Tag: M.W=300-400

Heng, Ya Gao; Wen, Li Peng; Pan, Pan Meng; Xue, Feng Feng; Jian, Qiang Li; Hui, Qiong Wu; Chang, Sheng Yan; Yang, Yang Xiong; Luo, Feng published the artcile< Lanthanide separation using size-selective crystallization of Ln-MOFs>, Formula: C14H8N2Na2O6, the main research area is size selective crystallization separation lanthanide olsalazine MOF; crystal structure lanthanide olsalazine MOF preparation.

Herein, the authors report an elaborate method, size-selective crystallization of Ln-MOFs, to isolate lanthanide (Ln) ions. Herein, 13 lanthanide ions, except for the radioactive Pm(III) ion and ytterbium, were separated by four types of Ln-MOFs: type I [La-Pr, Ln2(OLZ)(H2OLZ)(DMF)(H2O)2·2H2O], type II [Nd-Eu, Ln(OLZ)0.5(H2OLZ)0.5(DMF)(μ2-DMF)0.5], type III [Gd-Ho, Ln(OLZ)0.5(H2OLZ)0.5(DMF)(H2O)·H2O], and type IV [Er-Lu, Ln2(OLZ)(H2OLZ)(H2O)4 where OLZ = olsalazine]. Further systemic investigation also suggested the highly selective separation of lanthanide ions by this method.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Formula: C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Speen, Adam M.; Hoffman, Jessica R.; Kim, Hye-Young H.; Escobar, Yael N.; Nipp, Grace E.; Rebuli, Meghan E.; Porter, Ned A.; Jaspers, Ilona published the artcile< Small Molecule Antipsychotic Aripiprazole Potentiates Ozone-Induced Inflammation in Airway Epithelium>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is antipsychotic aripiprazole ozone inflammation airway epithelium.

Inhaled ground level ozone (O3) has well described adverse health effects, which may be augmented in susceptible populations. While conditions, such as pre-existing respiratory disease, have been identified as factors enhancing susceptibility to O3-induced health effects, the potential for chem. interactions in the lung to sensitize populations to pollutant-induced responses has not yet been studied. In the airways, inhaled O3 reacts with lipids, such as cholesterol, to generate reactive and electrophilic oxysterol species, capable of causing cellular dysfunction and inflammation. The enzyme regulating the final step of cholesterol biosynthesis, 7-dehydrocholesterol reductase (DHCR7), converts 7-dehydrocholesterol (7-DHC) to cholesterol. Inhibition of DHCR7 increases the levels of 7-DHC, which is much more susceptible to oxidation than cholesterol. Chem. anal. established the capacity for a variety of small mol. antipsychotic drugs, like Aripiprazole (APZ), to inhibit DHCR7 and elevate circulating 7-DHC. Our results show that APZ and the known DHCR7 inhibitor, AY9944, increase 7-DHC levels in airway epithelial cells and potentiate O3-induced IL-6 and IL-8 expression and cytokine release. Targeted immune-related gene array anal. demonstrates that APZ significantly modified O3-induced expression of 16 genes, causing dysregulation in expression of genes associated with leukocyte recruitment and inflammatory response. Addnl., we find that APZ increases O3-induced IL-6 and IL-8 expression in human nasal epithelial cells from male but not female donors. Overall, the evidence we provide describes a novel mol. mechanism by which chems., such as APZ, that perturb cholesterol biosynthesis affect O3-induced biol. responses.

Chemical Research in Toxicology published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (C1R). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Levinson, Robert A. published the artcile< Disodium azodisalicylate>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is review azodisalicylate inflammatory bowel disease.

A review with 22 references on the use of azodisalicylate (I) [6054-98-4] in the treatment of inflammatory bowel disease.

American Journal of Gastroenterology published new progress about Inflammatory bowel disease. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saltiel, Jack; Krishnan, Sumesh B.; Gupta, Shipra; Hernberg, E. Aliea; Clark, Ronald J. published the artcile< Photochemistry and photophysics of cholesta-5,7,9(11)-trien-3β-ol: a fluorescent analogue of cholesterol>, Related Products of 434-16-2, the main research area is cholestatrienol fluorescent analog photochem photophysics; Cholestatrienol rearrangement; Endoperoxide phototoproducts; Fluorescence triplet yields.

Cholesta-5,7,9(11)-trien-3β-ol (9,11-dehydroprovitamin D3, CTL) is used as a fluorescent probe to track the presence and migration of cholesterol in vivo. CTL is known to be photochem. active, but little consideration has been given to the formation efficiency and possible toxicity of its photoproducts. In degassed THF (THF) solution, we isolated the photoproduct of CTL and of its 25-hydroxy derivative (HOCTL), and X-ray crystal structures were obtained for HOCTL and the photorearrangement product. The X-ray crystal structure and its 1H NMR spectrum confirm the product structure as a pentacyclic HOCTL isomer. In the presence of air in THF, endoperoxide formation via [2+4] addition of 1O2* across the B ring of CTL or HOCTL becomes the dominant photoreaction. The UV spectrum and decay kinetics of the triplet state of HOCTL, the precursor of 1O2*, are determined by transient absorption spectroscopy. We confirm the proposed structure of the endoperoxide by X-ray crystallog. Kinetics anal. of quantum yields provides rate constants for photophys. and photochem. events.

Photochemical & Photobiological Sciences published new progress about Crystal structure. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Related Products of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Jiahe; Shi, Jiaqi; Han, Shuo; Zheng, Pai; Chen, Zhangjian; Jia, Guang published the artcile< Titanium dioxide nanoparticles induced reactive oxygen species (ROS) related changes of metabolomics signatures in human normal bronchial epithelial (BEAS-2B) cells>, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is titanium dioxide nanoparticle reactive oxygen species bronchial epithelial; Lipid metabolism; Liquid chromatography; Metabolomics; Reactive oxygen pecies; Titanium dioxide nanoparticles.

Titanium dioxide often enters the respiratory tract in the form of nano-dust in occupational sites. Metabolomics may be a promising method for studying the toxicol. of nano titanium dioxide. The intention of this study was to explore the possible impact of titanium dioxide nanoparticles (TiO2 NPs) on the metabolomics signatures of human normal bronchial epithelial (BEAS-2B) cells and to search for investigate the role of reactive oxygen species (ROS). In this study, BEAS-2B cells were treated by TiO2 NPs (0, 25, 50 and 100μg/mL) for 48 h. The metabolites extracted from BEAS-2B cells were determined by untargeted metabolomics technique, and the differential metabolites and metabolic pathways were discovered by using multivariate anal. Intracellular ROS was detected by DCFH-DA probe and flow cytometry method. Machine learning was used to explore the relationship between ROS and metabolomics changes. Totally, seventy-six differential metabolites and the steroid biosynthesis pathway of BEAS-2B cells were observed after treatment of TiO2 NPs. Lipid and lipid-like metabolites were the most significant classes among the metabolite products induced by TiO2 NPs. TiO2 NPs resulted in a dose-dependent increase in intracellular ROS levels, and correlated with most of the differential metabolites. In conclusion, TiO2 NPs increased the level of the oxidative stress, which could contribute to the altered signature represented by lipid metabolism in BEAS-2B cells.

Toxicology and Applied Pharmacology published new progress about Bronchial epithelium. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rubin, David T.; LoSavio, Andelka; Yadron, Nicole; Huo, Dezheng; Hanauer, Stephen B. published the artcile< Aminosalicylate therapy in the prevention of dysplasia and colorectal cancer in ulcerative colitis>, Application In Synthesis of 6054-98-4, the main research area is dysplasia colorectal cancer ulcerative colitis asacol dipentum azulfidine antitumor.

Background & Aims: Aminosalicylates have been suggested as chemopreventive agents for colorectal cancer (CRC) in ulcerative colitis (UC). We studied the effect of aminosalicylate use on dysplasia and CRC risk in chronic UC. Methods: UC patients with dysplasia or CRC were matched with controls by disease duration, extent, and age at diagnosis. The total amount of aminosalicylates over the duration of the disease and the mean daily amount of drug was calculated Conditional logistic regression was used to examine the relationship of aminosalicylates to the risk of neoplasia; potential confounders were controlled in a multivariable model. Results: Twenty-six cases (8 CRC, 18 dysplasia) were matched with 96 controls. Cases and controls were similar in age (median, 43 vs 42.5 y), age at diagnosis of UC (median, 29.5 vs 30.5 y), duration of UC (median, 11.5 vs 9 y), and extent of disease (58% pancolitis), sex, family history of UC, history of primary sclerosing cholangitis, and smoking history. Cases were more likely to have a family history of CRC than controls (27% of cases, 9% of controls, P = .036). Conditional logistic regression adjusted for disease duration, age at diagnosis, and family history of CRC showed that aminosalicylate use of 1.2 g/day or more was associated with a 72% reduction in the odds of dysplasia/CRC (odds ratio, 0.28; 95% confidence interval, 0.09-0.85). As the total dose of aminosalicylates increased, the odds of dysplasia/CRC decreased (P = .056). Conclusions: This case-control study shows a significant risk reduction of dysplasia and CRC in UC patients exposed to aminosalicylate therapy.

Clinical Gastroenterology and Hepatology published new progress about Antitumor agents. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application In Synthesis of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wikberg, Martin; Alderborn, Goeran published the artcile< Compression characteristics of granulated materials. IV. The effect of granule porosity on the fragmentation propensity and the compactibility of some granulations>, Application of C14H8N2Na2O6, the main research area is granulation granule porosity fragmentation compactibility; compression granulation tablet property.

Eleven granulations of a common filler (lactose) and 3 granulations of a high-dosage drug (dipentum) were produced by wet granulation with poly(vinylpyrrolidone) as binder in a high shear mixer. The agglomeration process was varied to produce granulations with varying granule porosity. The size fraction 500-710 μm was separated and characterized on binder content (lactose granulations), granule porosity and friability. The granule fragmentation during compaction was evaluated by measurements of the air permeability of the tablets. Finally, the diametral compression strength of tablets compacted from unlubricated granulations and lactose granulations lubricated with 0.5% by weight magnesium stearate at 150 MPa was measured. The results showed that the degree of granule fragmentation during compaction was related to the granule porosity before compaction. A granulation with a higher porosity had a higher fragmentation propensity, as evaluated by the permeametry measurements, and the tablet strength was less affected by magnesium stearate addition The tablet strength correlated well with the degree of fragmentation, i.e. a granulation with higher degree of fragmentation gave tablets of a higher mech. strength. Variations in compactibility, when the same formulation is wet granulated under different process conditions, can be explained by variations in granule porosity.

International Journal of Pharmaceutics published new progress about Pharmaceutical granules. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mahmud, N.; O’Toole, D.; O’Hare, N.; Freyne, P. J.; Weir, D. G.; Kelleher, D. published the artcile< Evaluation of renal function following treatment with 5-aminosalicylic acid derivatives in patients with ulcerative colitis>, SDS of cas: 6054-98-4, the main research area is mesalazine olsalazine aminosalicylate ulcerative colitis nephrotoxicity microalbuminuria prognosis.

A number of cases of nephrotoxicity have been reported in patients with inflammatory bowel disease taking oral 5-aminosalicylic acid (5-ASA). The aim of this study was to evaluate the effects of 9 mo of therapy with mesalazine or olsalazine on renal function in patients with ulcerative colitis in remission. Forty patients with ulcerative colitis in complete remission for 6 mo were randomized to either olsalazine (n = 20) or mesalazine (n = 20 for nine months). Thirty-six of the 40 patients were on prior salicylate therapy. Disease activity was the measure of clin. efficacy and was assessed by the Harvey-Bradshaw Index (HBI). Laboratory efficacy measurements included glomerular filtration rate (GFR), microalbuminuria, urinary glutathione S-transferase (GST) and serum C-reactive protein (CRP). Safety anal. consisted of documentation of adverse events and laboratory values. There was no significant reduction in the GFR overall on therapy. The levels of GFR adjusted for baseline were similar in the two treatment groups after 3, 6 and 9 mo. A significantly higher percentage of mesalazine-treated patients experienced drug related adverse events, all of a minor nature. The incidence of adverse events causing early withdrawal was similar in the two treatment groups. Treatment with mesalazine or olsalazine for 9 mo had no significant impact on GFR.

Alimentary Pharmacology and Therapeutics published new progress about C-reactive protein Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, SDS of cas: 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shin, Mi Hee; Lee, Yuri; Kim, Min-Kyoung; Lee, Dong Hun; Chung, Jin Ho published the artcile< UV increases skin-derived 1α,25-dihydroxyvitamin D3 production, leading to MMP-1 expression by altering the balance of vitamin D and cholesterol synthesis from 7-dehydrocholesterol>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is UV radiation dihydroxyvitamin D3 MMP1 vitamin D cholesterol dehydrocholesterol; 1α,25-dihydroxyvitamin D(3); 7-dehydrocholesterol; 7-dehydrocholesterol reductase; CYP27B1; Cholesterol; MMP-1; UV.

Here, we investigated the effect of skin-derived 1α,25(OH)2D3, synthesized purely within the keratinocytes, on MMP-1 expression. Treatment of human epidermal keratinocytes with 1α,25(OH)2D3, but not 7DHC or 25OHD3, significantly increased MMP-1 expression. UV irradiation increases 1α,25(OH)2D3 levels, and ketoconazole inhibits UV-induced production of 1α,25(OH)2D3. Upregulation of MMP-1 by UV was reversed by inhibition of 1α,25(OH)2D3 synthesis using ketoconazole or CYP27B1 siRNA. In keratinocytes, 7DHC is a substrate for both cholesterol and 1α,25(OH)2D3 synthesis. We demonstrated that UV irradiation leads to decreased expression of DHCR7 (7-dehydrocholesterol reductase), the enzyme that converts 7DHC to cholesterol. Inhibition of DHCR7 with its inhibitor BM15766 decreased cholesterol synthesis and increased UV-induced MMP-1 expression, which was attenuated by ketoconazole. These findings suggest that UV-induced reduction of DHCR7 leads to a decrease in cholesterol synthesis, thereby increasing 7DHC availability for 1α,25(OH)2D3 production, which enhances MMP-1 expression. Finally, UV irradiation in human skin in vivo significantly increased CYP27B1 mRNA and decreased DHCR7 mRNA expression.

Journal of Steroid Biochemistry and Molecular Biology published new progress about Homo sapiens. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mahmud, N.; O’Toole, D.; O’Hare, N.; Freyne, P. J.; Weir, D. G.; Kelleher, D. published the artcile< Evaluation of renal function following treatment with 5-aminosalicylic acid derivatives in patients with ulcerative colitis>, SDS of cas: 6054-98-4, the main research area is mesalazine olsalazine aminosalicylate ulcerative colitis nephrotoxicity microalbuminuria prognosis.

A number of cases of nephrotoxicity have been reported in patients with inflammatory bowel disease taking oral 5-aminosalicylic acid (5-ASA). The aim of this study was to evaluate the effects of 9 mo of therapy with mesalazine or olsalazine on renal function in patients with ulcerative colitis in remission. Forty patients with ulcerative colitis in complete remission for 6 mo were randomized to either olsalazine (n = 20) or mesalazine (n = 20 for nine months). Thirty-six of the 40 patients were on prior salicylate therapy. Disease activity was the measure of clin. efficacy and was assessed by the Harvey-Bradshaw Index (HBI). Laboratory efficacy measurements included glomerular filtration rate (GFR), microalbuminuria, urinary glutathione S-transferase (GST) and serum C-reactive protein (CRP). Safety anal. consisted of documentation of adverse events and laboratory values. There was no significant reduction in the GFR overall on therapy. The levels of GFR adjusted for baseline were similar in the two treatment groups after 3, 6 and 9 mo. A significantly higher percentage of mesalazine-treated patients experienced drug related adverse events, all of a minor nature. The incidence of adverse events causing early withdrawal was similar in the two treatment groups. Treatment with mesalazine or olsalazine for 9 mo had no significant impact on GFR.

Alimentary Pharmacology and Therapeutics published new progress about C-reactive protein Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, SDS of cas: 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts