Tag: M.W=250-300

Panda, Chakadola; Doyle, Lorna M.; Gericke, Robert; McDonald, Aidan R. published the artcile< Rapid Iron(III)-Fluoride-Mediated Hydrogen Atom Transfer>, Product Details of C19H16O, the main research area is pyridylmethylamine iron fluoride preparation oxidant hydrogen atom transfer; crystal mol structure pyridylmethylamine iron fluoride; hydrocarbon oxidative carbon hydrogen activation kinetics pyridylmethylamine iron fluoride; biomimetic chemistry; fluoride oxidant; high-valent oxidants; nonheme iron; proton-coupled electron transfer.

Authors anticipate high-valent metal-fluoride species will be highly effective hydrogen atom transfer (HAT) oxidants because of the magnitude of the H-F bond (in the product) that drives HAT oxidation They prepared a dimeric FeIII(F)-F-FeIII(F) complex (1) by reacting [FeII(NCCH3)2(TPA)](ClO4)2 (TPA = tris(2-pyridylmethyl)amine) with difluoro(phenyl)-λ3-iodane (difluoroiodobenzene). 1 Was a sluggish oxidant, however, it was readily activated by reaction with Lewis or Broensted acids to yield a monomeric [FeIII(TPA)(F)(X)]+ complex (2) where X = F/OTf. 1 And 2 were characterized using NMR, EPR, UV/Vis, and FT-IR spectroscopies and mass spectrometry. 2 Was a remarkably reactive FeIII reagent for oxidative C-H activation, demonstrating reaction rates for hydrocarbon HAT comparable to the most reactive FeIII and FeIV oxidants.

Angewandte Chemie, International Edition published new progress about Activation energy. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Chenghua; Wu, Keliang; Huang, Long; Sun, Kenan; Zou, Yurong; Xiong, Zhihui; Li, Bingke published the artcile< Virtual Screening and Discovery of Matrix Metalloproteinase-12 Inhibitors by Swarm Intelligence Optimization Algorithm-Based Machine Learning>, COA of Formula: C19H16O, the main research area is screening MMP inhibitor swarm intelligence optimization algorithm machine learning.

Matrix metalloproteinase-12 (MMP-12) is an attractive therapeutic target for drug design and discovery for many human conditions. In this study, six swarm intelligence optimization algorithms were applied to optimize the parameters of the model generated using the LibSVM toolkit in MATLAB to identify potential MMP-12 inhibitors (MMP-12is); six types of optimized support vector machine (SVM) models were established. The highest prediction accuracy obtained was 98.89%, which was equivalent to the effect of the optimal “”RF+opt”” model. All six models passed the Y-randomization test and showed excellent performance with reliable results. Virtual screening identified 371 mols. with a predictive probability score greater than 0.9. The optimized SVM models, in addition to “”RF+opt”” and “”SVM2″” models, were combined to establish a consistency evaluation system. Our results revealed six non-toxic potential MMP-12is. This process provides a strong theor. basis for the design, synthesis, and development of novel drugs targeting MMP-12.

ChemistrySelect published new progress about Algorithm. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, COA of Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 24034-73-9, formula is C20H34O, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Reference of 24034-73-9

Hamid, Khaled J.;Kurji, Badoor M.;Abed, Khalid M. research published 《 Extraction and mass transfer study of Cupressus sempervirens L. oil by hydro-distillation method》, the research content is summarized as follows. The extraction of Cupressus sempervirens L. or cypress essential oil was studied in this paper. This cypress oil was extracted by using the hydro-distillation method, using a clevenger apparatus Cupressus sempervirens L. leaves were collected from Hit city in Al-Anbar province – Iraq. The influences of three important parameters on the process of oil extraction; water which used as a solvent to the solid ratio (5:1 and 14:1) (ml solvent/g plant), temperature (30 to 100°C) and processing time, were examined to obtain the best processing conditions to achieve the maximum yield of the essential oil. Also, the math. model was described to calculate the mass transfer coefficient Therefore, the best conditions, that were obtained in this study, were at 4hr as a reaction time, the temperature of about 100°C, solvent to solid ratios of 10:1 mL solvent/g plant. The volumetric mass transfer coefficient at ratios 10:1 and 14:1 solvent to solid ratio were 0.017 and 0.007 min-1 resp. Thus, it took less time to extract the Cupressus sempervirens L. oil by using the 10:1 compared to using 14:1 solvent to solid ratio. The composition compounds of extracted C. sempervirens L. essential oil was analyzed and identified by Gas Chromatog. Mass Spectrometry (GC-MS).

Reference of 24034-73-9, Geranylgeraniol is a diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1. It has a role as a plant metabolite, a volatile oil component and an antileishmanial agent. It is a diterpenoid and a polyprenol.

Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro. When working with statins, Geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. Additionally Geranylgeraniol has been found to induce apoptosis in HL-60 cells.
, 24034-73-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 24034-73-9, formula is C20H34O, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Name: (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol

Fei, Xitong;Qi, Yichen;Lei, Yu;Wang, Shujie;Hu, Haichao;Wei, Anzhi research published 《 Transcriptome and metabolome dynamics explain aroma differences between green and red prickly ash fruit》, the research content is summarized as follows. Green prickly ash (Zanthoxylum armatum) and red prickly ash (Zanthoxylum bungeanum) fruit have unique flavor and aroma characteristics that affect consumers′ purchasing preferences. However, differences in aroma components and relevant biosynthesis genes have not been systematically investigated in green and red prickly ash. Here, through the anal. of differentially expressed genes (DEGs), differentially abundant metabolites, and terpenoid biosynthetic pathways, we characterize the different aroma components of green and red prickly ash fruits and identify key genes in the terpenoid biosynthetic pathway. Gas chromatog.-mass spectrometry (GC-MS) was used to identify 41 terpenoids from green prickly ash and 61 terpenoids from red prickly ash. Piperitone was the most abundant terpenoid in green prickly ash fruit, whereas limonene was most abundant in red prickly ash. Intergroup correlation anal. and redundancy anal. showed that HDS2, MVK2, and MVD are key genes for terpenoid synthesis in green prickly ash, whereas FDPS2 and FDPS3 play an important role in the terpenoid synthesis of red prickly ash. In summary, differences in the composition and content of terpenoids are the main factors that cause differences in the aromas of green and red prickly ash, and these differences reflect contrasting expression patterns of terpenoid synthesis genes.

24034-73-9, Geranylgeraniol is a diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1. It has a role as a plant metabolite, a volatile oil component and an antileishmanial agent. It is a diterpenoid and a polyprenol.

Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro. When working with statins, Geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. Additionally Geranylgeraniol has been found to induce apoptosis in HL-60 cells.
, Name: (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts