Tag: M.W=300-400

Knuschke, Peter published the artcile< Sun Exposure and Vitamin D.>, Reference of 434-16-2, the main research area is .

Vitamin D is generally accepted in its importance on the regulation of calcium homeostasis and bone metabolism. Moreover, further health effects due to vitamin D are under discussion. In its effect, vitamin D is more like a hormone. In the classic view, a vitamin is an essential nutrient, which cannot be synthesized independently in the body. Besides nutrition, vitamin D will be produced in the body itself. The skin contains the provitamin D3 7-dehydrocholesterol, a precursor of vitamin D. Provitamin D3 will be photoconverted to previtamin D3 by UVB radiation that penetrates the skin superficially. In this way, the vitamin D metabolism will be started independent of the nutrition. In everyday life, this photosynthesis will be carried out due to the solar UVB radiation penetrating the uncovered skin. In the same spectral waveband range of UVB radiation, which causes the beneficial health effect of starting the vitamin D metabolism, the UVB radiation causes simultaneously acute and chronic harmful health effects as UV erythema (sunburn), skin aging and skin cancer. There is no vitamin D production in the skin without simultaneous DNA damage in the skin. Against this background, risks and benefits have to be balanced carefully.

Current problems in dermatology published new progress about 434-16-2. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Reference of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kumar, Ravi; Rajarajeshwari, N.; Swamy V. B., Narayana published the artcile< Borassus flabellifer fruit mucilage: potential biodegradable carrier for colon specific drug delivery>, Formula: C14H8N2Na2O6, the main research area is olsalazine sodium Borassus mucilage colon matrix tablet drug delivery.

The present study was undertaken to assess the potential of Borassus flabellifer mucilage (BFM) to act as a biodegradable carrier for colon specific drug delivery. Hence an attempt was made to develop matrix tablet of olsalazine sodium based formulation using BFM which protects the drug in upper GIT and release the major amount of drug in colon due to degradation by bacterial enzymes. Colon targeted matrix tablets of olsalazine sodium were prepared by direct compression method using different concentrations viz; 5, 10, 15, 20 and 25 % weight/weight of BFM. Tablets were evaluated for hardness, friability, weight variation, drug content, in vitro dissolution test in simulated gastric, intestinal and colonic fluid with and without 4% (w/v) rat cecal matter and stability study. FT-IR and DSC studies confirmed the absence of any drug polymer interaction. In vitro studies revealed that the tablets containing 25% weight/weight of BFM (F5) have limited the drug release in stomach and small intestinal environment and released maximum amount of drug in the colonic environment. Optimized formulation (F5) showed no change either in phys. appearance, drug content or in dissolution pattern after storage at 40°C/RH 75% for 3 mo. Math. modeling showed that release pattern follows the Peppas model. X-ray images were taken to investigate the movement, location and the integrity of the tablets in different parts of gastro intestinal tract in rabbits and it clearly supported the in vitro study. The study showed that BFM can be used successfully for colon specific drug delivery system.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about Biodegradability. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Formula: C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McKay, G.; Blair, H. S.; Gardner, J. published the artcile< The adsorption of dyes in chitin. III. Intraparticle diffusion processes>, Application of C14H8N2Na2O6, the main research area is intraparticle diffusion dye adsorption chitin.

Intraparticle diffusion processes for the adsorption of dyes, i.e. C.I. Acid Blue 25  [6408-78-2], C.I. Acid Blue 158  [6370-08-7], C.I. Mordant Yellow 5  [6054-98-4], and C.I. Direct Red 84  [6409-83-2], onto chitin (I) [1398-61-4] were studied. Intraparticle diffusion rate, defined as the slope of the plot of the amount of dye adsorbed per g I vs. square root of time (t), was determined for a number of process variables, including initial dye concentration, agitation, I particle size and mass, temperature, and solution pH. Intraparticle diffusion was rate controlling for the adsorption process; initially the plots of dye adsorbed against t were nonlinear, indicating that boundary layer resistance is predominant; however, after this relatively short period, the plots became linear and were valid for up to several h depending on dye-I system, and the different gradients observed indicated that the internal pore size of I particles offers resistance to dye adsorption.

Journal of Applied Polymer Science published new progress about Adsorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Klouda, Jan; Benesova, Lenka; Kocovsky, Pavel; Schwarzova-Peckova, Karolina published the artcile< Voltammetry of 7-dehydrocholesterol as a new and useful tool for Smith-Lemli-Opitz syndrome diagnosis>, Related Products of 434-16-2, the main research area is 7-dehydrocholesterol; Artificial serum; Bare electrodes; Cholecalciferol; Voltammetry.

7-Dehydrocholesterol is an essential biomarker of Smith-Lemli-Opitz syndrome, a congenital autosomal recessive disorder. This study shows for the first time that electrochem. oxidation of 7-dehydrocholesterol can be used for its voltammetric determination Two classes of supporting electrolytes in acetonitrile and a mixture of acetonitrile-water were used: inorganic acids known to promote structural changes of steroids and indifferent electrolytes. Oxidation of 7-dehydrocholesterol at ca +0.8 V (vs. Ag/AgNO3 in acetonitrile) in 0.1 mol L-1 NaClO4 in acetonitrile is useful for its voltammetric detection using common bare electrode materials. Detection limits for 7-dehydrocholesterol lie in the low micromolar range for all the working electrodes, including boron-doped diamond (0.4 μmol L-1) and disposable thin-film platinum electrodes (0.5 μmol L-1), which are advantageous because of the low volumes of studied solutions After Bligh-Dyer extraction, quantification of 7-dehydrocholesterol concentration (boron-doped diamond) or concentration range (thin-film platinum) is easily attainable in artificial serum. The mere knowledge of the concentration range provides clin. valuable information, as 7-dehydrocholesterol levels are employed for SLOS diagnosis as a binary criterion (elevated, tens to hundreds μmol L-1 in symptomatic/non-elevated, typically bellow 1 μmol L-1 in healthy individuals in plasma). Moreover, it is shown that 7-dehydrocholesterol (provitamin D3) and cholecalciferol (vitamin D3) can be oxidized in 0.1 mol L-1 HClO4 in acetonitrile. Under these conditions, their voltammetric response changes dramatically, and their oxidation p.d. transiently increases from 0.08 V to 0.25 V, which should facilitate their simultaneous voltammetric determination This work constitutes a foundation for a reliable and straightforward method for Smith-Lemli-Opitz syndrome diagnosis and monitoring 7-dehydrocholesterol′s biotransformation to cholecalciferol.

Talanta published new progress about 434-16-2. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Related Products of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McKay, G.; Blair, H. S.; Gardner, J. published the artcile< Rate studies for the adsorption of dyestuffs onto chitin>, Application In Synthesis of 6054-98-4, the main research area is dye adsorption chitin model; film mass transfer dye model.

The rate of adsorption of dyestuffs on chitin in the initial stages of the adsorption process depends on the film mass transfer coefficient A model has been developed to determine the film mass transfer coefficients The anal. is based on a nonlinear equilibrium isotherm and utilizes a computer program to predict theor. concentration vs. time curves. The overall average external mass transfer coefficients are 2.8 × 10-3, 2.9 × 10-3, 3.8 × 10-3, and 0.9 × 10-3 cm/s for Acid Blue 25  [6408-78-2], Acid Blue 158  [6370-08-7], Mordant Yellow 5  [6054-98-4], and Direct Red 84  [6409-83-2], resp. Equilibrium data for the adsorption of the 4 dyestuffs on chitin are presented and analyzed using the Langmuir, Freundlich, and general isotherm expressions. The adsorption capacity of chitin at monolayer coverage is 190 and 200 mg dye/g for Acid Blue 25 and Acid Blue 158, resp. Mordant Yellow 5 and Direct Red 84 adsorption capacities are 50 and 40 mg dye/g chitin, resp.

Journal of Colloid and Interface Science published new progress about Adsorptive wastewater treatment. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application In Synthesis of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Patel, Rikin D.; Prasanth Kumar, Sivakumar; Pandya, Himanshu A.; Solanki, Hitesh A. published the artcile< MDCKpred: a web-tool to calculate MDCK permeability coefficient of small molecule using membrane-interaction chemical features>, Application of C14H8N2Na2O6, the main research area is MDCK cell permeability small mol membrane interaction MDCKpred tool; Caco-2; MDCK; QSAR; permeability; permeability coefficient; web-tool.

Structure-based models to understand the transport of small mols. through biol. membrane can be developed by enumerating intermol. interactions of the small mol. with a biol. membrane, usually a dimyristoylphosphatidylcholine (DMPC) monolayer. This ADME (absorption, distribution, metabolism, and excretion) property based on Madin-Darby Canine Kidney (MDCK) cell line demonstrates intestinal drug absorption of small mols. and correlated to human intestinal absorption which acts as a determining factor to forecast small-mol. prioritization in drug-discovery projects. We present here the development of MDCKpred web-tool which calculates MDCK permeability coefficient of small mol. based on the regression model, developed using membrane-interaction chem. features. The web-tool allows users to calculate the MDCK permeability coefficient (nm/s) instantly by providing simple descriptor inputs. The chem.-interaction features are derived from different parts of the DMPC mol. viz. head, middle, and tail regions and accounts overall intermol. contacts of the small mol. when passively diffused through the phospholipid-rich biol. membrane. The MDCKpred model is both internally (R2 = .76; = .68; Rtrain = .87; Rtest = .69) and externally (Rext = .55) validated. Furthermore, we used natural mols. as application examples to demonstrate its utility in lead exploration and optimization projects. The MDCKpred web-tool can be accessed freely at http://www.mdckpred.in. This web-tool is designed to offer an intuitive way of prioritizing small mols. based on calculated MDCK permeabilities.

Toxicology Mechanisms and Methods published new progress about Absorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rojare, Camille; Opdenakker, Yasmin; Laborde, Amélie; Nicot, Romain; Mention, Karine; Ferri, Joel published the artcile< The Smith-Lemli-Opitz syndrome and dentofacial anomalies diagnostic: Case reports and literature review.>, Safety of (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is Dentofacial deformities; Diagnosis; Diagnostic; Malformations dento-faciales; Smith–Lemli–Opitz Syndrome.

OBJECTIVE: Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive disorder. It is due to a deficiency of 7-dehydrocholesterol reductase (DHCR7) that catalyses the reduction of 7-dehydrocholesterol (7-DHC) to cholesterol. The aim of this review is to gather all information, concerning diagnostic characteristics of this syndrome, with an emphasis on intraoral symptom presentation. MATERIALS AND METHODS: We conducted a review of the literature, including articles between 1964 and 2017. Data was collected regarding the clinical diagnosis, pathophysiology and treatment of SLOS patients. Moreover, two clinical cases are described, illustrating the oral and facial anomalies of SLOS patients, at the regional university hospital of Lille, France. DISCUSSION: Low cholesterol levels provoke a broad spectrum of clinical presentations, from mild to lethal forms. They can cause mental retardation, growth deficiency and congenital malformations. The SLOS features are often present at birth. Moreover, all the patients have facial anomalies. The dento-maxillofacial symptoms consist of crowded teeth, widely spaced incisors, oligodontia, polydontia, premature tooth eruption, enamel hypoplasia, a bifid uvula, broad alveolar ridges, bifid tongue, and Pierre-Robin syndrome symptoms (glossoptosis, retrognathia and cleft palate). These symptoms are warning signs and should increase the awareness of clinicians. CONCLUSIONS: All healthcare professionals can contribute to the SLOS patient diagnostics. The dento-maxillofacial anomalies, illustrated by two case reports, could help to detect undiagnosed patients. An early detection might improve the outcome of these patients, as cholesterol supplementation can improve symptoms. This study can benefit orthodontists by enabling them to recognize the clinical signs of SLOS in order to refer these young patients to a specialist if the diagnosis has not been established.

International orthodontics published new progress about 434-16-2. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Safety of (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Klouda, Jan; Benesova, Lenka; Kocovsky, Pavel; Schwarzova-Peckova, Karolina published the artcile< Voltammetry of 7-dehydrocholesterol as a new and useful tool for Smith-Lemli-Opitz syndrome diagnosis>, Related Products of 434-16-2, the main research area is 7-dehydrocholesterol; Artificial serum; Bare electrodes; Cholecalciferol; Voltammetry.

7-Dehydrocholesterol is an essential biomarker of Smith-Lemli-Opitz syndrome, a congenital autosomal recessive disorder. This study shows for the first time that electrochem. oxidation of 7-dehydrocholesterol can be used for its voltammetric determination Two classes of supporting electrolytes in acetonitrile and a mixture of acetonitrile-water were used: inorganic acids known to promote structural changes of steroids and indifferent electrolytes. Oxidation of 7-dehydrocholesterol at ca +0.8 V (vs. Ag/AgNO3 in acetonitrile) in 0.1 mol L-1 NaClO4 in acetonitrile is useful for its voltammetric detection using common bare electrode materials. Detection limits for 7-dehydrocholesterol lie in the low micromolar range for all the working electrodes, including boron-doped diamond (0.4 μmol L-1) and disposable thin-film platinum electrodes (0.5 μmol L-1), which are advantageous because of the low volumes of studied solutions After Bligh-Dyer extraction, quantification of 7-dehydrocholesterol concentration (boron-doped diamond) or concentration range (thin-film platinum) is easily attainable in artificial serum. The mere knowledge of the concentration range provides clin. valuable information, as 7-dehydrocholesterol levels are employed for SLOS diagnosis as a binary criterion (elevated, tens to hundreds μmol L-1 in symptomatic/non-elevated, typically bellow 1 μmol L-1 in healthy individuals in plasma). Moreover, it is shown that 7-dehydrocholesterol (provitamin D3) and cholecalciferol (vitamin D3) can be oxidized in 0.1 mol L-1 HClO4 in acetonitrile. Under these conditions, their voltammetric response changes dramatically, and their oxidation p.d. transiently increases from 0.08 V to 0.25 V, which should facilitate their simultaneous voltammetric determination This work constitutes a foundation for a reliable and straightforward method for Smith-Lemli-Opitz syndrome diagnosis and monitoring 7-dehydrocholesterol′s biotransformation to cholecalciferol.

Talanta published new progress about 434-16-2. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Related Products of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McKay, G.; Blair, H. S.; Gardner, J. published the artcile< Rate studies for the adsorption of dyestuffs onto chitin>, Application In Synthesis of 6054-98-4, the main research area is dye adsorption chitin model; film mass transfer dye model.

The rate of adsorption of dyestuffs on chitin in the initial stages of the adsorption process depends on the film mass transfer coefficient A model has been developed to determine the film mass transfer coefficients The anal. is based on a nonlinear equilibrium isotherm and utilizes a computer program to predict theor. concentration vs. time curves. The overall average external mass transfer coefficients are 2.8 × 10-3, 2.9 × 10-3, 3.8 × 10-3, and 0.9 × 10-3 cm/s for Acid Blue 25  [6408-78-2], Acid Blue 158  [6370-08-7], Mordant Yellow 5  [6054-98-4], and Direct Red 84  [6409-83-2], resp. Equilibrium data for the adsorption of the 4 dyestuffs on chitin are presented and analyzed using the Langmuir, Freundlich, and general isotherm expressions. The adsorption capacity of chitin at monolayer coverage is 190 and 200 mg dye/g for Acid Blue 25 and Acid Blue 158, resp. Mordant Yellow 5 and Direct Red 84 adsorption capacities are 50 and 40 mg dye/g chitin, resp.

Journal of Colloid and Interface Science published new progress about Adsorptive wastewater treatment. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application In Synthesis of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Patel, Rikin D.; Prasanth Kumar, Sivakumar; Pandya, Himanshu A.; Solanki, Hitesh A. published the artcile< MDCKpred: a web-tool to calculate MDCK permeability coefficient of small molecule using membrane-interaction chemical features>, Application of C14H8N2Na2O6, the main research area is MDCK cell permeability small mol membrane interaction MDCKpred tool; Caco-2; MDCK; QSAR; permeability; permeability coefficient; web-tool.

Structure-based models to understand the transport of small mols. through biol. membrane can be developed by enumerating intermol. interactions of the small mol. with a biol. membrane, usually a dimyristoylphosphatidylcholine (DMPC) monolayer. This ADME (absorption, distribution, metabolism, and excretion) property based on Madin-Darby Canine Kidney (MDCK) cell line demonstrates intestinal drug absorption of small mols. and correlated to human intestinal absorption which acts as a determining factor to forecast small-mol. prioritization in drug-discovery projects. We present here the development of MDCKpred web-tool which calculates MDCK permeability coefficient of small mol. based on the regression model, developed using membrane-interaction chem. features. The web-tool allows users to calculate the MDCK permeability coefficient (nm/s) instantly by providing simple descriptor inputs. The chem.-interaction features are derived from different parts of the DMPC mol. viz. head, middle, and tail regions and accounts overall intermol. contacts of the small mol. when passively diffused through the phospholipid-rich biol. membrane. The MDCKpred model is both internally (R2 = .76; = .68; Rtrain = .87; Rtest = .69) and externally (Rext = .55) validated. Furthermore, we used natural mols. as application examples to demonstrate its utility in lead exploration and optimization projects. The MDCKpred web-tool can be accessed freely at http://www.mdckpred.in. This web-tool is designed to offer an intuitive way of prioritizing small mols. based on calculated MDCK permeabilities.

Toxicology Mechanisms and Methods published new progress about Absorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts