Tag: M.W=300-350

Elam, Christopher published the artcileDiscovery of novel SERCA inhibitors by virtual screening of a large compound library, Name: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is European Journal of Medicinal Chemistry (2011), 46(5), 1512-1523, database is CAplus and MEDLINE.

Two screening protocols based on recursive partitioning and computational ligand docking methodologies, resp., were employed for virtual screens of a compound library with 345,000 entries for novel inhibitors of the enzyme sarco/endoplasmic reticulum calcium ATPase (SERCA), a potential target for cancer chemotherapy. A total of 72 compounds that were predicted to be potential inhibitors of SERCA were tested in bioassays and 17 displayed inhibitory potencies at concentrations below 100 μM. The majority of these inhibitors were composed of two Ph rings tethered to each other by a short link of one to three atoms. Putative interactions between SERCA and the inhibitors were identified by inspection of docking-predicted poses and some of the structural features required for effective SERCA inhibition were determined by anal. of the classification pattern employed by the recursive partitioning models.

European Journal of Medicinal Chemistry published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Name: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

van Dyck, Jeroen F. published the artcileNative mass spectrometry for the characterization of structure and interactions of membrane proteins, SDS of cas: 85618-21-9, the publication is Methods in Molecular Biology (New York, NY, United States) (2017), 205-232, database is CAplus and MEDLINE.

Over the past years, native mass spectrometry and ion mobility have grown into techniques that are widely applicable to the study of aspects of protein structure. More recently, it has become apparent that this approach provides a very promising avenue for the investigation of integral membrane proteins in lipid or detergent environments. In this chapter, we discuss applications of native mass spectrometry and ion mobility in membrane protein research-what is important to take into consideration when working with membrane proteins, and what the requirements are for sample preparation for native mass spectrometry. Furthermore, we will discuss the types of information provided by the measurements, including the oligomeric state, subunit composition and stoichiometry, interactions with detergents or lipids, conformational transitions, and the binding and structural effect of ligands and drugs.

Methods in Molecular Biology (New York, NY, United States) published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C5H10O2S, SDS of cas: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Koroleva, Sofia V. published the artcileMolecular Thermodynamic Modeling of the Specific Effect of Salt on the Aggregation of Nonionic Surfactants, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Journal of Chemical & Engineering Data (2020), 65(3), 987-992, database is CAplus.

The specific chem. of added salt has a strong effect on the aggregation of surfactants. Although the mol. mechanism of this effect is still debated in the literature and there is no generally accepted quant. theory, substantial progress has recently been achieved in the mol. thermodn. modeling of ion-specific effects for solutions of ionic surfactants. In this work, we extend our previous aggregation model of ionic surfactants to solutions of nonionic surfactants in the presence of salts. Within this model, the specificity of ions is reflected by the difference in ionic diameters, the dispersion interaction with the micelle, and an effective parameter δ_± that takes into account the hydration/dehydration of an ion in the micellar corona and is specific to every ion-surfactant head pair. The effect of specific salt on the hydrophobic contribution to the aggregation free energy is described via the Setchenov salting-out constants We apply the model for sugar-based surfactants: n-alkyl glucosides and N-acyl-N-methylglucosides. This choice is motivated by the importance of this family of surfactants in biotechnol. We report the set of model parameters, including the Setchenov constants, for the surfactants in this family in combination with a number of 1:1 salts and illustrate good performance of the model in the description of the specific effect of added salt on the critical micelle concentration (CMC) and the growth of micellar aggregates.

Journal of Chemical & Engineering Data published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gonzalez-Gil, Lorena published the artcileBiotransformation of organic micropollutants by anaerobic sludge enzymes, Quality Control of 85618-21-9, the publication is Water Research (2019), 202-214, database is CAplus and MEDLINE.

Biotransformation of organic micropollutants (OMPs) in wastewater treatment plants ultimately depends on the enzymic activities developed in each biol. process. However, few research efforts have been made to clarify and identify the role of enzymes on the removal of OMPs, which is an essential knowledge to determine the biotransformation potential of treatment technologies. Therefore, the purpose of the present study was to investigate the enzymic transformation of 35 OMPs under anaerobic conditions, which have been even less studied than aerobic systems. Initially, 13 OMPs were identified to be significantly biotransformed (>20%) by anaerobic sludge obtained from a full-scale anaerobic digester, predestining them as potential targets of anaerobic enzymes. Native enzymes were extracted from this anaerobic sludge to perform transformation assays with the OMPs. In addition, the effect of detergents to recover membrane enzymes, as well as the effects of cofactors and inhibitors to promote and suppress specific enzymic activities were evaluated. In total, it was possible to recover enzymic activities towards 10 out of these 13 target OMPs (acetyl-sulfamethoxazole and its transformation product sulfamethoxazole, acetaminophen, atenolol, clarithromycin, citalopram, climbazole, erythromycin, and terbutryn, venlafaxine) as well as towards 8 non-target OMPs (diclofenac, iopamidol, acyclovir, acesulfame, and 4 different hydroxylated metabolites of carbamazepine). Some enzymic activities likely involved in the anaerobic biotransformation of these OMPs were identified. Thereby, this study is a starting point to unravel the still enigmatic biotransformation of OMPs in wastewater treatment systems.

Water Research published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Quality Control of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Scott, W. E. published the artcileVernonia anthelmintica. Effect of storage on the epoxy content of the seed oil and trivernolin, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is Journal of the American Oil Chemists’ Society (1965), 42(2), 147-9, database is CAplus.

V. anthelmintica seeds from India and Pakistan varied somewhat in the amount of oil that they contained, but the oils did not vary significantly in their epoxy content. Storage of the whole seed for periods of up to 3 years did not affect the quality of the oil, but the activity of the seed enzyme system seemed to increase with time. Free fatty acid (I) develops rapidly after the seed is ground. The epoxy content of low-I V. anthelmintica oil and trivernolin changed only slightly when these products were stored at room temperature for 6 months. The viscosity of the samples that were exposed to light increased greatly, indicating changes in the phys. nature of the products. A similar behavior was exhibited by both products when they were stored under N at 100° and by trivernolin at 4°.

Journal of the American Oil Chemists’ Society published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C6H4ClNO2, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Grabosch, Carsten published the artcileGlycoarrays by a New Tandem Noncovalent-Covalent Modification of Polystyrene Microtiter Plates and their Interrogation with Live Cells, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is ChemBioChem (2012), 13(13), 1874-1879, S1874/1-S1874/18, database is CAplus and MEDLINE.

Thiourea bridging was used for fabrication of glycoarrays on polystyrene microtiter plates, to allow assaying of carbohydrate recognition in a optimally easy and flexible way. For the noncovalent modification of polystyrene microtiter plates, dodecylamine and dodecyl isothiocyanate were selected. This first immobilization step was followed by thiourea bridging with a suitable carbohydrate derivative and subsequent carbohydrate-specific read out. For the testing system, mannose-specific bacterial adhesion was employed with green fluorescent protein (GFP)-tagged Escherichia coli bacteria (pPKLl 162). A selection of inhibitors of type 1 fimbriae-mediated bacterial adhesion was used. Tandem noncovalent-covalent modification of polystyrene microtiter plates led to stable glycoarrays that yield valuable and valid data in adhesion inhibition tests with live bacterial cells. Nonspecific adhesion to polystyrene is excluded in this protocol. In addition to polystyrene plates, polypropylene (PP) microtiter plates were tested by the same approach and showed results that were in good accordance with the assays on analogously modified polystyrene plates.

ChemBioChem published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Hu-Lin published the artcileMannosylated chitosan-graft-polyethylenimine as a gene carrier for Raw 264.7 cell targeting, Application In Synthesis of 96345-79-8, the publication is International Journal of Pharmaceutics (2009), 375(1-2), 133-139, database is CAplus and MEDLINE.

Gene transfer using non-viral vectors is a promising approach for the safe delivery of therapeutic genes. Among non-viral vectors, chitosans have been proposed as alternative, biocompatible cationic polymers for non-viral gene delivery. However, the low transfection efficiency and low specificity of chitosan needs to be addressed prior to clin. application. In this study, mannosylated chitosan-graft-polyethylenimine (Man-CHI-g-PEI) copolymer was prepared by thiourea reaction between the isothiocyanate group of mannopyranosylphenylisothiocyanate and the amine groups of chitosan-graft-PEI (CHI-g-PEI) for targeting into antigen presenting cells (APCs) having mannose receptors. The composition and mol. weight were characterized using ¹H NMR and GPC, resp. The copolymer was complexed with plasmid DNA in various copolymer/DNA (N/P) charge ratios, and the complexes were characterized. Man-CHI-g-PEI showed good DNA binding ability and high protection of DNA from nuclease attack and had low cytotoxicity compared with PEI 25K. The transfection efficiency of Man-CHI-g-PEI/DNA complexes into the Raw 264.7 macrophage cell line, which has mannose receptors, was higher than CHI-g-PEI itself as well as PEI 25K, indicating Man-CHI-g-PEI can be used as an APCs’ targeting gene delivery carrier.

International Journal of Pharmaceutics published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Application In Synthesis of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Grabosch, Carsten published the artcileA dual Click’ strategy for the fabrication of bioselective, glycosylated self-assembled monolayers as glycocalyx models, Quality Control of 96345-79-8, the publication is Organic & Biomolecular Chemistry (2013), 11(24), 4006-4015, database is CAplus and MEDLINE.

Solid surfaces decorated with specific saccharide patterns can serve as a model for the chem. and structurally highly complex glycocalyx of eukaryotic cells. Here we present an approach based on self-assembled monolayers on gold, which are built up in a three-step manner to provide a solid basis, a biorepulsive oligoethylene glycol part, and a specific glycoside terminus, e.g. I, in a modular way. Of the different reaction sequences, the one with two consecutive click reactions’ (the copper(I)-catalyzed 1,3-dipolar cycloaddition of alkynes with azides and the thiourea-bridging of isothiocyanates with amines) directly on SAM’ results in the densest layers, as demonstrated by IR absorption reflection spectroscopy and ellipsometry. As a real life’ test, the surfaces obtained this way were used for bacterial adhesion experiments Here the biorepulsivity of the middle part of the SAMs as well as specific binding to the carbohydrate termini could be clearly demonstrated.

Organic & Biomolecular Chemistry published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Quality Control of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ishii, Fumio published the artcileOxidation of hydroquinone and catechols with aqueous sodium hypochlorite under phase-transfer catalysis, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is Synthesis (1980), 706-8, database is CAplus.

Hydroquinones I (R = H, Me, Me₃C, tert-octyl, Ph, 4-MeC₆H₄, EtCMe₂; R¹, R³ = H, Me; R² = H, Me₃C, EtCMe₂, tert-octyl; RR¹ = CH:CHCH:CH) and II (R⁴ = H, Me₃C) were treated with 10% NaOCl in the presence of Bu₄N⁺.HSO₄^– to give 14-91% III and 91-92% IV, resp.

Synthesis published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Son, Young Ju published the artcileMultifunctional Nanorods Serving as Nanobridges To Modulate T Cell-Mediated Immunity, Application In Synthesis of 96345-79-8, the publication is ACS Nano (2013), 7(11), 9771-9779, database is CAplus and MEDLINE.

Electrodeposited nanorods serving as multivalent bridges were fabricated and surface-decorated with ligands for immune cells. Gold and nickel solutions were sequentially electrodeposited on nanoporous anodized disk templates and the template was dissolved to retrieve bisegmented nanorods with different lengths. Gold and nickel segmented nanorods were surface-immobilized with mannose and RGD peptides to prepare immune-cell recruiting nanorods. Surface-functionalization of nanorods were confirmed by fluorescence-labeling of each ligands and confocal microscopy. Dendritic cells and T cells were co-incubated with the surface-functionalized nanorods, and the proximity between the nanorods and the immune cells was visualized by variable pressure SEM and confocal microscopy. The long nanorods were associated with the immune cells, whereas the shorter nanorods were rather endocytosed by cells, suggesting a feasibility of the longer nanorods as bridging for the cells. Cytokine releases from the immune cells were monitored by cultivating lipopolysaccharide-activated dendritic cells with T cells. Interleukin-2 and interferon-γ release profiles showed a strong correlation with the length of the nanorod, where the 4 μm nanorods induced the highest levels of cytokine release compared to 1 or 2 μm nanorods. Thus, the authors concluded that the proximity of the immune cells increased by bridging the immune cells with the nanobridging system, which subsequently increased cytokine release by facilitating the antigen presentation process.

ACS Nano published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H22OSi, Application In Synthesis of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts