOD inhibitors from 3167 approved small compounds/drugs. The inhibitory activities of the ten compounds with the highest scores were tested on XOD in vitro. Interestingly, all the ten compounds inhibited the activity of XOD at certain degrees. Particularly, the anti-ulcerative-colitis drug olsalazine sodium demonstrated a great inhibitory activity for XOD (IC50 = 3.4 mg/L). Enzymic kinetic studies revealed that the drug was a hybrid-type inhibitor of xanthine oxidase. Furthermore, the drug strikingly decreased serum urate levels, serum/hepatic activities of XOD at a dose-dependent manner in vivo. Thus, we demonstrated a successful hunting process of compounds/drugs for hyperuricemia through virtual screening, supporting a potential usage of olsalazine sodium in the treatment of hyperuricemia.

Journal of Pharmacological Sciences (Amsterdam, Netherlands) published new progress about Gout. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adhitama, Nikko; Kato, Yasuhiko; Matsuura, Tomoaki; Watanabe, Hajime published the artcile< Roles of and cross-talk between ecdysteroid and sesquiterpenoid pathways in embryogenesis of branchiopod crustacean Daphnia magna>, Computed Properties of 434-16-2, the main research area is Daphnia embryogenesis ecdysteroid sesquiterpenoid signaling pathway.

In this study, we report on the functions of Spo and Jhamt and the cross-talk between them in embryos of branchiopod crustacean Daphnia magna. This phenotype could be partially rescued by supplementation with 20-hydroxyecdysone, indicating that Spo may play the same role in ecdysteroid biosynthesis in early embryos, as reported in insects. After hatching, Spo expression was repressed, while Jhamt expression was activated transiently, despite its silencing during other embryonic stages. Jhamt RNAi showed little effect on survival, but shortened the embryonic period. Exposure to sesquiterpenoid analog Fenoxycarb extended the embryonic period and rescued the Jhamt RNAi phenotype, demonstrating a previously unidentified role of sesquiterpenoid in repression of precocious embryogenesis. Interestingly, the knockdown of Jhamt resulted in derepression of ecdysteroid biosynthesis genes, including Spo, similar to regulation during insect hormonal biosynthesis. Sesquiterpenoid signaling via Methoprene-tolerant gene was found to be responsible for the repression of ecdysteroid biosynthesis genes. It upregulated an ortholog of CYP18a1 that degrades ecdysteroid in insects. These results illuminate the conserved and specific functions of the ecdysteroid and sesquiterpenoid pathways in Daphnia embryos. We also infer that the common ancestor of branchiopod crustaceans and insects exhibited antagonism between the two endocrine hormones before their divergence 400 million years ago.

PLoS One published new progress about Adult, nonmammalian. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Computed Properties of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Koczok, Katalin; Horvath, Laszlo; Korade, Zeljka; Mezei, Zoltan Andras; Szabo, Gabriella P.; Porter, Ned A.; Kovacs, Eszter; Mirnics, Karoly; Balogh, Istvan published the artcile< Biochemical and Clinical Effects of Vitamin E Supplementation in Hungarian Smith-Lemli-Opitz Syndrome Patients>, Quality Control of 434-16-2, the main research area is vitamin E Hungarian Smith Lemli Opitz syndrome skin photosensitivity; Smith-Lemli-Opitz syndrome; behavioral disturbance; skin photosensitivity; vitamin A; vitamin E.

Smith-Lemli-Opitz syndrome (SLOS) is a severe monogenic disorder resulting in low cholesterol and high 7-dehydrocholesterol (7-DHC) levels. 7-DHC-derived oxysterols likely contribute to disease pathophysiol., and thus antioxidant treatment might be beneficial because of high oxidative stress. In a three-year prospective study, we investigated the effects of vitamin E supplementation in six SLOS patients already receiving dietary cholesterol treatment. Plasma vitamin A and E concentrations were determined by the high-performance liquid chromatog. (HPLC) method. At baseline, plasma 7-DHC, 8-dehydrocholesterol (8-DHC) and cholesterol levels were determined by liquid chromatog.-tandem mass spectrometry (LC-MS/MS) method. The clin. effect of the supplementation was assessed by performing structured parental interviews. At baseline, patients were characterized by low or low-normal plasma vitamin E concentrations (7.19-15.68μmol/L), while vitamin A concentrations were found to be normal or high (1.26-2.68μmol/L). Vitamin E supplementation resulted in correction or significant elevation of plasma vitamin E concentration in all patients. We observed reduced aggression, self-injury, irritability, hyperactivity, attention deficit, repetitive behavior, sleep disturbance, skin photosensitivity and/or eczema in 3/6 patients, with notable individual variability. Clin. response to therapy was associated with a low baseline 7-DHC + 8-DHC/cholesterol ratio (0.2-0.4). We suggest that determination of vitamin E status is important in SLOS patients. Supplementation of vitamin E should be considered and might be beneficial.

Biomolecules published new progress about Antioxidants. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Quality Control of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Peladeau, Christine; Adam, Nadine; Bronicki, Lucas M.; Coriati, Adele; Thabet, Mohamed; Al-Rewashdy, Hasanen; Vanstone, Jason; Mears, Alan; Renaud, Jean-Marc; Holcik, Martin; Jasmin, Bernard J. published the artcile< Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles>, HPLC of Formula: 6054-98-4, the main research area is muscular dystrophy relaxant utrophin A eEF1A2 therapeutic target.

Abstract: Up-regulation of utrophin in muscles represents a promising therapeutic strategy for the treatment of Duchenne Muscular Dystrophy. We previously demonstrated that eEF1A2 associates with the 5’UTR of utrophin A to promote IRES-dependent translation. Here, we examine whether eEF1A2 directly regulates utrophin A expression and identify via an ELISA-based high-throughput screen, FDA-approved drugs that upregulate both eEF1A2 and utrophin A. Our results show that transient overexpression of eEF1A2 in mouse muscles causes an increase in IRES-mediated translation of utrophin A. Through the assessment of our screen, we reveal 7 classes of FDA-approved drugs that increase eEF1A2 and utrophin A protein levels. Treatment of mdx mice with the 2 top leads results in multiple improvements of the dystrophic phenotype. Here, we report that IRES-mediated translation of utrophin A via eEF1A2 is a critical mechanism of regulating utrophin A expression and reveal the potential of repurposed drugs for treating DMD via this pathway.

Nature Communications published new progress about Anterior tibial muscle. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, HPLC of Formula: 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Suyeon; Thapa, Ishwor; Zhang, Ling; Ali, Hesham published the artcile< On identifying candidates for drug repurposing for the treatment of ulcerative colitis using gene expression data>, HPLC of Formula: 6054-98-4, the main research area is gene expression antiinflammatory agent drug repurposing ulcerative colitis.

The notion of repurposing of existing drugs to treat both common and rare diseases has gained traction from both academia and pharmaceutical companies. Given the high attrition rates, massive time, money, and effort of brand-new drug development, the advantages of drug repurposing in terms of lower costs and shorter development time have become more appealing. Computational drug repurposing is promising approach and has shown great potential in tailoring genomic findings to the development of treatments for diseases. However, there are still challenges involved in building a standard computational drug repurposing solution for high-throughput anal. and the implementation to clin. practice. In this study, we applied the computational drug repurposing approaches for Ulcerative Colitis (UC) patients to provide better treatment for this disabling disease. Repositioning drug candidates were identified, and these findings provide a potentially effective therapeutics for the treatment of UC patients. This preliminary computational drug repurposing pipeline will be extended in the near future to help realize the full potential of drug repurposing.

Lecture Notes in Bioinformatics published new progress about Chemotherapy. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, HPLC of Formula: 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fuss, Werner published the artcile< Previtamin D: Z-E photoisomerization via a Hula-twist conical intersection>, Category: alcohols-buliding-blocks, the main research area is previtamin photoisomerization conical intersection rotamer CD.

On photoisomerization of previtamin D – a steroid Z-triene – produced in situ by ring opening of 7-dehydrocholesterol in a cold matrix, it was found in A.M.Muller et al. [Angew.Chem., Int.Ed., 1998, 37, 505-507] that the product (tachysterol) had rotated not only its central double bond but also an adjacent single bond. This is called a Hula twist (HT) due to the alternative description, in which it is just one central CH group that rotates. It was pointed out that the results directly support the calculated mol. structure at a conical intersection, which mediates the Z-E isomerization of polyenes. With a more sophisticated technique, Saltiel et al. (J.Phys.Chem.Lett., 2013, 4, 716-721) confirmed this tachysterol rotamer as the main product but found two addnl. conformers. They believed to have seen also three previtamin D conformers, suggested to be a result of hot-ground-state reactions from the primary rotamer, and interpreted all tachysterol products to be a result of a double-bond twist (DBT), not a HT. On the basis of published CD data and consideration of other reactions, it is here shown that under these conditions hot-ground-state reactions are unimportant or even negligible and that there is practically only a single conformer of previtamin D after ring opening. All products can be easily understood on the basis of an HT-type conical intersection, which is thus further supported. Invoking a published pretwist model even rationalizes product ratios. The two twists in HT are concerted. Furthermore HT is fully consistent with the NEER principle (nonequilibration of excited rotamers) and even offers addnl. possibilities for conformer control.

Physical Chemistry Chemical Physics published new progress about Bond angle, torsional. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tang, Yun-Zhi; Tan, Yu-Hui; Zhu, Jian-Wu; Ji, Fa-Ming; Xiong, Ting-Ting; Xiao, Wen-Zhong; Liao, Chun-Fa; Xiong, Ren-Gen published the artcile< Novel Three-Dimensional Anion-Type Eight-Coordinated Cd(II) Coordination Polymer with Binuclear Cadmium Building Units>, Application of C14H8N2Na2O6, the main research area is cadmium dipentum DMF polymeric preparation structure; crystal structure cadmium dipentum eight coordinate polymeric.

The 3-dimensional polymeric complex {[Cd2(DPT)3(DMF)6]·(2H3O)+} n (DPT = dipentum = 3,3-azo-bis(6-hydroxybenzoic carboxylic acid), DMF = N,N’- dimethylformamide) with binuclear Cd as building block was obtained from hydrothermal reaction of CdCl2·4H2O with medicine dipentum Na.

Crystal Growth & Design published new progress about Coordination number, eight. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Slominski, Andrzej T.; Chaiprasongsuk, Anyamanee; Janjetovic, Zorica; Kim, Tae-Kang; Stefan, Joanna; Slominski, Radomir M.; Hanumanthu, Vidya Sagar; Raman, Chander; Qayyum, Shariq; Song, Yuwei; Song, Yuhua; Panich, Uraiwan; Crossman, David K.; Athar, Mohammad; Holick, Michael F.; Jetten, Anton M.; Zmijewski, Michal A.; Zmijewski, Jaroslaw; Tuckey, Robert C. published the artcile< Photoprotective Properties of Vitamin D and Lumisterol Hydroxyderivatives>, Quality Control of 434-16-2, the main research area is vitamin D lumisterol hydroxyderivative photoprotective property review; DNA damage; Lumisterol; Oxidative stress; Skin; Ultraviolet B; Vitamin D.

A review. Abstract: We have previously described new pathways of vitamin D3 activation by CYP11A1 to produce a variety of metabolites including 20(OH)D3 and 20,23(OH)2D3. These can be further hydroxylated by CYP27B1 to produce their C1α-hydroxyderivatives. CYP11A1 similarly initiates the metabolism of lumisterol (L3) through sequential hydroxylation of the side chain to produce 20(OH)L3, 22(OH)L3, 20,22(OH)2L3 and 24(OH)L3. CYP11A1 also acts on 7-dehydrocholesterol (7DHC) producing 22(OH)7DHC, 20,22(OH)27DHC and 7-dehydropregnenolone (7DHP) which can be converted to the D3 and L3 configurations following exposure to UVB. These CYP11A1-derived compounds are produced in vivo and are biol. active displaying anti-proliferative, anti-inflammatory, anti-cancer and pro-differentiation properties. Since the protective role of the classical form of vitamin D3 (1,25(OH)2D3) against UVB-induced damage is recognized, we recently tested whether novel CYP11A1-derived D3- and L3-hydroxyderivatives protect against UVB-induced damage in epidermal human keratinocytes and melanocytes. We found that along with 1,25(OH)2D3, CYP11A1-derived D3-hydroxyderivatives and L3 and its hydroxyderivatives exert photoprotective effects. These included induction of intracellular free radical scavenging and attenuation and repair of DNA damage. The protection of human keratinocytes against DNA damage included the activation of the NRF2-regulated antioxidant response, p53-phosphorylation and its translocation to the nucleus, and DNA repair induction. These data indicate that novel derivatives of vitamin D3 and lumisterol are promising photoprotective agents. However, detailed mechanisms of action, and the involvement of specific nuclear receptors, other vitamin D binding proteins or mitochondria, remain to be established.

Cell Biochemistry and Biophysics published new progress about Absorption Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Quality Control of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Teruel, Adrian H.; Perez-Esteve, Edgar; Gonzalez-Alvarez, Isabel; Gonzalez-Alvarez, Marta; Costero, Ana M.; Ferri, Daniel; Gavina, Pablo; Merino, Virginia; Martinez-Manez, Ramon; Sancenon, Felix published the artcile< Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel Disease>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is silica microparticle hydrocortisone inflammatory bowel disease antiinflammatory; colon targeted release; gated materials; inflammatory bowel disease; mesoporous silica microparticles; smart drug delivery materials.

Silica mesoporous microparticles loaded with both rhodamine B fluorophore (S1) or hydrocortisone (S2), and capped with an olsalazine derivative, are prepared and fully characterized. Suspensions of S1 and S2 in water at an acidic and a neutral pH show negligible dye/drug release, yet a notable delivery took place when the reducing agent sodium dithionite is added because of hydrolysis of an azo bond in the capping ensemble. Addnl., olsalazine fragmentation induced 5-aminosalicylic acid (5-ASA) release. In vitro digestion models show that S1 and S2 solids are suitable systems to specifically release a pharmaceutical agent in the colon. In vivo pharmacokinetic studies in rats show a preferential rhodamine B release from S1 in the colon. Moreover, a model of ulcerative colitis is induced in rats by oral administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS) solutions, which was also used to prove the efficacy of S2 for colitis treatment. The specific delivery of hydrocortisone and 5-ASA from S2 material to the colon tissue in injured rats markedly lowers the colon/body weight ratio and the clin. activity score. Histol. studies showed a remarkable reduction in inflammation, as well as an intensive regeneration of the affected tissues.

Molecular Pharmaceutics published new progress about Anti-inflammatory agents. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts