Tag: M.W=300-350

Ge, Jun published the artcileSustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide, Related Products of alcohols-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(47), 9034-9036, database is CAplus and MEDLINE.

A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO₂. The microemulsion consists of a tRNA aqueous solution (water phase), dichloromethane containing poly(L-lactic acid)-poly(ethylene glycol) (oil phase), the surfactant n-octyl β-D-glucopyranoside, and the cosurfactant n-butanol.

Chemical Communications (Cambridge, United Kingdom) published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheng, Feixiong published the artcileIn Silico Assessment of Chemical Biodegradability, COA of Formula: C22H38O2, the publication is Journal of Chemical Information and Modeling (2012), 52(3), 655-669, database is CAplus and MEDLINE.

Biodegradation is the principal environmental dissipation process. Due to a lack of comprehensive exptl. data, high study cost and time-consuming, in silico approaches for assessing the biodegradable profiles of chems. are encouraged and is an active current research topic. We developed in-silico methods to estimate chem. biodegradability in the environment. At SST, 1440 diverse compounds tested under the Japanese Ministry of International Trade and Industry (MI-TI) protocol were used. Four different methods (support vector machine, k-nearest neighbor, naive B-ayes, and CU.5 decision tree) were used to build the combinatorial classification probability models of ready vs. not ready biodegradability using physicochem. descriptors and fingerprints sep. The overall predictive accuracies of the best models were >80% for the external test set of 164 diverse compounds Some privileged substructures were further identified for ready or not ready biodegradable chems. by combining information gain and substructure fragment anal. Here, 27 new predicted chems. were selected for exptl. assay through the Japanese MI-TI test protocols, which validated that all 27 compounds were predicted correctly. The predictive accuracies of our models outperform the commonly used software of the E-PI Suite. Our study provided critical tools for early assessment of biodegradability of new organic chems. in environmental hazard assessment.

Journal of Chemical Information and Modeling published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, COA of Formula: C22H38O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Free, Paul published the artcileMannose-pepstatin conjugates as targeted inhibitors of antigen processing, Application of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Organic & Biomolecular Chemistry (2006), 4(9), 1817-1830, database is CAplus and MEDLINE.

The mol. details of antigen processing, including the identity of the enzymes involved, their intracellular location and their substrate specificity, are still incompletely understood. Selective inhibition of proteolytic antigen processing enzymes such as cathepsins D and E, using small mol. inhibitors such as pepstatin, has proven to be a valuable tool in investigating these pathways. However, pepstatin is poorly soluble in water and has limited access to the antigen processing compartment in antigen presenting cells. We have synthesized mannose-pepstatin conjugates, and neomannosylated BSA-pepstatin conjugates, as tools for the in vivo study of the antigen processing pathway. Conjugation to mannose and to neomannosylated BSA substantially improved the solubility of the conjugates relative to pepstatin. The mannose-pepstatin conjugates showed no reduction in inhibition of cathepsin E, whereas the neomannosylated BSA-pepstatin conjugates showed some loss of inhibition, probably due to steric factors. However, a neomannosylated BSA-pepstatin conjugate incorporating a cleavable disulfide linkage between the pepstatin and the BSA showed the best uptake to dendritic cells and the best inhibition of antigen processing.

Organic & Biomolecular Chemistry published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Application of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wolfe, Aaron J. published the artcileInterrogating Detergent Desolvation of Nanopore-Forming Proteins by Fluorescence Polarization Spectroscopy, Safety of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Analytical Chemistry (Washington, DC, United States) (2017), 89(15), 8013-8020, database is CAplus and MEDLINE.

Understanding how membrane proteins interact with detergents is of fundamental and practical significance in structural and chem. biol. as well as in nanobiotechnol. Current methods for inspecting protein-detergent complex (PDC) interfaces require high concentrations of protein and are of low throughput. Here, the authors describe a scalable, spectroscopic approach that uses nanomolar protein concentrations in native solutions This approach, which is based on steady-state fluorescence polarization (FP) spectroscopy, kinetically resolves the dissociation of detergents from membrane proteins and protein unfolding. For satisfactorily solubilizing detergents, at concentrations much greater than the critical micelle concentration (CMC), the fluorescence anisotropy was independent of detergent concentration In contrast, at detergent concentrations comparable with or below the CMC, the anisotropy readout underwent a time-dependent decrease, showing a specific and sensitive protein unfolding signature. Functionally reconstituted membrane proteins into a bilayer membrane confirmed predictions made by these FP-based determinations with respect to varying refolding conditions. From a practical point of view, this 96-well anal. approach will facilitate a massively parallel assessment of the PDC interfacial interactions under a fairly broad range of micellar and environmental conditions. The authors expect that these studies will potentially accelerate research in membrane proteins pertaining to their extraction, solubilization, stabilization, and crystallization, as well as reconstitution into bilayer membranes.

Analytical Chemistry (Washington, DC, United States) published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C18H24N6O6S4, Safety of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Paula, Stefan published the artcileNovel phenolic inhibitors of the sarco/endoplasmic reticulum calcium ATPase: identification and characterization by quantitative structure-activity relationship modeling and virtual screening, Synthetic Route of 903-19-5, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2015), 30(1), 1-8, database is CAplus and MEDLINE.

Inhibitors of the sarco/endoplasmic reticulum calcium ATPase (SERCA) are valuable research tools and hold promise as a new generation of anti-prostate cancer agents. Based on previously determined potencies of phenolic SERCA inhibitors, we created quant. structure-activity relationship (QSAR) models using three independent development strategies. The obtained QSAR models facilitated virtual screens of several com. compound collections for novel inhibitors. Sixteen compounds were subsequently evaluated in SERCA activity inhibition assays and 11 showed detectable potencies in the micro- to millimolar range. The exptl. results were then incorporated into a comprehensive master QSAR model, whose phys. interpretation by partial least squares anal. revealed that properly positioned substituents at the central Ph ring capable of forming hydrogen bonds and of undergoing hydrophobic interactions were prerequisites for effective SERCA inhibition. The established SAR was in good agreement with findings from previous structural studies, even though it was obtained independently using standard QSAR methodologies.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Synthetic Route of 903-19-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Lei published the artcileEngineering Polymeric Prodrug Nanoplatform for Vaccination Immunotherapy of Cancer, SDS of cas: 96345-79-8, the publication is Nano Letters (2020), 20(6), 4393-4402, database is CAplus and MEDLINE.

Neoantigen-based cancer vaccines are promising for boosting cytotoxic T lymphocyte (CTL) responses. However, the therapeutic effect of cancer vaccines is severely blunted by functional suppression of the dendritic cells (DCs). Herein, we demonstrated an acid-responsive polymeric nanovaccine for activating the stimulator of interferon genes (STING) pathway and improving cancer immunotherapy. The nanovaccines were fabricated by integrating an acid-activatable polymeric conjugate of the STING agonist and neoantigen into one single nanoplatform. The nanovaccines efficiently accumulated at the lymph nodes for promoting DC uptake and facilitating cytosol release of the neoantigens. Meanwhile, the STING agonist activated the STING pathway in the DCs to elicit interferon-β secretion and to boost T-cell priming with the neoantigen. The nanovaccine dramatically inhibited tumor growth and occurrence of B16-OVA melanoma and 4T1 breast tumors in immunocompetent mouse models. Combination immunotherapy with the nanovaccines and anti-PD-L1 antibody demonstrated further improved antitumor efficacy in a 4T1 breast tumor model.

Nano Letters published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C16H20BNO3, SDS of cas: 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Molina-Bolivar, J. A. published the artcileEffect of NaCl on the Self-Aggregation of n-Octyl β-D-Thioglucopyranoside in Aqueous Medium, Product Details of C14H28O5S, the publication is Journal of Physical Chemistry B (2006), 110(24), 12089-12095, database is CAplus and MEDLINE.

This report investigates the effect of sodium chloride (NaCl) on the micellization, surface activity, and the evolution in the shape and size of n-octyl β-D-thioglucopyranoside (OTG) aggregates. By using surface tension measurements, information was obtained on both changes in the critical micelle concentration and adsorption behavior in the air-liquid interface with the electrolyte concentration These data were used to obtain the thermodn. properties of micellization along with the corresponding adsorption parameters in the air-liquid interface. From extended static and dynamic light scattering measurements, the micelle mol. weight, the mean aggregation number, and the second virial coefficient, the apparent diffusion coefficient and the mean hydrodynamic radius of micelles in a range of NaCl concentrations were obtained. The light scattering data have shown that when the surfactant concentration is lower to 4.5 g/L, only spherical micelles are formed. However, an increase in the surfactant concentration induces an increase in micellar size, suggesting a rodlike growth of the micelles. This deviation of micelle geometry from spherical to rodlike is supported both by the ratio between the hydrodynamic radius and the radius of gyration and by the angular dependence of light scattering. On the other hand, the studies performed in the presence of high NaCl concentration (0.2 and 0.5 M) provide strong support for the view that the micelles may overlap together to form an entangled network above certain crossover concentration

Journal of Physical Chemistry B published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Product Details of C14H28O5S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ruiz, C. Carnero published the artcileInteraction between n-octyl-β-D-thioglucopyranoside and bovine serum albumin, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Open Macromolecules Journal (2008), 6-18, database is CAplus.

The binding of the nonionic surfactant n-octyl-β-D-thioglucopyranoside (OTG) to the globular protein bovine serum albumin (BSA) has been investigated by using exptl. techniques such as surface tension, steady-state fluorescence and dynamic light scattering. It was observed that the surfactant micellization is delayed in the presence of protein; this was interpreted as a consequence of the fact that part of the surfactant is not available for the formation of micelles, because it is partitioned into the protein hydrophobic sites. This was taken as an evidence of the interaction between surfactant and protein. The fluorescence emission spectra of intrinsic tryptophans revealed that the protein is partially denatured in the presence of high surfactant concentrations The anal. of the binding features as obtained by two different methods, (i) one based on surface tension measurements, and (ii) another based on the behavior of the intrinsic BSA fluorescence, indicated that the binding process is non-cooperative at low surfactant concentration, but becomes cooperative when it is high enough. The reduction of the average aggregation number in the presence of protein interpreted as a sign of the formation of clusters of surfactant adsorbed on the protein surface. A slight conformational change in the protein structure at low surfactant concentration was revealed by resonance energy transfer from tryptophan residues to 8-anilinonaphthalene-1-sulfonate. A treatment of the autocorrelation functions as obtained by dynamic light scattering measurements, based on the application of appropriate fitting techniques, allowed for the discrimination between two kinds of structures in the OTG/BSA system: surfactant-protein complexes, with a “pearl necklace” structure, in equilibrium with the free micelles of OTG.

Open Macromolecules Journal published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Konidala, Praveen published the artcileMolecular dynamics characterization of n-octyl-β-D-glucopyranoside micelle structure in aqueous solution, SDS of cas: 85618-21-9, the publication is Journal of Molecular Graphics & Modelling (2006), 25(1), 77-86, database is CAplus and MEDLINE.

N-Octyl-β-D-glucopyranoside (OG) is a non-ionic glycolipid, which is used widely in biotech. and biochem. applications. All-atom mol. dynamics simulations from two different initial coordinates and velocities in explicit solvent have been performed to characterize the structural behavior of an OG aggregate at equilibrium conditions. Geometric packing properties determined from the simulations and small angle neutron scattering experiment state that OG micelles are more likely to exist in a non-spherical shape, even at the concentration range near to the critical micelle concentration (0.025 M). Despite few large deviations in the principal moment of inertia ratios, the average micelle shape calculated from both simulations is a prolate ellipsoid. The deviations at these time scales are presumably the temporary shape change of a micelle. However, the size of the micelle and the accessible surface areas were constant during the simulations with the micelle surface being rough and partially elongated. Radial distribution functions computed for the hydroxyl oxygen atoms of an OG show sharper peaks at a min. van der Waals contact distance than the acetal oxygen, ring oxygen, and anomeric carbon atoms. This result indicates that these atoms are pointed outwards at the hydrophilic/hydrophobic interface, form hydrogen bonds with the water mols., and thus hydrate the micelle surface effectively.

Journal of Molecular Graphics & Modelling published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, SDS of cas: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Szabo, Lajos Z. published the artcilePreparation of S-glycoside surfactants and cysteine thioglycosides using minimally competent Lewis acid catalysis, Category: alcohols-buliding-blocks, the publication is Carbohydrate Research (2016), 1-4, database is CAplus and MEDLINE.

Here we report a method for the preparation of anomerically pure β-S-glycopyranosides (1,2-trans-glycosides) from the corresponding peracetate donors. S-glycosylation was performed in CHCl₃ at reflux in the presence of a catalytic amount of InBr₃. Deacylation of the intermediate peracetates were achieved under Zemplén conditions. Five pyranose examples, monosaccharides D-glucose and D-galactose and disaccharides cellobiose, maltose, and lactose, were used as donors, and five thiols including an α/ω dithiol and Fmoc-L-cysteine were used as acceptors. M.ps., high res MS, [α]_D and NMR data (¹H and ¹³C, including COSY, HSQC and HMBC) are reported for compounds not previously described.

Carbohydrate Research published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H17BF3NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts