Tag: M.W=300-350

Li, Xiuru published the artcileMultifunctional Surface Modification of Gold-Stabilized Nanoparticles by Bioorthogonal Reactions, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Journal of the American Chemical Society (2011), 133(29), 11147-11153, database is CAplus and MEDLINE.

Nanocarriers that combine multiple properties in an all-in-one system hold great promise for drug delivery. The absence of technol. to assemble highly functionalized devices has, however, hindered progress in nanomedicine. To address this deficiency, the authors have chem. synthesized poly(ethylene oxide)-β-poly(ε-caprolactone) (PEO-b-PCL) block polymers modified at the apolar PCL terminus with thioctic acid and at the polar PEO terminus with an acyl hydrazide, amine, or azide moiety. The resulting block polymers were employed to prepare nanoparticles that have a gold core, an apolar polyester layer for drug loading, a polar PEO corona to provide biocompatibility, and three different types of surface reactive groups for surface functionalization. The acyl hydrazide, amine, or azide moieties of the resulting nanoparticles could be reacted with high efficiencies with modules having a ketone, isocyanate, or active ester and alkyne function, resp. To demonstrate proof of principle of the potential of multisurface functionalization, nanoparticles that have various combinations of an oligo-arginine peptide were prepared to facilitate cellular uptake, a histidine-rich peptide to escape from lysosomes, and an Alexa Fluor 488 tag for imaging purposes. It has been shown that uptake and subcellular localization of the nanoparticles can be controlled by multisurface modification. It is to be expected that the modular synthetic methodol. provides unique opportunities to establish optimal configurations of nanocarriers for disease-specific drug delivery.

Journal of the American Chemical Society published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cavez, Damien published the artcileMaize black Mexican sweet suspension cultured cells are a convenient tool for studying aquaporin activity and regulation, Synthetic Route of 85618-21-9, the publication is Plant Signaling & Behavior (2009), 4(9), 890-892, database is CAplus and MEDLINE.

Aquaporins (AQPs) are channel proteins that facilitate and regulate the permeation of water across biol. membranes. Black Mexican sweet suspension cultured cells are a convenient model for studying the regulation of maize AQP expression and activity. Among other advantages, a single cell system allows the contribution of plasma membrane AQPs (PIPs, plasma membrane intrinsic proteins) to the membrane water permeability coefficient (P_f) to be determined using biophys. measurement methods, such as the cell pressure probe or protoplast swelling assay. We generated a transgenic cell culture line expressing a tagged version of ZmPIP2;6 and used this material to demonstrate that the ZmPIP2;6 and ZmPIP2;1 isoforms phys. interact. This kind of interaction could be an addnl. mechanism for regulating membrane water permeability by acting on the activity and/or trafficking of PIP hetero-oligomers.

Plant Signaling & Behavior published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Synthetic Route of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Capalbi, Antonio published the artcileSolution properties of alkyl glucosides, alkyl thioglucosides and alkyl maltosides, HPLC of Formula: 85618-21-9, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2004), 246(1-3), 99-108, database is CAplus.

Aqueous solutions containing sugar-based surfactants, alkyl glucosides, thioglucosides and maltosides, were studied in a wide concentration range, at different temperatures Colligative properties (f.p. and vapor pressure depression), volumetric, adiabatic compressibility, surface tension and calorimetric methods were used. The results give information on the Gibbs energy of transfer from H₂O to a micellar environment and on other thermodn. contributions to the overall aggregate stability. The thermodn. quantities derived from the above exptl. methods were interpreted by taking into account the role of polar head groups in modulating micelle formation. Use of a mass action approach allows determining micelle aggregation numbers, 〈N〉, from partial molal quantities. The differences between values obtained from calorimetric, colligative, compressibility, surface and volumetric properties were rationalized on proper grounds.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, HPLC of Formula: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kilcoyne, Michelle published the artcileSurface chemistry and linker effects on lectin-carbohydrate recognition for glycan microarrays, Synthetic Route of 96345-79-8, the publication is Analytical Methods (2012), 4(9), 2721-2728, database is CAplus.

Glycan microarrays are an increasingly utilized tool for anal. of protein-carbohydrate interactions and a variety of glycan-containing mols. and slide chemistries have been used to array carbohydrates on microarray surfaces. Slide surface chem. can have significant impact on the ligand presentation, background noise, spot size and morphol. and reproducibility of the arrayed mols., which in turn impacts upon lectin-carbohydrate recognition. The linker used to attach the carbohydrate to the mol. scaffold is another variable in ligand presentation. To evaluate these effects, three different microarray surface chemistries were arrayed with the same mono- and di-saccharide neoglycoconjugates and natural glycoproteins and incubated with four well-characterized plant lectins. Analogs of three monosaccharide neoglycoconjugates, with two common linkers each, were included in the test group to evaluate the linker effect on lectin recognition. Based on lowest background noise, expected lectin-ligand interaction, good spot morphol. and best reproducibility, the three-dimensional hydrogel slide surface proved most suitable for lectin interrogation of carbohydrate ligands, and the more flexible phenylisothiocyanate linker afforded greater recognition of the carbohydrates by the relevant lectins.

Analytical Methods published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Synthetic Route of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Van Truong, Thien published the artcilePromoting crystallization of intrinsic membrane proteins with conjugated micelles, SDS of cas: 85618-21-9, the publication is Scientific Reports (2020), 10(1), 12199, database is CAplus and MEDLINE.

A new technique for promoting nucleation and growth of membrane protein (MP) crystals from micellar environments is reported. It relies on the conjugation of micelles that sequester MPs in protein detergent complexes (PDCs). Conjugation via amphiphilic [metal:chelator] complexes presumably takes place at the micelle/water interface, thereby bringing the PDCs into proximity, promoting crystal nucleation and growth. We have successfully applied this approach to two light-driven proton pumps: bacteriorhodopsin (bR) and the recently discovered King Sejong 1-2 (KS1-2), using the amphiphilic 4,4′-dinonyl-2,2′-dipyridyl (Dinonyl) (0.7 mM) chelator in combination with Zn²⁺, Fe²⁺, or Ni²⁺ (0.1 mM). Crystal growth in the presence of the [metal-chelator] complexes leads to purple, hexagonal crystals (50-75μm in size) of bR or pink, rectangular/square crystals (5-15μm) of KS1-2. The effects of divalent cation identity and concentration, chelator structure and concentration, ionic strength and pH on crystal size, morphol. and process kinetics, are described.

Scientific Reports published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H19Br2ClN2O, SDS of cas: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Berger, Bryan W. published the artcileRelating surfactant properties to activity and solubilization of the human adenosine A₃ receptor, Synthetic Route of 85618-21-9, the publication is Biophysical Journal (2005), 89(1), 452-464, database is CAplus and MEDLINE.

The effects of various surfactants on the activity and stability of the human adenosine A₃ receptor (A₃) were investigated. The receptor was expressed using stably transfected HEK293 cells at a concentration of 44 pmol functional receptor per mg membrane protein and purified using over 50 different nonionic surfactants. A strong correlation was observed between a surfactant’s ability to remove A₃ from the membrane and the ability of the surfactant to remove A₃ selectively relative to other membrane proteins. The activity of A₃ once purified also correlates well with the selectivity of the surfactant used. The effects of varying the surfactant were much stronger than those achieved by including A₃ ligands in the purification scheme. Notably, all surfactants that gave high efficiency, selectivity and activity fall within a narrow range of hydrophile-lipophile balance values. This effect may reflect the ability of the surfactant to pack effectively at the hydrophobic transmembrane interface. These findings emphasize the importance of identifying appropriate surfactants for a particular membrane protein, and offer promise for the development of rapid, efficient, and systematic methods to facilitate membrane protein purification

Biophysical Journal published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Synthetic Route of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Breyton, Cecile published the artcileMicellar and biochemical properties of (hemi)fluorinated surfactants are controlled by the size of the polar head, Category: alcohols-buliding-blocks, the publication is Biophysical Journal (2009), 97(4), 1077-1086, database is CAplus and MEDLINE.

Surfactants with fluorinated and hemifluorinated alkyl chains have yielded encouraging results in terms of membrane protein stability; however, the mols. used hitherto have either been chem. heterogeneous or formed heterogeneous micelles. A new series of surfactants whose polar head size is modulated by the presence of one, two, or three glucose moieties has been synthesized. Anal. ultracentrifugation and small-angle neutron scattering show that fluorinated surfactants whose polar head bears a single glucosyl group form very large cylindrical micelles, whereas those with two or three glucose moieties form small, homogeneous, globular micelles. We studied the homogeneity and stability of the complexes formed between membrane proteins and these surfactants by using bacteriorhodopsin and cytochrome b₆f as models. Homogeneous complexes were obtained only with surfactants that form homogeneous micelles. Surfactants bearing one or two glucose moieties were found to be stabilizing, whereas those with three moieties were destabilizing. Fluorinated and hemifluorinated surfactants with a two-glucose polar head thus appear to be very promising mols. for biochem. applications and structural studies. They were successfully used for cell-free synthesis of the ion channel MscL.

Biophysical Journal published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tamargo Santos, Beatriz published the artcileRemote induction of cellular immune response in mice by anti-meningococcal nanocochleates – nanoproteoliposomes, Product Details of C14H28O5S, the publication is Science of the Total Environment (2019), 1055-1063, database is CAplus and MEDLINE.

New adjuvant formulations, based on proteoliposomes <40 nm and cochleates <100 nm, without Al(OH)₃ adjuvant, were evaluated regarding their ability to generate Th1 immune response through a Delayed-Type Hypersensitivity Test, at the mouse model, by using a Neisseria meningitidis B protein complex as antigen. The formulations were administered by i.m. (IM) (2 inoculations – at baseline and after 14 days) and intranasal (IN) (3 inoculations at 7 days) immunization pathways. All IM immunized groups were able to induce similar response to these formulations as well as to VA-MENGOC-BC vaccine – containing Al(OH)₃ adjuvant (used as pos. control of the trial). In all groups, the induced inflammation (IP) rate was statistically higher than in the neg. control group (CN) (p < 0.05). Immunogenicity, measured by HSR and CD4⁺ lymphocyte increase was equivalent to the control vaccine and most important, granuloma reactogenicity at the site of injection was eliminated, fact demonstrated by histol. study. All groups of animals immunized by IN route showed HSR reactions and statistically significant differences with respect to the CN group. However, IP values were lower, with statistical differences (p < 0.05) for the same adjuvant formulation IM administered, except the AIF2-nCh formulation that generated statistically similar induction (p > 0.05) by both immunization pathways, suggesting it to be the best candidate for the next IN trial. Proteoliposome and cochleate formulations tested were able to mount potent Th1 immune response, equivalent to the original vaccine formulation, with the advantage of less reactogenicity in the site of the injection, caused by the toxicity of Al(OH)₃ adjuvant gel.

Science of the Total Environment published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C4H11NO, Product Details of C14H28O5S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ryan, Timothy M. published the artcileSmall Amphipathic Molecules Modulate Secondary Structure and Amyloid Fibril-forming Kinetics of Alzheimer Disease Peptide Aβ_1-42, Application of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Journal of Biological Chemistry (2012), 287(20), 16947-16954, database is CAplus and MEDLINE.

Amyloid fibril formation is associated with a number of debilitating systemic and neurodegenerative diseases. One of the most prominent is Alzheimer disease in which aggregation and deposition of the Aβ peptide occur. Aβ is widely considered to mediate the extensive neuronal loss observed in this disease through the formation of soluble oligomeric species, with the final fibrillar end product of the aggregation process being relatively inert. Factors that influence the aggregation of these amyloid-forming proteins are therefore very important. The authors have screened a library of 96 amphipathic mols. for effects on Aβ_1-42 aggregation and self-association The authors find, using thioflavin T fluorescence and electron microscopy assays, that 30 of the mols. inhibit the aggregation process, whereas 36 activate fibril formation. Several activators and inhibitors were subjected to further anal. using anal. ultracentrifugation and CD. Activators typically display a 1:10 peptide:detergent stoichiometry for maximal activation, whereas the inhibitors are effective at a 1:1 stoichiometry. Anal. ultracentrifugation and CD experiments show that activators promote a mixture of unfolded and β-sheet structures and rapidly form large aggregates, whereas inhibitors induce α-helical structures that form stable dimeric/trimeric oligomers. The results suggest that Aβ_1-42 contains at least one small mol. binding site, which modulates the secondary structure and aggregation processes. Further studies of the binding of these compounds to Aβ may provide insight for developing therapeutic strategies aimed at stabilizing Aβ in a favorable conformation.

Journal of Biological Chemistry published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Application of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jin, Yongdong published the artcileBacteriorhodopsin-monolayer-based planar metal-insulator-metal junctions via biomimetic vesicle fusion: preparation, characterization, and bio-optoelectronic characteristics, Related Products of alcohols-buliding-blocks, the publication is Advanced Functional Materials (2007), 17(8), 1417-1428, database is CAplus.

A reliable and reproducible method for preparing bacteriorhodopsin (bR)-containing metal-biomol.-monolayer-metal planar junctions via vesicle fusion tactics and soft deposition of Au top electrodes is reported. Optimum monolayer and junction preparations, including contact effects, are discussed. The electron-transport characteristics of bR-containing membranes are studied systematically by incorporating native bR or artificial bR pigments derived from synthetic retinal analogs, into single solid-supported lipid bilayers. Current-voltage (I-V) measurements at ambient conditions show that a single layer of such bR-containing artificial lipid bilayers pass current in solid electrode/bilayer/solid electrode structures. The current is passed only if retinal or its analog is present in the protein. Furthermore, the preparations show photoconductivity as long as the retinal can isomerize following light absorption. Optical characterization suggests that the junction photocurrents might be associated with a photochem. induced M-like intermediate of bR. I-V measurements along with theor. estimates reveal that electron transfer through the protein is over four orders of magnitude more efficient than what would be estimated for direct tunneling through 5 nm of water-free peptides. The authors’ results furthermore suggest that the light-driven proton-pumping activity of the sandwiched solid-state bR monolayer contributes negligibly to the steady-state light currents that are observed, and that the orientation of bR does not significantly affect the observed I-V characteristics.

Advanced Functional Materials published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts