Tag: M.W=300-350

Jana, Rabindranath published the artcileStructural transition dynamics of biologically active flavins in alkylglucoside surfactants aggregates, Application of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2020), 117346, database is CAplus and MEDLINE.

The photophysics and structural transition dynamics of a bio-active flavin lumichrome (LM) entrapped in two sugars based neutral surfactants are reported. Sugar-based surfactants, which were used for research purpose are potential environmentally friendly, green alternative amphiphilic surface active substance compared to other kinds of common surfactants. Here, two alkyl glucoside surfactants n-octyl-β-D-glucopyranoside (OBG) and n-octyl-β-D-thioglucopyranoside (OBTG) were used. This work was carried out by using steady-state absorption and fluorescence emission spectroscopy along with time-resolved fluorescence emission techniques. Photophysics of LM was modulated several folds in these two sugar-based neutral micelles. LM exhibits excitation and emission wavelength dependent fluorescence properties in these two sugars based neutral micelles. LM confined in the micellar environments exhibited structural transition dynamism, i.e. different kinds of conformers are equilibrated. Herein, different conformers of LM are identified and explained with the help of spectroscopic methods. From the fluorescence anisotropy measurement, the rotational relaxation time of LM in OBG micelle was more compared to that in OBTG micelle, which indicates that the LM mol. faced much more constrained environment in OBG micellar media.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Application of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shao, Jun published the artcileCharacterization of a mannosylphospholipid liposome system for drug targeting to alveolar macrophages, Quality Control of 96345-79-8, the publication is Drug Delivery (1997), 4(1), 43-48, database is CAplus.

The potential that mannose receptors on alveolar macrophages (AMs) may be targeted using mannose-conjugated liposomes for intracellular drug delivery to AMs was investigated. A mannosylphospholipid was synthesized via the reaction of α-D-mannopyranosylphenylisothiocyanate with dipalmitoyl phosphatidylethanolamine, and the product was identified using thin-layer chromatog. and NMR spectroscopy. Liposomes containing this mannosylated phospholipid were made using a high-pressure homogenization method and analyzed using freeze-etch electron transmission microscopy. These liposomes were shown to exhibit unilamellar structure with a mean diameter of 140 ± 59 nm. The uptake of liposomes by rat alveolar macrophages, by measurement of internalized, liposome-encapsulated fluorescein, was found to be both dose and time dependent. The uptake of liposomes containing 40% mannosylphospholipid was 3.6-fold higher than that of liposomes without the mannosylated lipid (16% to 4.5%). Fluorescein in solution was not internalized by AMs. The enhancement of uptake by conjugation of mannose onto the liposome surface was markedly inhibited by the addition of free mannose at various concentrations, indicating an uptake process involving mannose receptor-mediated endocytosis.

Drug Delivery published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C11H8O3, Quality Control of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Ce published the artcileLymphatic-targeted cationic liposomes: A robust vaccine adjuvant for promoting long-term immunological memory, Name: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Vaccine (2014), 32(42), 5475-5483, database is CAplus and MEDLINE.

Although retaining antigens at the injection site (the so-called “depot effect”) is an important strategy for vaccine development, increasing evidence showed that lymphatic-targeted vaccine delivery with liposomes could be a promising approach for improving vaccine efficacy. However, it remains unclear whether antigen depot or lymphatic targeting would benefit long-term immunol. memory, a major determinant of vaccine efficacy. In the present study, OVA antigen was encapsulated with DOTAP cationic liposomes (LP) or DOTAP-PEG-mannose liposomes (LP-Man) to generate depot or lymphatic-targeted liposome vaccines, resp. The result of in vivo imaging showed that LP mostly accumulated near the injection site, whereas LP-Man not only effectively accumulated in draining lymph nodes (LNs) and the spleen, but also enhanced the uptake by resident antigen-presenting cells. Although LP vaccines with depot effect induced anti-OVA IgG more potently than LP-Man vaccines did on day 40 after priming, they failed to mount an effective B-cell memory response upon OVA re-challenge after three months. In contrast, lymphatic-targeted LP-Man vaccines elicited sustained antibody production and robust recall responses three months after priming, suggesting lymphatic targeting rather than antigen depot promoted the establishment of long-term memory responses. The enhanced long-term immunol. memory by LP-Man was attributed to vigorous germinal center responses as well as increased Tfh cells and central memory CD4⁺ T cells in the secondary lymphoid organs. Hence, lymphatic-targeted vaccine delivery with LP-Man could be an effective strategy to promote long-lasting immunol. memory.

Vaccine published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H26N2, Name: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Layek, Buddhadev published the artcileAPC targeted micelle for enhanced intradermal delivery of hepatitis B DNA vaccine, HPLC of Formula: 96345-79-8, the publication is Journal of Controlled Release (2015), 143-153, database is CAplus and MEDLINE.

Chronic hepatitis B is a serious liver disease and puts people at high risk of death from cirrhosis and liver cancer. Although DNA vaccination has been emerged as a potential immunotherapeutic strategy for the treatment of chronic hepatitis B, the efficiencies were not adequate in clin. trials. Here we describe the design, synthesis, and evaluation of mannosylated phenylalanine grafted chitosan (Man-CS-Phe) as a DNA delivery vector for direct transfection of antigen presenting cells to improve cellular and humoral immunity to plasmid-coded antigen. The cationic Man-CS-Phe micelles condense plasmid DNA into nanoscale polyplexes and provide efficient protection of complexed DNA from nuclease degradation The mannose receptor-mediated enhanced cell uptake and high in vitro transfection efficiency of the polyplexes were demonstrated in RAW 264.7 and DC 2.4 cells using GFP-expressing plasmid DNA. Furthermore, intradermal immunization of BALB/c mice indicated that hepatitis B DNA vaccine/Man-CS-Phe polyplexes not only induced multi-fold higher serum antibody titer in comparison to all other formulations including FuGENE HD, but also significantly stimulated T-cell proliferation and skewed T helper toward Th1 polarization. These results illustrate that the Man-CS-Phe can serve as a promising DNA delivery vector to harness both cellular and humoral arms of immune system.

Journal of Controlled Release published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, HPLC of Formula: 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Reading, Eamonn published the artcileThe Role of the Detergent Micelle in Preserving the Structure of Membrane Proteins in the Gas Phase, Computed Properties of 85618-21-9, the publication is Angewandte Chemie, International Edition (2015), 54(15), 4577-4581, database is CAplus and MEDLINE.

Despite the growing importance of the mass spectrometry of membrane proteins, it is not known how their transfer from solution into vacuum affects their stability and structure. To address this we have carried out a systematic investigation of ten membrane proteins solubilized in different detergents and used mass spectrometry to gain physicochem. insight into the mechanism of their ionization and desolvation. We show that the chem. properties of the detergents mediate the charge state, both during ionization and detergent removal. Using ion mobility mass spectrometry, we monitor the conformations of membrane proteins and show how the surface charge d. dictates the stability of folded states. We conclude that the gas-phase stability of membrane proteins is increased when a greater proportion of their surface is lipophilic and is consequently protected by the phys. presence of the micelle.

Angewandte Chemie, International Edition published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Computed Properties of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Studer, Peggy published the artcileSynthesis and Characterization of Poly(ethylene oxide)-block-poly(methylidene malonate 2.1.2) Block Copolymers Bearing a Mannose Group at the PEO Chain End, Application of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Bioconjugate Chemistry (2005), 16(1), 223-229, database is CAplus and MEDLINE.

A poly(ethylene oxide)-block-poly(methylidene malonate 2.1.2) block copolymer (PEO-b-PMM 2.1.2) bearing a mannose moiety at the poly(ethylene oxide) chain end was synthesized by sequential anionic polymerization of ethylene oxide (EO) and methylidene malonate 2.1.2 (MM 2.1.2), followed by a coupling reaction between its poly(ethylene oxide) amino- or aldehyde-end group and a sugar derivative Different coupling procedures, either in organic media or in aqueous micellar solutions, were examined in order to optimize the poly(ethylene oxide) end-glycosylation yield. The micellar size of the functionalized block copolymers was determined by dynamic light scattering.

Bioconjugate Chemistry published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C10H23N, Application of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kieburg, Christoffer published the artcileGlycodendrimer synthesis without using protecting groups, Quality Control of 96345-79-8, the publication is Tetrahedron Letters (1997), 38(22), 3885-3888, database is CAplus.

Oligoantennary neoglycoconjugates can act as powerful inhibitors of carbohydrate-protein interactions and thus serve as anti-adhesives in carbohydrate-based adhesion systems. They were obtained by a procedure that does not require protecting groups. Various unprotected NCS-functionalized saccharides were coupled with oligoamines in aqueous solution This versatile method is generally applicable to the synthesis of thiourea-bridged glycodendrimers.

Tetrahedron Letters published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Quality Control of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Harder, John W. published the artcileNew interlayer scavenger technology, Formula: C22H38O2, the publication is IS&T’s Annual Conference (1997), 206-209, database is CAplus.

Poor color reproduction can occur when oxidized color developer diffuses from the imaging layer in which it is formed into the color records. Typically, scavengers for oxidized color developers (also known as interlayer scavengers) reduce or eliminate by chem. reaction, the oxidized developer without forming any permanent dyes or other colored stains, nor releasing fragments that have photog. activity. One known class of scavengers are substituted hydroquinones. However, these materials are often prone to aerial oxidation leading to poor film keeping properties. It has been found that both 2-(N,N-disubstitutedcarbamoyl)-1,4-hydroquinones (Formula I) and 4-(N,N-disubstitutedcarbamoyl)-pyrocatechols (Formula II) are reactive scavengers with excellent aerial stability. Another known class of scavengers are acylhydrazides. Although stable to aerial oxidation, these materials are prone to poor activity and undesirable side reactions during processing. It has been found that acylhydrazides of Formula III, where X = an electron-withdrawing and water solubilizing group, are reactive scavengers that avoid undesirable side reactions.

IS&T’s Annual Conference published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Formula: C22H38O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Elam, Christopher published the artcileDiscovery of novel SERCA inhibitors by virtual screening of a large compound library, Name: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is European Journal of Medicinal Chemistry (2011), 46(5), 1512-1523, database is CAplus and MEDLINE.

Two screening protocols based on recursive partitioning and computational ligand docking methodologies, resp., were employed for virtual screens of a compound library with 345,000 entries for novel inhibitors of the enzyme sarco/endoplasmic reticulum calcium ATPase (SERCA), a potential target for cancer chemotherapy. A total of 72 compounds that were predicted to be potential inhibitors of SERCA were tested in bioassays and 17 displayed inhibitory potencies at concentrations below 100 μM. The majority of these inhibitors were composed of two Ph rings tethered to each other by a short link of one to three atoms. Putative interactions between SERCA and the inhibitors were identified by inspection of docking-predicted poses and some of the structural features required for effective SERCA inhibition were determined by anal. of the classification pattern employed by the recursive partitioning models.

European Journal of Medicinal Chemistry published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Name: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Harder, John W. published the artcileNew interlayer scavenger technology, Formula: C22H38O2, the publication is IS&T’s Annual Conference (1997), 206-209, database is CAplus.

Poor color reproduction can occur when oxidized color developer diffuses from the imaging layer in which it is formed into the color records. Typically, scavengers for oxidized color developers (also known as interlayer scavengers) reduce or eliminate by chem. reaction, the oxidized developer without forming any permanent dyes or other colored stains, nor releasing fragments that have photog. activity. One known class of scavengers are substituted hydroquinones. However, these materials are often prone to aerial oxidation leading to poor film keeping properties. It has been found that both 2-(N,N-disubstitutedcarbamoyl)-1,4-hydroquinones (Formula I) and 4-(N,N-disubstitutedcarbamoyl)-pyrocatechols (Formula II) are reactive scavengers with excellent aerial stability. Another known class of scavengers are acylhydrazides. Although stable to aerial oxidation, these materials are prone to poor activity and undesirable side reactions during processing. It has been found that acylhydrazides of Formula III, where X = an electron-withdrawing and water solubilizing group, are reactive scavengers that avoid undesirable side reactions.

IS&T’s Annual Conference published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Formula: C22H38O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts