Tag: M.W=300-400

McKay, G.; Blair, H. S.; Gardner, J. G.; McConvey, I. F. published the artcile< Two-resistance mass transfer model for the adsorption of various dyestuffs onto chitin>, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is dye adsorption chitin wastewater; mass transfer model chitin dye.

The kinetics of the adsorption of various dyes onto chitin (I) [1398-61-4] were studied. The dyes used are Neoland Blue 2G (II) [6370-08-7], Eriochrome Flavin A (III) [6054-98-4], and Solophenyl Brown 3RL (IV) [6409-83-2] and a number of process variables were considered, such as adsorbent mass and dye concentration The mass transfer model is based on the assumption of a pseudoirreversible isotherm and 2 resistances to mass transfer. These are external mass transfer and internal pore diffusion mass transfer. The rate of adsorption of dyes onto I can be described by an external mass transfer coefficient and a pore diffusion coefficient The external mass transfer coefficients are 5.0 × 10-5, 5.0 × 10-5, and 1.0 × 10-5 m/s and the pore diffusivities are 3.0 × 10-10 and 4.0 × 10-11 m2/s for II, III, and IV, resp.

Journal of Applied Polymer Science published new progress about Adsorptive wastewater treatment. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tallman, Keri A.; Allen, Luke B.; Klingelsmith, Korinne; Anderson, Allison; Genaro-Mattos, Thiago C.; Mirnics, Karoly; Porter, Ned A.; Korade, Zeljka published the artcile< Prescription Medications Alter Neuronal and Glial Cholesterol Synthesis>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is drug toxicity placenta blood brain barrier cholesterol neurodevelopmental disorder; antipsychotic antidepressant antiarrhythmic neuron astrocyte dehydrocholesterol DHCR7 enzyme; 7-DHC; DHCR7; DMG method; cholesterol; desmosterol; pharmaceuticals.

Mouse brain contains over 100 million neuronal, glial, and other support cells. Developing neurons and astrocytes synthesize their own cholesterol, and disruption of this process can occur by both genetic and chem. mechanisms. In this study we have exposed cultured murine neurons and astrocytes to six different prescription medications that cross the placenta and blood-brain barriers and analyzed the effects of these drugs on cholesterol biosynthesis by an LC-MS/MS protocol that assays 14 sterols and 7 oxysterols in a single run. Three antipsychotics (haloperidol, cariprazine, aripiprazole), two antidepressants (trazodone and sertraline), and an antiarrhythmic (amiodarone) inhibited one or more sterol synthesis enzymes. The result of the exposures was a dose-dependent increase in levels of various sterol intermediates and a decreased level of cholesterol in the cultured cells. Four prescription medications (haloperidol, aripiprazole, cariprazine, and trazodone) acted primarily on the DHCR7 enzyme. The result of this exposure was an increase in 7-dehydrocholesterol in neurons and astrocytes to levels that were comparable to those found in cultured neurons and astrocytes from transgenic mice that carried a Dhcr7 pathogenic mutation modeling the neurodevelopmental disorder Smith-Lemli-Opitz syndrome.

ACS Chemical Neuroscience published new progress about Antiarrhythmics. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simpson, W. S. published the artcile< Photoprotection of wool fabrics by dyestuffs>, Application In Synthesis of 6054-98-4, the main research area is photodegradation prevention wool yellow dye; fading dye wool.

Photodegradation of wool fabrics was retarded by yellow dyes, presumably because their absorption spectra extend to the near-UV wavelengths. The effects of >50 dyes on the photodegradation of wool were determined by monitoring tensile strength, work-to-break, and alkali solubility Fading of a great majority of the dyes occurred as rapidly as the wool substrate was degraded. A small number of yellow dyes of the highest lightfastness gave good appearance retention of the fabric and extended its phys. useful by a factor of ≥2.

Wool Research Organisation of New Zealand Communications published new progress about Dyes. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application In Synthesis of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sandberg-Gertzen, H.; Kjellander, J.; Sundberg-Gillaa, B.; Jaarnerot, G. published the artcile< In vitro effects of sulphasalazine, azodisal sodium, and their metabolites on Clostridium difficile and some other fecal bacteria>, Quality Control of 6054-98-4, the main research area is Clostridium sulphasalazine azodisal sodium sensitivity; fecal bacteria sulphasalazine azodisal sodium sensitivity.

The effects of sulphasalazine (SASP), azodisal sodium (ADS), and their metabolites were tested in vitro on aerobic and anaerobic fecal bacterial strains. Sulphapyridine (SP) had a mild-to-moderate effect on Escherichia coli and Streptococcus faecalis. SASP also had a growth-inhibitory effect on S. faecalis. The other substances had no effect on aerobic strains. SASP, SP, 5-aminosalicylic acid, and, to a certain extent, N-acetyl-5-aminosalicylic acid exerted a growth-inhibitory effect on anaerobic strains. Of special interest was the inhibitory effect on Clostridium difficile strains. Some studies suggested that SASP treatment could predispose to C. difficile superinfection, whereas others found SASP more probable to exert a prophylactic effect. The findings support the theory that SASP treatment reduces rather than promotes the risk of C. difficile superinfection.

Scandinavian Journal of Gastroenterology published new progress about Clostridium difficile. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Quality Control of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Capell-Hattam, Isabelle M.; Sharpe, Laura J.; Qian, Lydia; Hart-Smith, Gene; Prabhu, Anika V.; Brown, Andrew J. published the artcile< Twin enzymes, divergent control: the cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally>, Safety of (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is human cholesterol biosynthesis enzyme DHCR14 LBR post translational regulation; dehydrocholesterol reductase DHCR14 human regulation lamin B receptor LBR; DHCR14; LBR; TM7SF2; cholesterol; cholesterol regulation; endoplasmic reticulum-associated protein degradation (ERAD); enzyme degradation; protein degradation.

Cholesterol synthesis is a tightly regulated process, both transcriptionally and post-translationally. Transcriptional control of cholesterol synthesis is relatively well-understood. However, of the ~20 enzymes in cholesterol biosynthesis, post-translational regulation has only been examined for a small number Three of the four sterol reductases in cholesterol production, 7-dehydrocholesterol reductase (DHCR7), 14-dehydrocholesterol reductase (DHCR14), and lamin-B receptor (LBR), share evolutionary ties with a high level of sequence homol. and predicted structural homol. DHCR14 and LBR uniquely share the same Δ-14 reductase activity in cholesterol biosynthesis, yet little is known about their post-translational regulation. We have previously identified specific modes of post-translational control of DHCR7, but it is unknown whether these regulatory mechanisms are shared by DHCR14 and LBR. Using CHO-7 cells stably expressing epitope-tagged DHCR14 or LBR, we investigated the post-translational regulation of these enzymes. We found that DHCR14 and LBR undergo differential post-translational regulation, with DHCR14 being rapidly turned over, triggered by cholesterol and other sterol intermediates, whereas LBR remained stable. DHCR14 is degraded via the ubiquitin-proteasome system, and we identified several DHCR14 and DHCR7 putative interaction partners, including a number of E3 ligases that modulate DHCR14 levels. Interestingly, we found that gene expression across an array of human tissues showed a neg. relationship between the C14-sterol reductases; one enzyme or the other tends to be predominantly expressed in each tissue. Overall, our findings indicate that whereas LBR tends to be the constitutively active C14-sterol reductase, DHCR14 levels are tunable, responding to the local cellular demands for cholesterol.

Journal of Biological Chemistry published new progress about Follicular fluid. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Safety of (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

St. Clair, Johnna Wellman; London, Erwin published the artcile< Effect of sterol structure on ordered membrane domain (raft) stability in symmetric and asymmetric vesicles>, Application of C27H44O, the main research area is sterol structure ordered membrane domain lipid raft stability; FRET; Lipid asymmetry; Liquid ordered; Steroid; Sterol.

Sterol structure influences liquid ordered domains in membranes, and the dependence of biol. functions on sterol structure can help identify processes dependent on ordered domains. In this study we compared the effect of sterol structure on ordered domain formation in sym. vesicles composed of mixtures of sphingomyelin, 1, 2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and cholesterol, and in asym. vesicles in which sphingomyelin was introduced into the outer leaflet of vesicles composed of DOPC and cholesterol. In most cases, sterol behavior was similar in sym. and asym. vesicles, with ordered domains most strongly stabilized by 7-dehydrocholesterol (7DHC) and cholesterol, stabilized to a moderate degree by lanosterol, epicholesterol and desmosterol, and very little if at all by 4-cholesten-3-one. However, in asym. vesicles desmosterol stabilized ordered domain almost as well as cholesterol, and to a much greater degree than epicholesterol, so that the ability to support ordered domains decreased in the order 7-DHC > cholesterol > desmosterol > lanosterol > epicholesterol > 4-cholesten-3-one. This contrasts with values for intermediate stabilizing sterols in sym. vesicles in which the ranking was cholesterol > lanosterol ∼ desmosterol ∼ epicholesterol or prior studies in which the ranking was cholesterol ∼ epicholesterol > lanosterol ∼ desmosterol. The reasons for these differences are discussed. Based on these results, we re-evaluated our prior studies in cells and conclude that endocytosis levels and bacterial uptake are even more closely correlated with the ability of sterols to form ordered domains than previously thought, and do not necessarily require that a sterol have a 3β-OH group.

Biochimica et Biophysica Acta, Biomembranes published new progress about Bilayer biological membrane. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Application of C27H44O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Eriksson, Alf; Nyholm, Leif published the artcile< Electrochemical detection of disodium 3,3'-azobis-(6-hydroxy-)benzoate (olsalazine sodium)>, Synthetic Route of 6054-98-4, the main research area is olsalazine sodium electrochem detection liquid chromatog; solubility olsalazine sodium electrochem detection LC.

Electrochem. detection of disodium 3,3′-azobis-(6-hydroxy-)benzoate, olsalazine sodium, in reversed phase liquid chromatog. is shown to provide a detection limit of 40 fmol and a linear range extending up to 4 nmol for an injection volume of 20 μL. The method has been used for the determination of the solubility of olsalazine sodium in aqueous solutions The solubility was found to be 2 × 10-8 M and 4 × 10-6 M at pH 1.0 and 3.5, resp.

Electroanalysis published new progress about Reversed phase liquid chromatography. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Synthetic Route of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yamaji-Hasegawa, Akiko; Murate, Motohide; Inaba, Takehiko; Dohmae, Naoshi; Sato, Masayuki; Fujimori, Fumihiro; Sako, Yasushi; Greimel, Peter; Kobayashi, Toshihide published the artcile< A novel sterol-binding protein reveals heterogeneous cholesterol distribution in neurite outgrowth and in late endosomes/lysosomes>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is cholesterol affinity neurite outgrowth endosome endocytosis; Endocytosis; Lipid domains; Lipid imaging; Lipid-binding protein; Membrane lipids.

We identified a mushroom-derived protein, maistero-2 that specifically binds 3-hydroxy sterol including cholesterol (Chol). Maistero-2 bound lipid mixture in Chol-dependent manner with a binding threshold of around 30%. Changing lipid composition did not significantly affect the threshold concentration EGFP-maistero-2 labeled cell surface and intracellular organelle Chol with higher sensitivity than that of well-established Chol probe, D4 fragment of perfringolysin O. EGFP-maistero-2 revealed increase of cell surface Chol during neurite outgrowth and heterogeneous Chol distribution between CD63-pos. and LAMP1-pos. late endosomes/lysosomes. The absence of strictly conserved Thr-Leu pair present in Chol-dependent cytolysins suggests a distinct Chol-binding mechanism for maistero-2.

Cellular and Molecular Life Sciences published new progress about Affinity. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Duchow, Elizabeth G.; Duchow, Mark W.; Plum, Lori A.; DeLuca, Hector F. published the artcile< Vitamin D binding protein greatly improves bioactivity but is not essential for orally administered vitamin D>, Quality Control of 434-16-2, the main research area is vitaminD calcium homeostasis 7dehydrocholesterol; ultraviolet light; vitamin D; vitamin D binding protein.

Vitamin D3 is a prohormone that is essential for calcium homeostasis. It is naturally produced in the skin by UV-B (UVB) irradiation of 7-dehydrocholesterol. In the absence of skin production, vitamin D3 can also be obtained from oral sources. However, the actual biol. equivalence of naturally produced (i.e., UVB-irradiation of skin) and oral vitamin D3 has not been determined We previously identified a unique and specific transport mechanism for skin-generated vitamin D3 which requires vitamin D binding protein (DBP); a mechanism that differs from absorption and transport of oral vitamin D3. In the following report, we examined the impact of this difference on the biol. activity of vitamin D3. We report that UVB-generated vitamin D3 is more potent at raising serum calcium compared to oral vitamin D3, with the total biol. activity being twofold higher. By examining the excretion of radiolabeled vitamin D3 injected unbound or pre-bound by DBP, we attributed the increased activity of skin-generated vitamin D3 to a significant reduction in biliary excretion of DBP-bound vitamin D relative to unbound vitamin D. Thus, removal of vitamin D3 from the skin by the natural DBP system markedly improves biol. activity compared to that given orally.

Physiological Reports published new progress about Homeostasis, calcium. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Quality Control of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ullah, Shafi; Khan, Shafi Ullah; Khan, Abbas; Junaid, Muhammad; Rafiq, Humaira; Htar, Thet Thet; Zhao, Yaxue; Shah, Syed Adnan Ali; Wadood, Abdul published the artcile< Prospect of Anterior Gradient 2 homodimer inhibition via repurposing FDA-approved drugs using structure-based virtual screening>, Related Products of 6054-98-4, the main research area is anterior Gradient homodimer inhibition FDA approved drug structure screening; AGR2 homodimer; Cancer; Dimer inhibitor; Drug repositioning; Virtual screening.

Anterior Gradient 2 (AGR2) has recently been reported as a tumor biomarker in various cancers, i.e., breast, prostate and lung cancer. Predominantly, AGR2 exists as a homodimer via a dimerization domain (E60-K64); after it is self-dimerized, it helps FGF2 and VEGF to homo-dimerize and promotes the angiogenesis and the invasion of vascular endothelial cells and fibroblasts. Up till now, no small mol. has been discovered to inhibit the AGR2-AGR2 homodimer. Therefore, the present study was performed to prepare a validated 3D structure of AGR2 by homol. modeling and discover a small mol. by screening the FDA-approved drugs library on AGR2 homodimer as a target protein. Thirteen different homol. models of AGR2 were generated based on different templates which were narrowed down to 5 quality models sorted by their overall Z-scores. The top homol. model based on PDB ID = 3PH9 was selected having the best Z-score and was further assessed by Verify-3D, ERRAT and RAMPAGE anal. Structure-based virtual screening narrowed down the large library of FDA-approved drugs to ten potential AGR2-AGR2 homodimer inhibitors having FRED score lower than – 7.8 kcal/mol in which the top 5 drugs’ binding stability was counter-validated by mol. dynamic simulation. To sum up, the present study prepared a validated 3D structure of AGR2 and, for the first time reported the discovery of 5 FDA-approved drugs to inhibit AGR2-AGR2 homodimer by using structure-based virtual screening. Moreover, the binding of the top 5 hits with AGR2 was also validated by mol. dynamic simulation. A validated 3D structure of Anterior Gradient 2 (AGR2) was prepared by homol. modeling, which was used in virtual screening of FDA-approved drugs library for the discovery of prospective inhibitors of AGR2-AGR2 homodimer.

Molecular Diversity published new progress about Anterior gradient protein 2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Related Products of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts