Tag: M.W=300-400

Li, Jie; Scarano, Aurelia; Gonzalez, Nestor Mora; D’Orso, Fabio; Yue, Yajuan; Nemeth, Krisztian; Saalbach, Gerhard; Hill, Lionel; de Oliveira Martins, Carlo; Moran, Rolando; Santino, Angelo; Martin, Cathie published the artcile< Biofortified tomatoes provide a new route to vitamin D sufficiency>, Synthetic Route of 434-16-2, the main research area is biofortified tomatoe provide vitamin D sufficiency.

Poor vitamin D status is a global health problem; insufficiency underpins higher risk of cancer, neurocognitive decline and all-cause mortality. Most foods contain little vitamin D and plants are very poor sources. We have engineered the accumulation of provitamin D3 in tomato by genome editing, modifying a duplicated section of phytosterol biosynthesis in Solanaceous plants, to provide a biofortified food with the added possibility of supplement production from waste material.

Nature Plants (London, United Kingdom) published new progress about Alkaloidal steroidal glycosides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Synthetic Route of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stokstad, Erik published the artcile< Engineered tomatoes get a healthy dose of vitamin D.>, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is .

Knocking out a gene boosts precursors of essential nutrient.

Science (New York, N.Y.) published new progress about 434-16-2. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Delle Bovi, Richard J.; Kim, JiHyun; Suresh, Pavana; London, Erwin; Miller, W. Todd published the artcile< Sterol structure dependence of insulin receptor and insulin-like growth factor 1 receptor activation>, Synthetic Route of 434-16-2, the main research area is insulin receptor IGF1R autophosphorylation cholesterol sterol plasma membrane; Autophosphorylation; Cholesterol; Receptor tyrosine kinase.

The plasma membrane is a dynamic environment with a complex composition of lipids, proteins, and cholesterol. Areas enriched in cholesterol and sphingolipids are believed to form lipid rafts, domains of highly ordered lipids. The unique phys. properties of these domains have been proposed to influence many cellular processes. Here, we demonstrate that the activation of insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) depends critically on the structures of membrane sterols. IR and IGF1R autophosphorylation in vivo was inhibited by cholesterol depletion, and autophosphorylation was restored by the replacement with exogenous cholesterol. We next screened a variety of sterols for effects on IR activation. The ability of sterols to support IR autophosphorylation was strongly correlated to the propensity of the sterols to form ordered domains. IR autophosphorylation was fully restored by the incorporation of ergosterol, dihydrocholesterol, 7-dehydrocholesterol, lathosterol, desmosterol, and allocholesterol, partially restored by epicholesterol, and not restored by lanosterol, coprostanol, and 4-cholesten-3-one. These data support the hypothesis that the ability to form ordered domains is sufficient for a sterol to support ligand-induced activation of IR and IGF1R in intact mammalian cells.

Biochimica et Biophysica Acta, Biomembranes published new progress about Cell membrane. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Synthetic Route of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lee, Seung Mi; Moon, Ju-Yeon; Lim, Byeong-Yun; Kim, Sun Min; Park, Chan-Wook; Kim, Byoung Jae; Jun, Jong Kwan; Norwitz, Errol R.; Choi, Man Ho; Park, Joong Shin published the artcile< Increased biosynthesis and accumulation of cholesterol in maternal plasma, but not amniotic fluid in pre-eclampsia>, Category: alcohols-buliding-blocks, the main research area is preeclampsia amniotic fluid diagnosis metabolomics cholesterol.

We undertook this study to compare the metabolic signatures of cholesterol in serum and amniotic fluid collected from women who delivered in the late preterm period. Matching serum and amniotic fluid samples were collected from women who delivered in the late preterm period (34-0/7-36-6/7 wk), had undergone amniocentesis within 3 days of delivery, had no evidence of rupture of membranes or intra-amniotic infection/inflammation, and who had not received antenatal corticosteroid prior to amniocentesis. A total of 39 women were included in the anal. (n = 14 in Group 1, n = 16 in Group 2, n = 9 in Group 3). In maternal blood, patients in Group 1 had higher ratios of cholesterol/desmosterol and cholesterol/7-dehydrocholesterol (which represent 24- and 7-reductase enzyme activity, resp.) than those in Group 3 (p < 0.05 for each), which suggests increased cholesterol biosynthesis. In contrast, patients in Group 1 had decreased ratios of individual cholesterol esters/cholesterol and total cholesterol esters/cholesterol than those in Groups 3 (p < 0.01 for each), suggesting increased reverse cholesterol transport. No differences in cholesterol ratios were found in amniotic fluid among the 3 groups. In conclusion, the metabolic signatures of cholesterol suggest increased cholesterol biosynthesis and accumulation in the maternal blood (but not amniotic fluid) of women with preeclampsia. Scientific Reports published new progress about Amniotic fluid. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Eriksson, Alf; Nyholm, Leif published the artcile< A comparison of the electrochemical properties of some azosalicylic acids at glassy carbon electrodes by cyclic and hydrodynamic voltammetry>, Product Details of C14H8N2Na2O6, the main research area is azo salicylic acid glassy carbon electrode cyclic hydrodynamic voltammetry; electrochem reduction azo salicylic acid glassy carbon electrode 21345678; oxidation electrochem azo salicylic acid glassy carbon electrode 21345678.

The electrochem. properties of a number of azosalicylic acid derivatives were compared at glassy carbon electrodes using cyclic and hydrodynamic voltammetry. The reduction of all studied compounds, except one, is irreversible giving rise to disruption of the azo bridge and formation of the corresponding amines. The rate of cleavage of the azo bridge depended on the position of the hydroxy substituents on the aromatic rings of the azosalicylic compounds A reoxidation wave, most likely due to the oxidation of a hydrazo intermediate, was observed for compounds with either only one hydroxyl group, or hydroxyl groups in the meta-para or meta-meta positions relative to the azo bridge. The oxidation of the azosalicylic compounds with no, or only one, hydroxy group in the para position was generally found to be irreversible yielding poorly defined oxidation waves. Azosalicylic acids with two hydroxy groups, either in the para position of both rings or in the ortho position of one ring and para position of the other, gave rise to well defined oxidation peaks at significantly less pos. potentials. For the compounds with the hydroxyl groups in the para position of both rings, reredn. waves were also seen on the return scan, indicating that the oxidation products were stable on the voltammetric time scale.

Electrochimica Acta published new progress about Amines Role: FMU (Formation, Unclassified), PRP (Properties), FORM (Formation, Nonpreparative). 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Product Details of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Irvine, Jennifer D.; Takahashi, Lori; Lockhart, Karen; Cheong, Jonathan; Tolan, John W.; Selick, H. E.; Grove, J. Russell published the artcile< MDCK (Madin-Darby canine kidney) cells: a tool for membrane permeability screening>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is membrane permeability drug screening MDCK Caco2; high throughput screening MDCK Caco2 drug bioavailability; assay membrane permeability screening drug pharmacokinetics.

The goal of this work was to investigate the use of MDCK (Madin-Darby canine kidney) cells as a possible tool for assessing the membrane permeability properties of early drug discovery compounds Apparent permeability (Papp) values of 55 compounds with known human absorption values were determined using MDCK cell monolayers. For comparison, Papp values of the same compounds were also determined using Caco-2 cells, a well-characterized in vitro model of intestinal drug absorption. Monolayers were grown on 0.4-μm Transwell-COL membrane culture inserts. MDCK cells were seeded at high d. and cultured for 3 days, and Caco-2 cells were cultured under standard conditions for 21 to 25 days. Compounds were tested using 100 μM donor solutions in transport medium (pH 7.4) containing 1% DMSO. The Papp values in MDCK cells correlated well with those in Caco-2 cells (r2 = 0.79). Spearman’s rank correlation coefficient for MDCK Papp and human absorption was 0.58 compared with 0.54 for Caco-2 Papp and human absorption. These results indicate that MDCK cells may be a useful tool for rapid membrane permeability screening.

Journal of Pharmaceutical Sciences published new progress about Analysis. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Uslu, B.; Yilmaz, S.; Ozkan, S. A. published the artcile< Determination of olsalazine sodium in pharmaceuticals by differential pulse voltammetry>, Application of C14H8N2Na2O6, the main research area is olsalazine sodium determination pharmaceutical voltammetry.

The electrochem. oxidation of olsalazine Na was studied by cyclic, linear sweep, differential pulse and square wave voltammetry using glassy C disk electrode in different buffer systems. Best results were obtained for the determination of olsalazine using the differential pulse voltammetric technique in phosphate buffer at pH 7.0. The electroactive species exhibits a diffusion-controlled voltammetric wave and its differential pulse peak current shows a linear dependence on olsalazine concentration in the range between 2 × 10-6 M and 2 × 10-4 M. This relation was applied to the determination of olsalazine in com. capsule dosage forms. The recovery study shows good accuracy and precision for the assay developed. A UV spectrophotometric assay is also reported for comparison.

Pharmazie published new progress about Differential pulse voltammetry. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cutolo, Maurizio; Soldano, Stefano; Sulli, Alberto; Smith, Vanessa; Gotelli, Emanuele published the artcile< Influence of seasonal vitamin D changes on clinical manifestations of rheumatoid arthritis and systemic sclerosis>, Category: alcohols-buliding-blocks, the main research area is review vitamin D rheumatoid arthritis systemic sclerosis; circadian rhythms; connective tissue diseases; rheumatoid arthritis; systemic sclerosis; vitamin D.

A review. Vitamin D [1,25(OH)2D-calcitriol] is basically a steroid hormone with pleiotropic biol. effects, and its impact on the regulation of immune system may influence several clin. conditions. Calcidiol (25OHD), as precursor of calcitriol, derives, for the most part (80%), from cutaneous cholesterol (7-dehydrocholesterol) under the action of UV-B (sunlight). Consequently, serum concentrations fluctuate during the year following the circannual rhythm of sun exposition. We will update about the available evidence regarding the complex influence of seasonal vitamin D changes on two different chronic connective tissue diseases, namely rheumatoid arthritis (RA) and systemic sclerosis (SSc). Notably, RA is an emblematic model of autoimmune disease with prevalent joint inflammatory features, while SSc is mainly an autoimmune progressive pro-fibrotic disease. However, in both conditions, low serum concentrations of 25OHD are involved in the pathogenesis of the diseases, and emerging data report their impact on clin. manifestations.

Frontiers in Immunology published new progress about Autoimmune disease. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tallman, Keri A.; Allen, Luke B.; Klingelsmith, Korinne; Anderson, Allison; Genaro-Mattos, Thiago C.; Mirnics, Karoly; Porter, Ned A.; Korade, Zeljka published the artcile< Prescription Medications Alter Neuronal and Glial Cholesterol Synthesis>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is drug toxicity placenta blood brain barrier cholesterol neurodevelopmental disorder; antipsychotic antidepressant antiarrhythmic neuron astrocyte dehydrocholesterol DHCR7 enzyme; 7-DHC; DHCR7; DMG method; cholesterol; desmosterol; pharmaceuticals.

Mouse brain contains over 100 million neuronal, glial, and other support cells. Developing neurons and astrocytes synthesize their own cholesterol, and disruption of this process can occur by both genetic and chem. mechanisms. In this study we have exposed cultured murine neurons and astrocytes to six different prescription medications that cross the placenta and blood-brain barriers and analyzed the effects of these drugs on cholesterol biosynthesis by an LC-MS/MS protocol that assays 14 sterols and 7 oxysterols in a single run. Three antipsychotics (haloperidol, cariprazine, aripiprazole), two antidepressants (trazodone and sertraline), and an antiarrhythmic (amiodarone) inhibited one or more sterol synthesis enzymes. The result of the exposures was a dose-dependent increase in levels of various sterol intermediates and a decreased level of cholesterol in the cultured cells. Four prescription medications (haloperidol, aripiprazole, cariprazine, and trazodone) acted primarily on the DHCR7 enzyme. The result of this exposure was an increase in 7-dehydrocholesterol in neurons and astrocytes to levels that were comparable to those found in cultured neurons and astrocytes from transgenic mice that carried a Dhcr7 pathogenic mutation modeling the neurodevelopmental disorder Smith-Lemli-Opitz syndrome.

ACS Chemical Neuroscience published new progress about Antiarrhythmics. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tang, Yun-Zhi; Tan, Yu-Hui; Chen, Shao-Hu; Chao, Yan-Wen; Wang, Ping published the artcile< Synthesis, characterization and crystal structures of two alkaline-earth metal complexes of olsalazine>, Reference of 6054-98-4, the main research area is olsalazine magnesium calcium aqua polymer complex preparation structure; crystal structure magnesium calcium olsalazine aqua polymer complex.

Two one-dimensional linear coordination polymers, [Mg(L)·4(H2O)] (1, H2L = olsalazine) and [Ca(L)·4(H2O)] (2) were obtained from self-assembly of CaCl2 or MgSO4 with olsalazine and their structures determined by single crystal x-ray diffraction. Both complexes are one-dimensional polymers, with crystal data for complex 1: P2(1)/c, a 9.5224(18), b 11.309(2), c 16.211(3) Å, β 106.648(3)°, V 1672.6(6) Å3, Z = 4, space group R1 = 0.0695, wR2 = 0.2183, for complex 2: space group P4(3)2(1)2, a 10.4006(2), b 10.4006(2), c 32.0746(10) Å, V 3469.59(14) Å3, Z = 8, R1 = 0.0332, wR2 = 0.1015. In the complexes, Mg and Ca adopt totally different coordination modes. Alk.-earth Mg has a six-coordinate octahedral geometry, however, in 2, the local coordination geometry around calcium atom can be best described as a slightly distorted pentagonal bipyramid crystallizing in a homo-chiral space group. Olsalazine in both compounds also adopts dissimilar coordination modes.

Journal of Coordination Chemistry published new progress about Crystal structure. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Reference of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts