Tag: M.W=250-300

Wang, Yulei; Huang, Zhidao; Huang, Zheng published the artcile< Catalyst as colour indicator for endpoint detection to enable selective alkyne trans-hydrogenation with ethanol>, Category: alcohols-buliding-blocks, the main research area is trans alkene stereoselective preparation; internal alkyne ethanol trans hydrogenation iridium catalyst.

An iridium complex catalyzed semi-hydrogenation of internal alkynes using ethanol as hydrogen donor to afford E-alkenes and Et acetate was reported. Importantly, issues of over-reduction and stereoselection was successfully addressed by using a color change effect due to shift of catalyst resting states, thereby precisely detecting the endpoint of the reaction. This catalytic system was applicable to a wide variety of internal alkynes bearing many auxiliary functional groups, and its utility for synthesis of biol. relevant mols. was also demonstrated.

Nature Catalysis published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alhamed, Samiyah; Alnakhli, Jawzah; Boadi, William; Beni, Ryan published the artcile< Triphenylmethanol conjugates of triptorelin as anti-lipid peroxidation prodrugs>, Electric Literature of 76-84-6, the main research area is triphenylmethanol triptorelin antilipid peroxidation.

Antioxidants are substances that can prevent or slow damage to cells caused by free radicals, unstable mols. that the body produces as a reaction to environmental and other pressures. Free radicals may play a role in heart disease, cancer and other diseases. If the body cannot process and remove free radicals efficiently, oxidative stress can result. This can harm cells and body function. Free radicals are also known as reactive oxygen species (ROS). In this research, Triptorelin (TRP) conjugates of triphenylmethanol derivatives (TPMs) were synthesized to evaluate their in vitro lipid peroxidation potency. Comparative lipid peroxidation assays between TRP-TPMs conjugates and the corresponding TPMs derivatives were measured using thiobarbituric reactive substance (TBARS) in a dose- and time-dependent manner following the Fenton’s pathway. Overall, TBARS decreased between 20% – 30% for the treated samples of synthesized conjugates compared to their resp. control phys. mixtures These data suggest that TRP-TPMs derivatives can be used to improve the biol. activity of TRP.

Open Journal of Medicinal Chemistry published new progress about Lipid peroxidation. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Electric Literature of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Jicheng; Li, Xiaolei; Qi, Xiaotian; Duan, Xiyan; Cracraft, Weston L.; Guzei, Ilia A.; Liu, Peng; Tang, Weiping published the artcile< Site-Selective and Stereoselective O-Alkylation of Glycosides by Rh(II)-Catalyzed Carbenoid Insertion>, Application In Synthesis of 4064-06-6, the main research area is transition state crystal structure glycoside preparation disaccharide; crystal structure glycoside preparation stereoselective glycosylation catalyst disaccharide; rhodium catalyzed regioselective stereoselective glycosylation alkylation glycoside preparation DFT; regioselective stereoselective glycosylation protecting group alkylation glycoside carbenoid catalyzed.

Carbohydrates are synthetically challenging mols. with vital biol. roles in all living systems. Selective synthesis and functionalization of carbohydrates provide tremendous opportunities to improve our understanding on the biol. functions of this fundamentally important class of mols. However, selective functionalization of seemingly identical hydroxyl groups in carbohydrates remains a long-standing challenge in chem. synthesis. We herein describe a practical and predictable method for the site- and stereoselective alkylation of carbohydrate hydroxyl groups via Rh(II)-catalyzed insertion of metal carbenoid intermediates. This represents one of the mildest alkylation methods for the systematic modification of carbohydrates. D. functional theory (DFT) calculations suggest that the site-selectivity is determined in the Rh(II)-carbenoid insertion step, which prefers insertion into hydroxyl groups with an adjacent axial substituent. The subsequent intramol. enolate protonation determines the unexpected high stereoselectivity. The most prevalent trans-1,2-diols in various pyranoses can be systematically and predictably differentiated based on the model derived from DFT calculations We also demonstrated that the selective O-alkylation method could significantly improve the efficiency and stereoselectivity of glycosylation reactions. The alkyl groups introduced to carbohydrates by OH insertion reaction can serve as functional groups, protecting groups, and directing groups.

Journal of the American Chemical Society published new progress about Alkylation. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Application In Synthesis of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Diemoz, Kayla M.; Franz, Annaliese K. published the artcile< NMR Quantification of Hydrogen-Bond-Activating Effects for Organocatalysts including Boronic Acids>, Synthetic Route of 76-84-6, the main research area is NMR quantification hydrogen bond activation organocatalyst boronic acid.

The hydrogen-bonding activation for 66 organocatalysts has been quantified using a 31P NMR binding experiment with triethylphosphine oxide (TEPO). Diverse structural classes, including phenols, diols, silanols, carboxylic acids, boronic acids, and phosphoric acids, were examined with a variety of steric and electronic modifications to understand how the structure and secondary effects contribute to hydrogen-bonding ability and catalysis. Hammett plots demonstrate high correlation for the Δδ 31P NMR shift to Hammett parameters, establishing the ability of TEPO binding to predict electronic trends. Upon correlation to catalytic activity in a Friedel-Crafts addition reaction, data demonstrate that 31P NMR shifts correlate to catalytic activity better than pKa values. Boronic acids were investigated, and 31P NMR binding experiments predicted strong hydrogen-bonding ability, for which catalytic activity was confirmed, resulting in the greatest rate enhancement observed in the Friedel-Crafts addition of all organocatalysts studied. A detailed investigation supports that boronic acid activation proceeds through hydrogen-bonding interactions and not coordination with the Lewis acidic boron center. Using 31P NMR spectroscopy offers a simple and rapid tool to quantify and predict hydrogen-bonding abilities for the design and applications of new organocatalysts and supramol. synthons.

Journal of Organic Chemistry published new progress about Alcohols Role: CAT (Catalyst Use), PEP (Physical, Engineering or Chemical Process), PRP (Properties), USES (Uses), PROC (Process). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Graton, J.; Besseau, F.; Goupille, A.; Le Questel, J.-Y. published the artcile< Hydrogen-bond acidity of silanols: A combined experimental and theoretical study>, Name: Triphenylmethanol, the main research area is quantum chem hydrogen bond acidity silanol.

The hydrogen-bond (H-bond) donating ability of a series of silanol derivatives has been determined by FTIR spectrometry and complemented by quantum chem. calculations at the DFT (MPWB1K/6-31+G(d,p)) level. The equilibrium constants of complexation with N-methylpyrrolidinone have been measured in CCl4 solutions These data expand the pKAHY scale previously covering the field of aliphatic alcs., phenols and fluorohydrins. Compared to the corresponding alc. derivatives, the silanol chem. function is a stronger H-bond donor, although the observed frequency shifts, ΔνOH, suggest much greater differences in donor strength than is actually observed The electrostatic potential descriptor, Vα(r), is successfully used to complete the pKAHY vs. Vα(r) relationship, a helpful methodol. to validate the exptl. data and to estimate the H-bond acidity of unavailable, unstable, or immiscible compounds

Journal of Molecular Structure published new progress about Acidity. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Name: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Geringer, Scott A.; Singh, Yashapal; Hoard, Daniel J.; Demchenko, Alexei V. published the artcile< A Highly Efficient Glycosidation of Glycosyl Chlorides by Using Cooperative Silver(I) Oxide-Triflic Acid Catalysis>, Synthetic Route of 4064-06-6, the main research area is cooperative silver catalyzed glycosidation benzoyl benzyl protected glycosyl chloride; activation; carbohydrates; glycosyl chlorides; glycosylation; silver oxide.

Following our discovery that silver(I) oxide-promoted glycosylation with glycosyl bromides can be greatly accelerated in the presence of catalytic TMSOTf or TfOH, we report herein a new discovery that glycosyl chlorides are even more effective glycosyl donors under these reaction conditions. The developed reaction conditions work well with a variety of glycosyl chlorides. Both benzoylated and benzylated chlorides have been successfully glycosidated, and these reaction conditions proved to be effective in coupling substrates containing nitrogen and sulfur atoms. Another convenient feature of this glycosylation is that the progress of the reaction can be monitored visually; its completion can be judged by the disappearance of the characteristic dark color of Ag2O.

Chemistry – A European Journal published new progress about Benzoyl group (protecting). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Synthetic Route of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Graton, J.; Besseau, F.; Goupille, A.; Le Questel, J.-Y. published the artcile< Hydrogen-bond acidity of silanols: A combined experimental and theoretical study>, Name: Triphenylmethanol, the main research area is quantum chem hydrogen bond acidity silanol.

The hydrogen-bond (H-bond) donating ability of a series of silanol derivatives has been determined by FTIR spectrometry and complemented by quantum chem. calculations at the DFT (MPWB1K/6-31+G(d,p)) level. The equilibrium constants of complexation with N-methylpyrrolidinone have been measured in CCl4 solutions These data expand the pKAHY scale previously covering the field of aliphatic alcs., phenols and fluorohydrins. Compared to the corresponding alc. derivatives, the silanol chem. function is a stronger H-bond donor, although the observed frequency shifts, ΔνOH, suggest much greater differences in donor strength than is actually observed The electrostatic potential descriptor, Vα(r), is successfully used to complete the pKAHY vs. Vα(r) relationship, a helpful methodol. to validate the exptl. data and to estimate the H-bond acidity of unavailable, unstable, or immiscible compounds

Journal of Molecular Structure published new progress about Acidity. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Name: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Geringer, Scott A.; Singh, Yashapal; Hoard, Daniel J.; Demchenko, Alexei V. published the artcile< A Highly Efficient Glycosidation of Glycosyl Chlorides by Using Cooperative Silver(I) Oxide-Triflic Acid Catalysis>, Synthetic Route of 4064-06-6, the main research area is cooperative silver catalyzed glycosidation benzoyl benzyl protected glycosyl chloride; activation; carbohydrates; glycosyl chlorides; glycosylation; silver oxide.

Following our discovery that silver(I) oxide-promoted glycosylation with glycosyl bromides can be greatly accelerated in the presence of catalytic TMSOTf or TfOH, we report herein a new discovery that glycosyl chlorides are even more effective glycosyl donors under these reaction conditions. The developed reaction conditions work well with a variety of glycosyl chlorides. Both benzoylated and benzylated chlorides have been successfully glycosidated, and these reaction conditions proved to be effective in coupling substrates containing nitrogen and sulfur atoms. Another convenient feature of this glycosylation is that the progress of the reaction can be monitored visually; its completion can be judged by the disappearance of the characteristic dark color of Ag2O.

Chemistry – A European Journal published new progress about Benzoyl group (protecting). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Synthetic Route of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tang, Yu; Reddy, D. Prabhakar; Yu, Biao published the artcile< A dehydrative glycosylation protocol mediated by nonafluorobutanesulfonyl fluoride (NfF)>, HPLC of Formula: 4064-06-6, the main research area is stereoselective glycosylation catalyst nonafluorobutanesulfonyl fluoride dehydrative disaccharide glycoside preparation.

A new dehydrative glycosylation protocol that proceeds through selective activation of glycosyl hemiacetals with nonafluorobutanesulfonyl fluoride (NfF) has been disclosed. Contrary to the major classical glycosylation reactions that proceed under acidic or neutral conditions, the present glycosylation reaction proceeds under mild basic conditions. In the absence of an external acceptor, self-condensation of the glycosyl hemiacetal occurs, providing the corresponding sym. 1,1′-disaccharides in high yields.

Tetrahedron published new progress about Disaccharides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, HPLC of Formula: 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yadav, Vishal; Gordon, Jesse B.; Siegler, Maxime A.; Goldberg, David P. published the artcile< Dioxygen-Derived Nonheme Mononuclear FeIII(OH) Complex and Its Reactivity with Carbon Radicals>, Formula: C19H16O, the main research area is neopentylamine dioxygen nonheme mononuclear iron hydroxide preparation reactivity carbon; carbon radical reactivity neopentylamine dioxygen nonheme mononuclear iron hydroxide; crystal mol structure neopentylamine dioxygen nonheme mononuclear iron hydroxide.

A new tetradentate, monoanionic, mixed N/O donor ligand (BNPAPh2O-) with second coordination sphere H-bonding groups has been synthesized for stabilization of a terminal FeIII(OH) complex. The complex FeII(BNPAPh2O)(OTf) (1) reacts with O2 to give a mononuclear terminal FeIII(OH) complex, FeIII(OH)(BNPAPh2O)(OTf) (2), both of which were characterized by x-ray diffraction, electrospray ionization mass spectrometry, UV-vis, 1H and 19F NMR, 57Fe Moessbauer, and ESR spectroscopies. Treatment of 2 with carbon radicals (Ar3C·) gives Ar3COH and the FeII complex 1, in direct analogy with the elusive radical “”rebound”” process proposed for nonheme iron enzymes.

Journal of the American Chemical Society published new progress about Coordination sphere. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts