M.W=250-300 Archives - Page 54 of 59 - Alcohols-buliding-blocks

Li, Xiaorui’s team published research in Polymer Chemistry in 2022 | 76-84-6

Polymer Chemistry published new progress about Cationic polyelectrolytes. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, SDS of cas: 76-84-6.

Li, Xiaorui; Chai, Liyuan; Ren, Junyu; Jin, Linfeng; Wang, Haiying; Li, Yiming; Ma, Shengqian published the artcile< Efficient collection of perrhenate anions from water using poly(pyridinium salts) via pyrylium mediated transformation>, SDS of cas: 76-84-6, the main research area is perrhenate anion collection water poly pyridinium salt pyrylium transformation.

Poly(pyridinium salts) (PPSs) with pos. charges on the backbones were designed and synthesized from the transformation of bispyrylium salts. Such materials exhibited good uptake capacity for rhenium capture from water, and excellent selectivity of ReO4- from competing anions. Furthermore, the advantages of facile synthesis and large-scale preparation make this material promising for practical use in industry.

Polymer Chemistry published new progress about Cationic polyelectrolytes. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, SDS of cas: 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shaw, Mukta’s team published research in Journal of Organic Chemistry in 2019-01-18 | 4064-06-6

Journal of Organic Chemistry published new progress about Glycosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Safety of ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol.

Shaw, Mukta; Thakur, Rima; Kumar, Amit published the artcile< Gold(III)-Catalyzed Glycosylation using Phenylpropiolate Glycosides: Phenylpropiolic Acid, An Easily Separable and Reusable Leaving Group>, Safety of ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol, the main research area is disaccharide glycoside stereoselective glycosylation gold catalyst protecting group.

An efficient and operationally simple gold(III)-catalyzed glycosylation protocol was developed using newly synthesized bench top stable phenylpropiolate glycosyl (PPG) donors. Gold(III)-catalyzed activation of PPGs proceeds well with various carbohydrate and noncarbohydrate-based glycosyl acceptors and leads to their corresponding O/N-glycosides in good to excellent yields with regeneration of reusable and easily separable phenylpropiolic acid. Differentially protected PPGs reacted well under the optimized reaction conditions. In particular, good anomeric selectivity was observed with mannosyl and rhamnosyl PPG donors. A preliminary mechanistic study reveals that the presence of a triple bond adjacent to the ester group is essential for activation, and PPG-based donor shows higher reactivity than analogous acetate and benzoate donors.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Margarita, Cristiana’s team published research in Catalysis Science & Technology in 2021 | 76-84-6

Catalysis Science & Technology published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Category: alcohols-buliding-blocks.

Margarita, Cristiana; Villo, Piret; Tunon, Hernando; Dalla-Santa, Oscar; Camaj, David; Carlsson, Robin; Lill, Malin; Ramstroem, Anja; Lundberg, Helena published the artcile< Zirconium-catalysed direct substitution of alcohols: enhancing the selectivity by kinetic analysis>, Category: alcohols-buliding-blocks, the main research area is ether preparation; alc substitution zirconium catalyst; thioether preparation; thiol alc substitution zirconium catalyst.

Kinetic anal. was used as a tool for rational optimization of a catalytic, direct substitution of alcs. to enable the selective formation of unsym. ethers, thioethers, and Friedel-Crafts alkylation products using a moisture-tolerant and com. available zirconium complex (2 to 8 mol%). Operating in air and in the absence of dehydration techniques, the protocol furnished a variety of products in high yields, including glycosylated alcs. and sterically hindered ethers. In addition, the kinetic studies provided mechanistic insight into the network of parallel transformations that take place in the reaction, and helped to elucidate the nature of the operating catalyst.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Elorriaga, David’s team published research in ChemSusChem in 2021-05-01 | 76-84-6

ChemSusChem published new progress about Addition reaction. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.

Elorriaga, David; de la Cruz-Martinez, Felipe; Rodriguez-Alvarez, Maria Jesus; Lara-Sanchez, Agustin; Castro-Osma, Jose Antonio; Garcia-Alvarez, Joaquin published the artcile< Fast Addition of s-Block Organometallic Reagents to CO2-Derived Cyclic Carbonates at Room Temperature, Under Air, and in 2-Methyltetrahydrofuran>, Computed Properties of 76-84-6, the main research area is tertiary alc hydroxy ester ketone preparation green solvent methyltetrahydrofuran; organomagnesium lithium reagents cyclic carbonate addition ring opening; CO2; Grignard reagents; cyclic carbonates; green chemistry; organolithium compounds.

Fast addition of highly polar organometallic reagents (RMgX/RLi) to cyclic carbonates (derived from CO2 as a sustainable C1 synthon) has been studied in 2-methyltetrahydrofuran as a green reaction medium or in the absence of external volatile organic solvents, at room temperature, and in the presence of air/moisture. These reaction conditions are generally forbidden with these highly reactive main-group organometallic compounds The correct stoichiometry and nature of the polar organometallic alkylating or arylating reagent allows straightforward synthesis of highly substituted tertiary alcs., β-hydroxy esters, or sym. ketones, working always under air and at room temperature Finally, an unprecedented one-pot/two-step hybrid protocol is developed through combination of an Al-catalyzed cycloaddition of CO2 and propylene oxide with the concomitant fast addition of RLi reagents to the in situ and transiently formed cyclic carbonate, thus allowing indirect conversion of CO2 into the desired highly substituted tertiary alcs. without need for isolation or purification of any reaction intermediates.

ChemSusChem published new progress about Addition reaction. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mehdipour, Ebrahim’s team published research in Iranian Chemical Communication in 2019 | 76-84-6

Iranian Chemical Communication published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Recommanded Product: Triphenylmethanol.

Mehdipour, Ebrahim; Baharlouei, Ehsan; Zarnegar, Zohre published the artcile< Selective trimethylsilylation of alcohols and phenols with hexamethyldisilazane catalyzed by LaCoO3 perovskite>, Recommanded Product: Triphenylmethanol, the main research area is green trimethylsilylation alc phenol hexamethyldisilazane cobalt lanthanum perovskite catalyst.

Trimethylsilylation of alcs. and phenols were carried out under solvent-free conditions with hexamethyldisilazane (HMDS) using LaCoO3 perovskite. LaCoO3 as an efficient catalyst accelerated this reaction under milder condition. The advantages of this method are evident regarding, easy separation, low cost and low catalyst loading, lack of pollution, easy work-up, and selective protection of primary and secondary alcs.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chan, Jessica Z’s team published research in Journal of the American Chemical Society in 2020-09-23 | 76-84-6

Journal of the American Chemical Society published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (trimethylsilyl). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, SDS of cas: 76-84-6.

Chan, Jessica Z.; Yesilcimen, Ahmet; Cao, Min; Zhang, Yuyang; Zhang, Bochao; Wasa, Masayuki published the artcile< Direct Conversion of N-Alkylamines to N-Propargylamines through C-H Activation Promoted by Lewis Acid/Organocopper Catalysis: Application to Late-Stage Functionalization of Bioactive Molecules>, SDS of cas: 76-84-6, the main research area is diastereoselective enantioselective synthesis propargylamine; alkylamine conversion propargylamine Lewis acid copper catalysis; carbon hydrogen bond activation alkylamine conversion propargylamine.

An efficient catalytic method to convert an α-C-H bond of N-alkylamines into an α-C-alkynyl bond was developed. In the past, such transformations were carried out under oxidative conditions, and the enantioselective variants were confined to tetrahydroisoquinoline derivatives Here, we disclose a method for the union of N-alkylamines and trimethylsilyl alkynes, without the presence of an external oxidant and promoted through cooperative actions of two Lewis acids, B(C6F5)3 and a Cu-based complex. A variety of propargylamines can be synthesized in high diastereo- and enantioselectivity. The utility of the approach is demonstrated by the late-stage site-selective modification of bioactive amines. Kinetic investigations that shed light on various mechanistic nuances of the catalytic process are presented.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Trinderup, Helle H’s team published research in European Journal of Organic Chemistry in 2021-06-14 | 4064-06-6

European Journal of Organic Chemistry published new progress about Disaccharides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, SDS of cas: 4064-06-6.

Trinderup, Helle H.; Andersen, Sofie M.; Heuckendorff, Mads; Jensen, Henrik H. published the artcile< How do Various Reaction Parameters Influence Anomeric Selectivity in Chemical Glycosylation with Thioglycosides and NIS/TfOH Activation?>, SDS of cas: 4064-06-6, the main research area is disaccharide preparation stereoselective glycosylation catalyst menthol thioglucopyranoside.

The reaction of glycosyl donor Ph 2,3,4,6-tetra-O-benzyl-1-thio-β-D-glucopyranoside with NIS/TfOH(cat.) was systematically studied under various reaction conditions. Neither the mol. sieve pore size nor amount of NIS activator was found to have an effect on the α/β-ratio in the reaction with L-menthol as glycosyl acceptor. Increasing concentration and the amount of triflic acid catalyst, however was found to increase the β-selectivity in certain cases. Moreover, lowering temperature was found to have a strong effect on the glycosylation outcome.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Si, Xiaojia’s team published research in Organic Letters in 2020-08-07 | 4064-06-6

Organic Letters published new progress about Acetalization. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Related Products of 4064-06-6.

Si, Xiaojia; Zhang, Lumin; Wu, Zuozuo; Rudolph, Matthias; Asiri, Abdullah M.; Hashmi, A. Stephen K. published the artcile< Visible Light-Induced α-C(sp3)-H Acetalization of Saturated Heterocycles Catalyzed by a Dimeric Gold Complex>, Related Products of 4064-06-6, the main research area is acetalization heterocycle gold catalyst visible light; cross coupling dehydrogenative ether tetrahydrothiophene pyrrolidine gold catalyst.

Saturated heterocyclic acetals are useful fragments in organic synthesis and other fields. Herein, C(sp3)-H dehydrogenative cross-couplings of ethers, tetrahydrothiophene, and N-Boc-pyrrolidine were achieved under visible light irradiation by using 4-iodoanisole and an in situ-formed gold complex. The broad functional group compatibility and substrate scope indicate that our strategy is a promising way to synthesize acetal analogs. The method was successfully applied in late-stage modifications of bioactive mols. Gram scale syntheses and mechanistic studies are also presented.

Organic Letters published new progress about Acetalization. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Related Products of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kephart, Jonathan A’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2020 | 76-84-6

Chemical Communications (Cambridge, United Kingdom) published new progress about Cluster compounds Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Kephart, Jonathan A.; Hecht, Zachary; Livesay, Brooke N.; Bhowmick, Indrani; Shores, Matthew P.; Popescu, V. Codrina; Arulsamy, Navamoney; Hulley, Elliott B. published the artcile< Self-assembly of an organometallic Fe9O6 cluster from aerobic oxidation of (tmeda)Fe(CH2tBu)2>, Product Details of C19H16O, the main research area is magnetic susceptibility moment iron oxygen cluster optimized preparation; crystal structure mol iron oxygen cluster optimized preparation.

Aerobic oxidation of (tmeda)Fe(CH2tBu)2 in toluene or THF solution leads to the self-assembly of a magic-sized all-ferrous oxide cluster containing the Fe9O6 subunit and bearing organometallic and diamine ligands. Moessbauer studies of the cluster are consistent with an all-ferrous assignment and magnetometry reveals complex intracluster and intercluster magnetic interactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sodano, Federica’s team published research in Molecular Pharmaceutics in 2019-10-07 | 4064-06-6

Molecular Pharmaceutics published new progress about Analgesia. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Safety of ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol.

Sodano, Federica; Lazzarato, Loretta; Rolando, Barbara; Spyrakis, Francesca; De Caro, Carmen; Magliocca, Salvatore; Marabello, Domenica; Chegaev, Konstantin; Gazzano, Elena; Riganti, Chiara; Calignano, Antonio; Russo, Roberto; Rimoli, Maria Grazia published the artcile< Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug>, Safety of ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol, the main research area is paracetamol galactose prodrug analgesic; X-ray diffraction; hepatotoxicity; hyperalgesia; metabolism; paracetamol; prodrug.

Paracetamol has been one of the most commonly used and prescribed analgesic drugs for more than a hundred years. Despite being generally well tolerated, it can result in high liver toxicity when administered in specific conditions, such as overdose, or in vulnerable individuals. We have synthesized and characterized a paracetamol galactosylated prodrug (PARgal) with the aim of improving both the pharmacodynamic and pharmacol. profile of paracetamol. PARgal shows a range of physicochem. properties, solubility, lipophilicity, and chem. stability at differing physiol. pH values and in human serum. PARgal could still be preclinically detected 2 h after administration, meaning that it displays reduced hepatic metabolism compared to paracetamol. In overdose conditions, PARgal has not shown any cytotoxic effect in in vitro analyses performed on human liver cells. Furthermore, when tested in an animal pain model, PARgal demonstrated a sustained analgesic effect up to the 12th hour after oral administration. These findings support the use of galactose as a suitable carrier in the development of prodrugs for analgesic treatment.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts