Tag: M.W=300-400

Tang, Yun-Zhi; Tan, Yu-Hui; Zhu, Jian-Wu; Ji, Fa-Ming; Xiong, Ting-Ting; Xiao, Wen-Zhong; Liao, Chun-Fa; Xiong, Ren-Gen published the artcile< Novel Three-Dimensional Anion-Type Eight-Coordinated Cd(II) Coordination Polymer with Binuclear Cadmium Building Units>, Application of C14H8N2Na2O6, the main research area is cadmium dipentum DMF polymeric preparation structure; crystal structure cadmium dipentum eight coordinate polymeric.

The 3-dimensional polymeric complex {[Cd2(DPT)3(DMF)6]·(2H3O)+} n (DPT = dipentum = 3,3-azo-bis(6-hydroxybenzoic carboxylic acid), DMF = N,N’- dimethylformamide) with binuclear Cd as building block was obtained from hydrothermal reaction of CdCl2·4H2O with medicine dipentum Na.

Crystal Growth & Design published new progress about Coordination number, eight. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Slominski, Andrzej T.; Chaiprasongsuk, Anyamanee; Janjetovic, Zorica; Kim, Tae-Kang; Stefan, Joanna; Slominski, Radomir M.; Hanumanthu, Vidya Sagar; Raman, Chander; Qayyum, Shariq; Song, Yuwei; Song, Yuhua; Panich, Uraiwan; Crossman, David K.; Athar, Mohammad; Holick, Michael F.; Jetten, Anton M.; Zmijewski, Michal A.; Zmijewski, Jaroslaw; Tuckey, Robert C. published the artcile< Photoprotective Properties of Vitamin D and Lumisterol Hydroxyderivatives>, Quality Control of 434-16-2, the main research area is vitamin D lumisterol hydroxyderivative photoprotective property review; DNA damage; Lumisterol; Oxidative stress; Skin; Ultraviolet B; Vitamin D.

A review. Abstract: We have previously described new pathways of vitamin D3 activation by CYP11A1 to produce a variety of metabolites including 20(OH)D3 and 20,23(OH)2D3. These can be further hydroxylated by CYP27B1 to produce their C1α-hydroxyderivatives. CYP11A1 similarly initiates the metabolism of lumisterol (L3) through sequential hydroxylation of the side chain to produce 20(OH)L3, 22(OH)L3, 20,22(OH)2L3 and 24(OH)L3. CYP11A1 also acts on 7-dehydrocholesterol (7DHC) producing 22(OH)7DHC, 20,22(OH)27DHC and 7-dehydropregnenolone (7DHP) which can be converted to the D3 and L3 configurations following exposure to UVB. These CYP11A1-derived compounds are produced in vivo and are biol. active displaying anti-proliferative, anti-inflammatory, anti-cancer and pro-differentiation properties. Since the protective role of the classical form of vitamin D3 (1,25(OH)2D3) against UVB-induced damage is recognized, we recently tested whether novel CYP11A1-derived D3- and L3-hydroxyderivatives protect against UVB-induced damage in epidermal human keratinocytes and melanocytes. We found that along with 1,25(OH)2D3, CYP11A1-derived D3-hydroxyderivatives and L3 and its hydroxyderivatives exert photoprotective effects. These included induction of intracellular free radical scavenging and attenuation and repair of DNA damage. The protection of human keratinocytes against DNA damage included the activation of the NRF2-regulated antioxidant response, p53-phosphorylation and its translocation to the nucleus, and DNA repair induction. These data indicate that novel derivatives of vitamin D3 and lumisterol are promising photoprotective agents. However, detailed mechanisms of action, and the involvement of specific nuclear receptors, other vitamin D binding proteins or mitochondria, remain to be established.

Cell Biochemistry and Biophysics published new progress about Absorption Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Quality Control of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Teruel, Adrian H.; Perez-Esteve, Edgar; Gonzalez-Alvarez, Isabel; Gonzalez-Alvarez, Marta; Costero, Ana M.; Ferri, Daniel; Gavina, Pablo; Merino, Virginia; Martinez-Manez, Ramon; Sancenon, Felix published the artcile< Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel Disease>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is silica microparticle hydrocortisone inflammatory bowel disease antiinflammatory; colon targeted release; gated materials; inflammatory bowel disease; mesoporous silica microparticles; smart drug delivery materials.

Silica mesoporous microparticles loaded with both rhodamine B fluorophore (S1) or hydrocortisone (S2), and capped with an olsalazine derivative, are prepared and fully characterized. Suspensions of S1 and S2 in water at an acidic and a neutral pH show negligible dye/drug release, yet a notable delivery took place when the reducing agent sodium dithionite is added because of hydrolysis of an azo bond in the capping ensemble. Addnl., olsalazine fragmentation induced 5-aminosalicylic acid (5-ASA) release. In vitro digestion models show that S1 and S2 solids are suitable systems to specifically release a pharmaceutical agent in the colon. In vivo pharmacokinetic studies in rats show a preferential rhodamine B release from S1 in the colon. Moreover, a model of ulcerative colitis is induced in rats by oral administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS) solutions, which was also used to prove the efficacy of S2 for colitis treatment. The specific delivery of hydrocortisone and 5-ASA from S2 material to the colon tissue in injured rats markedly lowers the colon/body weight ratio and the clin. activity score. Histol. studies showed a remarkable reduction in inflammation, as well as an intensive regeneration of the affected tissues.

Molecular Pharmaceutics published new progress about Anti-inflammatory agents. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Holick, Michael F. published the artcile< Sunlight, UV Radiation, Vitamin D, and Skin Cancer: How Much Sunlight Do We Need?>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is vitaminD UV radiation sunlight skin cancer human health; 25-hydroxyvitamin D; Melanoma; Photobiology; Previtamin D; Skin cancer; Sunlight; Ultraviolet radiation; Vitamin D; Vitamin D deficiency; Vitamin D sufficiency.

Vitamin D is the sunshine vitamin for good reason. During exposure to sunlight, the UV B photons enter the skin and photolyze 7-dehydrocholesterol to previtamin D3 which in turn is isomerized by the body′s temperature to vitamin D3. Most humans have depended on sun for their vitamin D requirement. Skin pigment, sunscreen use, aging, time of day, season, and latitude dramatically affect previtamin D3 synthesis. Vitamin D deficiency was thought to have been conquered, but it is now recognized that more than 50% of the world′s population is at risk for vitamin D deficiency. This deficiency is in part due to the inadequate fortification of foods with vitamin D and the misconception that a healthy diet contains an adequate amount of vitamin D. Vitamin D deficiency causes growth retardation and rickets in children and will precipitate and exacerbate osteopenia, osteoporosis and increase risk of fracture in adults. The vitamin D deficiency pandemic has other serious consequences including increased risk of common cancers, autoimmune diseases, infectious diseases, and cardiovascular disease. There needs to be a renewed appreciation of the beneficial effect of moderate sensible sunlight for providing all humans with their vitamin D requirement for health.

Advances in Experimental Medicine and Biology published new progress about Osteopenia. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McKay, G.; Blair, H. S.; Gardner, J. R. published the artcile< The adsorption of dyes onto chitin in fixed bed columns and batch adsorbers>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is dye adsorption chitin textile wastewater.

Chitin has the ability to adsorb substantial quantities of dyestuffs from aqueous solutions Consequently, it is a useful adsorbent for effluent treatment from textile mills. The design procedures for batch and continuous fixed-bed adsorption columns have been investigated for 4 dyes, namely, CI Acid Blue 25  [6408-78-2], CI Acid Blue 158  [6370-08-7], CI Mordant Yellow 5  [6054-98-4], and CI Direct Red 84  [6409-83-2]. The main-fixed bed system variables studied are bed height, dye flow rate, and chitin particle size, and these effects have been incorporated into a simplified design model.

Journal of Applied Polymer Science published new progress about Adsorptive wastewater treatment. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guez, B. A. Rbara Socas-Rodri; Sandahl, Margareta; Holm, Cecilia; Turner, Charlotta published the artcile< Recent advances in the analysis of vitamin D and its metabolites in food matrices>, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is review food analysis vitamin D metabolites chromatog.

A review. Vitamin D and its analogs are fat-soluble vitamins that carry out important functions in human and animal organisms. Many studies have pointed out the relationship between the deficiency of these substances and the development of both skeletal- and extra-skeletal diseases. Although vitamin D is fundamentally derived from the bio-transformation of its precursor, 7-dehydrocholesterol, through the action of UV-B radiation in the skin, dietary intake also plays an important role in the regulation of its status in an organism. For this reason, the application of reliable methodologies that enable monitoring the content of vitamin D and its analogs in food and supplements constitutes an aspect of special relevance to establish adequate habits, which avoid the deficiency of these substances in organisms and, consequently, the appearance of related diseases. The use of chromatog. techniques in combination with conventional and novel sample pre-treatments has become a suitable strategy to achieve this aim. This review compiles the most relevant methodologies reported in the last ten years for vitamin D analogs anal. in food matrixes. Particular attention has been paid to provide a general overview of the most suitable approaches in terms of reliability, sensitivity and simplicity, used in the field of food anal.

Separations published new progress about Chromatography. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hakkou, Khalid; Molina-Pinilla, Inmaculada; Rangel-Nunez, Cristian; Suarez-Cruz, Adrian; Pajuelo, Eloisa; Bueno-Martinez, Manuel published the artcile< Synthesis of novel (bio) degradable linear azo polymers conjugated with olsalazine>, Product Details of C14H8N2Na2O6, the main research area is biodegradable linear conjugated olsalazine based polyazoester triazole preparation property.

Click Cu(I)-catalyzed polymerization of diynes and diazides was performed to obtain a novel type of linear copolymer, which were prepared from monomers derived from poly(ethylene glycol), 5,5′-azodisalicylic acid [olsalazine] and 1,4-butanediol diglycidyl ether. The resulting copolymers will carry ester and azo functions along the polymer backbone, so they will be sensitive to pH as well as be degraded by azoreductase enzymes present in the colonic microbiota. Most of the copoly(azoester triazole)s obtained were water soluble, and all of them were characterized by Fourier transform IR, NMR, and gel permeation chromatog.. Differential scanning calorimetry revealed them to be amorphous, and in general, the polymers were stable up to 250 °C under nitrogen as demonstrated by thermogravimetric anal.. The degradation behavior of the polymers was evaluated in vitro. Degradation studies were carried out at 37 °C in buffered salt solution at pH 7.4, and were monitored by GPC and NMR spectroscopies. A biodegradation experiment of a water-soluble prototype polymer showed that they are biodegradable via a strain of Enterococcus faecalis. The experiment was monitored using UV-visible spectroscopy.

Polymer Degradation and Stability published new progress about Azide-alkyne 1,3-dipolar cycloaddition reaction. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Product Details of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Allen, Luke B.; Genaro-Mattos, Thiago C.; Porter, Ned A.; Mirnics, Karoly; Korade, Zeljka published the artcile< Desmosterolosis and desmosterol homeostasis in the developing mouse brain>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is desmosterolosis desmosterol homeostasis brain; 7-dehydrocholesterol; Dhcr24; Dhcr7; cholesterol; desmosterol.

Cholesterol serves as a building material for cellular membranes and plays an important role in cellular metabolism The brain relies on its own cholesterol biosynthesis, which starts during embryonic development. Cholesterol is synthesized from two immediate precursors, desmosterol and 7-dehydrocholesterol (7-DHC). Mutations in the DHCR24 enzyme, which converts desmosterol into cholesterol, lead to desmosterolosis, an autosomal recessive developmental disorder. In this study, we assessed the brain content of desmosterol, 7-DHC, and cholesterol from development to adulthood, and analyzed the biochem., mol., and anatomical consequences of Dhcr24 mutations on the sterol profile in a mouse model of desmosterolosis and heterozygous Dhcr24+/- carriers. Our HPLC-MS/MS studies revealed that by P0 desmosterol almost entirely replaced cholesterol in the Dhcr24-KO brain. The greatly elevated desmosterol levels were also present in the Dhcr24-Het brains irresp. of maternal genotype, persisting into adulthood. Furthermore, Dhcr24-KO mice brains showed complex changes in expression of lipid and sterol transcripts, nuclear receptors, and synaptic plasticity transcripts. Cultured Dhcr24-KO neurons showed increased arborization, which was also present in the Dhcr24-KO mouse brains. Finally, we observed a shared pathophysiol. mechanism between the mouse models of desmosterolosis and Smith-Lemli-Opitz syndrome (a genetic disorder of conversion of 7-DHC to cholesterol).

Journal of Inherited Metabolic Disease published new progress about Apolipoprotein A-II Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zakany, Florina; Pap, Pal; Papp, Ferenc; Kovacs, Tamas; Nagy, Peter; Peter, Maria; Szente, Lajos; Panyi, Gyorgy; Varga, Zoltan published the artcile< Determining the target of membrane sterols on voltage-gated potassium channels>, Electric Literature of 434-16-2, the main research area is sterol voltage gated potassium channel intracellular domain transmembrane helix; Cholesterol; Ion channel gating; K(V)1.3; K(V)10.1; Pore domain; Voltage-sensor.

Cholesterol, an essential lipid component of cellular plasma membranes, regulates fluidity, mech.integrity, raft structure and may specifically interact with membrane proteins. Numerous effects on ion channels by cholesterol, including changes in current amplitude, voltage dependence and gating kinetics, have been reported. We have previously described such changes in the voltage-gated potassium channel Kv1.3 of lymphocytes by cholesterol and its analog 7-dehydrocholesterol (7DHC). In voltage-gated channels membrane depolarization induces movement of the voltage sensor domains (VSD), which is transmitted by a coupling mechanism to the pore domain (PD) to open the channel. Here, we investigated whether cholesterol effects were mediated by the VSD to the pore or the PD was the direct target. Specificity was tested by comparing Kv1.3 and Kv10.1 channels having different VSD-PD coupling mechanisms. Current recordings were performed with two-electrode voltage-clamp fluorometry, where movement of the VSDs was monitored by attaching fluorophores to external cysteine residues introduced in the channel sequence. Loading the membrane with cholesterol or 7DHC using methyl-β-cyclodextrin induced changes in the steady-state and kinetic parameters of the ionic currents while leaving fluorescence parameters mostly unaffected in both channels. Non-stationary noise anal.revealed that reductionof single channel conductance rather than that of open probability caused the observedcurrent decrease. Furthermore, confocal laser scanning and stimulated emission depletion microscopy demonstrated significant changes in the distribution of these ion channels in response to sterol loading. Our results indicate that sterol-induced effects on ion channel gating directly target the pore and do not act via the VSD.

Biochimica et Biophysica Acta, Molecular and Cell Biology of Lipids published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Electric Literature of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiu, Xiang; Sun, Yi; Wu, Yaokang; Jin, Ke; Qu, Lisha; Liu, Yanfeng; Li, Jianghua; Du, Guocheng; Lv, Xueqin; Liu, Long published the artcile< Modular remodeling of sterol metabolism for overproduction of 7-dehydrocholesterol in engineered yeast>, Category: alcohols-buliding-blocks, the main research area is 7-Dehydrocholesterol; CRISPR-mediated regulatory system; Compartmentalization; Endoplasmic reticulum; Saccharomyces cerevisiae.

Vitamin D3 is a fat-soluble vitamin essential for the human body, and the biosynthesis of its precursor, 7-dehydrocholesterol (7-DHC), gains extensive attention. In this work, six genes (tHMG1, IDI1, ERG1, ERG11, ADH2, ERG7) and a transcription factor mutant UPC2G888A were overexpressed, increasing the 7-DHC titer from 1.2 to 115.3 mg/L. The CRISPR-mediated activation and repression systems were constructed and applied to the synthesis of 7-DHC, increasing the 7-DHC titer to 312.4 mg/L. Next, enzymes were compartmentalized into the endoplasmic reticulum (ER) and the ER lumen was enlarged by overexpressing INO2. The 7-DHC titer of the finally engineered yeast reached 455.6 mg/L in a shake flask and 2870 mg/L in a 5 L bioreactor, the highest 7-DHC titer reported so far. Overall, this study achieved a highly efficient 7-DHC synthesis by remodeling the complicated sterol synthesis modules, paving the way for large-scale 7-DHC bioprodn. in the future.

Bioresource Technology published new progress about 434-16-2. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts