Tag: M.W=250-300

Zheng, Weijia published the artcileCatalytic C-H Trifluoromethoxylation of Arenes and Heteroarenes, HPLC of Formula: 20880-92-6, the publication is Angewandte Chemie, International Edition (2018), 57(31), 9645-9649, database is CAplus and MEDLINE.

The intermol. C-H trifluoromethoxylation of arenes remains a long-standing and unsolved problem in organic synthesis. Herein, is reported the first catalytic protocol employing a trifluoromethoxylating reagent and redox-active catalysts for the direct (hetero)aryl C-H trifluoromethoxylation. The approach is operationally simple, proceeds at room temperature, uses easy-to-handle reagents, requires only 0.03 mol % of redox-active catalysts, does not need specialized reaction apparatus, and tolerates a wide variety of functional groups and complex structures such as sugars and natural product derivatives Importantly, both ground-state and photoexcited redox-active catalysts are effective. Detailed computational and exptl. studies suggest a unique reaction pathway where photoexcitation of the trifluoromethoxylating reagent releases the OCF₃ radical that is trapped by (hetero)arenes. The resulting cyclohexadienyl radicals are oxidized by redox-active catalysts and deprotonated to form the desired products of trifluoromethoxylation.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C9H9NO6S, HPLC of Formula: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Yanru published the artcileRegioselective C(sp³)-H alkylation of a fructopyranose derivative by 1,6-HAT, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Organic & Biomolecular Chemistry (2021), 19(14), 3124-3127, database is CAplus and MEDLINE.

Regioselective C(sp³)-H alkylation of a fructopyranose derivative using electron-deficient alkenes as alkylation reagents was achieved. The reaction proceeded via 1,6-hydrogen atom transfer under photoredox iridium catalysis. Several functional groups were introduced into the fructopyranose derivative

Organic & Biomolecular Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kovacic, Ana published the artcileDegradation of bisphenol A and S in wastewater during cold atmospheric pressure plasma treatment, Application In Synthesis of 80-09-1, the publication is Science of the Total Environment (2022), 155707, database is CAplus and MEDLINE.

Developing novel, fast and efficient ecol. benign processes for removing organic contaminants is important for the continued development of water treatment. For this reason, this study investigates the implementation of Cold Atm. pressure Plasma (CAP) generated in ambient air as an efficient tool for the removal of Bisphenol A (BPA) and Bisphenol S (BPS)-known endocrine disrupting compounds in water and wastewater, by monitoring degradation kinetics and its transformation products. The highest removal efficiencies of BPA (>98%) and BPS (>70%) were obtained after 480 s of CAP exposure. A pseudo-first-order kinetic revealed that BPA (-k_t = 4.4 – 9.0 ms^-1) degrades faster than BPS (-k_t = 0.4 – 2.4 ms^-1) and that the degradation is also time- and CAP power-dependent, while the initial concentration or matrix type had a negligible effect. This study also tentatively identified three previously reported and one novel transformation product of BPA and four novel transformation products of BPS. Their postulated structures suggested similar breakdown mechanisms, i.e., hydroxylation followed by ring cleavage. The results demonstrate that CAP technol. is an effective process for the degradation of both BPA and BPS without the need for addnl. chems., indicating that CAP is a promising technol. for water and wastewater remediation worthy of further investigation and optimization.

Science of the Total Environment published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Application In Synthesis of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ferreira Azevedo, L. published the artcileThe alternative analog plasticizer BPS displays similar phenotypic and metabolomic responses to BPA in HepG2 and INS-1E cells, COA of Formula: C12H10O4S, the publication is Food and Chemical Toxicology (2022), 167(Suppl._1), 113266, database is CAplus and MEDLINE.

Bisphenols A (BPA) and S (BPS) are endocrine-disrupting chems. that affect energy metabolism, leading to impairment of glucose and lipid homeostasis. We aimed at identifying metabolic pathways regulated by both compounds in human liver cells and rat pancreatic β-cells that could impair energy homeostasis regulation. We assessed the effects on growth, proliferation, and viability of hepatocarcinoma (HepG2) and insulinoma (INS-1E) cells exposed to either BPA or BPS in a full range concentration between 0.001 and 100μM. Both the dose and duration of exposure caused a differential response on growth and viability of both cells. Effects were more pronounced on HepG2, as these cells exhibited non-linear dose-responses following exposure to xenobiotics. For INS-1E, effect was observed only at the highest concentration In addition, we profiled their intracellular state by untargeted metabolomics at 24, 48, and 72 h of exposure. This anal. revealed time- and dose-dependently mol. changes for HepG2 and INS-1E that were similar between BPA and BPS. Both increased levels of inflammatory mediators, such as metabolites pertaining to linolenic and linoleic acid metabolic pathway. In summary, this study shows that BPS also disrupts mol. functions in cells that regulate energy homeostasis, displaying similar but less pronounced responses than BPA.

Food and Chemical Toxicology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, COA of Formula: C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abellan, Alicia published the artcileIn utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts, Related Products of alcohols-buliding-blocks, the publication is Environment International (2022), 107178, database is CAplus and MEDLINE.

In utero exposure to bisphenols, widely used in consumer products, may alter lung development and increase the risk of respiratory morbidity in the offspring. However, evidence is scarce and mostly focused on bisphenol A (BPA) only. To examine the associations of in utero exposure to BPA, bisphenol F (BPF), and bisphenol S (BPS) with asthma, wheeze, and lung function in school-age children, and whether these associations differ by sex. We included 3,007 mother-child pairs from eight European birth cohorts. Bisphenol concentrations were determined in maternal urine samples collected during pregnancy (1999-2010). Between 7 and 11 years of age, current asthma and wheeze were assessed from questionnaires and lung function by spirometry. Wheezing patterns were constructed from questionnaires from early to mid-childhood. We performed adjusted random-effects meta-anal. on individual participant data. Exposure to BPA was prevalent with 90% of maternal samples containing concentrations above detection limits. BPF and BPS were found in 27% and 49% of samples. In utero exposure to BPA was associated with higher odds of current asthma (OR = 1.13, 95% CI = 1.01, 1.27) and wheeze (OR = 1.14, 95% CI = 1.01, 1.30) (p-interaction sex = 0.01) among girls, but not with wheezing patterns nor lung function neither in overall nor among boys. We observed inconsistent associations of BPF and BPS with the respiratory outcomes assessed in overall and sex-stratified analyses. This study suggests that in utero BPA exposure may be associated with higher odds of asthma and wheeze among school-age girls.

Environment International published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Olechowska, Karolina published the artcileThe effect of selected bisphenols on model erythrocyte membranes of different cholesterol content, Category: alcohols-buliding-blocks, the publication is Chemistry and Physics of Lipids (2022), 105224, database is CAplus and MEDLINE.

Bisphenols belong to the group of environmental pollutants with proven harmful impact on human red blood cells. However, the exact effect of these substances may vary depending on the lipid composition of the cell membrane, since this structure is the first barrier between the cell interior and the external environment. The aim of this work was to analyze the influence of bisphenol A (BPA), bisphenol S (BPS) and their 1:1 mixture on model human erythrocyte membranes, composed of sphingomyelin (SM), phospatidylcholine (PC) and cholesterol (Chol). Due to the postulated correlation between the content of cholesterol in biomembranes and the toxic effect of bisphenols the model systems of different sterol concentrations (10, 20 and 40 mol% of Chol) were used in the studies. In the experiments, Langmuir monolayer technique accompanied with Brewster Angle Microscopy were applied and liposome properties were investigated. The obtained findings reveal that, in the investigated range of the sterol content, the effect of BPA, namely the changes of the organization and stability of model membranes and weakening of the attractive lipid-lipid interactions, is strongly dependent on the concentration of Chol in the system. The higher the sterol content, the stronger the BPA-induced alterations in membrane properties. However taking into account the results reported previously for the system containing 33.3% of cholesterol, it seems that the relationship between the effect of BPA and the amount of Chol is not linear for higher sterol concentrations In contrast, BPS shows a much weaker influence on model erythrocyte membranes and does not act selectively on the systems studied. The effect of a mixture of BPA and BPS is intermediate between that of BPA and BPS used sep., however, the observed effects appear to be determined only by the presence of BPA in the system. Thus, the concentration of cholesterol in human erythrocyte membranes, which depends on factors such as age or health status, may play a key role in the toxic effects of BPA but not BPS.

Chemistry and Physics of Lipids published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Goosen, Andre published the artcileReactions of 9-hydroperoxy-9-phenylxanthene: oxidation of sulfides, sulfoxides, and thiols, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol, the publication is South African Journal of Chemistry (1989), 42(3), 107-12, database is CAplus.

Sulfides have been oxidized selectively to sulfoxides with 9-hydroperoxy-9-phenylxanthene at ambient and reflux temperatures resp. Excellent yields of dialkyl and aralkyl sulfoxides were obtained; diaryl sulfides gave moderate-to-poor yields of sulfoxides. Selective oxidation of allyl Ph sulfide to form sulfoxide without epoxidation was accomplished. These reactions have been proposed to proceed via a heterolytic path which does not involve the intermediacy of the hydroperoxy anion. Trifluoroacetic acid, benzyltrimethylammonium hydroxide, and molybdenum(0) hexacarbonyl catalyzed the oxidation reaction to give high yields of sulfoxides or sulfones, depending on the reaction conditions. Mechanistic aspects of these catalyzed oxidations have been discussed. Advantages of the reaction include the ease of separation of the peroxidic ancillary products from the formed sulfoxides and sulfones, as well as the relatively high stability of the hydroperoxide as compared to other known peroxide reagents.

South African Journal of Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Goosen, Andre published the artcileReactions of 9-hydroperoxy-9-phenylxanthene: the epoxidation of alkenes, Related Products of alcohols-buliding-blocks, the publication is South African Journal of Chemistry (1989), 42(3), 121-3, database is CAplus.

Alkyl-substituted alkenes have been epoxidized with 9-hydroperoxy-9-phenylxanthene in the presence of molybdenum(0) hexacarbonyl as catalyst, in moderate yields. Excellent yields of chalcone epoxides were obtained by epoxidizing a series of substituted chalcones with the hydroperoxide in basic nonaqueous medium.

South African Journal of Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Okuma, Kentaro published the artcileReaction of benzyne with 2-hydroxy-and 2-aminophenyl ketones. Synthesis of xanthenes and acridines, SDS of cas: 596-38-3, the publication is Fukuoka Daigaku Rigaku Shuho (2011), 41(1), 23-27, database is CAplus.

Reaction of benzyne with 2-hydroxybenzophenone afforded 9-phenyl-9-hydroxyxanthene, whereas reaction with 2-hydroxyacetophenone yielded 9-methylenexanthene. 9-Methyl-9-hydroxyxanthene, initial cycloadduct, further dehydrated to give exo-methylene xanthene. Reaction of benzyne with 2-aminophenyl ketones gave acridines in good yields.

Fukuoka Daigaku Rigaku Shuho published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, SDS of cas: 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chunarrom, Wannida published the artcileThe dielectric and polarization behavior of polyurethane-based polycarbonate diols with different content levels of fluorinated hard segments, Synthetic Route of 129301-42-4, the publication is Polymer Chemistry (2021), 12(8), 1136-1146, database is CAplus.

A novel series of polyurethane-based polycarbonate diols containing fluorinated hard segments in the main chain (FPU) were synthesized using a prepolymer method. The fluorinated hard segment content was varied to study the effects on the dielec. and polarization behaviors under an applied elec. field (P-E loop). The addition of a fluorinated chain notably improved the polarization via an induced dipole moment in the PU films and higher dielec. constant, including allowing the relaxation peak to move to a lower frequency. Paraelec. loop behavior was observed with thinner loops as the fluorinated group content was increased. The nature of the solvent used for the synthesis affected the H-bonding capabilities and fluorinated group content. FPU synthesized in DMF showed a higher dielec. constant than that synthesized in dimethylsulfoxide due to its higher fluorine content.

Polymer Chemistry published new progress about 129301-42-4. 129301-42-4 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), and the molecular formula is C6H6F8O4, Synthetic Route of 129301-42-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts