Zhang, Yueteng’s team published research in ACS Catalysis in 2021-01-15 | 4064-06-6

ACS Catalysis published new progress about C-C bond formation. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Electric Literature of 4064-06-6.

Zhang, Yueteng; Ji, Peng; Gao, Feng; Huang, He; Zeng, Fanxun; Wang, Wei published the artcile< Photoredox Asymmetric Nucleophilic Dearomatization of Indoles with Neutral Radicals>, Electric Literature of 4064-06-6, the main research area is chiral indolines preparation photochem regioselective diastereoselective chemoselective; indole tertiary amine neutral radical photoredox asym dearomatization.

The dearomatization of indoles represents the most efficient approach for accessing highly valued indolines. The inherent nucleophilic reactivity of indoles has dictated indole dearomatization development in both 1e- and 2e- processes. However, the dearomatization of electron-deficient indoles has been challenging. Herein, authors introduce a conceptually distinct photoredox-mediated Giese-type transformation strategy, which is generally used for the conjugate addition of radicals to simple α, β-unsaturated systems, for chemoselectively breaking C=C bonds embedded in the aromatic structure. Moreover, highly diastereoselective addition of challenging neutral radicals has been achieved by Oppolzer camphorsultam chiral auxiliary. Structurally diverse amine-functionalized chiral indolines carrying distinct functional and stereochem. diversity are produced from a wide array of amines as radical precursors. Furthermore, the mild, powerful manifold is capable of the late-stage modification of complex natural products and pharmaceuticals. DFT studies are performed to elucidate the observed stereochem. outcomes.

ACS Catalysis published new progress about C-C bond formation. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Electric Literature of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Bo-Shun’s team published research in Organic & Biomolecular Chemistry in 2020 | 4064-06-6

Organic & Biomolecular Chemistry published new progress about Antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Related Products of 4064-06-6.

Huang, Bo-Shun; Lowary, Todd L. published the artcile< β-Selective xylulofuranosylation via a conformationally-restricted glycosyl donor>, Related Products of 4064-06-6, the main research area is xylulofuranosylation stereoselective glycosylation lipopolysaccharide antigen; crystal structure xylulofuranose lipopolysaccharide antigen Yersinia enterocolitica oligosaccharide.

Reported is the first stereoselective method for β-xylulofuranosylation, which employs 3,4-O-xylylene-protected thioglycoside donors. For most acceptors, the best results were observed with a donor that possesses both the xylylene group and a benzoate ester at O-1. To demonstrate its utility, the methodol. was applied to the first synthesis of the pentasaccharide repeating unit from the lipopolysaccharide O-antigen of Yersinia enterocolitica serovars, a structure containing two β-xylulofuranose residues.

Organic & Biomolecular Chemistry published new progress about Antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Related Products of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Su, Min’s team published research in Materials Chemistry Frontiers in 2020 | 76-84-6

Materials Chemistry Frontiers published new progress about Crystal structure. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Application In Synthesis of 76-84-6.

Su, Min; Jing, Ya-Nan; Bao, Hongli; Wan, Wen-Ming published the artcile< Triarylmethanolation as a versatile strategy for the conversion of PAHs into amorphization-induced emission luminogens for extremely sensitive explosive detection and fabrication of artificial light-harvesting systems>, Application In Synthesis of 76-84-6, the main research area is triarylmethanolation.

Current synthetic strategies involving π-system coupling reactions for the mol. design of luminescent materials suffer from the challenging precise synthesis on the desired reactive site and also difficulty in solubility derived from the rigid structures of π-systems. Herein, a novel and versatile triarylmethanolation strategy for the mol. design of luminescent materials with facile synthesis and good solubility is reported. The prepared luminescent materials exhibit unique amorphization-induced emission (AmIE) behaviors, which represent an entropy-favored and ubiquitous type of aggregation-induced emission that is currently famous and is contrary to crystallization-induced emission. Due to the outstanding AmIE behaviors, the luminescent materials exhibit applications in the fields of rewritable display and storage, extremely sensitive explosive detection at the ppb level, and high-efficiency artificial light-harvesting system with an antenna effect up to 21.3. This work therefore expands the methodol., structure, and functionality libraries of luminescent materials with outstanding properties in the application fields of explosive detection, energy transfer, and artificial light-harvesting systems.

Materials Chemistry Frontiers published new progress about Crystal structure. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Application In Synthesis of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shaw, Mukta’s team published research in Chemistry – An Asian Journal in 2019 | 4064-06-6

Chemistry – An Asian Journal published new progress about Conformation. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Related Products of 4064-06-6.

Shaw, Mukta; Kumar, Amit published the artcile< Additive-Free Gold(III)-Catalyzed Stereoselective Synthesis of 2-Deoxyglycosides Using Phenylpropiolate Glycosides as Donors>, Related Products of 4064-06-6, the main research area is deoxyglycoside stereoselective synthesis catalytic gold chloride; glycoside stereoselective glycosylation catalyzed gold disaccharide preparation phenylpropiolic acid; conformation transition state gold catalyzed stereoselective glycosylation disaccharide preparation; bifunctional donors; deoxy-phenylpropiolate; reusable and recyclable leaving group; stereoselective glycosylation.

Stereoselective synthesis of deoxyglycosides has been achieved from deoxy-phenylpropiolate glycosides (D-PPGs) using gold(III) salt as catalyst under external additive-free conditions. Under a simple catalytic system, D-PPGs reacted with a variety of sugar and non-sugar acceptors to produce major α-stereoselective O/N-deoxyglycosides in good to excellent yields and regenerate easily separable and reusable phenylpropiolic acid. Deoxy-PPGs containing armed and disarmed groups survived well under the optimized reaction conditions. In addition, the orthogonal nature of D-PPGs was showcased, and 1,1′-linked trehalose-type sugar was also synthesized.

Chemistry – An Asian Journal published new progress about Conformation. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Related Products of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Matthew, Susan’s team published research in Proceedings of the National Academy of Sciences of the United States of America in 2021-03-02 | 76-84-6

Proceedings of the National Academy of Sciences of the United States of America published new progress about (Fluorenylmethoxy)carbonyl group. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Matthew, Susan; Chen, Qi-Yin; Ratnayake, Ranjala; Fermaintt, Charles S.; Lucena-Agell, Daniel; Bonato, Francesca; Prota, Andrea E.; Lim, Seok Ting; Wang, Xiaomeng; Diaz, J. Fernando; Risinger, April L.; Paul, Valerie J.; Oliva, Maria Angela; Luesch, Hendrik published the artcile< Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site>, Product Details of C19H16O, the main research area is natural product marine cyanobacterium cyclodepsipeptide Gatorbulin1 total synthesis; antitumor agent tubulin targeted chemotherapy microtubule drug mechanism action; GB1 total synthesis esterification protection peptide coupling macrolactamization reduction; crystal structure tubulin CB1 complex NMR conformer chelation fluorescence; cyanobacteria; marine natural product; microtubules; total synthesis; tubulin.

Tubulin-targeted chemotherapy has proven to be a successful and wide spectrum strategy against solid and liquid malignancies. Therefore, new ways to modulate this essential protein could lead to new antitumoral pharmacol. approaches. Currently known tubulin agents bind to six distinct sites at α/β-tubulin either promoting microtubule stabilization or depolymerization We have discovered a seventh binding site at the tubulin intradimer interface where a novel microtubule-destabilizing cyclodepsipeptide, termed gatorbulin-1 (GB1), binds. GB1 has a unique chemotype produced by a marine cyanobacterium. We have elucidated this dual chem. and mechanistic novelty through multidimensional characterization, starting with bioactivity-guided natural product isolation and multinuclei NMR-based structure determination, revealing the modified pentapeptide with a functionally critical hydroxamate group. and validation by total synthesis. The modified pentapeptide was validated by total synthesis. We have investigated the pharmacol. using isogenic cancer cell screening, cellular profiling, and complementary phenotypic assays, and unveiled the underlying mol. mechanism by in vitro biochem. studies and high-resolution structural determination of the α/β-tubulin-GB1 complex.

Proceedings of the National Academy of Sciences of the United States of America published new progress about (Fluorenylmethoxy)carbonyl group. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zheng, Lifang’s team published research in Biomacromolecules in 2020-12-14 | 4064-06-6

Biomacromolecules published new progress about RAFT polymerization. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, COA of Formula: C12H20O6.

Zheng, Lifang; Luo, Yan; Chen, Kui; Zhang, Zexin; Chen, Gaojian published the artcile< Highly Branched Gradient Glycopolymer: Enzyme-Assisted Synthesis and Enhanced Bacteria-Binding Ability>, COA of Formula: C12H20O6, the main research area is highly branched glycopolymer preparation.

A one-pot strategy was applied to synchronize enzymic monomer transformation with reversible addition fragmentation chain transfer (RAFT) polymerization for the synthesis of glycopolymers with highly branched gradient architectures. Also, the linear analogs, block glycopolymers, and gradient glycopolymers were also synthesized for comparison. The binding ability of glycopolymers toward bacteria was then studied by optical d. (OD) test, confocal laser scanning microscopy (CLSM), and quartz crystal microbalance with dissipation (QCM-D). The results show that the highly branched gradient glycopolymers have the most remarkable bacteria-binding ability compared with the two linear analogs, gradient glycopolymers, and block glycopolymers. The highly branched glycopolymers were further used as inhibitors in the anti-infection test, demonstrating a significant inhibitory effect on preventing bacteria from infecting the cells.

Biomacromolecules published new progress about RAFT polymerization. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, COA of Formula: C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Haifan’s team published research in Journal of the American Chemical Society in 2019-05-08 | 76-84-6

Journal of the American Chemical Society published new progress about Amyloid fibril. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Wu, Haifan; Saltzberg, Daniel J.; Kratochvil, Huong T.; Jo, Hyunil; Sali, Andrej; DeGrado, William F. published the artcile< Glutamine Side Chain 13C=18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly>, Synthetic Route of 76-84-6, the main research area is glutamine carbon oxygen isotope amyloid fibril IR spectroscopy.

IR spectroscopy has provided considerable insight into the structures, dynamics, and formation mechanisms of amyloid fibrils. IR probes, such as main chain 13C=18O, have been widely employed to obtain site-specific structural information, yet only secondary structures and strand-to-strand arrangements can be probed. Very few nonperturbative IR probes are available to report on the side-chain conformation and environments, which are critical to determining sheet-to-sheet arrangements in steric zippers within amyloids. Polar residues, such as glutamine, contribute significantly to the stability of amyloids and thus are frequently found in core regions of amyloid peptides/proteins. Furthermore, polyglutamine (polyQ) repeats form toxic aggregates in several neurodegenerative diseases. Here the authors report the synthesis and application of a new nonperturbative IR probe-glutamine side chain 13C=18O. The authors use side chain 13C=18O labeling and isotope dilution to detect the presence of intermolecularly hydrogen-bonded arrays of glutamine side chains (Gln ladders) in amyloid-forming peptides. Moreover, the line width of the 13C=18O peak is highly sensitive to its local hydration environment. The IR data from side chain labeling allows us to unambiguously determine the sheet-to-sheet arrangement in a short amyloid-forming peptide, GNNQQNY, providing insight that was otherwise inaccessible through main chain labeling. With several different fibril samples, the authors also show the versatility of this IR probe in studying the structures and aggregation kinetics of amyloids. Finally, the authors demonstrate the capability of modeling amyloid structures with IR data using the integrative modeling platform (IMP) and the potential of integrating IR with other biophys. methods for more accurate structural modeling. Together, the authors believe that side chain 13C=18O will complement main chain isotope labeling in future IR studies of amyloids and integrative modeling using IR data will significantly expand the power of IR spectroscopy to elucidate amyloid assemblies.

Journal of the American Chemical Society published new progress about Amyloid fibril. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Longwitz, Lars’s team published research in Journal of Organic Chemistry in 2019-06-21 | 76-84-6

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Name: Triphenylmethanol.

Longwitz, Lars; Jopp, Stefan; Werner, Thomas published the artcile< Organocatalytic Chlorination of Alcohols by P(III)/P(V) Redox Cycling>, Name: Triphenylmethanol, the main research area is alkyl chloride preparation organocatalyst alc chlorination.

A catalytic system for the chlorination of alcs. under Appel conditions was developed. Benzotrichloride was used as a cheap and readily available chlorinating agent in combination with trioctylphosphine as the catalyst and phenylsilane as the terminal reductant. The reaction has several advantages over other variants of the Appel reaction, e.g., no addnl. solvent is required and the phosphine reagent was used only in catalytic amounts In total, 27 different primary, secondary, and tertiary alkyl chlorides were synthesized in yields up to 95%. Under optimized conditions, it was also possible to convert epoxides and an oxetane to the dichlorinated products.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Name: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Xiaona’s team published research in Organic Letters in 2019-12-06 | 4064-06-6

Organic Letters published new progress about Glycosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol.

Li, Xiaona; Li, Chenyu; Liu, Rongkun; Wang, Jiazhe; Wang, Zixuan; Chen, Yan; Yang, You published the artcile< Gold(I)-Catalyzed Glycosylation with Glycosyl Ynenoates as Donors>, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol, the main research area is stereoselective glycosylation catalyst glycoside oligosaccharide preparation polysaccharide.

A simple and versatile glycosylation method with both armed and disarmed glycosyl ynenoates as donors is developed. Employing a gold(I) complex as catalyst with or without the assistance of TfOH, the scope of the present glycosylation protocol is very wide. The utility of the present ynenoate donors is demonstrated in the efficient synthesis of oligosaccharides via the latent-active strategy and the multiple orthogonal one-pot strategy. Finally, this approach enables the formal synthesis of the tetrasaccharide hapten of Streptococcus pneumoniae serotype 3 and the highly convergent synthesis of the 32mer polymannoside.

Organic Letters published new progress about Glycosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Shao-Qian’s team published research in Journal of the American Chemical Society in 2021-05-19 | 4064-06-6

Journal of the American Chemical Society published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (conjugated). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Computed Properties of 4064-06-6.

Yang, Shao-Qian; Wang, Yi-Fan; Zhao, Wei-Cheng; Lin, Guo-Qiang; He, Zhi-Tao published the artcile< Stereodivergent Synthesis of Tertiary Fluoride-Tethered Allenes via Copper and Palladium Dual Catalysis>, Computed Properties of 4064-06-6, the main research area is fluoroester conjugated enyne copper palladium hydrocarbonation catalyst; allene stereoselective preparation gold cyclization; fluorinated hydrofuran stereoselective preparation.

Herein we describe a protocol for the unprecedented stereodivergent synthesis of tertiary fluoride-tethered allenes bearing a stereogenic center and stereogenic axis via Cu/Pd synergistic catalysis. A broad scope of conjugated enynes are coupled with various α-fluoroesters in high yields with high diastereoselectivities and generally >99% ee. In addition, the four stereoisomers of the allene products ensure precise access to the corresponding four stereoisomers of the fluorinated hydrofurans via a novel stereodivergent axial-to-central chirality transfer process.

Journal of the American Chemical Society published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (conjugated). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Computed Properties of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts