Tag: M.W=300-350

Park, In Young published the artcileMannosylated polyethylenimine coupled mesoporous silica nanoparticles for receptor-mediated gene delivery, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is International Journal of Pharmaceutics (2008), 359(1-2), 280-287, database is CAplus and MEDLINE.

Organic-inorganic nanohybrids have been studied for their use as nonviral transfection agents. The purpose of this study was to examine the ability of mesoporous silica nanoparticles (MSN) coupled with mannosylated polyethylenimine (MP) to transfect plasmid DNA in vitro. Although MSN is biocompatible and has low cytotoxicity, it is not easily transfected into a variety of cell types. To overcome this barrier, MP was coupled to MSN (abbreviated as MPS) to target macrophage cells with mannose receptors and enhance transfection efficiency. The DNA conveyance ability of MPS was examined by evaluating properties such as particle size, zeta potential, complex formation, protection of plasmid DNA against DNase-I, and the release of DNA upon cell entry. Particle sizes of the MPS/DNA complexes decreased with increasing weight ratio of MPS to DNA, while the zeta potential increased. Complete MPS/DNA complexes were formed at a weight ratio of five, and their resistance to DNase-I was evaluated. Cytotoxicity studies showed that MPS/DNA complexes resulted in a high percentage of cell viability, compared with PEI 25K as a vector. The transfection efficiency of MPS/DNA complexes was evaluated on Raw 264.7 and HeLa cell lines. It was found that MPS/DNA complexes showed enhanced transfection efficiency through receptor-mediated endocytosis via mannose receptors. These results indicate that MPS can be employed in the future as a potential gene carrier to antigen presenting cells.

International Journal of Pharmaceutics published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Erkan, Sultan published the artcileStructural, spectral characterization and molecular docking analyses of mer-ruthenium (II) complexes containing the bidentate chelating ligands, Name: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2020), 117399, database is CAplus and MEDLINE.

The authors analyzed some monofunctional Ru (II) complexes containing chlorine, bromine and fluorine atoms around the central atom. The best calculation level among HF, B3LYP and M062X methods for [Ru (Cl-Ph-tpy)(N-N)X]⁺ (X = F, Cl, Br) was determined in the light of Benchmark anal. and according to this anal. results, the best level is shown as B3LYP-LANL2DZ/6-31G(d). In addition to this, the spectroscopic data (IR, NMR and UV-visible) were also obtained in agreement with exptl. results. The tendency of anticancer activity and structural activity relation (SAR) parameters are predicted with some quantum chem. methods. Surface and contour diagrams, as well as electron densities on mentioned complexes were interpreted through theor. obtained results. Finally, the anticancer activity tendency of the relevant complexes on the human cervical carcinoma cell line (ID: 1 M17) is supported by mol. docking calculations

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Name: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Santonicola, Gabriella M. published the artcileMixtures of n-Octyl-β-D-glucoside and Triethylene Glycol Mono-n-octyl Ether: Phase Behavior and Micellar Structure near the Liquid-Liquid Phase Boundary, Related Products of alcohols-buliding-blocks, the publication is Langmuir (2005), 21(22), 9955-9963, database is CAplus and MEDLINE.

The phase behavior and microstructure of aqueous mixtures of n-octyl-β-D-glucoside (C₈βG₁) and triethylene glycol mono-n-octyl ether (C₈E₃) is presented. C₈βG₁ forms a one-phase micellar solution in water at surfactant concentrations up to 60 wt %, whereas mixtures with C₈E₃ show a liquid-liquid phase transition at low surfactant concentration The position of this phase boundary for mixtures can be rationally shifted in the temperature-composition window by altering the ratio of the two surfactants. Small-angle neutron scattering is used to determine the size and shape of the mixed micelles and to characterize the nature of the fluctuations near the cloud point of the micellar solutions The C₈βG₁/C₈E₃ solutions are characterized by concentration fluctuations that become progressively stronger upon approach to the liquid-liquid phase boundary, whereas micellar growth is negligible. Such observations confirm previous views of the role of the surfactant phase boundary in tuning attractive micellar interactions, which can be used effectively to change the nature and strength of interparticle interactions in colloidal dispersions. Colloidal silica particles were then added to these surfactant mixtures and were found to aggregate at conditions near the cloud point. This finding is relevant to current strategies for protein crystallization

Langmuir published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sheng, Kuo-Ching published the artcileDelivery of antigen using a novel mannosylated dendrimer potentiates immunogenicity in vitro and in vivo, Computed Properties of 96345-79-8, the publication is European Journal of Immunology (2008), 38(2), 424-436, database is CAplus and MEDLINE.

Antigen mannosylation has been shown to be an effective approach to potentiate antigen immunogenicity, due to the enhanced antigen uptake and presentation by APC. To overcome disadvantages associated with conventional methods used to mannosylate antigens, we have developed a novel mannose-based antigen delivery system that utilizes a polyamidoamine (PAMAM) dendrimer. It is demonstrated that mannosylated dendrimer ovalbumin (MDO) is a potent immune inducer. With a strong binding avidity to DC, MDO potently induced OVA-specific T cell response in vitro. It was found that the immunogenicity of MDO was due not only to enhanced antigen presentation, but also to induction of DC maturation. Mice immunized with MDO generated strong OVA-specific CD4⁺/CD8⁺ T cell and antibody responses. MDO also targeted lymph node DC to cross-present OVA, leading to OTI CD8⁺ T cell proliferation. Moreover, upon challenge with B16-OVA tumor cells, tumors in mice pre-immunized with MDO either did not grow or displayed a much more delayed onset, and had slower kinetics of growth than those of OVA-immunized mice. This mannose-based antigen delivery system was applied here for the first time to the immunization study. With several advantages and exceptional adjuvanticity, we propose mannosylated dendrimer as a potential vaccine carrier.

European Journal of Immunology published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C15H12O8, Computed Properties of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tran, Chieu D. published the artcileChiral separation of amino acids by capillary electrophoresis with octyl-β-thioglucopyranoside as chiral selector, Synthetic Route of 85618-21-9, the publication is Journal of Chromatography A (2002), 978(1-2), 221-230, database is CAplus and MEDLINE.

1-S-Octyl-β-D-thioglucopyranoside (OTG) was evaluated as a chiral selector for the separation of dansylamino acids by capillary electrophoresis. Enantiomeric separations of the amino acids can be accomplished by judiciously adjusting the pH of the solution and the concentration of OTG. Better separation can be achieved, however, when OTG was used, not as a sole chiral selector but rather together with sodium dodecyl sulfate (SDS) and cyclodextrin (CD). Not only can this OTG-SDS-CD system provide better separation than OTG alone but also it can sep. compounds which cannot be separated when only CD or CD and SDS were used. All amino acids were baseline separated with this OTG-SDS-CD system at optimal conditions.

Journal of Chromatography A published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C8H15ClN2, Synthetic Route of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Thomann-Harwood, L. J. published the artcileNanogel vaccines targeting dendritic cells: Contributions of the surface decoration and vaccine cargo on cell targeting and activation, Related Products of alcohols-buliding-blocks, the publication is Journal of Controlled Release (2013), 166(2), 95-105, database is CAplus and MEDLINE.

Dendritic cells (DCs) play crucial roles in initiating and promoting immune defences, providing a pivotal target for vaccines. Although nanoparticle/nanogel-based delivery vehicles are showing potential for delivering vaccines to the immune system, there is little information on their characteristics of interaction with DCs. While particle uptake by DCs has been shown, the mechanism of cell targeting has not been studied. Moreover, it is still unclear how particle surface decoration influences the handling of such vaccines by DCs. Accordingly, chitosan nanogels carrying a model antigen, ovalbumin (ova), were analyzed for interaction with and processing by DCs. Nanogel surfaces decorated with alginate (alg) or mannosylated alginate (alg-man), were used for targeting particular DC receptors. DC uptake of particles was observed, being dependent on endosomal-based processes. Inhibiting PI3-kinase or lipid raft activities impaired the uptake, which was only reduced, indicating the involvement of more than one endocytic pathway; notably, this was observed with both nanogel-delivered or free ova. Importantly, surface decoration of particles was less influential on particle uptake, contrasting with the ova cargo which played the major role. Such influence of the vaccine cargo has to date been largely ignored. When receptors interacting directly with ova were blocked, this altered the uptake of alg-nanogels and alg-man-nanogels carrying ova. The nanogels did have an influential role, in that modulation of DC functional activity owed more to the nanogel structure. Using an in vitro restimulation assay with ova-specific lymphocytes, nanogel-delivered and free ova were similarly effective at inducing specific antibody. Nanogel-delivered ova with mannose surface decoration was superior to free ova for inducing interferon-γ production by T-lymphocytes. Together, the data demonstrates that particle-based vaccine delivery should consider the influences of both the surface decoration and the vaccine cargo; each can influence different aspects of the interaction with DCs. Such combined influences are likely to impinge on the characteristics of the immune response induced.

Journal of Controlled Release published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C16H20N2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kim, NaJung published the artcileSynthesis and characterization of mannosylated pegylated polyethylenimine as a carrier for siRNA, Quality Control of 96345-79-8, the publication is International Journal of Pharmaceutics (Amsterdam, Netherlands) (2012), 427(1), 123-133, database is CAplus and MEDLINE.

Regulation of gene expression using small interfering RNA (siRNA) is a promising strategy for research and treatment of numerous diseases. In this study, we develop and characterize a delivery system for siRNA composed of polyethylenimine (PEI), polyethylene glycol (PEG), and mannose (Man). Cationic PEI complexes and compacts siRNA, PEG forms a hydrophilic layer outside of the polyplex for steric stabilization, and mannose serves as a cell binding ligand for macrophages. The PEI-PEG-mannose delivery system was constructed in two different ways. In the first approach, mannose and PEG chains are directly conjugated to the PEI backbone. In the second approach, mannose is conjugated to one end of the PEG chain and the other end of the PEG chain is conjugated to the PEI backbone. The PEI-PEG-mannose delivery systems were synthesized with 3.45-13.3 PEG chains and 4.7-3.0 mannose mols. per PEI. The PEI-PEG-Man-siRNA polyplexes displayed a coarse surface in SEM images. Polyplex sizes were found to range from 169 to 357 nm. Gel retardation assays showed that the PEI-PEG-mannose polymers are able to efficiently complex with siRNA at low N/P ratios. Confocal microscope images showed that the PEI-PEG-Man-siRNA polyplexes could enter cells and localized in the lysosomes at 2 h post-incubation. Pegylation of the PEI reduced toxicity without any adverse reduction in knockdown efficiency relative to PEI alone. Mannosylation of the PEI-PEG could be carried out without any significant reduction in knockdown efficiency relative to PEI alone. Conjugating mannose to PEI via the PEG spacer generated superior toxicity and gene knockdown activity relative to conjugating mannose and PEG directly onto the PEI backbone.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Quality Control of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kim, T. H. published the artcileReceptor-mediated gene delivery using chemically modified chitosan, SDS of cas: 96345-79-8, the publication is Biomedical Materials (Bristol, United Kingdom) (2007), 2(3), S95-S100, database is CAplus and MEDLINE.

Chitosan has been investigated as a non-viral vector because it has several advantages such as biocompatibility, biodegradability and low toxicity with high cationic potential. However, the low specificity and low transfection efficiency of chitosan need to be solved prior to clin. application. In this paper, we focused on the galactose or mannose ligand modification of chitosan for enhancement of cell specificity and transfection efficiency via receptor-mediated endocytosis in vitro and in vivo.

Biomedical Materials (Bristol, United Kingdom) published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, SDS of cas: 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Choi, Jae Yeon published the artcileDevelopment of ⁶⁸Ga-labeled mannosylated human serum albumin (MSA) as a lymph node imaging agent for positron emission tomography, Product Details of C13H15NO6S, the publication is Nuclear Medicine and Biology (2011), 38(3), 371-379, database is CAplus and MEDLINE.

Introduction: Although many sentinel lymph node (SLN) imaging agents labeled with ^99mTc have been developed, no positron-emitting agent has been specifically designed for SLN imaging. Furthermore, the development of the beta probe and the requirement for better image resolution have increased the need for a positron-emitting SLN imaging agent. Here, we describe the development of a novel positron-emitting SLN imaging agent labeled with ⁶⁸Ga. Methods: A mannosylated human serum albumin (MSA) was synthesized by conjugating α-D-mannopyranosylphenyl isothiocyanate to human serum albumin in sodium carbonate buffer (pH 9.5), and then 2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid was conjugated to synthesize NOTA-MSA. Numbers of mannose and NOTA units conjugated in NOTA-MSA were determined by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. NOTA-MSA was labeled with ⁶⁸Ga at room temperature The stability of ⁶⁸Ga-NOTA-MSA was checked in labeling medium at room temperature and in human serum at 37°C. Biodistribution in normal ICR mice was investigated after tail vein injection, and micro-positron emission tomog. (PET) images were obtained after injecting ⁶⁸Ga-NOTA-MSA into a tail vein or a footpad. Results: The numbers of conjugated α-D-mannopyranosylphenyl isothiocyanate and 2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid units in NOTA-MSA were 10.6 and 6.6, resp. The labeling efficiency of ⁶⁸Ga-NOTA-MSA was greater than 99% at room temperature, and its stability was greater than 99% at 4 h. Biodistribution and micro-PET studies of ⁶⁸Ga-NOTA-MSA showed high liver and spleen uptakes after i.v. injection. ⁶⁸Ga-NOTA-MSA injected into a footpad rapidly migrated to the lymph node. Conclusions: ⁶⁸Ga-NOTA-MSA was successfully developed as a novel SLN imaging agent for PET. NOTA-MSA is easily labeled at high efficiency, and s.c. administered ⁶⁸Ga-NOTA-MSA was found to migrate rapidly to the lymph node.

Nuclear Medicine and Biology published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Product Details of C13H15NO6S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Westerman, Larry E. published the artcileLiposomes composed of reconstituted membranes for induction of tumor-specific immunity, Application of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Methods in Enzymology (2003), 118-127, database is CAplus and MEDLINE.

The methods to generate exptl. cell-free cancer vaccines consisting of reconstituted tumor membrane liposomes with incorporated immunomodulatory mols. are described. Using a detergent dialysis technique, tumor cell membranes can be reassembled with the addition of purified membranes included to promote tumor-specific immune responses. A major advantage of this approach is that immunostimulatory proteins can be presented on a membrane like structure that resembles the tumor cell plasma membrane.

Methods in Enzymology published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C10H12O5, Application of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts