Tag: M.W=250-300

Chelcea, Ioana published the artcilePhysiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation, Name: 4,4′-Sulfonyldiphenol, the publication is Environmental Science & Technology (2022), 56(14), 10216-10228, database is CAplus and MEDLINE.

Bisphenol A (BPA) is an industrial chem., which has raised human health and environmental concerns due to its endocrine-disrupting properties. BPA analogs are less well-studied despite their wide use in consumer products. These analogs have been detected in water and aquatic organisms around the world, with some analogs showing toxic effects in various species including fish. Here, we present novel organ-specific time-course distribution data of bisphenol Z (BPZ) in female zebrafish (Danio rerio), including concentrations in the ovaries, liver, and brain, a rarely sampled organ with high toxicol. relevance. Furthermore, fish-specific in vitro biotransformation rates were determined for 11 selected bisphenols. A physiol. based toxicokinetic (PBTK) model was adapted for four of these bisphenols, which was able to predict levels in the gonads, liver, and brain as well as the whole body within a 2-5-fold error with respect to exptl. data, covering several important target organs of toxicity. In particular, predicted liver concentrations improved compared to currently available PBTK models. Predicted data indicate that studied bisphenols mainly distribute to the carcass and gonads and less to the brain. Our model provides a tool to increase our understanding on the distribution and kinetics of a group of emerging pollutants.

Environmental Science & Technology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Name: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sutili, Felipe K. published the artcileLipase immobilized in microemulsion based organogels (MBGs) as an efficient catalyst for continuous-flow esterification of protected fructose, COA of Formula: C12H20O6, the publication is RSC Advances (2015), 5(47), 37287-37291, database is CAplus.

Sugar-based organogels are important esters for the cosmetic, food and pharmaceutical industries due to their intrinsic properties. Chem. routes to obtain these mols. suffer from low yields and undesirable side products. In this way, biocatalysis can be an interesting and efficient alternative, which meets the green chem. principles. Herein we report our results on the development of a continuous flow process for the production of sugar-based surfactants mediated by immobilized enzymes in microemulsion based organogels, leading to the desired product in high productivities (66.8 to 88.1 g of ester per h per g of lipase).

RSC Advances published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C17H19N3O7S, COA of Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Okuma, Kentaro published the artcileReaction of Benzyne with Salicylaldehydes: General Synthesis of Xanthenes, Xanthones, and Xanthols, Category: alcohols-buliding-blocks, the publication is Organic Letters (2009), 11(1), 169-171, database is CAplus and MEDLINE.

The reaction of salicylaldehydes with benzyne prepared from o-trimethylsilylphenyl triflate and CsF gave xanthenes and xanthones. When the reaction was carried out under basic conditions, 9-hydroxyxanthenes (xanthols) were obtained in good yields.

Organic Letters published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Terao, Yoshito published the artcilePalladium-catalyzed dehydroarylation of triarylmethanols and their coupling with unsaturated compounds accompanied by C-C bond cleavage, Related Products of alcohols-buliding-blocks, the publication is Journal of Organic Chemistry (2004), 69(20), 6942-6944, database is CAplus and MEDLINE.

Triarylmethanols were effectively dehydroarylated and reacted with some unsaturated compounds by using an appropriate palladium catalyst system such as Pd(OAc)₂-P(1-Nap)₃ to give the corresponding arenes and hydroarylation products, e.g., I, resp., along with diaryl ketones.

Journal of Organic Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C6H10N2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dracheva, Elena published the artcileIn Silico Identification of Potential Thyroid Hormone System Disruptors among Chemicals in Human Serum and Chemicals with a High Exposure Index, Category: alcohols-buliding-blocks, the publication is Environmental Science & Technology (2022), 56(12), 8363-8372, database is CAplus and MEDLINE.

Data on toxic effects are at large missing the prevailing understanding of the risks of industrial chems. Thyroid hormone (TH) system disruption includes interferences of the life cycle of the thyroid hormones and may occur in various organs. In the current study, high-throughput screening data available for 14 putative mol. initiating events of adverse outcome pathways, related to disruption of the TH system, were used to develop 19 in silico models for identification of potential thyroid hormone system-disrupting chems. The conformal prediction framework with the underlying Random Forest was used as a wrapper for the models allowing for setting the desired confidence level and controlling the error rate of predictions. The trained models were then applied to two different databases: (i) an inhouse database comprising xenobiotics identified in human blood and (ii) currently used chems. registered in the Swedish Product Register, which have been predicted to have a high exposure index to consumers. The application of these models showed that among currently used chems., fewer were overall predicted as active compared to chems. identified in human blood. Chems. of specific concern for TH disruption were identified from both databases based on their predicted activity.

Environmental Science & Technology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lambi, John N. published the artcileSynthesis, spectral properties and thermal behaviour of zinc(II) acetylsalicylate, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol, the publication is Thermochimica Acta (2003), 398(1-2), 145-151, database is CAplus.

The thermal behavior of Zn(II) acetylsalicylate [Zn(acsa)₂(H₂O)₂] with respect to phase transitions, pyrolysis both in air and inert (N₂) atm., and product identification was studied. The complex was synthesized by metathesis in hot EtOH solution using aspirin (acetylsalicylic acid) as precursor and characterized via electronic and IR spectral analyses. Optical observations showed that the white salt does not undergo a direct transition from the solid to the liquid phase but rather goes slowly through an intermediate mesophase around 80° before melting rapidly to the brick-brown isotropic liquid around 134-136°. No liquid crystalline phases are however formed. This result was complemented by that from thermogravimetric (TG) studies in the ∼25-600° range, which showed three main weight-loss phases of 8.0, 50.0 and 14.0% (around 200, 250 and 400°) corresponding, resp., to the elimination of CO₂, xanthone and HOAc. The pyrolysis products, as identified using a combination of instrumental (GC-MS) and wet chem. techniques are: CO₂; nonstoichiometric Zn oxide, most likely in the form: Zn_1+xO (0.0000 ≤ x ≤ 0.0003); and a mixture of organic products resulting from further decomposition, charring and other attendant thermal effects at the relatively high temperatures (∼600°) involved. Six of the principal organic products were identified and included salsalate and benorylate which are pro-drugs of salicylic acid, a known pharmaceutical.

Thermochimica Acta published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chateauneuf, John E. published the artcileAn investigation of Friedel-Crafts alkylation reactions in super- and subcritical CO₂ and under solventless reaction conditions, Application of 9-Phenyl-9H-xanthen-9-ol, the publication is ACS Symposium Series (2002), 136-150, database is CAplus.

A symposium report. The Friedel-Crafts alkylation reaction of triphenylmethanol with methoxybenzene in supercritical and subcritical carbon dioxide, and under solventless reaction conditions was investigated. The reaction was initiated using trifluoroacetic acid to produce triphenylmethlycarbocation as the reaction intermediate. Isolated product yields of the Friedel-Crafts product, p-methoxytetraphenylmethane, are reported. The possibility of using the above reaction as an alternative synthesis in an undergraduate organic laboratory to teach some of the tenets of green chem. was also investigated. Addnl., the use of benzhydrol, 9-hydroxyxanthene and 9-phenylxanthen-9-ol as potential carbocation sources for supercritical carbon dioxide synthesis was studied and preliminary results are reported.

ACS Symposium Series published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Application of 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Yifei published the artcileStrontium oxides with enzyme-like activity: A colorimetric sensor array for highly sensitive discrimination of bisphenols, Safety of 4,4′-Sulfonyldiphenol, the publication is Sensors and Actuators, B: Chemical (2022), 131869, database is CAplus.

Bisphenols are widely used in food packaging materials, and because of their endocrine disrupting effects on the human body, fast yet facile detection is essential for food safety and human health. Traditional anal. methods face disadvantages of cumbersome operation and the need of bulk instruments. To circumvent these issues, we constructed colorimetric sensor arrays based on peroxidase-like activities of three strontium oxides for four bisphenols determination Bisphenols are absorbed on surface of strontium oxides, blocking catalytic sites and leading to decline of enzyme-like activities in turn. Different bisphenols have diverse inhibition effect on catalytic activities of the three nanozymes, and each bisphenol possesses a unique fingerprint. Though principal component anal., bisphenol A, bisphenol S, bisphenol B and bisphenol AF with concentrations ranging from 0.0002 to 1μg mL^-1 were discerned well by the developed sensor arrays. Addnl., different concentrations of each bisphenol and different ratios of mixed bisphenols were successfully discriminated, and canned fruit as real sample was applied to evaluate practical applicability of the nanozyme based sensor arrays. This work is expected to provide a simple and fast method for discrimination of structural analogs and contribute to food quality and safety monitoring aspects.

Sensors and Actuators, B: Chemical published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Safety of 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sasikumar, M. published the artcileSimple and efficient synthesis of (S)-dapoxetine, Related Products of alcohols-buliding-blocks, the publication is Synthetic Communications (2012), 42(20), 3061-3067, database is CAplus.

A refinement in the synthetic strategy for (S)-dapoxetine was described. The key features of synthetic strategy include (a) a Sharpless asym. epoxidation and regioselective reductive ring opening of a 2,3-epoxy alc. to elaborate the hydroxy-bearing stereogenic center at the benzylic position; (b) regioselective functionalization of the 1-naphthol and the amine functionality through Mitsunobu procedures; and (c) Eschweiler-Clarke reductive methylation to access the target mol.

Synthetic Communications published new progress about 156453-53-1. 156453-53-1 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Benzene,Naphthalene,Alcohol,Ether, name is (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-ol, and the molecular formula is C19H18O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tikker, Priit published the artcileOxidation of aqueous bisphenols A and S by pulsed corona discharge: Impacts of process control parameters and oxidation products identification, SDS of cas: 80-09-1, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 135602, database is CAplus.

Widespread usage of bisphenol A (BPA) and its potential replacement bisphenol S (BPS) has led to their presence in natural waterbodies. The exptl. research into degradation of both aqueous pollutants by application of gas-phase pulsed corona discharge (PCD) was undertaken with variation of process control parameters, pulse repetition frequency, gas-liquid contact surface and addition of surfactant OH-radical scavenger sodium dodecyl sulfate (SDS). Although the contact surface variation had only a moderate impact on bisphenols degradation, its effect was stronger in total organic carbon removal. The addition of SDS showed a moderately neg. impact on energy efficiency at all studied conditions. The obtained results showed energy efficiency surpassing the closest competitors, ozonation and other elec. discharge processes. The detected major oxidation intermediates were mainly formed through hydroxylation and cracking of benzene rings, followed by further degradation into short chained aliphatic acids. The oxidation end-products were quantified as acetate, formate and oxalate.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C14H26O2, SDS of cas: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts