Tag: M.W=250-300

Nishimura, Mitsugu published the artcileEfficient GC/MS analysis of hydroxy lipid compounds from geochemical samples using tertiary-butyldimethylsilyl etherification, Application In Synthesis of 13099-34-8, the main research area is hydroxy lipid compound analysis geochem sample GC MS; butyldimethylsilyl etherification hydroxy lipid compound analysis GC MS.

To improve GC/MS anal. of hydroxy compounds from various sources, such as alkanols, sterols, diols, keto-ols and hydroxy fatty acids (FAs) with complex compositions, the authors evaluated their column-chromatog. separation after silylation. N-tertiary-butyldimethylsilylimidazole (t-BDMS) was expected to be the most effective silylating reagent to make -OH groups more inert and hence to promote separation according to the chem. and structural differences in their individual alkyl groups. The t-BDMS etherification of hydroxy compounds remarkably improved their purification and separation by strongly constraining or enhancing the chromatog. different behavior possibly caused by chem. and structural differences in the alkyl groups. Thus, the complex mixtures of hydroxy compounds from lacustrine and marine sediments were clearly fractionated into each major compound group, i.e., alkanols, sterols, diols, hydroxy FAs and keto-ols. Also, the individual sterols, diols and hydroxy FAs were separated into four, two and five specific sub-groups, resp. It is worth noting that, by using only one column, this anal. improvement was achieved with excellent reproducibility. Such fine fractionations resulted in a substantial decrease in the complexity of the gas chromatograms of all major hydroxy compounds The improvement enabled the authors to simply and accurately identify and quantify major as well as trace homologs and isomers of various hydroxy compounds with a high level of sensitivity using GC/MS. Consequently, the authors found some series of hitherto unknown compounds to serve as information sources for organisms and environments. The chromatog. fractionation following t-BDMS etherification of lipids from various geochem. samples provides not only a greater understanding of their mol. distributions and stable carbon isotopic ratios, but also substantially upgrades lipid anal. efficiency as a whole.

Organic Geochemistry published new progress about Etherification. 13099-34-8 belongs to class alcohols-buliding-blocks, name is 17-Hydroxyheptadecanoic acid, and the molecular formula is C17H34O3, Application In Synthesis of 13099-34-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Quan-Fei published the artcileIn-Depth Annotation Strategy of Saturated Hydroxy Fatty Acids Based on Their Chromatographic Retention Behaviors and MS Fragmentation Patterns, Application of 17-Hydroxyheptadecanoic acid, the main research area is hydroxy fatty acid annotation LC MS.

Hydroxy fatty acids are a class of bioactive compounds in a variety of organisms. The identification of hydroxy fatty acids in biol. samples has still been a challenge because of their low abundance, high structural similarity, and limited availability of authentic hydroxy fatty acid standards Here, we present a strategy for the annotation of saturated monohydroxyl fatty acids (OH-FAs) based on the integration of chromatog. retention rules and MS2 fragmentation patterns. Thirty-nine authentic OH-FA standards were used to investigate their retention behavior on a reversed-phase stationary phase (C18) of liquid chromatog., and we found that their retention simultaneously follows two kinds of “”carbon number rules””. Using the “”carbon number rules””, the retention index (RI) of all OH-FAs that contain carbon numbers from 8 to 18 (C8-18) can be predicted. Addnl., by studying the MS2 fragmentation of OH-FAs under collision-induced dissociation, we found that the intensity ratio (IR) of the characteristic fragment ions ([M + H]+-63 and [M + H]+-45) is closely related to the position of the hydroxyl group on the OH-FA structure, which is helpful to further identify and confirm the OH-FA isomers. As a result, 97 of 107 potential OH-FAs detected in honey, human serum, and rice seedling by chem. isotope labeling-assisted liquid chromatog.-mass spectrometry were annotated upon the RI matching and IR confirming. Furthermore, in order to simplify the annotation process of OH-FAs, we constructed an OH-FA library to facilitate the annotation of OH-FAs. Overall, this study provides a new and promising tool for the in-depth annotation of OH-FA isomers.

Analytical Chemistry (Washington, DC, United States) published new progress about Blood analysis. 13099-34-8 belongs to class alcohols-buliding-blocks, name is 17-Hydroxyheptadecanoic acid, and the molecular formula is C17H34O3, Application of 17-Hydroxyheptadecanoic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Musachio, Elize Aparecida Santos published the artcileSex-specific changes in oxidative stress parameters and longevity produced by Bisphenol F and S compared to Bisphenol A in Drosophila melanogaster, Name: 4,4′-Sulfonyldiphenol, the publication is Comparative Biochemistry and Physiology, Part C: Toxicology & Pharmacology (2022), 109329, database is CAplus and MEDLINE.

Female and male Drosophila melanogaster were exposed sep. for seven days to Bisphenol A (BPA), Bisphenol F (BPF), and Bisphenol S (BPS) at concentrations of 0.25, 0.5, and 1 mM. We observed that males exposed to 0.5 and 1 mM BPS showed lower catalase (CAT) activity and higher superoxide dismutase (SOD) and reactive species (RS); CAT activity decreased for BPF 0.5 and 1 mM. Nevertheless, BPA 0.5 and 1 mM decreased CAT activity, increased RS and lipid peroxidation (LPO), and reduced mitochondrial viability. None of the bisphenols altered the cell viability of male flies, although BPA 0.5 and 1 mM reduced longevity. In female flies, BPA and BPS 0.5 and 1 mM increased RS and LPO levels and decreased CAT activity and glutathione-S-transferase (GST), which may have contributed to lower mitochondrial and cell viability. Furthermore, BPS decreased SOD activity at the 1 mM concentration, and BPA reduced the SOD activity at concentrations of 0.5 and 1 mM. In the BPF 1 mM group, there was a reduction in GST activity and an increase in RS and LPO levels. The toxicol. effects were different between sexes, and BPA was more harmful than BPF and BPS in male flies. Thus, our findings showed that females were more susceptible to oxidative cell damage when exposed to BPA and BPS than to BPF, and daily exposure to BPA and BPS at all concentrations reduced female longevity, as well as in BPF 1 mM.

Comparative Biochemistry and Physiology, Part C: Toxicology & Pharmacology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Name: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nischang, Ivo published the artcileHydrodynamic Analysis Resolves the Pharmaceutically-Relevant Absolute Molar Mass and Solution Properties of Synthetic Poly(ethylene glycol)s Created by Varying Initiation Sites, Product Details of C12H20O6, the publication is Analytical Chemistry (Washington, DC, United States) (2017), 89(2), 1185-1193, database is CAplus and MEDLINE.

The solution behavior originating from mol. characteristics of synthetic macromols. plays a pivotal role in many areas, in particular the life sciences. This situation necessitates the use of complementary hydrodynamic anal. methods as the only means for a complete structural understanding of any macromol. in solution To this end, we present a combined hydrodynamic approach for studying inhouse prepared, low dispersity poly(ethylene glycols)s (PEGs), also known as poly (ethylene oxide)s (PEOs) depending on the classification used, synthesized from varying initiation sites by living anionic ring opening polymerization The series of linear PEGs in the molar mass range of only a few thousand to 50 000 g mol-1 were studied in detail via viscometry, and sedimentation-diffusion anal. by anal. ultracentrifugation. The obtained estimations for intrinsic viscosity, diffusion coefficients, and sedimentation coefficients of the macromols. in the solution-based anal. clearly showed self-consistency of the followed hydrodynamic approach. This self-consistency is underpinned by appropriate and phys.-sound values of hydrodynamic invariants, indicating adequate values of derived absolute molar masses. The classical scaling relations of Kuhn-Mark-Houwink-Sakurada of all molar-mass dependent hydrodynamic estimates show linear trends, allowing for interrelation of all parametric macromol. characteristics. Differences among these are ascribed to the observation of α-end and chain-length dependent solvation of the macromols., identified from viscometric studies. This important information al-lows for anal. tracing of variations of scaling relationships and a phys.-sound estimation of hydrodynamic characteristics. The demonstrated self-sufficient methodol. paves an important way for a complete structural understanding and potential replacement of pharmaceutically-relevant PEGs by alternative macromols. offering a suite of similar or tractably distinct physicochem. properties.

Analytical Chemistry (Washington, DC, United States) published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zeng, Zhuo published the artcilePolyfluoroalkyl, Polyethylene Glycol, 1,4-Bismethylenebenzene, or 1,4-Bismethylene-2,3,5,6-Tetrafluorobenzene Bridged Functionalized Dicationic Ionic Liquids: Synthesis and Properties as High Temperature Lubricants, Quality Control of 129301-42-4, the publication is Chemistry of Materials (2008), 20(8), 2719-2726, database is CAplus.

A new class of geminal dicationic ionic liquids was formed with a bridging moiety, such as a polyalkyl ether, polyfluoroalkyl, 1,4-bismethylenebenzene, or 1,4-bismethylene-2,3,5,6-tetrafluorobenzene link, between alkyl-substituted imidazolium rings. Their properties were modified by varying the linker chains and/or alkyl substituents on the imidazolium ring. The polyfluoroalkyl bridged dicationic ionic liquids exhibit the highest densities and viscosities. Although m.ps. are directly proportional to the length of the alkyl substituent, the densities decrease concomitantly. With 1,4-bismethylene-2,3,5,6-tetrafluorobenzene as the linking chain and with longer alkyl substituents on the imidazolium rings, the nonpolar character of the ionic liquid greatly increases, e.g., the solubilities in toluene of dicationic ionic liquids 36 and 37, where the ring substituents are C₁₀H₂₁ and C₁₄H₂₉, increase markedly. Some of the salts exhibit higher conductivities than an equimolar tetrabutylammonium iodide solution in acetonitrile/toluene. These new ionic liquids (except with PF₆^– as anion) display outstanding tribol. properties in temperature ramp tests by performing very well at 300 °C, thus meeting one criterion for high-temperature lubricants.

Chemistry of Materials published new progress about 129301-42-4. 129301-42-4 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), and the molecular formula is C2H4ClNO, Quality Control of 129301-42-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Peng published the artcileNickel-Catalyzed Reductive Csp³-Ge Coupling of Alkyl Bromides with Chlorogermanes, Product Details of C12H20O6, the publication is Organic Letters (2022), 24(9), 1802-1806, database is CAplus and MEDLINE.

Reductive cross-coupling provides facile access to organogermanes, but it remains largely unexplored. Herein the authors report a Ni-catalyzed reductive Csp³-Ge coupling of alkyl bromides with chlorogermanes. This work established a new method for producing alkylgermanes. The reaction proceeds under very mild conditions and tolerates various functionalities including ether, alc., alkene, nitrile, amine, ester, phosphonates, amides, ketone, and aldehyde. The application of this method to the modification of bioactive mols. is demonstrated.

Organic Letters published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lee, Handule published the artcileEffects of consumer products chemicals ingredients and their mixtures on the estrogen receptor/androgen receptor transcriptional activation, Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Chemosphere (2022), 134866, database is CAplus and MEDLINE.

Unlike the environmental pollutants or industrial chems., the chems. in consumer products may pose higher levels of risks, depending on how the chems. are used in the products and how humans interact with the products. Recently, endocrine disrupting chems. in cosmetics, personal care products, cleaners, sunscreens, and vinyl products were anal. quantified and many active chems. including phthalates, parabens and bisphenols were detected. This indicates a wide range of exposures from common products. In this study, 35 chems. known to be ingredients of consumer products were selected and screened for the transactivation of estrogen receptors and androgen receptors. From the results of individual chems., the activity of binary/ternary mixture prepared from the agonists for the ER transcription activity was measured, and compared to the predicted values obtained by the full logistic model. The measured and the predicted values were found to be very similar. This study may suggest that prediction of mixture activity by proper models would be one of the supportive tools for the risk assessment and sound regulation of chem. mixtures which have potential endocrine disrupting effects in consumer products.

Chemosphere published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hu, Peipei published the artcileAssociations between exposure to a mixture of phenols, parabens, and phthalates and sex steroid hormones in children 6-19 years from NHANES, 2013-2016, COA of Formula: C12H10O4S, the publication is Science of the Total Environment (2022), 153548, database is CAplus and MEDLINE.

Humans are typically exposed to mixtures of environmental endocrine-disrupting chems. simultaneously, but most studies have considered only a single chem. or a class of similar chems. We examined the association of exposure to mixtures of 7 chems., including 2 phenols [bisphenol A (BPA) and bisphenol S (BPS)], 2 parabens [methylparaben (MeP) and Pr paraben (PrP)], and 3 phthalate metabolites [Mono-benzyl phthalate (MBzP), mono-iso-Bu phthalate (MiBP), mono (carboxyoctyl) phthalate (MCOP)] with sex steroid hormones. A total of 1179 children aged 6-19 years who had complete data on both 7 chems. and sex steroid hormones of estradiol (E2), total testosterone (TT), and sex hormone-binding globulin (SHBG) were analyzed from the U. S. National Health and Nutrition Examination Survey 2013-2016. Free androgen index (FAI) calculated by TT/SHBG, and the ratio of TT to E2 (TT/E2) were also estimated Puberty was defined if TT ≥ 50 ng/dL in boys, E2 ≥ 20 pg/mL in girls; otherwise prepuberty was defined. Linear regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) were performed to estimate the associations of individual chem. or chem. mixtures with sex hormones. The linear regression showed that 2 phenols, 2 parabens, and 3 phthalate metabolites were generally neg. associated with E2, TT, FAI, and TT/E2, while pos. with SHBG. Moreover, these associations were more pronounced among pubertal than prepubertal children. The aforementioned associations were confirmed when further applying WQS and BKMR, and the 3 phthalates metabolites were identified to be the most heavily weighing chems. Exposure to phenols, parabens, and phthalates, either individuals or as a mixture, was neg. associated with E2, TT, FAI and TT/E2, while pos. with SHBG. Those associations were stronger among pubertal children.

Science of the Total Environment published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, COA of Formula: C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Montero Bastidas, Jose R. published the artcilePara-Selective, Iridium-Catalyzed C-H Borylations of Sulfated Phenols, Benzyl Alcohols, and Anilines Directed by Ion-Pair Electrostatic Interactions, Quality Control of 1400755-06-7, the publication is Journal of the American Chemical Society (2019), 141(39), 15483-15487, database is CAplus and MEDLINE.

Para C-H borylations (CHB) of tetraalkylammonium sulfates [R₄N][ArOSO₃] (R = n-Pr, Bu) and sulfamates [Bu₄N][ArNHSO₃] have been achieved using bipyridine-ligated Ir boryl catalysts, 4,4′-R₂bpy/[Ir(cod)(OMe)]₂/B₂pin₂, yielding borylated phenols 4-(pinB)-RC₆H₃OH (R = halo, Me, CN, CF₃, CF₃O, OMe), together with minor amounts of meta-isomers. Selectivities can be modulated by both the length of the alkyl groups in the tetraalkylammonium cations and the substituents on the bipyridine ligands. Ion pairing, where the alkyl groups of the cation shield the meta C-H bonds in the counteranions, is proposed to account for para selectivity. The 4,4′-dimethoxy-2,2′-bipyridine ligand gave superior selectivities.

Journal of the American Chemical Society published new progress about 1400755-06-7. 1400755-06-7 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Boronic acid and ester,Benzene,Alcohol,Boronic Acids,Boronate Esters, name is (3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol, and the molecular formula is C13H18BFO3, Quality Control of 1400755-06-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shah, Deep B. published the artcileEffect of Anion Size on Conductivity and Transference Number of Perfluoroether Electrolytes with Lithium Salts, Application of 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), the publication is Journal of the Electrochemical Society (2017), 164(14), A3511-A3517, database is CAplus.

Mixtures of perfluoropolyethers (PFPE) and Li salts with fluorinated anions are a new class of electrolytes for Li batteries. Unlike conventional electrolytes wherein electron-donating O groups interact primarily with the Li cations, the properties of PFPE-based electrolytes appear to be dependent on interactions between the fluorinated anions and the fluorinated backbones. We study these interactions by examining a family of Li salts wherein the size of the fluorinated anion is systematically increased: Li bis(fluorosulfonyl)imide (LiFSI), bis(trifluoromethanesulfonyl)imide (LiTFSI) salts and Li bis(pentafluoroethanesulfonyl)imide (LiBETI). Two short chain perfluoroethers (PFE), one with 3 repeat units, C6-DMC, and another with four repeat units, C8-DMC were studied; both systems have di-Me carbonate end groups. We find that LiFSI provides the highest conductivity in both C6-DMC and C8-DMC. These systems also present the lowest interfacial resistance against Li metal electrodes. The steady-state transference number (t⁺_ss) was >0.6 for all of the electrolytes and was an increasing function of anion size. The product of conductivity and the steady-state transference number, a convenient measure of the efficacy of the electrolytes for Li battery applications, exhibited a maximum at ∼20 weight% salt in all electrolytes. Amongst the systems studied, LiFSI/PFE mixtures were the most efficacious electrolytes.

Journal of the Electrochemical Society published new progress about 129301-42-4. 129301-42-4 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), and the molecular formula is C15H21BO2, Application of 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol).

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts