Tag: M.W=250-300

Hu, Liangzhen; Hussain, Muhammad Ijaz; Deng, Qingfu; Liu, Qing; Feng, Yangyang; Zhang, Xiaohui; Xiong, Yan published the artcile< I2/Li2CO3-promoted cyanation of diarylalcohols through a dual activation process>, Safety of Triphenylmethanol, the main research area is unsaturated nitrile phenylnitirile preparation dual activated cyanation diarylalc.

One-step base promoted strategy for cyanation of α,α-diaryl alcs. has been developed under mild and transition metal-free conditions. This method provides a straightforward and facile way towards the synthesis of β,γ-unsaturated nitriles and α-phenylnitiriles from α-vinyl carbinols and α,α-diaryl methanols, resp., up to 99% yield. Moreover, various azides and ethers could also be accessed from their resp. nucleophiles under standard reaction conditions.

Tetrahedron published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (α,α-diaryl). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghosh, Titli; Mukherji, Ananya; Kancharla, Pavan K. published the artcile< Open-Close Strategy toward the Organocatalytic Generation of 2-Deoxyribosyl Oxocarbenium Ions: Pyrrolidine-Salt-Catalyzed Synthesis of 2-Deoxyribofuranosides>, Formula: C12H20O6, the main research area is stereoselective glycosylation catalyst organocatalytic disaccharide preparation; organocatalytic deoxyribosyl oxocarbenium pyrrolidine catalyzed synthesis disaccharide deoxyribofuranoside.

The reaction of secondary amine salts with 2-deoxy-ribofuranoses under forcible conditions leads to the putative furanosyl oxocarbenium ion that is trapped with various alcs. to provide 2-deoxy-ribofuranosides. The observed anomeric selectivities range from an equimolar mixture to complete α-selectivity in the case of bulky sugar acceptors. Owing to the mechanism and temperature of the transformation, the generated oxocarbenium ion shows little or no facial preference towards the nucleophilic attack of non-carbohydrate acceptors and leads to a mixture of anomers in the case of benzyl and acetyl protected donors. However, the conformationally less flexible tetraisopropylsilyl protected donor reacted with both sugar and non-sugar acceptors in a stereoselective fashion. Besides, the glycosylation with 2-cyanoethanol gave the product with unexpected beta-selectivity presumably due to nitrile effect. The operationally simple organocatalytic protocol provides easy access to otherwise difficult 2-deoxy-ribofuranosides/disaccharides.

European Journal of Organic Chemistry published new progress about Disaccharides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Formula: C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pal, Kumar Bhaskar; Guo, Aoxin; Das, Mrinmoy; Bati, Gabor; Liu, Xue-Wei published the artcile< Superbase-Catalyzed Stereo- and Regioselective Glycosylation with 2-Nitroglycals: Facile Access to 2-Amino-2-deoxy-O-glycosides>, SDS of cas: 4064-06-6, the main research area is aminoglycoside regioselective stereoselective glycosylation catalyst DFT glycoconjugate nitroglucal aminodeoxyglycoside.

An efficient super-base-catalyzed stereo- and regioselective glycosylation of 2-nitroglycals with high functional group compatibility is reported. The ion pair generated from alc. and a catalytic amount of P4-t-Bu was vital for the successful implementation of this stereoselective glycosylation under mild conditions, producing moderate to good yields. Under reported reaction conditions, 2-nitrogalactals produce α-stereoisomers exclusively, while 2-nitroglucal yielded more β-products. The notable difference between the outcomes was investigated by the d. functional theory (DFT) study. In addition, we have synthesized the key intermediate of a mucin-type core-6 glycoconjugate, thus illustrating the synthetic potency of this method.

ACS Catalysis published new progress about Aminoglycosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, SDS of cas: 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Si-Xuan; Ding, Yan; Wang, Jun-Jie; Shen, Chuanji; Zhou, Xiaocong; Chu, Xue-Qiang; Ma, Mengtao; Shen, Zhi-Liang published the artcile< Titanium(IV)-Mediated Ring-Opening/Dehydroxylative Cross-Coupling of Diaryl-Substituted Methanols with Cyclopropanol Derivatives>, Safety of Triphenylmethanol, the main research area is diaryl ester preparation; ethoxycyclopropoxy trimethylsilane diaryl methanol ring opening dehydroxylative cross coupling.

A titanium(IV)-mediated ring-opening/dehydroxylative cross-coupling of diaryl-substituted methanols R(R1)C(OH)R2 (R = Ph, 2-methylphenyl, 4-iodophenyl, naphthalen-1-yl, etc.; R1 = H, Ph, 4-methylphenyl, 4-chlorophenyl; R2 = Ph, 4-methoxyphenyl, 4-fluorophenyl, etc.) with a (1-ethoxycyclopropoxy)trimethylsilane was developed. The reactions proceeded efficiently to provide synthetically useful γ,γ-diaryl esters R(R1)C((CH2)2C(O)OCH2CH3)R2 in moderate to good yields, which could be applied to the functionalization of complex mols. I and II derived from bioactive fenofibrate and isoxepac and the synthesis of a precursor of Zoloft III.

Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Si-Yu; Hu, Xin-Ping; Liu, Hui-Juan; Zhang, Qing-Ju; Liao, Jin-Xi; Tu, Yuan-Hong; Sun, Jian-Song published the artcile< 8-(Methyltosylaminoethynyl)-1-naphthyl (MTAEN) Glycosides: Potent Donors in Glycosides Synthesis>, Electric Literature of 4064-06-6, the main research area is crystal structure oligosaccharide synthesis glycosylation glycoside; phase transfer catalysis oligosaccharide synthesis MTAEN methyltosylaminoethynylnaphthyl glycosylation glycoside.

With 8-(methyltosylaminoethynyl)-1-naphthyl (MTAEN) glycoside as donors, a novel and efficient glycosylation protocol has been established. The MTAEN glycosylation protocol exhibits the merits of shelf-stable donors, mild catalytic promotion conditions, considerably extended substrate scope encompassing both free alcs., silylated alcs., nucleobases, primary amides, and C-type nucleophile acceptors, and applicability to various one-pot strategies for highly efficient synthesis of oligosaccharides, such as orthogonal one-pot, single-catalyst one-pot, and acceptor reactivity-controlled one-pot strategies.

Organic Letters published new progress about Catalysis. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Electric Literature of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mukherji, Ananya; Kancharla, Pavan K. published the artcile< C-H···Anion Interactions Assisted Addition of Water to Glycals by Sterically Hindered 2,4,6-Tri-tert-butylpyridinium Hydrochloride>, Quality Control of 4064-06-6, the main research area is pyridinium hydrochloride catalyst stereoselective hydroxylation glycoside preparation glycal; crystal structure steric effect silyl hemiacetal disaccharide glycosylation glycoside.

The conjugate acid of the bulky base 2,4,6-tri-tert-butylpyridine, under mild conditions, catalyzes the synthesis of silyl-protected 2-deoxy-hemiacetals and their dimerized products from glycals at varying concentrations of water. The criticality of the concentration of water in the reaction outcome is indicative of a unique mechanistic pathway for the bulky pyridine salt and not via the general Bronsted acid mechanism. The various silyl-protected hemiacetals thus synthesized were successfully utilized in the stereoselective synthesis of both α and β glycosides.

Organic Letters published new progress about Crystal structure. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Quality Control of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Afewerki, Samson; Palo-Nieto, Carlos; Cordova, Armando published the artcile< Efficient Heterogeneous Palladium-Catalyzed Transfer Hydrogenolysis of Benzylic Alcohols by Formic Acid>, Product Details of C19H16O, the main research area is benzylic alc formic acid palladium catalyst chemoselective transfer hydrogenolysis; alkyl benzene preparation.

An efficient heterogeneous palladium-catalyzed transfer hydrogenolysis of primary, secondary and tertiary benzylic alcs. using formic acid as hydrogen source was developed. The resulting hydrocarbon products were obtained in excellent yields. Moreover, the system exhibited high chemoselectivity, reacting only with the hydroxy groups in the presence of other functional groups and excellent recyclability.

Synthesis published new progress about Alkylbenzenes Role: SPN (Synthetic Preparation), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Uehara, Tomoya; Kanazawa, Naoki; Suzuki, Chie; Mizuno, Yuki; Suzuki, Hiroyuki; Hanaoka, Hirofumi; Arano, Yasushi published the artcile< Renal Handling of 99mTc-Labeled Antibody Fab Fragments with a Linkage Cleavable by Enzymes on Brush Border Membrane>, Related Products of 76-84-6, the main research area is technetium 99m Fab fragment linkage cleavage renal brush border.

The high and persistent renal radioactivity levels after injection of radiolabeled low-mol.-weight polypeptides constitute a significant problem for their diagnostic and therapeutic applications, especially when they are labeled with metallic radionuclides. To improve the renal radioactivity levels of technetium-99m (99mTc)-labeled Fab fragments, a mercaptoacetyltriglycine (MAG3)-based new bifunctional chelating agent with a cleavable glycyl-phenylalanyl-lysine (GFK) linkage, MAG3-GFK-suc-TFP, was designed, synthesized, and evaluated. 99mTc-labeled Fab was obtained by reacting MAG3-GFK-Fab conjugate with 99mTc-glucarate. The GFK linkage remained stable in plasma but was cleaved by enzymes on the renal brush border membrane. The comparative biodistribution studies with indium-111 (111In)-labeled Fab using SCN-CHX-A”-DTPA showed that while both radiolabeled Fabs exhibited similar elimination rates from the blood, [99mTc]Tc-MAG3-GFK-Fab registered much lower renal radioactivity levels from 30 min post-injection onward due to the release and subsequent urinary excretion of [99mTc]Tc-MAG3-Gly. However, [99mTc]Tc-MAG3-GFK-Fab showed an increase in the intestinal radioactivity levels with the time that was not observed with 111In-labeled Fab. The anal. of the intestinal contents suggested the redistribution of [99mTc]Tc-MAG3-Gly to the intestine. The retrospective comparison of [99mTc]Tc-MAG3-GFK-Fab with the radiolabeled Fabs so far prepared under the identical concept suggested that some portion of [99mTc]Tc-MAG3-Gly was generated after the coated vesicle formation and they were excreted into the blood, and subsequently redistributed in the intestine via hepatobiliary excretion. In conclusion, MAG3-GFK-suc-TFP provided 99mTc-labeled Fabs that exhibit low renal radioactivity shortly after injection by the post-labeling procedure. The present study indicated that, contrary to our earlier proposal, the generation of the radiometabolites would proceed not only during the internalization process of the parental antibody fragments but also after coated vesicle formation. This study also showed that the intracellular behaviors of radiometabolites played crucial roles in the elimination rates and the routes of the radioactivity from the kidney.

Bioconjugate Chemistry published new progress about Brush border. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Related Products of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Ashima; Gupta, Shruti; Khurana, Jitender M. published the artcile< Zinc Chloride Mediated Nucleophilic Substitution: Amination and Thioetherification of Alcohols at Room Temperature>, SDS of cas: 76-84-6, the main research area is zinc chloride catalyst nucleophilic substitution amination thioetherification alc.

The authors report a high yielding, waste-free, efficient synthesis of thioethers and amines from secondary or tertiary alcs. and anilines or thiophenols in dichloromethane in the presence of ZnCl2 at room temperature

Organic Preparations and Procedures International published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, SDS of cas: 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kato, Yuichi; Inoue, Tomoka; Furuyama, Yuuki; Ohgane, Kenji; Sadaie, Mahito; Kuramochi, Kouji published the artcile< Deoxygenation of tertiary and secondary alcohols with sodium borohydride, trimethylsilyl chloride, and potassium iodide in acetonitrile>, Recommanded Product: Triphenylmethanol, the main research area is alkane preparation; tertiary secondary alc deoxygenation.

In this study, a deoxygenation method was developed for tertiary and secondary alcs., ROH [R = triphenylmethyl, 9-phenyl-9H-xanthen-9-yl, bis(4-methoxyphenyl)(thiophen-2-yl)methyl, etc.] using trimethylsilane and trimethylsilyl iodide generated in situ from sodium borohydride and trimethylsilyl chloride, and trimethylsilyl chloride and potassium iodide, resp. In this method, tertiary and secondary alcs., which provided stable carbocations, were converted into the corresponding alkanes RH. This paper also presents the optimization of the reaction conditions, the reaction mechanism, as well as the scope and limitations of the method.

Tetrahedron Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Recommanded Product: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts